Article
Behavioral Sciences
Hermann Wagner, Ina Pappe, Hans-Ortwin Nalbach
Summary: Research shows that adult barn owls' optocollic response is less asymmetric than that of chickens at all tested velocities. Additionally, the response is symmetric at low speeds, resembling that of primates. The response becomes moderately asymmetric at middle-range velocities.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2022)
Article
Behavioral Sciences
Hermann Wagner, Ina Pappe, Sandra Brill, Hans-Ortwin Nalbach
Summary: The study found that barn owls have initially asymmetric reflexes after birth, but gradually become symmetric with time, similar to adult barn owls. The binocular horizontal optocollic responses show symmetry in juvenile barn owls, while monocular responses develop at different rates with varying stimulus velocities and directions.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2022)
Article
Clinical Neurology
Haike Dietrich, Cauchy Pradhan, Felix Heidger, Roman Schniepp, Max Wuehr
Summary: This study found that ocular-motor deficits in patients with downbeat nystagmus (DBN) were attenuated and nystagmus frequency was reduced during walking. This suggests that ocular-motor control disturbances are selectively suppressed during locomotion in DBN.
JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Kei Kanari, Moe Kikuchi-Ito
Summary: This study found that eye movement patterns exhibited by individuals with autism spectrum disorder (ASD) can serve as biomarkers for ASD diagnosis, and the gain of slow-phase OKN may predict individual differences in the degree of ASD.
Article
Biochemistry & Molecular Biology
Timour Al-Khindi, Michael B. Sherman, Takashi Kodama, Preethi Gopal, Zhiwei Pan, James K. Kiraly, Hao Zhang, Loyal A. Goff, Sascha du Lac, Alex L. Kolodkin
Summary: This study focuses on the upward-preferring ON direction-selective ganglion cell (up-oDSGC) in the mouse visual system. Single-cell transcriptomic profiling reveals that the transcription factor Tbx5 is selectively expressed in up-oDSGCs. Loss of Tbx5 results in a defect in up-oDSGC formation and an inability to detect vertical motion.
Article
Neurosciences
Ting-Feng Lin, Melody Ying-Yu Huang
Summary: To optimize performance, animals can adjust rhythmic neural signals for repetitive behaviors. In this study, larval zebrafish showed adaptive properties in their eye movements during prolonged optokinetic stimulation, revealing a potential animal model for eye movement disorders.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
Makoto Ozawa, Yasuyuki Suzuki, Taishin Nomura
Summary: The study found that involuntary eye movements, including drifts and microsaccades, occur during gaze fixation. In healthy individuals, the eyes exhibit oscillatory movements between centripetal drift and centrifugal microsaccades during eccentric fixation. The balance between drifts and microsaccades was found to be dependent on target displacement.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Geochemistry & Geophysics
Nicolas Brantut
Summary: Dilatancy associated with fault slip can lead to a transient pore pressure drop and an increase in frictional strength, requiring higher stress intensity factor for rupture propagation. This dilation-induced strengthening effect results in slower rupture speeds at a larger scale. Additionally, thermal pressurization may counteract the dilatant strengthening effect, potentially leading to premature frictional melting.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2021)
Review
Ophthalmology
Michael Leo Strupp, Dominik Straumann, Christoph Helmchen
Summary: The diagnosis of ocular motor disorders requires a systematic clinical examination of various eye movements to understand underlying diseases. Due to lesions in different brain regions, abnormalities in eye movements may present with distinct clinical manifestations.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2021)
Article
Neurosciences
Adriana L. Hotz, Ahmed Jamali, Nicolas N. Rieser, Stephanie Niklaus, Ecem Aydin, Sverre Myren-Svelstad, Laetitia Lalla, Nathalie Jurisch-Yaksi, Emre Yaksi, Stephan C. F. Neuhauss
Summary: The loss of function in the astroglia predominant eaat2a gene in zebrafish leads to altered neuronal and astroglial networks, resulting in epileptic seizures and increased extracellular glutamate levels. Interestingly, while hyperexcitability is observed during seizures, basal neuronal and astroglial activity is reduced, leading to decreased overall locomotion in eaat2a(-/-) mutant animals.
Article
Computer Science, Interdisciplinary Applications
Sandro Ropelato, Marino Menozzi, Melody Ying-Yu Huang
Summary: Hyper-reoriented walking is a new reorientation technique that reduces the physical space required in VR applications by allowing users to walk along gridlines with twice the speed of real walking and perform turns at cross-points with half the rotation speed in physical space. Experiment results showed that walking accuracy was good, but a correction algorithm was needed for slight errors when turning at T-junctions in a grid-like labyrinth.
Article
Cell Biology
Karin Tuschl, Richard J. White, Chintan Trivedi, Leonardo E. Valdivia, Stephanie Niklaus, Isaac H. Bianco, Chris Dadswell, Ramon Gonzalez-Mendez, Ian M. Sealy, Stephan C. F. Neuhauss, Corinne Houart, Jason Rihel, Stephen W. Wilson, Elisabeth M. Busch-Nentwich
Summary: This study identified potential targets of manganese neurotoxicity using a slc39a14(-/-) mutant zebrafish model exposed to MnCl2. The findings suggest that dysregulation of Ca2+ homeostasis and activation of the unfolded protein response are key features of manganese neurotoxicity. Additionally, manganese exposure led to locomotor defects and changes in visual and neuronal activity.
DISEASE MODELS & MECHANISMS
(2022)
Article
Immunology
Maja Houseman, Melody Ying-Yu Huang, Markus Huber, Matthias Staiger, Lan Zhang, Anneliese Hoffmann, Christoph Lippuner, Frank Stueber
Summary: HLA-DR is a cell-surface receptor that plays a key role in immune responses. This study identified potential microRNA regulators of HLA-DR expression and investigated the underlying gene regulations. The results provide insights into the role of microRNAs in HLA-DR regulation and may have potential clinical applications.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Markus Masek, Christelle Etard, Claudia Hofmann, Andreas J. Huelsmeier, Jingjing Zang, Masanari Takamiya, Matthias Gesemann, Stephan C. F. Neuhauss, Thorsten Hornemann, Uwe Straehle, Ruxandra Bachmann-Gagescu
Summary: The study identifies the role of Bbs1 in lipid homeostasis of photoreceptor outer segments, which may contribute to vision loss in patients with Bardet-Biedl syndrome.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Lan Zhang, Ulrike M. Stamer, Melody Ying-Yu Huang, Frank Stuber
Summary: Under inflammatory conditions, the nociceptin system plays an anti-inflammatory role in monocytes, with antagonistic effects observed between the nociceptin and TLR systems.
Article
Biology
Charles Capdeville, Linda Russo, David Penton, Jessica Migliavacca, Milica Zecevic, Alexandre Gries, Stephan Cf Neuhauss, Michael A. Grotzer, Martin Baumgartner
Summary: This study using spatial proteomics approach found that hepatocyte growth factor (HGF) can change the composition of the plasma membrane-associated proteome of Medulloblastoma (MB) tumor cells, thereby affecting cell adhesion and invasiveness. The study also revealed the important role of MAP4K4 in controlling the plasma membrane-associated proteome of MB cells.
LIFE SCIENCE ALLIANCE
(2022)
Article
Clinical Neurology
Sverre Myren-Svelstad, Ahmed Jamali, Sunniva S. Ophus, Percival P. D'gama, Anna M. Ostenrath, Aytac Kadir Mutlu, Helene Homme Hoffshagen, Adriana L. Hotz, Stephan C. F. Neuhauss, Nathalie Jurisch-Yaksi, Emre Yaksi
Summary: This study investigated neural excitability and dynamics in multiple zebrafish seizure and epilepsy models. The researchers found divergent and convergent features in spontaneous and photically evoked neural and locomotor activity. The study suggests that understanding the interplay between elevated and depressed excitability states could lead to tailored epilepsy therapies.
Article
Multidisciplinary Sciences
Ludovica Ciampi, Federica Mantica, Laura Lopez-Blanch, Jon Permanyer, Cristina Rodriguez-Marin, Jingjing Zang, Damiano Cianferoni, Senda Jimenez-Delgado, Sophie Bonnal, Samuel Miravet-Verde, Verena Ruprecht, Stephan C. F. Neuhauss, Sandro Banfi, Sabrina Carrella, Luis Serrano, Sarah A. Head, Manuel Irimia
Summary: Retinal photoreceptors have a unique transcriptomic profile, including distinct microexons and a microexon program regulated by Srrm3. Deletion of Srrm3 may lead to retinal diseases, highlighting the transcriptomic specialization and functionality of photoreceptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Developmental Biology
Sara Caviglia, Iris A. Unterweger, Akvile Gasiunaite, Alexandre E. Vanoosthuyse, Francesco Cutrale, Le A. Trinh, Scott E. Fraser, Stephan C. F. Neuhauss, Elke A. Ober
Summary: Visualizing cell shapes and interactions is crucial for understanding organ development and repair. However, integrating multi-fluorophore information into developing zebrafish tissues is challenging. In this study, the researchers developed FRaeppli, a method for efficient cell shape analysis and tracking using specific fluorescent proteins.
Article
Neurosciences
Ting-Feng Lin, Melody Ying-Yu Huang
Summary: To optimize performance, animals can adjust rhythmic neural signals for repetitive behaviors. In this study, larval zebrafish showed adaptive properties in their eye movements during prolonged optokinetic stimulation, revealing a potential animal model for eye movement disorders.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Fabian F. F. Voigt, Anna Maria Reuss, Thomas Naert, Sven Hildebrand, Martina Schaettin, Adriana L. L. Hotz, Lachlan Whitehead, Armin Bahl, Stephan C. F. Neuhauss, Alard Roebroeck, Esther T. T. Stoeckli, Soeren S. S. Lienkamp, Adriano Aguzzi, Fritjof Helmchen
Summary: Imaging of large, cleared samples is achieved using a multi-immersion 'Schmidt objective' consisting of a spherical mirror and an aspherical correction plate. This objective is compatible with all homogeneous immersion media and achieves an NA of 1.08 at a refractive index of 1.56, with a 1.1-mm FOV and 11-mm WD.
NATURE BIOTECHNOLOGY
(2023)
Article
Neurosciences
Matthias Gesemann, Stephan C. F. Neuhauss
Summary: Membrane guanylyl cyclase receptors play a crucial role in regulating cGMP production and have various physiological functions. This report focuses on the visual guanylyl cyclase receptors GC-E and GC-F and their activating proteins GCAP1/2/3. Different species have different expression patterns of GC-F receptors, and their absence is related to changes in visual sensitivity and variations in activating proteins.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Robotics
Zhiyuan Zhang, Leonardo K. K. Allegrini, Naoki Yanagisawa, Yong Deng, Stephan C. F. Neuhauss, Daniel Ahmed
Summary: This study presents a miniaturized acoustic rotation platform, called SonoRotor, for animal models. By controlling the voltage applied to the device, the rotation speed of zebrafish can be adjusted. The developed acoustic rotation manipulation platform is simple, cost-effective, allows multiview imaging, high-throughput operation, and can be combined with downstream analytical techniques to perform various biological micromanipulations on small animal models.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2023)
Article
Multidisciplinary Sciences
Melody Ying-Yu Huang, Christoph Lippuner, Marcel Schiff, Malte Book, Frank Stueber
Summary: In this study, the impact of surgical trauma on NETosis and monocytic HLA-DR expression was investigated. The results showed that NETosis decreased after surgery, with a more pronounced decrease in ACB patients. ACB surgery also led to a down regulation of monocytic HLA-DR expression. These findings suggest that the ability of neutrophils to form NETs may be compromised following severe surgical trauma, and there may be a post-operative immunosuppressed state.
SCIENTIFIC REPORTS
(2023)