Article
Biochemistry & Molecular Biology
Maret G. Traber, Brian Head
Summary: This narrative review focuses on the structures, functions, biological determinants, and deficiency symptoms of vitamin E in humans, discussing the mechanisms for alpha-T tissue enrichment, potential new biomarkers, pharmacokinetic data, and approaches to evaluate alpha-T dietary requirements. The possible role of alpha-T supplements in delaying chronic diseases and the evaluation of vitamin E safety are also considered in this review.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hiroyuki Arai, Nozomu Kono
Summary: Alpha-Tocopherol transfer protein (alpha-TTP) is the only known protein that specifically recognizes alpha-tocopherol, playing a major role in determining plasma alpha-Toc concentrations. Mutations in the alpha-TTP gene cause familial vitamin E deficiency. In hepatocytes, alpha-TTP facilitates the vectorial transport of alpha-Toc by targeting phosphatidylinositol phosphates at the plasma membrane.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Brian Head, Maret G. Traber
Summary: Vitamin E is essential for embryo development, as its deficiency can cause metabolic dysregulation and morphological changes, particularly affecting neurodevelopment.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Angelo Azzi
Summary: Vitamin E, specifically alpha-tocopherol, was identified in the 1930s, followed by the isolation of beta-tocopherol, delta-tocopherol, and tocotrienol in subsequent years. In 1981, inherited vitamin E deficiency causing a neuromyopathy, known as AVED, was localized to chromosome 8q due to a mutation in the aTTP gene.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, General & Internal
Sangharsha Thapa, Sangam Shah, Swati Chand, Sanjit Kumar Sah, Pawan Gyawali, Sandip Paudel, Pitambar Khanal
Summary: Ataxia with vitamin E deficiency (AVED) is a rare hereditary ataxia characterized by ataxia, areflexia, and sensory loss. Vitamin E supplementation can improve symptoms and prevent disease progression.
CLINICAL CASE REPORTS
(2022)
Article
Nutrition & Dietetics
Jiao Luo, Fleur L. Meulmeester, Leon G. Martens, Nadia Ashrafi, Renee de Mutsert, Dennis O. Mook-Kanamori, Frits R. Rosendaal, Ko Willems van Dijk, Saskia le Cessie, Kevin Mills, Raymond Noordam, Diana van Heemst
Summary: A study on middle-aged individuals found that urinary oxidized metabolites were associated with glucose homeostasis, while blood alpha-TOH was not. This suggests that estimates of the conversion of alpha-TOH in urine may be more informative in relation to insulin resistance.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Joan M. Cook-Mills, Samantha H. Averill, Jacquelyn D. Lajiness
Summary: Asthma and allergic disease are the result of interactions between environmental exposures and genetics. Different isoforms of vitamin E have opposite functions in regulating allergic inflammation and development of allergic disease, which may explain the varying outcomes of vitamin E on allergies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ishani Jhamb, Alyssa Freeman, Michelle R. Lotfi, Matthew VanOrmer, Corrine Hanson, Ann Anderson-Berry, Melissa Thoene
Summary: This study aimed to evaluate the concentrations of alpha- and gamma-tocopherol in placental tissue and assess their relationships with maternal and umbilical cord plasma concentrations. The results demonstrated significant positive correlations of gamma-tocopherol concentrations among all sample types. Placental tissue had significantly lower alpha:gamma-tocopherol concentration ratio compared to maternal and umbilical cord plasma.
Review
Nutrition & Dietetics
Debora Gabriela Fernandes Assuncao, Lorena Thalia Pereira da Silva, Juliana Dantas de Araujo Santos Camargo, Ricardo Ney Cobucci, Karla Danielly da Silva Ribeiro
Summary: Vitamin E deficiency is not only associated with preterm newborns but also found in full-term newborns. This deficiency can compromise neurogenesis in children. Further studies are needed to assess the difference in vitamin E status among newborns of different gestational ages to support neonatal monitoring protocols.
Review
Nutrition & Dietetics
Stepan Feduniw, Lidia Korczynska, Konrad Gorski, Magdalena Zgliczynska, Monika Baczkowska, Maciej Byrczak, Jakub Kociuba, Mohamed Ali, Michal Ciebiera
Summary: Menopause is a physiological change in women, but its symptoms can be difficult to accept and hormone therapy may not always be desirable. Vitamin E, as a phytoestrogen, is believed to be useful in alleviating some menopausal symptoms. This review aimed to assess the effectiveness of vitamin E in alleviating menopausal symptoms and found that it influences hot flashes, vascular modulation, lipid profile, and vaginal changes. However, estrogen administration has better clinical effects. Additional high-quality data is needed for conclusive findings.
Review
Plant Sciences
Yue Niu, Qian Zhang, Jiaojiao Wang, Yanjie Li, Xinhua Wang, Yan Bao
Summary: Vitamin E is a lipid-soluble antioxidant that is essential for both humans and plants. The biosynthesis pathway of vitamin E has been extensively studied, but the chlorophyll-derived prenyl precursors for synthesizing vitamin E are still unknown. Recent research has made significant progress in understanding vitamin E and its role in plant stress response and signaling.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Angelo Azzi, Jeffrey Atkinson, Nesrin Kartal Ozer, Danny Manor, Maria Wallert, Francesco Galli
Summary: This article proposes revising the nomenclature of vitamin E and argues that only RRR-alpha-tocopherol should be considered as vitamin E. Other tocochromanols have not been scientifically proven to function as vitamins. Prescribing molecules as vitamin E without proper testing could result in ineffective therapy and potential risks for patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
M. J. Kuhn, L. M. Sordillo
Summary: This study explored the antioxidant functions of various vitamin E analogs in bovine cells, finding that gamma-tocopherol and gamma-tocotrienol may have better abilities to reduce oxidative stress and protect cellular viability compared to alpha-tocopherol. Gamma-tocotrienol was shown to have significant cytotoxicity and reductions in viability at higher doses, suggesting a potential negative impact at supraphysiological levels. Further research is needed to fully understand the antioxidant properties of different vitamin E analogs in different cell types or animal models.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jeffrey Atkinson, Drew Marquardt, Mitchell DiPasquale, Thad Harroun
Summary: Vitamin E was one of the last fat-soluble vitamins discovered, and it plays important roles as an antioxidant and structural component in phospholipid bilayer membranes. Despite our detailed understanding of the orientation and dynamics of alpha-tocopherol in lipid bilayers, gaps still exist in our knowledge regarding its effects and potential receptors in controlling gene transcription.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Plant Sciences
Estanislao Burgos, Maria Belen De Luca, Isidore Diouf, Luis A. de Haro, Elise Albert, Christopher Sauvage, Zhao J. Tao, Luisa Bermudez, Ramon Asis, Adriano N. Nesi, Michel Matringe, Claire Brehelin, Thomas Guiraud, Carine Ferrand, Isabelle Atienza, Joana Jorly, Jean P. Mauxion, Pierre Baldet, Alisdair R. Fernie, Leandro Quadrana, Christophe Rothan, Mathilde Causse, Fernando Carrari
Summary: By studying the genetic determinants of tocochromanol accumulation in tomato fruits and genetically engineering their biosynthetic pathway, a total of 25 quantitative trait loci were identified across the genome. By bypassing specific pathway points, the engineered tomatoes showed increased tocopherols and tocotrienols content, indicating a trade-off between VTE and natural variation in chorismate metabolism.
Article
Physiology
James H. Finigan, Vihas T. Vasu, Jyoti V. Thaikoottathil, Rangnath Mishra, Mohammad A. Shatat, Robert J. Mason, Jeffrey A. Kern
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Rangnath Mishra, Daniel Foster, Vihas T. Vasu, Jyoti V. Thaikoottathil, Beata Kosmider, Hong Wei Chu, Russell P. Bowler, James H. Finigan
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2016)
Meeting Abstract
Oncology
Akash K. Kaushik, Ali Shojaie, Katrin Panzitt, Rajni Sonavane, Harene Venghatakrishnan, Mohan Manikkam, Alexander Zaslaysky, Vasanta Putluri, Vihas Vasu, Yiqing Zhang, Ayesha Khan, Stacy Lloyd, Adam Szafran, Subhamoy Dasgupta, David Bader, Fabio Stossi, Hangwen Li, Susmita Samanta, Xuhong Cao, Efrosini Tsouko, Shixia Huang, Daniel Frigo, Lawrence Chan, Dean Edwards, Benny Kaipparettu, Nicholas Mitsiades, Nancy Weigel, Michael Mancini, Michael Ittnnann, Arul Chinnaiyan, Nagireddy Putluri, Ganesh Palapattu, George Michailidis, Arun Sreekumar
Article
Multidisciplinary Sciences
Akash K. Kaushik, Ali Shojaie, Katrin Panzitt, Rajni Sonavane, Harene Venghatakrishnan, Mohan Manikkam, Alexander Zaslavsky, Vasanta Putluri, Vihas T. Vasu, Yiqing Zhang, Ayesha S. Khan, Stacy Lloyd, Adam T. Szafran, Subhamoy Dasgupta, David A. Bader, Fabio Stossi, Hangwen Li, Susmita Samanta, Xuhong Cao, Efrosini Tsouko, Shixia Huang, Daniel E. Frigo, Lawrence Chan, Dean P. Edwards, Benny A. Kaipparettu, Nicholas Mitsiades, Nancy L. Weigel, Michael Mancini, Sean E. McGuire, Rohit Mehra, Michael M. Ittmann, Arul M. Chinnaiyan, Nagireddy Putluri, Ganesh S. Palapattu, George Michailidis, Arun Sreekumar
NATURE COMMUNICATIONS
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
Ankit Khandelwal, Himadri Bhatt, Tejal Gajaria, Vihas T. Vasu
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Toxicology
Brad A. Hobson, Silvia Siso, Douglas J. Rowland, Danielle J. Harvey, Donald A. Bruun, Joel R. Garbow, Pamela J. Lein
TOXICOLOGICAL SCIENCES
(2017)
Article
Toxicology
Silvia Siso, Brad A. Hobson, Danielle J. Harvey, Donald A. Bruun, Douglas J. Rowland, Joel R. Garbow, Pamela J. Lein
TOXICOLOGICAL SCIENCES
(2017)
Article
Neurosciences
Brad A. Hobson, Douglas J. Rowland, Suangsuda Supasai, Danielle J. Harvey, Pamela J. Lein, Joel R. Garbow
Article
Biochemistry & Molecular Biology
Sonia M. Leach, Jay Finigan, Vihas T. Vasu, Rangnath Mishra, Moumita Ghosh, Daniel Foster, Robert Mason, Beata Kosmider, Eveline Farias Hesson, Jeffrey A. Kern
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Review
Neurosciences
Michelle Guignet, Kiran Dhakal, Brenna M. Flannery, Brad A. Hobson, Dorota Zolkowska, Ashish Dhir, Donald A. Bruun, Shuyang Li, Abdul Wahab, Danielle J. Harvey, Jill L. Silverman, Michael A. Rogawski, Pamela J. Lein
NEUROBIOLOGY OF DISEASE
(2020)
Article
Toxicology
Brad A. Hobson, Douglas J. Rowland, Silvia Siso, Michelle A. Guignet, Zachary T. Harmany, Suren B. Bandara, Naomi Saito, Danielle J. Harvey, Donald A. Bruun, Joel R. Garbow, Abhijit J. Chaudhari, Pamela J. Lein
TOXICOLOGICAL SCIENCES
(2019)
Article
Biotechnology & Applied Microbiology
Tejal K. Gajaria, Himadri Bhatt, Ankit Khandelwal, Vihas T. Vasu, C. R. K. Reddy, D. Shanthana Lakshmi
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2020)
Review
Biology
Nidhi Nagariya, Kaushal Chaudhari, Vihas T. Vasu
Summary: Despite significant advancements in lung cancer research and treatment, lung cancer remains the leading cause of cancer-related deaths worldwide. Circadian rhythms play a crucial role in organisms, and disruptions in modern society can increase the risk of diseases like lung cancer. The study emphasizes the importance of understanding the molecular interactions controlling circadian rhythms and cell division for developing new treatments for lung cancer.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Biophysics
Vidhi Shah, Bhavesh Bharatiya, Santosh Gawali, Puthusserickal A. Hassan, Atindra D. Shukla, Ankit Khandelwal, Himadri Bhatt, Vihas Vasu, Dinesh O. Shah
Summary: In an attempt to address the limitations of the currently available marketed formulation of exemestane, a study was conducted using a lamellar liquid crystal based formulation for topical application. Results showed that the formulation exhibited gel-like properties at low shear rate, transitioning to a flowing liquid at higher shear rate. This alternative route of drug delivery may offer improved bioavailability of exemestane due to enhanced solubility, permeability, and absorption.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nutrition & Dietetics
Maret G. Traber, Scott W. Leonard, Vihas T. Vasu, Brian M. Morrissey, Huangshu (John) Lei, Jeffrey Atkinson, Carroll E. Cross
Summary: This study investigated the absorption and plasma concentration of tocopherol in patients with cystic fibrosis (CF) after vitamin C supplementation. The results showed that vitamin C supplementation increased the concentration of alpha-tocopherol and decreased its disappearance rate. Therefore, vitamin C supplementation may have positive effects in CF patients.