Article
Immunology
Wei Dai, Ping Zheng, Deqiang Luo, Qian Xie, Fen Liu, Qiang Shao, Ning Zhao, Kejian Qian
Summary: This study aimed to identify ferroptosis-related genes in sepsis and provide potential therapeutic targets for translation. Through analysis of gene co-expression networks and differentially expressed genes, LPIN1 was identified as a reliable biomarker for patient survival in sepsis and was associated with immune and inflammation status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu Yin, Kunjian Liu, Guofeng Li
Summary: In this study, the role of Prim-O-glucosylcimifugin (POG) in the treatment of ulcerative colitis (UC) and its underlying mechanisms were discussed. The results from animal studies and in vitro experiments showed that POG could protect against UC by regulating intestinal flora, repairing the intestinal barrier, and suppressing inflammatory responses.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Yueli Cui, Xin Zhao, Yuqiu Tang, Yanxue Zhang, Le Sun, Xuelan Zhang
Summary: The study revealed significant differences in chemical components and gastrointestinal functions between raw Polygala tenuifolia and licorice-simmered Polygala tenuifolia. Simmering with licorice can effectively reduce the inhibitory effect of Polygala tenuifolia on gastrointestinal function in rats and reduce damage to gastrointestinal tissue.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shuang Chen, Chun-Lei Zhang, Hai-Qing Shen, Xiao-Fei Zhou, Jing-He Li, Jia-Lin Yu, Qiang An, Ben-Dong Fu, Peng-Fei Yi
Summary: The study showed that sesamin has protective effects on colitis in mice induced by DSS, reducing colon damage and inflammatory responses. Sesamin alleviates colon damage by modulating the NF-kappa B and MAPK signaling pathways.
Article
Biochemistry & Molecular Biology
Haolong Zhang, Yan Wang, Yingchun Su, Xuedong Fang, Wenjin Guo
Summary: Bilobalide (BI) demonstrates anti-inflammatory properties that can alleviate the severity of ulcerative colitis (UC) by promoting repair of the intestinal epithelial barrier and normalizing the microbial communities. Additionally, BI treatment enhances the expression of tight junction proteins associated with intestinal barrier integrity compared to control groups.
Article
Chemistry, Medicinal
Yishan Zhou, Bingling Zhong, Xiangjing Min, Ying Hou, Ligen Lin, Qin Wu, Jingshan Shi, Xiuping Chen
Summary: This study demonstrated that isobavachalcone (IBC) could ameliorate colitis in mice possibly through inhibition of NF-kappa B p65.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Amir Mohamed Abdelhamid, Mahmoud E. Youssef, Simona Cavalu, Gomaa Mostafa-Hedeab, Amal Youssef, Sara T. Elazab, Samar Ibrahim, Shady Allam, Rehab Mohamed Elgharabawy, Eman El-Ahwany, Noha A. Amin, Ahmed Shata, Osama A. Mohammed, Mahmoud Said Ibrahim Abdeldaiem, Ahmed Alhowail, Gaber El-Saber Batiha, Engy A. El-Mahmoudy, Maram Attia, Alaa Allam, Mona Y. Zaater, Mona M. Osman, Manar Nader, Aya Taha, Nada Abul Makarem, Sameh Saber
Summary: This study investigated the potential coloprotective role of carbocisteine in acetic acid-induced colitis in rats. The results showed that carbocisteine improved colon histology, macroscopic features, and disease activity. It also enhanced colon antioxidant defense mechanisms, suppressed neutrophil infiltration and activation, and modulated the expression of multiple cytokines. The study suggests that carbocisteine has the potential to be repurposed as a treatment for ulcerative colitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Cong, Yue Sun, Yi-Fan Sun, Wei-Bin Yan, Yu-Long Zhang, Zhong-Fei Gao, Chun-Hua Wang, Gui-Ge Hou, Jia-Jing Zhang
Summary: Trifluoromethyl-substituted BAPs show potential for anti-hepatoma and anti-inflammatory activities, with compound 16 standing out as the most promising due to its ability to regulate apoptosis-related protein expression and inhibit NF-kappa B activation.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Ting Zuo, Yinzi Yue, Xiaohui Wang, Huan Li, Shuai Yan
Summary: The study demonstrated that luteolin effectively improved colon health indicators and reduced inflammation levels in the affected areas by regulating the signaling pathways in the intestine to alleviate colitis.
Article
Pharmacology & Pharmacy
Qiuling Lin, Dingguo Zhang, Jian Zhang, Weixiang Luo, Zhenglei Xu, Jun Yao, Lisheng Wang
Summary: The incidence of ulcerative colitis (UC) in China has increased significantly. This study identified dysregulated lncRNA DLEU2 as a potential diagnostic biomarker and therapeutic target for UC. Through RNA sequencing, the expression of multiple lncRNAs and mRNAs was found to be significantly altered in the gut mucosa of UC patients. Mechanistically, DLEU2 exerts anti-inflammatory activity by inhibiting the NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Fang Wang, Yuanrong Chen, Kiyoshi Itagaki, Bin Zhu, Yajuan Lin, Haizhao Song, Luanfeng Wang, Ling Xiong, Zebin Weng, Xinchun Shen
Summary: Wheat-germ-derived peptide APEPEPAF (APE) has protective properties against ulcerative colitis by regulating the PKC zeta/NF-kappa B signaling pathway, preserving colon barrier function, and improving intestinal flora imbalance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Wenxuan Li, Weibin Yan, Yongjun Liu, Guige Hou, Chengbo Li
Summary: This study found that 6d has an inhibitory effect on inflammation and can protect the joints, making it a potential treatment for inflammatory diseases like rheumatoid arthritis.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Pharmacology & Pharmacy
Zixia Chen, Long Yi, Yanni Pan, Xingyao Long, Jianfei Mu, Ruokun Yi, Xin Zhao
Summary: The study showed that ZS40 could have positive effects on ulcerative colitis by regulating oxidative indicators, cytokine levels, NF-kappa B, MAPK pathways, etc.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Sameh Saber, Galal Yahya, Naglaa A. Gobba, Hossam Sharaf, Reem Alshaman, Abdullah Alattar, Noha A. Amin, Ruwyda El-Shedody, Farah H. Aboutouk, Yumna Abd El-Galeel, Amr El-Hefnawy, Dina Shabaka, Arwa Khalifa, Renad Saleh, Donya Osama, Ghada El-Zoghby, Mahmoud E. Youssef
Summary: The combination therapy of NSC328382/CRID3 showed significantly increased efficacy in treating ulcerative colitis, improving colon health, antioxidant functions, and reducing inflammation by downregulating proinflammatory cytokines. NSC328382 also interrupted the MyD88/NF-Kappa B axis and altered Th1/Th2 dominance. This suggests a novel approach for treating IBDs with potential clinical applications.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Irene Paterniti, Alessia Filippone, Irina Naletova, Valentina Greco, Sebastiano Sciuto, Emanuela Esposito, Salvatore Cuzzocrea, Enrico Rizzarelli
Summary: Spinal cord injury (SCI) can cause severe motor dysfunction and nervous system abnormalities. The conjugation of trehalose with l-carnosine (Tre-car) has been found to reduce inflammation in vitro and in vivo models of SCI. Tre-car decreased early inflammatory effects, oxidative stress, and apoptosis, and stimulated the release of neurotrophic factors and influenced Zn2+ homeostasis. Tre-car may be a promising therapeutic agent for treating SCI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Andrea Duranti, Francesco Monaco, Rosalba Siracusa, Roberta Fusco, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Idiopathic pulmonary fibrosis (IPF), a deadly lung condition, worsens over time and has no known cause. Traditional treatments for IPF, such as corticosteroids and immunomodulatory drugs, often have noticeable side effects and are not very effective. By inhibiting the fatty acid amide hydrolase (FAAH) enzyme, which breaks down endocannabinoids, it is possible to increase the levels of these natural pain-relieving compounds and reduce inflammation. In our study, we used a bleomycin-induced IPF model and found that administering URB878, an FAAH inhibitor, reduced histological changes, cell infiltration, pro-inflammatory cytokine production, inflammation, and nitrosative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Ylenia Marino, Roberta Fusco, Rosalba Siracusa, Marika Cordaro, Ramona D'Amico, Francesco Macri, Emanuela Raffone, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The study investigated the beneficial effects of fisetin, a naturally occurring polyphenol, on endometriosis. Fisetin treatment reduced the size and volume of endometriotic implants, as well as histological alterations and inflammatory responses. It also decreased markers of oxidative stress and increased apoptosis in endometrial lesions. Fisetin may represent a potential therapeutic strategy for endometriosis by targeting inflammatory pathways and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alessia Arangia, Ylenia Marino, Daniela Impellizzeri, Ramona D'Amico, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The phytoconstituents in the Mediterranean diet (MD) have been extensively studied for their beneficial effects on human health. Olive oil, a key component of the MD, has been particularly investigated due to its high content of hydroxytyrosol (HT), which possesses protective properties in various chronic disorders, including intestinal and gastrointestinal diseases. However, there is currently no comprehensive review summarizing the role of HT in these disorders. This review provides an overview of the anti-inflammatory and antioxidant properties of HT against intestinal and gastrointestinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Gianluca Antonio Franco, Livia Interdonato, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Neurodegenerative disorders are characterized by neuroinflammation, oxidative stress, and neuronal depletion, and there is currently no cure for these diseases. The Mediterranean diet, rich in antioxidants and omega-3 fatty acids, may have a protective effect on neurodegeneration. This review focuses on the therapeutic potential of natural products and the associations between the Mediterranean-style diet, neurodegenerative diseases, and markers and mechanisms of neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Alessia Filippone, Laura Cucinotta, Valentina Bova, Marika Lanza, Giovanna Casili, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: Moderate traumatic brain injury (mTBI) is associated with emotional dysregulation. This study investigates the role of LRRK2 in reducing depression-related symptoms after mTBI and tests the antidepressant effects of LRRK2 inhibition by PF-06447475. The results show that mTBI promotes the development of depression-like behavior, but LRRK2 inhibition reduces histological damage and behavioral disturbances, suggesting an antidepressant effect.
Article
Biochemistry & Molecular Biology
Marco Calapai, Luisa Puzzo, Giuseppe Bova, Daniele Alfio Vecchio, Rosario Blandino, Alessia Barbagallo, Ilaria Ammendolia, Luigi Cardia, Maria De Pasquale, Fabrizio Calapai, Emanuela Esposito, Fabio Trimarchi, Debora Di Mauro, Gioacchino Calapai, Carmen Mannucci
Summary: The aim of this study was to evaluate the effects of physical activity on chronic pain in post-mastectomy women. The results showed that adequate physical activity can reduce pain intensity and interference, and is associated with a reduction in blood biomarkers of inflammation.
Article
Biochemistry & Molecular Biology
Alessio Ardizzone, Alberto Repici, Anna Paola Capra, Federica De Gaetano, Valentina Bova, Giovanna Casili, Michela Campolo, Emanuela Esposito
Summary: Atopic dermatitis (AD) is a common inflammatory skin disease that mainly affects children. This study evaluated the effects of a cream formulation containing tempol in a murine model of AD. The results demonstrated that tempol reduced histological damage, mast cell infiltration, and improved skin barrier function by restoring tight junctions and filaggrin. Furthermore, tempol modulated inflammation and oxidative stress through the NF-κB/Nrf2 signaling pathways.
Review
Biochemistry & Molecular Biology
Federica Rey, Clarissa Berardo, Erika Maghraby, Alessia Mauri, Letizia Messa, Letizia Esposito, Giovanna Casili, Sara Ottolenghi, Eleonora Bonaventura, Salvatore Cuzzocrea, Gianvincenzo Zuccotti, Davide Tonduti, Emanuela Esposito, Irene Paterniti, Cristina Cereda, Stephana Carelli
Summary: Oxygen imbalance can have detrimental effects on the brain, leading to various neurological disorders. The dysfunctions caused by oxygen imbalance in neurodegenerative and pediatric neurological disorders result from redox imbalance. This review focuses on the underlying dysfunction in redox and potential therapeutic strategies for these conditions.
Article
Biochemistry & Molecular Biology
Marika Lanza, Laura Cucinotta, Giovanna Casili, Alessia Filippone, Rossella Basilotta, Anna Paola Capra, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study aimed to evaluate the inhibitory effect of Antrodia camphorata (AC) administration on neuroinflammation and oxidative stress in a murine model of Parkinson's disease (PD). The results showed that AC treatment significantly reduced PD-related pathological changes, increased tyrosine hydroxylase expression, reduced alpha-synuclein-positive neurons, restored the myelination process of neurons associated with PD, and attenuated neuroinflammation. Furthermore, AC was able to reduce oxidative stress induced by MPTP injection. This study highlights AC as a potential therapeutic agent for neurodegenerative disorders such as PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ylenia Marino, Ramona D'Amico, Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Francesco Macri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study investigates the molecular mechanisms underlying endometriosis and how they can be modulated by Actaea racemosa (AR). The findings show that AR can reduce the size and histological morphology of the lesions and suppress the disease development through regulating multiple pathways, including cell proliferation, apoptosis, antioxidant, and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Agnese Ragno, Marika Cordaro, Ramona D'Amico, Rosalba Siracusa, Roberta Fusco, Francesca Marino Merlo, Antonella Smeriglio, Daniela Impellizzeri, Salvatore Cuzzocrea, Giuseppina Mandalari, Rosanna Di Paola
Summary: The study evaluated the antioxidant and anti-inflammatory effects of almond skin extract (ASE) and found that it inhibited the formation of ROS and apoptosis in vitro, and restored tissue changes and decreased inflammation in an in vivo model. The mechanisms of action could be related to the inhibition of the pro-inflammatory nuclear factor NF-κB and activation of the Nrf2 antioxidant pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Alberto Repici, Alessio Ardizzone, Alessia Filippone, Cristina Colarossi, Marzia Mare, Gabriele Raciti, Deborah Mannino, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Summary: Brain tumors are a heterogeneous group of neoplasms affecting populations of all ages. Glioblastoma (GB), the most common primary brain tumor, often leads to death within a few months after diagnosis. Immunotherapy, particularly targeting interleukin 21 (IL-21), appears to be a promising approach to improve the survival rate of GB patients. The review evaluates the potential use of IL-21 and its mechanisms in the progression of GB.
Article
Pharmacology & Pharmacy
Fabrizio Calapai, Ilaria Ammendolia, Luigi Cardia, Mariaconcetta Curro, Gioacchino Calapai, Emanuela Esposito, Carmen Mannucci
Summary: Risankizumab is a safe and effective treatment for moderate-to-severe plaque psoriasis and psoriatic arthritis, according to post-marketing analysis of real-world data. The most frequently reported serious adverse reactions to risankizumab include infections, cancer, nervous system and cardiac disorders. Despite the limitations of the study, the safety profile of risankizumab is consistent with previous clinical trials and further research is needed to explore the occurrence of malignancies and their sex distribution as adverse reactions.
Review
Biochemistry & Molecular Biology
Livia Interdonato, Rosalba Siracusa, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Endometriosis, an estrogen-dependent gynecologic illness, is potentially influenced by endocrine-disrupting chemicals (EDCs). This review examines human evidence on EDCs and endometriosis, specifically focusing on chemical amounts in women. Dioxins, BPA, Phthalates, and other EDCs are implicated as environmental causes of endometriosis, highlighting the need for prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
