期刊
FREE RADICAL RESEARCH
卷 45, 期 1, 页码 89-100出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2010.534162
关键词
Glycation; oxidative stress; 3-nitrotyrosine; nitrosylation; proteomics; systems biology
资金
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- British Heart Foundation Funding Source: Medline
- Medical Research Council [MC_G0901472] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [MC_G0901472] Funding Source: UKRI
Increased protein glycation, oxidation and nitration are found in diabetes and renal failure. Steady state levels of glycated, oxidized and nitrated proteins are generally low, yet often have significant physiological effects-particularly linked to development and progression of vascular complications, including often fatal cardiovascular disease. Identification of sites activated toward damaging modifications or 'hotspots' in functional domains within proteins appears key to assessing targets of functional impairment. Disease progression is likely linked to instances where change in low level of hotspot damage influences metabolic control or physiological function. Examples discussed are: type IV collagen modification leading to endothelial cell detachment and anoikis, mitochondrial protein modification leading to oxidative stress and apolipoprotein B100 modification in low density lipoprotein leading to vascular retention and atherosclerosis. The role of mathematical systems biology, bioinformatics and proteome dynamics in future investigations is discussed.
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