Susceptibility of mitochondrial electron-transport complexes to oxidative damage. Focus on cytochrome c oxidase

Why does mitochondrial complex I have so many subunits?

(2011) Judy Hirst   BIOCHEMICAL JOURNAL

Radical formation in cytochrome c oxidase

(2011) Michelle A. Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Respiratory complex I: ‘steam engine’ of the cell?

(2011) Rouslan G Efremov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Loss of a Conserved Tyrosine Residue of CytochromebInduces Reactive Oxygen Species Production by Cytochromebc1

(2011) Dong-Woo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster

(2010) Jian-Ching Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Catalase Activity of Cytochrome c Oxidase Assayed with Hydrogen Peroxide-Sensitive Electrode Microsensor

(2010) I. A. Bolshakov et al.   BIOCHEMISTRY-MOSCOW

Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage

(2010) Raquel Requejo et al.   FEBS Journal

Ferricytochrome c protects mitochondrial cytochrome c oxidase against hydrogen peroxide-induced oxidative damage

(2010) Erik Sedlák et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reaction Mechanism of Superoxide Generation during Ubiquinol Oxidation by the Cytochromebc1Complex

(2010) Ying Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin: characterization of distinct oxidized molecular species

(2010) Junhwan Kim et al.   JOURNAL OF LIPID RESEARCH

Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

(2010) C. Hunte et al.   SCIENCE

Membrane Potential Greatly Enhances Superoxide Generation by the Cytochromebc1Complex Reconstituted into Phospholipid Vesicles

(2009) Hagai Rottenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degenerative diseases, oxidative stress and cytochrome c oxidase function

(2009) Bernhard Kadenbach et al.   TRENDS IN MOLECULAR MEDICINE

Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization–tandem mass spectrometry, and matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry

(2008) Patrizia Lemma-Gray et al.   ANALYTICAL BIOCHEMISTRY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Age-related decrease in expression of mitochondrial DNA encoded subunits of cytochrome c oxidase in Drosophila melanogaster

(2008) Rajindar S. Sohal et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria

(2008) Jiangang Long et al.   NEUROCHEMICAL RESEARCH