期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 16, 期 -, 页码 368-392出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3693
关键词
Ovary; Human; Cancer; Stem Cells; Xenograft; Transplantation; Review
资金
- Advanced Medical Research Foundation
- Ovarian Cancer Research Fund
- Ovarian Cancer Education and Awareness Network (O.C.E.A.N.)
- Vincent Memorial Research Funds
- Harvard Stem Cell Institute
- DFHCC Ovarian SPORE [5P50CA105009]
- NATIONAL CANCER INSTITUTE [P50CA105009] Funding Source: NIH RePORTER
Ovarian cancer represents the most lethal gynecologic malignancy, primarily due to a lack of early detection, which results in most patients being diagnosed at an advanced stage of disease. Though the ovarian surface epithelium is thought to provide the primary site of tumorigenesis, the exact etiology of the various tumor types associated with this disease remain undefined. Recent evidence suggests that ovarian tumors, like other solid tumors, contain distinct populations of cells that are responsible for tumor initiation, maintenance and growth. These specialized cells, termed cancer stem cells, display some of the hallmarks of normal stem cells and are thought to evade current chemotherapeutic strategies, resulting in an increased risk of recurrence. Here we review evidence for the existence of cancer stem cells in ovarian malignancies and their contribution to the pathology of this disease, critically evaluate the methods used for ovarian cancer stem cell definition and isolation, and discuss their clinical relevance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据