Article
Behavioral Sciences
Clare Press, Emily R. Thomas, Daniel Yon
Summary: Traditional theories of action control and action awareness propose that the brain cancels expected action outcomes from perception. However, recent research challenges this premise. This paper argues that while doubts about predictive cancellation may require a rethinking of how predictions shape perception, the overall framework for explaining action control and agency can remain intact. Some adaptive functions assigned to predictive cancellation can still be achieved through quasi-predictive processes, while other functions may rely on true predictions without canceling perception. Understanding these processes can help us move forward in understanding how agents optimize their interactions with the external world, even without predictive cancellation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychology, Multidisciplinary
Tara L. White, Meghan A. Gonsalves, Chloe Zimmerman, Hannah Joyce, Ronald A. Cohen, Uraina S. Clark, Lawrence H. Sweet, Carl W. Lejuez, Adam Z. Nitenson
Summary: This study introduces a concept called agentic anger, which is a negatively valenced state that motivates action to achieve risky goals. The neurobehavioral model was evaluated through two proof-of-concept studies, revealing the relationship between agentic anger, reward, and personality traits.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Liyu Cao, Michael B. Steinborn, Barbara F. Haendel
Summary: The study found a positive correlation between delusional thinking and action binding in healthy individuals, indicating that delusional thinking influences action time perception. These results support the notion of a continuous distribution of schizotypal traits with normal controls at one end and clinical patients at the other end.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Clinical
Catherine Hobbs, Jie Sui, David Kessler, Marcus R. Munafo, Katherine S. Button
Summary: This study examined the cognitive differences in self-reference, emotion, and reward processing among individuals with depression. The results showed that there was little association between self-reference and depression when measured independently. However, when self-reference was combined with emotion and reward processing, depression was associated with an increased positive bias towards others.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Chiara Baiano, Xavier Job, Louise P. P. Kirsch, Malika Auvray
Summary: Information can be perceived from different spatial perspectives, and interoception plays a role in our perception. However, the impact of perceiving our internal body signals on spatial perspective-taking is not well understood.
SCIENTIFIC REPORTS
(2023)
Article
History & Philosophy Of Science
Sophie Keeling
Summary: This paper argues that individuals have agency over their beliefs just like they do over their actions. According to the author, self-awareness is crucial for the agency of belief. Drawing on the philosophy of action, the author demonstrates how individuals exercise agency in forming and sustaining their beliefs through mental actions, being aware of these actions as part of reasoning and exerting agency over their beliefs.
Article
Psychology, Clinical
Ofir Shany, Netta Dunsky, Gadi Gilam, Ayam Greental, Eva Gilboa-Schechtman, Talma Hendler
Summary: This study investigates the brain activity related to threat and reward processing in the self-evaluation of power in social anxiety. The results suggest that self-evaluation of high power in social anxiety is associated with increased activity in the ventral striatum and ventromedial prefrontal cortex.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Zachary Adam Yaple, Serenella Tolomeo, Rongjun Yu
Summary: This study investigated prediction error processing in depression and schizophrenia patients through meta-analyses, finding differences in brain activity between the two patient groups, suggesting a potential role of dopamine-rich areas in encoding prediction errors in both disorders.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Mathematical
Kate Ergo, Luna De Vilder, Esther De Loof, Tom Verguts
Summary: Research shows that any type of reward prediction error (RPE), whether from the participant's own response or other sources, can drive declarative learning. This finding has important implications for declarative learning theory.
PSYCHONOMIC BULLETIN & REVIEW
(2021)
Article
Psychology, Clinical
Paola Fuentes-Claramonte, Maria Angeles Garcia-Leon, Pilar Salgado-Pineda, Nuria Ramiro, Joan Soler-Vidal, Maria Llanos Torres, Ramon Cano, Isabel Argila-Plaza, Francesco Panicali, Carmen Sarri, Nuria Jaurrieta, Manel Sanchez, Ester Boix-Quintana, Auria Albacete, Teresa Maristany, Salvador Sarro, Joaquim Radua, Peter. J. McKenna, Raymond Salvador, Edith Pomarol-Clotet
Summary: The negative symptoms of schizophrenia may be due to reduced responsiveness to rewarding stimuli, which is associated with abnormal dopamine function in the disorder. However, few imaging studies have examined whether patients with negative symptoms show reduced activation related to reward prediction error (RPE). The findings suggest that negative symptoms are not caused by a generalized reduction in RPE signaling, but rather by specific dysfunction in the lateral frontal and possibly the orbitofrontal cortex.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Ji Woon Jeong, Hyun Taek Kim, Seung-Hwan Lee, Hyejeen Lee
Summary: Individuals with schizophrenia have difficulty integrating facial and vocal information in emotion perception, but a multimodal training involving audiovisual stimuli may improve their recognition of anger, with sustained and generalized effects, while the improvement in recognizing happiness may not be sustained or generalized.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
E. Dawe-Lane, E. Flouri
Summary: Research explores the relationship between early parenting and self-harm in adolescence, and investigates the mediating role of emotion regulation and decision-making in childhood. The study finds indirect effects of parenting on self-harm through emotional dysregulation and identifies a positive association between delay aversion and self-harm in adolescence.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Mitchell G. Spring, Aaron Caccamise, Elizabeth A. Panther, Bethany M. Windsor, Karan R. Soni, Jayme R. McReynolds, Daniel S. Wheeler, John R. Mantsch, Robert A. Wheeler
Summary: Chronic stress diminishes task-related activity of brain pathways regulating approach behavior, reducing cue-directed behavior and impairing associated cortical activity. Stress disrupts reward processing by altering the incentive value of associated cues.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Daniel C. Mograbi, Jonathan Huntley, Hugo Critchley
Summary: This article explores self-awareness in dementia from a neurobiological perspective, presenting a taxonomy of self-awareness processes and discussing their structuring across different levels of cognitive complexity. Recent findings suggest that while higher-level cognitive processes may be impaired in dementia patients, capacities such as body ownership and agency are relatively preserved. An integrative framework based on predictive coding and compensatory abilities related to the resilience of self-awareness in dementia is discussed, highlighting potential avenues for future research.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Review
Behavioral Sciences
Kent C. Berridge
Summary: Individuals' desires are influenced not only by memories and learned predictions, but also by the independent operating rules of motivational incentive salience. Even outcomes that are remembered and predicted to be negative can be positively wanted.
TRENDS IN COGNITIVE SCIENCES
(2023)
Article
Clinical Neurology
Tim W. Rattay, Maximilian Voelker, Maren Rautenberg, Christoph Kessler, Isabel Wurster, Natalie Winter, Tobias B. Haack, Tobias Lindig, Holger Hengel, Matthis Synofzik, Rebecca Schule, Peter Martus, Ludger Schoels
Summary: This study explores early changes in the most common subtype of hereditary spastic paraplegia, SPG4, and identifies subclinical markers of disease activity in the prodromal stage. The findings suggest that certain clinical signs, such as increased reflexes and muscle weakness, may be more frequent in individuals who carry the genetic mutation associated with SPG4.
Article
Clinical Neurology
Adam P. Vogel, Lisa H. Graf, Michelle Magee, Ludger Schoels, Natalie Rommel, Matthis Synofzik
Summary: This study evaluated the efficacy of a home-delivered, ataxia-tailored biofeedback-driven speech therapy in individuals with CAG-SCA, and found that the treatment improved intelligibility in the patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Elizabeth Finger, Rubina Malik, Martina Bocchetta, Kristy Coleman, Caroline Graff, Barbara Borroni, Mario Masellis, Robert Laforce, Caroline Greaves, Lucy L. Russell, Rhian S. Convery, Arabella Bouzigues, David M. Cash, Markus Otto, Matthis Synofzik, James B. Rowe, Daniela Galimberti, Pietro Tiraboschi, Robert Bartha, Christen Shoesmith, Maria Carmela Tartaglia, John C. van Swieten, Harro Seelaar, Lize C. Jiskoot, Sandro Sorbi, Chris R. Butler, Alexander Gerhard, Raquel Sanchez-Valle, Alexandre de Mendonca, Fermin Moreno, Rik Vandenberghe, Isabelle Le Ber, Johannes Levin, Florence Pasquier, Isabel Santana, Jonathan D. Rohrer, Simon Ducharme
Summary: This study investigates the hypothesis that genetic mutations causing frontotemporal dementia (FTD) have neurodevelopmental consequences. The researchers examined brain structure and function in young adult mutation carriers and found differences between preclinical mutation carriers and familial non-carriers at a mean age of 26 years. These findings have implications for therapeutic interventions and further studies on early pathophysiologic processes in FTD.
Editorial Material
Biochemistry & Molecular Biology
Annemieke Aartsma-Rus, Willeke van Roon-Mom, Marlen Lauffer, Christine Siezen, Britt Duijndam, Tineke Coenen-de Roo, Rebecca Schuele, Matthis Synofzik, Holm Graessner
Summary: Splice-modulating antisense oligonucleotides (ASOs) provide treatment options for rare neurological diseases with rare mutations, and patient-specific ASOs need to be developed. The 1 Mutation 1 Medicine (1M1M) and Dutch Center for RNA Therapeutics (DCRT) aim to develop and treat eligible patients with patient-specific ASOs in Europe and the Netherlands, respectively, under a named patient setting.
Article
Neurosciences
Wolfram Ziegler, Theresa Schoelderle, Bettina Brendel, Verena Risch, Stefanie Felber, Katharina Ott, Georg Goldenberg, Mathias Vogel, Kai Boetzel, Lena Zettl, Stefan Lorenzl, Renee Lampe, Katrin Strecker, Matthis Synofzik, Tobias Lindig, Hermann Ackermann, Anja Staiger
Summary: This study investigated the relationship between commonly used nonspeech parameters in clinical dysarthria assessment and the speech characteristics of dysarthria in individuals with movement disorders. The findings suggest that the nonspeech parameters currently used in dysarthria diagnostics do not align with diagnostic measures of speech characteristics in individuals with dysarthria.
Letter
Clinical Neurology
Zofia Fleszar, Claudia Dufke, Marc Sturm, Rebecca Schuele, Ludger Schoels, Tobias B. Haack, Matthis Synofzik
JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
M. Grobe-Einsler, J. Faber, A. Taheri, J. Kybelka, J. Raue, J. Volkening, F. Helmhold, M. Synofzik, T. Klockgether
Summary: Ataxias refer to a group of movement disorders, characterized by progressive loss of balance, impaired coordination, and speech disturbance, resulting in a significant reduction in quality of life. Although speech disturbance can be clinically diagnosed, there is a lack of objective methods for assessing its severity. Through the analysis of 71 sets of speech recordings from ataxia patients, an automated classification system was developed. This system correctly predicted the expert ratings of speech disturbance in 80% of cases, demonstrating the feasibility of computer-assisted voice analysis for automated assessment of speech disturbance severity.
NPJ DIGITAL MEDICINE
(2023)
Article
Clinical Neurology
Curtiss A. Chapman, Maryna Polyakova, Karsten Mueller, Christopher Weise, Klaus Fassbender, Klaus Fliessbach, Johannes Kornhuber, Martin Lauer, Sarah Anderl-Straub, Albert Ludolph, Johannes Prudlo, Anja Staiger, Matthis Synofzik, Jens Wiltfang, Lina Riedl, Janine Diehl-Schmid, Markus Otto, Adrian Danek, Gesa Hartwigsen, Matthias L. Schroeter
Summary: Understanding the relationship between brain structure and language behavior in primary progressive aphasia is crucial for understanding the pathomechanisms of these diseases. This study found that there are networks of language task-associated brain regions, some of which show atrophy and others do not, suggesting regions of future network disruption and providing insights into task deficits beyond atrophied cortex.
BRAIN COMMUNICATIONS
(2023)
Article
Cell Biology
David Mengel, Isabel G. Wellik, Kristen H. Schuster, Sabrina I. Jarrah, Madeleine Wacker, Naila S. Ashraf, Gulin Oez, Matthis Synofzik, Maria do Carmo Costa, Hayley S. Mcloughlin
Summary: The study found that blood NfL levels gradually increase in a SCA3 mouse model during disease progression, and are associated with motor deficits and neurometabolite abnormalities related to ataxia. This further supports the utility of blood NfL as a peripheral biomarker for neurodegenerative diseases, and provides a timeline for different measures of SCA3 pathogenesis.
DISEASE MODELS & MECHANISMS
(2023)
Letter
Clinical Neurology
Holger Hengel, David Pellerin, Carlo Wilke, Zofia Fleszar, Bernard Brais, Tobias Haack, Andreas Traschuetz, Ludger Schoels, Matthis Synofzik
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Andreas Traschuetz, Felix Heindl, Muhammad Bilal, Annette M. Hartmann, Claudia Dufke, Olaf Riess, Andreas Zwergal, Dan Rujescu, Tobias Haack, Matthis Synofzik, Michael Strupp
Summary: Bilateral vestibulopathy is a chronic neurological disorder with unknown monogenic cause. This study identifies replication factor complex subunit 1 repeat expansions as a common cause of the disease and provides detailed characterization of its features and progression.
Article
Biology
Federico Zilio, Javier Gomez-Pilar, Ujwal Chaudhary, Stuart Fogel, Tatiana Fomina, Matthis Synofzik, Ludger Schols, Shumei Cao, Jun Zhang, Zirui Huang, Niels Birbaumer, Georg Northoff
Summary: EEG-based measures such as power-law exponent (PLE) and Lempel-Ziv complexity (LZC) can be used to identify biomarkers associated with complete locked-in syndrome (CLIS), allowing for better treatment and communication options.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Arian Taheri Amin, Jennifer Faber, Demet Onder, Okka Kimmich, Matthis Synofzik, Tetsuo Ashizawa, Thomas Klockgether, Marcus Grobe-Einsler
Summary: After conducting comprehensive SARA assessments on video recordings of 69 patients with cerebellar ataxia, it was found that there was a high level of agreement between live ratings by site investigators and remote video ratings by experienced ataxia clinicians, indicating that remote video ratings are a reliable means to assess the severity of ataxia.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Catherine Ashton, Elisabetta Indelicato, David Pellerin, Guillemette Clement, Matt C. Danzi, Marie-Josee Dicaire, Celine Bonnet, Henry Houlden, Stephan Zuechner, Matthis Synofzik, Phillipa J. Lamont, Mathilde Renaud, Sylvia Boesch, Bernard Brais
Summary: Ashton C et al report a retrospective multi-centre cohort study of 34 patients from Canada, France, Austria and Australia with spinocerebellar ataxia 27B. The study describes the common feature of episodic ataxia and other episodic features, and also highlights the ineffectiveness of acetazolamide in these patients.
BRAIN COMMUNICATIONS
(2023)
Article
Neurosciences
Filippo Santorelli, Hayley McLoughlin, Justin Wolter, Daniele Galatolo, Matthis Synofzik, David Mengel, Puneet Opal
Summary: The Ataxia Global Initiative (AGI) aims to facilitate clinical trial readiness for hereditary ataxias by addressing the lack of objective measures for disease study and treatment evaluation. The AGI fluid biomarker working group has developed protocols to standardize sampling and storage of biomarkers for both human and mouse studies, with the goal of reducing variability and improving statistical power in downstream analysis. Emphasis has been placed on harmonizing minimal biological sample collection and storage, while optional protocols are available for advanced biofluid processing and storage.