Cytotoxic effects of Mn(III)N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis

(2012) Nadine Hempel et al.   Anti-Cancer Agents in Medicinal Chemistry

Superoxide Dismutases: Anti- Versus Pro- Oxidants?

(2012) Irwin Fridovich   Anti-Cancer Agents in Medicinal Chemistry

Cellular Redox Modulator, ortho Mn(III) meso-tetrakis(N-n-Hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP5+ in the Treatment of Brain Tumors

(2012) Stephen T. Keir et al.   Anti-Cancer Agents in Medicinal Chemistry

A Combination of Two Antioxidants (An SOD Mimic and Ascorbate) Produces a Pro-Oxidative Effect Forcing Escherichia coli to Adapt Via Induction of oxyR Regulon

(2012) Ines Batinic-Haberle et al.   Anti-Cancer Agents in Medicinal Chemistry

Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress

(2012) Julien Verrax et al.   Anti-Cancer Agents in Medicinal Chemistry

Superoxide Dismutase in Redox Biology: The Roles of Superoxide and Hydrogen Peroxide

(2012) Garry R. Buettner   Anti-Cancer Agents in Medicinal Chemistry

A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy

(2012) Basir Tareen et al.   International Journal of Medical Sciences

S-Glutathionylation Reshapes Our Understanding of Endothelial Nitric Oxide Synthase Uncoupling and Nitric Oxide/Reactive Oxygen Species-Mediated Signaling

(2011) Jay L. Zweier et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Glutathionylation: From Molecular Mechanisms to Health Outcomes

(2011) Ying Xiong et al.   ANTIOXIDANTS & REDOX SIGNALING

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(iii) N-methoxyalkylpyridylporphyrins

(2011) Artak G. Tovmasyan et al.   DALTON TRANSACTIONS

Comment on “Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer,” i.e., all we are saying is, give C a chance

(2011) Joseph J. Cullen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics

(2011) Ines Batinic-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer

(2011) Michael Graham Espey et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer

(2011) Kenneth D. Tew et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective Efficacy from a Lipophilic Redox-Modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage

(2011) H. Sheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selective Ascorbate Toxicity in Malignant Mesothelioma

(2010) Elia Ranzato et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

(2010) Ines Batinić-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants: Molecules, medicines, and myths

(2010) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Metalloporphyrin Synergizes with Ascorbic Acid to Inhibit Cancer Cell Growth Through Fenton Chemistry

(2010) Junqiang Tian et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Accumulation of Porphyrin-based SOD Mimics in Mitochondria is Proportional to Their Lipophilicity: S. cerevisiae Study of ortho Mn(III) N-alkylpyridylporphyrins

(2010) Ivan Spasojevic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese Porphyrin Glutathionylates the p65 Subunit of NF-κB to Potentiate Glucocorticoid-induced Apoptosis in Lymphoma

(2010) Melba C. Jaramillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin

(2010) Aekyong Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site

(2010) Ivan Spasojevic et al.   FREE RADICAL RESEARCH

S-Glutathiolation in life and death decisions of the cell

(2010) Isabella Dalle-Donne et al.   FREE RADICAL RESEARCH

Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study

(2010) Raphaël Beck et al.   INVESTIGATIONAL NEW DRUGS

Regulation of Mitochondrial Glutathione Redox Status and Protein Glutathionylation by Respiratory Substrates

(2010) Jerome Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-Linked Inhibitor of Apoptosis Protein Inhibits Apoptosis in Inflammatory Breast Cancer Cells with Acquired Resistance to an ErbB1/2 Tyrosine Kinase Inhibitor

(2010) K. M. Aird et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Cancer Cells by an Oxidant-Based Therapy

(2010) P. Calderon et al.   Current Molecular Pharmacology

Hypoxia Activates NF-κB–Dependent Gene Expression Through the Canonical Signaling Pathway

(2009) Kathryn M. Oliver et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased Manganese Superoxide Dismutase Expression or Treatment with Manganese Porphyrin Potentiates Dexamethasone-Induced Apoptosis in Lymphoma Cells

(2009) Melba C. Jaramillo et al.   CANCER RESEARCH

Antioxidants and Novel Therapeutics

(2009)   FREE RADICAL BIOLOGY AND MEDICINE

Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia–telangiectasia cells

(2009) Julianne M. Pollard et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

(2009) Zahid N. Rabbani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat

(2009) Huaxin Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipophilicity of potent porphyrin-based antioxidants: Comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins

(2009) Ivan Kos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

(2009) Julien Verrax et al.   FREE RADICAL BIOLOGY AND MEDICINE

High Lipophilicity of meta Mn(III)N-Alkylpyridylporphyrin-Based Superoxide Dismutase Mimics Compensates for Their Lower Antioxidant Potency and Makes Them as Effective as Ortho Analogues in Protecting Superoxide Dismutase-DeficientEscherichia coli

(2009) Ivan Kos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell Growth and Size Homeostasis in Proliferating Animal Cells

(2009) A. Tzur et al.   SCIENCE

Inflammatory Breast Cancer

(2009) Wendy A. Woodward et al.   SEMINARS IN RADIATION ONCOLOGY

Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death

(2008) Raphael Beck et al.   BIOCHEMICAL PHARMACOLOGY

Altered redox status accompanies progression to metastatic human bladder cancer

(2008) N HEMPEL et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA