Editorial Material
Substance Abuse
Robert West, Sharon Cox
Summary: The 1988 US Surgeon General's Report on Nicotine Addiction highlighted the addictive nature of tobacco and the role of nicotine in addiction. While the report's main conclusions have held up well over 30 years, it is now understood that different nicotine products vary in addictiveness and there is a need for updated thinking on this topic.
Article
Neurosciences
Karim S. Elayouby, Masago Ishikawa, Angeline J. Dukes, Alexander C. W. Smith, Qun Lu, Christie D. Fowler, Paul J. Kenny
Summary: The study reveals that alpha 3 beta 4* nAChRs play a crucial role in regulating the stimulating effects of nicotine on brain neurons, thereby influencing nicotine avoidance behaviors.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
Kar-Hai Chu, Tina B. Hershey, Beth L. Hoffman, Riley Wolynn, Jason B. Colditz, Jaime E. Sidani, Brian A. Primack
Summary: This study examined discussions related to Puff Bar on Twitter and found that the ban of e-cigarette flavors did not reduce interest, but instead shifted the discussion to brands utilizing a legal loophole to continue selling flavored products. The study also identified nicotine dependence and tobacco policy as the main topics of discussion.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Psychology, Clinical
Stevens S. Smith, Megan E. Piper, Daniel M. Bolt, Jesse T. Kaye, Michael C. Fiore, Timothy B. Baker
Summary: The study describes the psychometric development of a revised version of the Wisconsin Smoking Withdrawal Scale (WSWS) to measure nine putative withdrawal constructs. Through derivation and validation sample analyses, a longer version with 19 items and six subscales (WSWS2-L) and a brief 6-item version (WSWS2-B) were developed, demonstrating good reliability, validity, and fit in confirmatory factor analyses. The WSWS2-L and WSWS2-B have improved construct coverage, fewer items, and other enhancements compared to the original WSWS.
PSYCHOLOGICAL ASSESSMENT
(2021)
Article
Neurosciences
Thomas C. Jhou
Summary: Between 2005 and 2009, a new region (RMTg/tVTA) was discovered to provide dense inhibitory input to midbrain dopamine neurons, playing critical roles in behavioral inhibition, punishment learning, and aversive responses to drugs like cocaine and alcohol. Despite progress, important questions remain about the molecular/genetic properties, projection targets, and applications of the RMTg in addiction, depression, and other neuropsychiatric disorders.
Article
Psychiatry
Lorenzo Zamboni, Simone Campagnari, Rosaria Giordano, Francesca Fusina, Silvia Carli, Alessio Congiu, Isabella Barbon, Silvia Melchiori, Rebecca Casari, Elisa Tedeschi, Roberta Vesentin, Giuseppe Verlato, Maurizio Valentino Infante, Fabio Lugoboni
Summary: The study aims to compare the effects of two different treatment approaches on nicotine addiction patients, as well as the importance of environmental cues in the smoking cessation process.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Julie Bailly, Florence Allain, Eric Schwartz, Chloe Tirel, Charles Dupuy, Florence Petit, Marco A. Diana, Emmanuel Darcq, Brigitte L. Kieffer
Summary: This study found that the mu opioid receptor in the brain can promote aversive emotional states, and it is controlled by two different neural pathways (Hb-MOR/interpeduncular nucleus and Hb-MOR/dorsal raphe nucleus) that regulate despair and anxiety, respectively. These findings are important for understanding emotional balance and addiction mechanisms.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leila Salhi, Laurence Seidel, Adelin Albert, France Lambert
Summary: The study found that the nicotine dependence level assessed by FTND could complement NCC as an important indicator in periodontal research, and the combination of both could better predict the severity of periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyeji Lee, Yoonji Jeon, Cheolin Yoo, HeeYoung Seon, Jiwon Park, Minho Hwang, Kwangyeol Baek, Dongil Chung
Summary: Smoking is highly addictive and often leads to relapse. The neurobiological changes associated with smoking addiction are well-known, but it is unclear whether these changes persist after long periods of abstinence. This study used resting state EEG to examine the brain activity of chronic smokers, successful quitters, and never-smokers. The results showed that both smokers and successful quitters had decreased theta power compared to never-smokers, indicating the persistent effect of smoking on the brain. Additionally, other EEG features in the alpha frequency band were found to differ between active smokers and never-smokers, but not between successful quitters and never-smokers, suggesting that these changes may be reversible after long-term abstinence.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Viktor A. Stratilov, Oleg V. Vetrovoy, Ekaterina Tyulkova
Summary: This study investigates the effects and mechanisms of prenatal severe hypoxia (PSH) on predisposition to nicotine addiction in adult rats. The findings suggest that PSH can increase nicotine consumption and enhance withdrawal symptoms, indicating its role as a predisposing factor for nicotine addiction. Additionally, the study reveals an altered glutamate signaling phenotype in PSH rats, which might contribute to the development of nicotine addiction.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
A. P. Varani, V. T. Pedron, A. J. Aon, E. M. Canero, G. N. Balerio
Summary: The GABA(B) agonist baclofen has shown to prevent somatic and motivational responses induced by nicotine withdrawal by affecting dopamine levels and alpha 4 beta 2 nicotinic acetylcholine receptor density. This highlights the importance of GABA(B) receptors in treating nicotine addiction in humans.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Imran Ibni Gani Rather, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Aditi Sharma, Saurabh Bhatia, Ahmed AL-Harrasi, Nadeem Khan, Haroon Khan, Simona Bungau
Summary: The RhoA gene is associated with nicotine dependence and smoking initiation. The study examined the effect of the Rho GTPase inhibitor ML141 on the progression of nicotine dependence in a mouse model, finding that inhibition of Rho GTPase reduced the severity of withdrawal syndrome, suggesting it as a potential target for drug discovery in regulating the brain reward system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Krishna Subedi, Ashish Shrestha, Tarakant Bhagat
Summary: The study found high levels of nicotine dependence among smokers and smokeless tobacco users visiting dental outreach programs. It is recommended to develop policies to control tobacco use and establish tobacco cessation centers.
Article
Psychiatry
Kerim Abdelkhalek, Mathias Rhein, Maximilian Deest, Vanessa Buchholz, Stefan Bleich, Ralf Lichtinghagen, Benjamin Vyssoki, Helge Frieling, Marc Muschler, Phileas Johannes Proskynitopoulos, Alexander Glahn
Summary: This study investigated the regulation of BDNF protein levels and gene methylation in smokers and during smoking cessation. The results showed that BDNF plasma levels and methylation levels were lower in healthy controls compared to smokers at all time points. BDNF levels decreased significantly during the cessation period. Female smokers had significantly lower plasma BDNF levels than healthy controls, while male and female smokers showed higher mean methylation rates than non-smokers at baseline. In male smokers, mean methylation levels decreased significantly during the cessation period.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biology
Monika Ostap-Chec, Monika Opalek, Daniel Stec, Krzysztof Miler
Summary: Honeybee workers exhibit withdrawal symptoms, with increased ethanol consumption and mortality rates, after prolonged exposure to ethanol spiked food, but do not display an increased appetite for ethanol diluted in water. These findings suggest that workers can develop alcohol dependence and may be a valuable model for studying alcohol addiction in a natural setting.
Article
Neurosciences
Humsini Viswanath, Kenia M. Velasquez, Ricky Savjani, David L. Molfese, Kaylah Curtis, Peter J. Molfese, David M. Eagleman, Philip R. Baldwin, B. Christopher Frueh, J. Christopher Fowler, Ramiro Salas
Book Review
Psychology, Developmental
David L. Molfese
DEVELOPMENTAL NEUROPSYCHOLOGY
(2010)
Article
Psychology, Developmental
David L. Molfese
DEVELOPMENTAL NEUROPSYCHOLOGY
(2011)
Review
Neurosciences
Humsini Viswanath, Asasia Q. Carter, Philip R. Baldwin, David L. Molfese, Ramiro Salas
FRONTIERS IN HUMAN NEUROSCIENCE
(2014)
Article
Neurosciences
Swati Gupta, Se Y. Kim, Sonja Artis, David L. Molfese, Armin Schumacher, J. David Sweatt, Richard E. Paylor, Farah D. Lubin
JOURNAL OF NEUROSCIENCE
(2010)
Article
Biophysics
Khader M. Hasan, David L. Molfese, Indika S. Walimuni, Karla K. Stuebing, Andrew C. Papanicolaou, Ponnada A. Narayana, Jack M. Fletcher
NMR IN BIOMEDICINE
(2012)
Article
Psychiatry
Selina Baeza-Loya, Humsini Viswanath, Asasia Carter, David L. Molfese, Kenia M. Velasquez, Philip R. Baldwin, Daisy G. Y. Thompson-Lake, Carla Sharp, J. Christopher Fowler, Richard De La Garza, Ramiro Salas
BULLETIN OF THE MENNINGER CLINIC
(2014)
Article
Biochemistry & Molecular Biology
JM Levenson, KJ O'Riordan, KD Brown, MA Trinh, DL Molfese, JD Sweatt
JOURNAL OF BIOLOGICAL CHEMISTRY
(2004)
Article
Neurosciences
TS Braver, DM Barch, JR Gray, DL Molfese, A Snyder
Article
Clinical Neurology
RK Fulbright, DL Molfese, AA Stevens, P Skudlarski, CM Lacadie, JC Gore
AMERICAN JOURNAL OF NEURORADIOLOGY
(2000)
Article
Audiology & Speech-Language Pathology
DL Molfese, DL Molfese, VJ Molfese
BRAIN AND LANGUAGE
(2000)