Review
Anatomy & Morphology
Fadya Adnane, Emad El-Zayat, Heba Mohamed Fahmy
Summary: This review discusses the therapeutic efficacy of photodynamic therapy and nanotechnology as combinational approaches in treating different types of skin cancer. It covers the mechanism and cell destruction capability of photodynamic therapy, different types of photosensitizers, and the ideal characteristics of nanoparticles used as drug delivery systems. The review also highlights the recent preclinical studies and clinical trials using nanoparticles loaded with different drugs and triggered with photodynamic therapy for skin cancer treatment.
Article
Chemistry, Multidisciplinary
Meijiang Liu, Huifang Liu, Ning Li, Chaofeng Zhang, Jian Zhang, Feng Wang
Summary: This study reveals a synergistic effect of photogenerated holes and superoxide radicals for the selective oxidation of glycerol to formic acid over a TiO2 catalyst. By controlling the oxygen and water contents, surface active species can be controlled to solve the problem of formic acid peroxidation.
Article
Nanoscience & Nanotechnology
Kexin Wang, Yunjian Xu, Zhenjiang Chen, Huixian Li, Rui Hu, Junle Qu, Yuan Lu, Liwei Liu
Summary: Researchers utilized squaric acid nanoparticles for photodynamic therapy of deep hypoxic tumors, achieving significant therapeutic effects and improving the survival rate of mice.
Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Article
Biochemistry & Molecular Biology
Clement Linger, Maxime Lancel, Marc Port
Summary: To improve the effectiveness of photodynamic therapy (PDT), it is crucial to develop new photosensitizers that can generate both hydroxyl radicals and singlet oxygen. This study established and validated experimental conditions for evaluating the relative efficiency of hydroxyl radicals and singlet oxygen production using a continuous flow UV-visible spectroscopy method. Mathematical modeling and statistical analysis were employed to analyze the kinetics and reliability of the results, and to compare different photosensitizers such as Methylene Blue and Brillant Blue G.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Joo-Eun Kim, Hyun-Wook Lee, Won-Jin Kwak
Summary: In this study, 4-carboxy-TEMPO was selected as a representative SODm, and its ability to effectively promote the disproportionation reaction and accelerate the generation of singlet oxygen was chemically verified. It was found that the release of singlet oxygen evolved by the SODm was decreased when using a quencher. This study provides important reference for the development of additives for practical application of LOBs.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Environmental
Jiaqian Sun, Jianzhong Ma, Lushi Lian, Shuwen Yan, Weihua Song
Summary: This study found that under simulated solar irradiation, methylhydroperoxide (MHP) is the only identified organic hydroperoxide (ROOH) formed in chromophoric dissolved organic matter (CDOM) solutions, with varying quantum yields. The formation mechanism of MHP involves the presence of superoxide radical ions and methyl radicals. Additionally, the degradation of MHP and H2O2 is similar in terms of photodegradation, hydrolysis, Fenton, and photoFenton reactions, providing insights into the photochemical formation of organic peroxides in surface waters.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Spectroscopy
Rodrigo C. Silva, Hilde H. Buzza, Eli S. A. Ducas, Kleber T. Oliveira, Vanderlei S. Bagnato, Guilherme R. L. Souza, Luciane M. Almeida, Pablo J. Goncalves
Summary: A supramolecular assembly of methylene blue and curcumin was synthesized and evaluated for its potential in photodynamic antiangiogenic therapy. The results demonstrated that the MB-Curc assembly exhibited a synergistic vascular effect, causing significant damage to the vascular network after irradiation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Wenyi Dong, Ke Li, Shijie Wang, Ling Qiu, Qingzhu Liu, Minhao Xie, Jianguo Lin
Summary: The study presents a novel photosensitizer compound 1 targeted at biotin receptors, demonstrating promising therapeutic effects on biotin receptor-positive tumors. Compound 1 selectively accumulates in A549 cells and shows anti-tumor activity in vivo, indicating potential applications in clinical PDT for lung cancers.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Ezel Ozturk Gunduz, M. Emre Gedik, Gurcan Gunaydin, Elif Okutan
Summary: The study demonstrates the successful development of efficient PDT applications against cancer using nanocarriers combined with advanced chemical molecules to generate singlet oxygen and ROS, leading to significant anti-tumor effects in vitro.
Article
Chemistry, Applied
Bingjie Hou, Wenyuan Zhang, Cuili Li, Xueqin Sun, Xiaoxia Feng, Jiacheng Liu
Summary: This study reports the synthesis and evaluation of four cationic porphyrins as potential photodynamic therapeutic agents. The results show that ZnP2 exhibits high phototoxicity towards cancer cells and low toxicity towards normal cells, making it a promising candidate for photodynamic therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Engineering, Chemical
Jinying Du, Chuang Wang, Zhiwei Zhao, Fuyi Cui, Qin Ou, Jie Liu
Summary: Vacuum UV radiation can generate hydroxyl radicals and H2O2 through the homolysis and ionization of water. Sufficient dissolved oxygen promotes the production and formation rate of H2O2, while UV254 radiation induces the decomposing of H2O2. The study also highlights the unfavorable effects of alkaline conditions and certain anions on H2O2 production.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Chemistry, Medicinal
Marie Halaskova, Asma Rahali, Veronica Almeida-Marrero, Miloslav Machacek, Radim Kucera, Bassem Jamoussi, Tomas Torres, Veronika Novakova, Andres de la Escosura, Petr Zimcik
Summary: This study synthesized zinc phthalocyanine photosensitizers with bulky phenoxy substituents, demonstrating high photodynamic activity and low cytotoxicity against cancer cells. The compounds localized primarily in lysosomes, leading to apoptotic cell death pathway.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Engineering, Environmental
Qian Li, Jingjing Zhao, Huan Shang, Zhong Ma, Haiyan Cao, Yue Zhou, Guisheng Li, Dieqing Zhang, Hexing Li
Summary: Based on porphyrin-coupled titanium dioxide, a bionic photocatalytic system was designed for efficient removal of low-concentration indoor NOx gas. This system achieved high removal efficiency and long stability, and the synergistic effect between singlet oxygen and mobile hydroxyl radicals was found to be crucial for the removal process.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Runfeng Lin, Junkai Liu, Weilin Xu, Zicheng Liu, Xiang He, Canze Zheng, Miaomiao Kang, Xue Li, Zhijun Zhang, Hai-Tao Feng, Jacky W. Y. Lam, Dong Wang, Ming Chen, Ben Zhong Tang
Summary: In this work, a pyrazine-based near-infrared type I photosensitizer (PS) with remarkable donor-acceptor effect and efficient intramolecular motions was developed. The PS exhibited high photothermal conversion efficiency and strong hydroxyl radical generation due to its vigorous intramolecular motions. It also demonstrated excellent imaging-guided cancer synergistic therapy, stimulating the development of advanced PS and solid-state intramolecular motions for biomedical applications.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Barbara Pucelik, Adam Sulek, Mariusz Borkowski, Agata Barzowska, Marcin Kobielusz, Janusz M. Dabrowski
Summary: This study reports the synthesis, characterization, and biological evaluation of AgNPs functionalized by different agents. The results showed that AgNPs with different sizes and surface charges exhibited antimicrobial activity and anticancer efficacy in various biological systems. The mechanism of action of AgNPs was attributed to the generation of reactive oxygen species, which correlated with their overall activity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Kamil Brzoska, Maria Wojewodzka, Malgorzata Szczygiel, Agnieszka Drzal, Martyna Sniegocka, Dominika Michalczyk-Wetula, Eva Biela, Martyna Elas, Malgorzata Kucinska, Hanna Piotrowska-Kempisty, Lucyna Kapka-Skrzypczak, Marek Murias, Krystyna Urbanska, Marcin Kruszewski
Summary: This study analyzed the impact of different silver nanoparticles on the development and metastatic potential of breast cancer using a mouse model. The results showed that citrate-coated silver nanoparticles had a significant effect on reducing tumor volume and lung metastases in mice treated intragastrically. However, no effect on lung metastases was observed after intravenous administration of silver nanoparticles. The findings suggest that the anticancer activity of silver nanoparticles may depend on the activation of the immune system.
Article
Oncology
Anna Markiewicz, Piotr Donizy, Monika Nowak, Mateusz Krzyzinski, Martyna Elas, Przemyslaw M. Plonka, Jolanta Orlowska-Heitzmann, Przemyslaw Biecek, Mai P. Hoang, Bozena Romanowska-Dixon
Summary: The degree of tumour pigmentation is an important prognostic factor for uveal melanoma. Patients with amelanotic tumours have longer survival and delayed tumour spread compared to heavily pigmented tumours. Heavily pigmented tumours also have unfavourable prognostic features. Amelanotic tumours with a lower clinical stage have the best prognosis.
Article
Chemistry, Medicinal
Stanislaw Malicki, Barbara Pucelik, Edyta Zyla, Malgorzata Benedyk-Machaczka, Wojciech Galan, Anna Golda, Alicja Sochaj-Gregorczyk, Marta Kaminska, Joao Crispim Encarnacao, Barbara Chruscicka, Hans-Peter Marti, Tony Jialiang Chen, Katarzyna Magiera-Mularz, Bartosz Zieba, Tad A. Holak, Janusz M. Dabrowski, Anna Czarna, Joanna Koziel, Piotr Mydel, Grzegorz Dubin
Summary: In this study, a molecular probe based on aptamer was developed, which specifically recognizes human PD-L1. The probe showed excellent potential in cancer imaging in both in vitro and in vivo experiments.
Article
Biochemistry & Molecular Biology
Rafael T. Aroso, Lucas D. Dias, Kate C. Blanco, Jennifer M. Soares, Fernanda Alves, Gabriela J. da Silva, Luis G. Arnaut, Vanderlei S. Bagnato, Mariette M. Pereira
Summary: This study investigates the influence of cationic imidazolyl-substituted photosensitizers and light on the activity of ciprofloxacin for inactivation of Escherichia coli. The results demonstrate that the optimized dual phototherapy protocol using these photosensitizers can reduce the amount of photosensitizer and ciprofloxacin required for full E. coli inactivation, and the combination therapy is superior to monotherapy in both in vitro and in vivo studies.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Drzal, Anthony Delalande, Gabriela Dziurman, Chantal Pichon, Jan Swakon, Martyna Elas
Summary: The inadequate oxygenation in tumors is associated with increased invasiveness of cancer cells and reduced sensitivity to anticancer therapies. Attempts to increase tumor oxygenation have been largely ineffective. The use of phospholipid-coated oxygen microbubbles (OMB) can increase tumor oxygenation, but it also affects tumor vasculature and promotes cancer cell spread.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Physical
Kamil Brzoska, Barbara Sochanowicz, Malgorzata Szczygiel, Agnieszka Drzal, Martyna Sniegocka, Dominika Michalczyk-Wetula, Martyna Elas, Lucyna Kapka-Skrzypczak, Marcin Kruszewski
Summary: The epigenetic effects induced by citrate- and PEG-coated silver nanoparticles (AgNPs) in a 4T1 breast cancer mouse model were analyzed. It was found that both types of AgNPs significantly decreased the level of 5-methylcytosine (5-mC) in tumor tissue, with the effect being more pronounced for citrate-coated AgNPs. PEG-coated AgNPs also caused a significant decrease in DNA methylation after intravenous administration, and both types of AgNPs led to a decrease in histone H3 methylation.
Article
Biochemistry & Molecular Biology
Agnieszka Drzal, Gabriela Dziurman, Pawel Hola, Jakub Lechowski, Anthony Delalande, Jan Swakon, Chantal Pichon, Martyna Elas
Summary: Radiotherapy is a crucial part of cancer treatment, but challenges such as tumor hypoxia and resistance to radiation still exist. Vascular normalization, which aims to improve oxygen supply, has shown promise. This study explores the combination of metformin, an anti-diabetic drug, and oxygen microbubbles to achieve vascular normalization and enhance the effectiveness of radiotherapy. The findings demonstrate that the combination treatment has a more pronounced and sustained effect on normalizing abnormal cancer vasculature compared to individual treatments. It also increases the radiosensitivity of the tumors, although resistance to treatment and recurrence of hypoxia remain as challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriela Dziurman, Agnieszka Drzal, Aleksandra Anna Murzyn, Maciej Mikolaj Kmiec, Martyna Elas, Martyna Krzykawska-Serda
Summary: This study compared the measurement of pO2 using continuous wave and pulse electron paramagnetic resonance spectroscopy. The researchers used the Oxychip particle spin probe to monitor pO2 in murine pancreatic tumor treated with gemcitabine. The results showed that both techniques offer reliable measurement of in vivo oxygen metabolism and the change in pO2 during therapy is correlated with survival.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Luis G. Arnaut, Mariette M. Pereira
Summary: This article offers a personal account of the discovery and development of a photosensitizer for photodynamic therapy of cancer. It focuses on the chemical aspects of drug discovery and development, including the chemical landscape at the time of discovery, the breakthrough offered by stable bacteriochlorins, challenges in synthesizing high purity products for preclinical studies, the relationship between molecular structure and pharmacology in PDT, and the interpretation of preclinical data and management of unexpected results. Special attention is given to the implications of atropisomerism and immune responses in PDT.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Maria Ines P. Mendes, Carlos D. F. Coelho, Fabio A. Schaberle, Maria Joao Moreno, Mario J. F. Calvete, Luis G. Arnaut
Summary: The explosive vaporization of nanodroplets triggered by laser pulses can generate large volume changes and intense photoacoustic waves. Nanodroplets have the potential to be used as contrast agents in photoacoustic tomography, and their performance can be improved with proper design.
Meeting Abstract
Biochemistry & Molecular Biology
D. A. Mendonca, I. Cadima-Couto, F. A. Schaberle, A. S. Veiga, L. G. Arnaut, M. A. R. B. Castanho, C. Cruz-Oliveira
Proceedings Paper
Acoustics
Carlos Serpa, Diogo A. Pereira, Tiago Pinto, Alexandre D. Silva, Luis G. Arnaut
Summary: In this study, it was demonstrated that the interaction between short laser pulses and tailor-made nanostructured materials can generate broadband high-frequency ultrasound. The potential applications of this technology include non-destructive ultrasound interaction with biological membranes and non-invasive material inspection.
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2022
(2022)
Proceedings Paper
Oncology
Luis G. Arnaut, Catarina S. Lobo, M. Ines P. Mendes, Diogo A. Pereira
Summary: This study investigated the distribution of a photosensitizer in tumors using photoacoustic tomography, and found that the amount of the photosensitizer in 4T1 tumors is mainly concentrated in the periphery, while it is less in CT26 tumors. Additionally, exposure to high-intensity photoacoustic waves increased the amount of the photosensitizer in 4T1 tumors, suggesting that photoacoustic waves are a promising non-invasive method for enhancing drug delivery to solid tumors.
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC AND PHOTOBIOMODULATION THERAPY XXX
(2022)
Article
Biochemistry & Molecular Biology
Catarina S. Lobo, Paulo Rodrigues-Santos, Dina Pereira, Jisette Nunez, Joao C. D. Trepa, David Lopes Sousa, Jorge Vaz Lourenco, Maria Filomena Coelho, Luis Pereira de Almeida, Jose Saraiva da Cunha, Luis G. Arnaut
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)