期刊
FREE RADICAL RESEARCH
卷 48, 期 6, 页码 706-715出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2014.901510
关键词
oxidative stress; coronary artery disease; mortality; copper; ceruloplasmin; inflammation
资金
- LURIC has received funding from the 6th Framework Program [LSHM-CT-2004- 503485]
- 7th Framework Program (Atheroremo) [201668]
- RiskyCAD of the European Union [305739]
- INTERREG IV Oberrhein Program [A28]
- Wissenschaftsoffensive TMO
- European Regional Development Fund (ERDF)
Background. Copper and its main transport protein ceruloplasmin have been suggested to promote the development of atherosclerosis. Most of the data come from experimental and animal model studies. Copper and mortality have not been simultaneously evaluated in patients undergoing coronary angiography. Methods and results. We examined whether serum copper and ceruloplasmin concentrations are associated with angiographic coronary artery disease (CAD) and mortality from all causes and cardiovascular causes in 3253 participants of the Ludwigshafen Risk and Cardiovascular Health Study. Age and sex-adjusted hazard ratios (HR) for death from any cause were 2.23 (95% CI, 1.85-2.68) for copper and 2.63 (95% CI, 2.17-3.20) for ceruloplasmin when we compared the highest with the lowest quartiles. Corresponding hazard ratios (HR) for death from cardiovascular causes were 2.58 (95% CI, 2.05-3.25) and 3.02 (95% CI, 2.36-3.86), respectively. Further adjustments for various risk factors and clinical variables considerably attenuated these associations, which, however, were still statistically significant and the results remained consistent across subgroups. Conclusions. The elevated concentrations of both copper and ceruloplasmin are independently associated with increased risk of mortality from all causes and from cardiovascular causes.
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