期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 13, 期 -, 页码 6653-6661出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3179
关键词
oxygen; pulmonary; cell death; apoptosis; necrosis; review
资金
- NHLBI NIH HHS [HL-74195] Funding Source: Medline
Hyperoxia-induced acute lung injury (HALI) is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. Reactive oxygen species have been postulated to have a significant role in HALI, in part, by inducing cell death responses regulated by shared common mediators of apoptotic and necrotic pathways. Significant differences exist in the response of the mature and developing lung to HALI.
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