期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 14, 期 -, 页码 1182-U7出版社
BIOSCIENCE RESEARCH INST-BRI
DOI: 10.2741/3302
关键词
PML; PML Nuclear Bodies; DNA damage; MHC; PML Nuclear Body Function; Nuclear Organization; Nuclear Architecture; Nuclear Compartments; Mammalian Nucleus; Spatial Organization; Spatial Relationships; Spatial Associations; Co-Localization; Immunofluorescence; Transcription; DNA Replication; Centromeres; Telomeres; Nucleoli; Chromatin; Proteolysis; Viral Response; Interferon; Stress; Review
资金
- BBSRC
Promyelocytic leukaemia nuclear bodies (PML NBs) are found within the nucleus of mammalian cells, and are formed from the constituent proteins PML and Sp100. Numbering between 10 and 30 per cell, they are an obvious feature of the nuclear landscape, yet their functions have still to be unambiguously defined. In the mammalian nucleus, compartmentalization of functions is apparent, as reflected in the wide-range of other nuclear compartments that can be identified. These include nucleoli, transcription foci, splicing speckles, chromosomal topological markers such as centromeres and telomeres, the nuclear boundary, and the nucleoplasm itself. Quantification of the otherwise qualitative observations of relationships between mammalian nuclear compartments is essential for a complete understanding of nuclear processes. Here we describe some of the interesting known associations between PML NBs and other nuclear compartments, and comment upon their implications for PML NB function.
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