期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 72, 期 -, 页码 23-40出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2014.03.039
关键词
Hemoglobinopathy; Thalassemia; Iron overload; Hemochromatosis; Sickle cell disease; Magnetic resonance imaging; Chelation; ROS; Iron toxicity; Transfusion
资金
- NHLBI NIH HHS [U01 HL117718] Funding Source: Medline
Iron overload and iron toxicity, whether because of increased absorption or iron loading from repeated transfusions, can be major causes of morbidity and mortality in a number of chronic anemias. Significant advances have been made in our understanding of iron homeostasis over the past decade. At the same time, advances in magnetic resonance imaging have allowed clinicians to monitor and quantify iron concentrations noninvasively in specific organs. Furthermore, effective iron chelators are now available, including preparations that can be taken orally. This has resulted in substantial improvement in mortality and morbidity for patients with severe chronic iron overload. This paper reviews the key points of iron homeostasis and attempts to place clinical observations in patients with transfusional iron overload in context with the current understanding of iron homeostasis in humans. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据