Article
Biology
Cecilia Gallego-Carracedo, Matthew G. Perich, Raeed H. Chowdhury, Lee E. Miller, Juan alvaro Gallego, Srdjan Ostojic
Summary: This study investigates the relationship between latent dynamics and local field potentials (LFPs), and finds that this relationship remains stable throughout behavior, bridging the gap between studies on neural correlates of behavior using different types of recordings.
Article
Multidisciplinary Sciences
Federico Rocchi, Carola Canella, Shahryar Noei, Daniel Gutierrez-Barragan, Ludovico Coletta, Alberto Galbusera, Alexia Stuefer, Stefano Vassanelli, Massimo Pasqualetti, Giuliano Iurilli, Stefano Panzeri, Alessandro Gozzi
Summary: This study investigates how inactivation of a cortical node affects brain-wide fMRI connectivity in mice, providing causal evidence that cortical inactivation can unexpectedly increase fMRI connectivity.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
David A. Feinberg, Alexander J. S. Beckett, An T. Vu, Jason Stockmann, Laurentius Huber, Samantha Ma, Sinyeob Ahn, Kawin Setsompop, Xiaozhi Cao, Suhyung Park, Chunlei Liu, Lawrence L. Wald, Jonathan R. Polimeni, Azma Mareyam, Bernhard Gruber, Ruediger Stirnberg, Congyu Liao, Essa Yacoub, Mathias Davids, Paul Bell, Elmar Rummert, Michael Koehler, Andreas Potthast, Ignacio Gonzalez-Insua, Stefan Stocker, Shajan Gunamony, Peter Dietz
Summary: To increase granularity in human neuroimaging science, a next-generation 7 Tesla magnetic resonance imaging scanner was designed and built. It implemented several hardware advancements to improve spatial resolution, image signal-to-noise ratio, and reduce acquisition time.
Article
Neurosciences
Wilf Gardner, Fanny Fuchs, Laura Durieux, Patrice Bourgin, Volker A. Coenen, Mate Doebroessy, Lucas Lecourtier
Summary: This study characterized sleep deficits in a rodent model of depression and investigated the effects of MFB stimulation on sleep-related phenotypes. The results showed abnormalities in slow wave sleep and replicated rapid eye movement sleep deficits. MFB stimulation had antidepressant effects on behavior but did not significantly impact sleep architecture.
Article
Neurosciences
Hyun Seok Moon, Haiyan Jiang, Thanh Tan Vo, Won Beom Jung, Alberto L. Vazquez, Seong-Gi Kim
Summary: This study investigated the roles of inhibitory and excitatory activity in the cortex using various methods, revealing different effects on BOLD fMRI between stimulating excitatory neurons and inhibitory neurons, with the latter showing biphasic responses and higher sensitivity to stimulation frequency.
Article
Multidisciplinary Sciences
Maelle C. M. Gueguen, Alizee Lopez-Persem, Pablo Billeke, Jean-Philippe Lachaux, Sylvain Rheims, Philippe Kahane, Lorella Minotti, Olivier David, Mathias Pessiglione, Julien Bastin
Summary: The debate on whether maximizing rewards and minimizing punishments rely on distinct brain systems continues. Using intracerebral recordings in humans, the authors provide evidence for brain regions differentially engaged in signaling reward and punishment prediction errors that prescribe repetition versus avoidance of past choices.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Xiaofeng Han, Shuxia Guo, Nan Ji, Tian Li, Jian Liu, Xiangqiao Ye, Yi Wang, Zhixi Yun, Feng Xiong, Jing Rong, Di Liu, Hui Ma, Yujin Wang, Yue Huang, Peng Zhang, Wenhao Wu, Liya Ding, Michael Hawrylycz, Ed Lein, Giorgio A. Ascoli, Wei Xie, Lijuan Liu, Liwei Zhang, Hanchuan Peng
Summary: In this study, a unique approach was proposed to collect three-dimensional images of brain neurons by injecting dyes into patients' brain tissues. The research found that human neurons are more diverse across brain regions than by subject age or gender. Furthermore, the strong stereotypy within brain region cohorts allows for the generation of a statistical tensor field of neuron morphology to characterize the anatomical modularity of a human brain.
Article
Neurosciences
Yun Lin, Xi Zhou, Yuji Naya, Justin L. Gardner, Pei Sun
Summary: The study assessed the linearity of both BOLD signal increments and decrements in the human primary visual cortex, finding that they remained linear for long stimuli but deviated for transient stimuli. Voxel-wise analysis revealed different deviation patterns for BOLD signal increments and decrements.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Marcin Leszczynski, Leila Chaieb, Tobias Staudigl, Simon Jonas Enkirch, Juergen Fell, Charles E. Schroeder
Summary: In natural vision, saccades induce a phase reset of neuronal oscillations in primary and higher-order visual cortices and in the medial temporal lobe, shifting neuron ensembles to a common state. Recordings in the human thalamus suggest that the anterior nuclei are predictively modulated before saccadic eye movements, with oscillatory phase concentration coinciding with the suppression of high-frequency activity. This study supports the idea that neural dynamics in the human anterior nuclei of the thalamus are influenced by visual and oculomotor events during natural vision, suggesting an additional role apart from episodic memory.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Atena Akbari, Saskia Bollmann, Tonima S. Ali, Markus Barth
Summary: Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast is a widely used noninvasive method for studying human brain function. However, spatial signal specificity in depth-dependent fMRI can be degraded due to signal leakage. VAscular-Space-Occupancy (VASO) contrast, which measures cerebral blood volume, has shown higher spatial specificity compared to BOLD. In this study, a cortical vascular model was used to predict layer-specific BOLD and VASO responses in the human primary visual cortex, and the model's predictions were compared with experimental results. The results confirmed that VASO is less affected by large vessel effects compared to BOLD.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Xiang Ji, Tiago Ferreira, Beth Friedman, Rui Liu, Hannah Liechty, Erhan Bas, Jayaram Chandrashekar, David Kleinfeld
Summary: The study found a common network topology and shared structural robustness against rarefaction of vessels in the brain. The orientation of capillaries is mostly weakly anisotropic, with a few strongly anisotropic regions. Furthermore, regional differences in metabolism can be connected to differences in length density, predicting a common value of maximum tissue oxygen tension across the brain.
Article
Neurosciences
Alexander N. Silchenko, Felix Hoffstaedter, Simon B. Eickhoff
Summary: Interactions within brain networks are directional, and spectral dynamic causal modeling (DCM) is used to detect them. However, the stability of connectivity parameters depends on sample size and nuisance signals. Analyzing data from 330 individuals, we find that a sample size of at least 50 is needed for stable DCM results and demonstrate the importance of subject-specific regression for weak connections.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Laura Biagi, Michela Tosetti, Sofia Allegra Crespi, Maria Concetta Morrone
Summary: Behavioral studies suggest that motion perception is rudimentary at birth and matures steadily over the first few years. Previous research shows that certain cortical areas involved in motion processing exhibit selective responses to coherent flow in 8-week-old infants. In this study, researchers found that 5-week-old infants also show similar motion responses in some areas, but not all, indicating a differential developmental trajectory for different occipital regions and possibly the central and peripheral visual field.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Xiaoxuan Yan, Ru Kong, Aihuiping Xue, Qing Yang, Csaba Orban, Lijun An, Avram J. Holmes, Xing Qian, Jianzhong Chen, Xi-Nian Zuo, Juan Helen Zhou, Marielle Fortier, Ai Peng Tan, Peter Gluckman, Yap Seng Chong, Michael J. Meaney, Danilo Bzdok, Simon B. Eickhoff, B. T. Thomas Yeo
Summary: Resting-state fMRI is used to derive brain parcellations, and researchers have developed a model for estimating areal-level cortical parcellations. They extended the model to derive homotopic parcellations and demonstrated their potential applications in studying brain lateralization. The results highlight the significance of homotopic parcellations in subdividing the cerebral cortex into functional regions.
Article
Neurosciences
Qingqing Zhang, Samuel R. Cramer, Kevin L. Turner, Thomas Neuberger, Patrick J. Drew, Nanyin Zhang
Summary: In this study, it was found that the multi-phase blood-oxygen-level dependent (BOLD) response observed in the visual cortices of unanesthetized rats during decreased illumination can be better explained by the high-frequency neuronal signal rather than non-neuronal physiological factors. The phases of the BOLD response were found to be reproducible and were not simply a result of the periodic stimulation structure.
Article
Clinical Neurology
E. Salari, Z. V. Freudenburg, M. J. Vansteensel, N. F. Ramsey
Article
Computer Science, Interdisciplinary Applications
Mark L. C. M. Bruurmijn, Wouter Schellekens, Mathijs A. H. Raemaekers, Nick F. Ramsey
Article
Engineering, Biomedical
Max A. van den Boom, Kai J. Miller, Nick F. Ramsey, Dora Hermes
Summary: The study investigated how the design and surgical placement of electrode grids impact the usability of ECoG measurements, finding that grid configurations with a higher number of densely-packed, large-size electrodes are optimal for capturing the dynamics of hand gesture information. In informative regions of the primary sensorimotor cortex, a grid configuration with 3x3 electrodes, 8 mm inter-electrode distance, and 3 mm electrode size achieved the highest decoding accuracy at around 70% three-class classification accuracy.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Anatomy & Morphology
Alessio Fracasso, Anna Gaglianese, Mariska J. Vansteensel, Erik J. Aarnoutse, Nick F. Ramsey, Serge O. Dumoulin, Natalia Petridou
Summary: This study found that positive blood oxygenation level-dependent (BOLD) responses are correlated with high-frequency band (HFB) responses in electrodes responding to visual stimulation, while negative BOLD responses are associated with an absence of HFB power responses and an unexpected decrease in alpha power responses.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Engineering, Biomedical
L. C. M. Bruurmijn, M. Raemaekers, M. P. Branco, M. J. Vansteensel, N. F. Ramsey
Summary: This study investigates the effects of denervation on the movement representation on the ipsilateral sensorimotor cortex, and the results show that decoding both hands from the same hemisphere is possible even years after denervation. This suggests that implantation of motor-electrodes for BCI control may only need to cover a single hemisphere, making surgery less invasive and providing more options for individuals with lateralized damage to the motor cortex.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Rehabilitation
Mariana P. Branco, Elmar G. M. Pels, Femke Nijboer, Nick F. Ramsey, Mariska J. Vansteensel
Summary: The development of effective Brain-Computer Interfaces (BCIs) relies on collaboration between end-users, caregivers, and researchers. This study compared the opinions of prospective BCI users, caregivers, and BCI researchers regarding BCI applications, mental strategies, and timing of information. The results highlighted the need to align research agendas with the needs of end-users and caregivers to advance the development and implementation of BCIs.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Neurosciences
Mark L. C. M. Bruurmijn, Mathijs Raemaekers, Mariana P. Branco, Nick F. Ramsey, Mariska J. Vansteensel
Summary: There is evidence suggesting the importance of the contralateral sensorimotor areas in movement generation, but the exact role of the ipsilateral sensorimotor cortex in unilateral movement control remains unclear. High-field fMRI data showed hand movement representation in the ipsilateral sensorimotor hand area, supporting the notion of transcallosal integrative processes for optimal coordination of hand movements.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Maxime Verwoert, Mariska J. Vansteensel, Zachary Freudenburg, Erik J. Aarnoutse, Frans S. S. Leijten, Nick F. Ramsey, Mariana P. Branco
Summary: The study demonstrates that four hand gestures can be effectively decoded using a single bipolar pair, showing the potential for further development of motor-based BCIs.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Mansoureh Fahimi Hnazaee, Maxime Verwoert, Zachary Freudenburg, Sandra M. A. van der Salm, Erik J. Aarnoutse, Sacha Leinders, Marc M. Van Hulle, Nick F. Ramsey, Mariska J. Vansteensel
Summary: This study investigates whether non-invasive scalp electroencephalography (EEG) can predict the performance of brain-computer interfaces (BCIs) based on electrocorticography (ECoG). By analyzing the experimental results of participants with locked-in syndrome (LIS) and healthy participants, it was found that EEG can detect the characteristics observed in ECoG signals. These findings provide new insights for predicting the performance of ECoG-BCIs.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Iris I. A. Groen, Giovanni Piantoni, Stephanie Montenegro, Adeen Flinker, Sasha Devore, Orrin Devinsky, Werner Doyle, Patricia Dugan, Daniel Friedman, Nick F. Ramsey, Natalia Petridou, Jonathan Winawer
Summary: Neural responses to visual stimuli exhibit complex temporal dynamics, which can be captured by a computational model. This study demonstrates the integration of various temporal features, such as subadditive temporal summation, adaptation, and slower dynamics at low contrast, within the same experiment. The model accurately captures the temporal dynamics in different regions of the visual cortex.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Julia Berezutskaya, Zachary Freudenburg, Mariska J. Vansteensel, Erik J. Aarnoutse, Nick F. Ramsey, Marcel A. J. van Gerven
Summary: This study optimized and validated a decoding approach for speech reconstruction from sensorimotor cortex recordings, demonstrating the importance of machine learning model optimization for achieving high accuracy reconstruction and the potential of sensorimotor cortex reconstruction for intelligible speech. This has significant implications for the development of next-generation BCI technology.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Mariska J. Vansteensel, Mariana P. Branco, Sacha Leinders, Zac F. Freudenburg, Anouck Schippers, Simon H. Geukes, Michael A. Gaytant, Peter H. Gosselaar, Erik J. Aarnoutse, Nick F. Ramsey
Summary: Implantable brain-computer interfaces (BCIs) can be used to restore communication with individuals with locked-in syndrome (LIS). However, further validation and speed improvement are needed for future clinical implementation. This article provides procedures and recommendations for recruitment, inclusion, implantation, and training of participants with LIS, aiming to contribute to the methodological standardization of implantable BCI research.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Clinical Neurology
Mariana P. Branco, Elmar G. M. Pels, Ruben H. Sars, Erik J. Aarnoutse, Nick F. Ramsey, Mariska J. Vansteensel, Femke Nijboer
Summary: The research assessed the preferences of potential cBCI users regarding applications, control strategies, and timing of information, finding that there was not much difference in opinions between individuals diagnosed with progressive and sudden onset disorders.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Engineering, Biomedical
M. Vermaas, M. C. Piastra, T. F. Oostendorp, N. F. Ramsey, P. H. E. Tiesinga
JOURNAL OF NEURAL ENGINEERING
(2020)
Article
Engineering, Biomedical
Mariana P. Branco, Simon H. Geukes, Erik J. Aarnoutse, Mariska J. Vansteensel, Zachary Freudenburg, Nick F. Ramsey
JOURNAL OF NEURAL ENGINEERING
(2019)