期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 14, 期 -, 页码 4719-4745出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3563
关键词
Bile; Cholestasis; Cholesterol; Gene Expression; Lipids; Liver; Nuclear Receptors; Intestine; Review
资金
- Italian Association for Cancer Research (AIRC, Milan, Italy)
- Fondazione NegriSud
- Telethon [GGP08259]
- University of Bari, Italy [ORBA08WEZJ, ORBA07X7Q1, ORBA06BXVC]
- CariChieti (Italy)
Recent discoveries highlighted intriguing molecular pathways that regulate synthesis, uptake, metabolism and excretion of bile acids and xenobiotics. The knowledge of factors that control these homeostatic processes is of clinical relevance to better understand the drug-drug interacting scenario as well as to control cholesterol detoxification, cholestasis and other conditions. Here we present evidences for the existence of a gut-liver safety network whereby activation of the nuclear receptor FXR, PXR, CAR trio provides protection against accumulation of exogenous and metabolic noxae.
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