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Biochemistry & Molecular Biology
Wei-Min Chen, Jui-Chung Chiang, Zengfu Shang, Guillermo Palchik, Ciara Newman, Yuanyuan Zhang, Anthony J. Davis, Hsinyu Lee, Benjamin P. C. Chen
Summary: DNA-PKcs plays a key role in DNA double-strand break repair and is involved in the cellular response to oxidative stress. It interacts with mitochondria proteins ANT2 and VDAC2 to maintain oxidative phosphorylation and mitochondrial membrane potential. The formation of the DAV complex is important for energizing the cell and its dissociation under oxidative stress helps reduce ROS production and promote cellular recovery.
Review
Biochemistry & Molecular Biology
Xiaochen Xie, Ye Zhang, Zhuo Wang, Shanshan Wang, Xiaoyou Jiang, Hongyan Cui, Tingting Zhou, Zheng He, Hao Feng, Qiqiang Guo, Xiaoyu Song, Liu Cao
Summary: ROS, initially considered pathological, are now recognized as signaling intermediates that promote cellular adaptation to stress through autophagy regulation. ATM protein, activated by ROS, is involved in autophagy regulation, maintaining genome stability and triggering cytoplasmic autophagy as a ROS sensor.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
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Genetics & Heredity
Tsutomu Shimura
Summary: AT is a disease characterized by extreme sensitivity to ionizing radiation, with AT patients and ATM-deficient mice displaying intrinsic mitochondrial dysfunction. ATM plays a critical role in maintaining cellular redox homeostasis.
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Cell Biology
Hao Gu, Jian Li, Rongrong Zhang
Summary: Melatonin was found to inhibit endothelial cell apoptosis under oxidative stress induced by H2O2 through modulation of the miR-101/DNA-PKcs/PI3K/AKT signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
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Cell Biology
Ana Mesquita, James Glenn, Andreas Jenny
Summary: Autophagy is a major catabolic pathway crucial for cellular homeostasis and stress response. Endosomal microautophagy can be induced under stress conditions and regulated by various signaling pathways, suggesting its important role in disease prevention.
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Environmental Sciences
Sonalin Rath, Surajit Das
Summary: Bacteria thriving in the mangrove ecosystem play a significant role in elemental cycles, but their performance is influenced by climate change and environmental stressors. This study investigates the genotoxic effect of such stressors on mangrove bacteria and their adaptation strategies. The results show cellular injuries and DNA damage in response to stressors, with different bacterial strains exhibiting varying levels of tolerance and adaptive mechanisms.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Aashish Soni, Xiaolu Duan, Martin Stuschke, George Iliakis
Summary: The activation of the intra-S-phase checkpoint is essential for maintaining genomic stability and involves the activities of ATM and ATR. DNA-PKcs also contributes to the recovery from the checkpoint. The organization of the intra-S-phase checkpoint is similar to that of the G(2) checkpoint.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Vidhya Tangeda, Yu Kang Lo, Ananth Ponneri Babuharisankar, Han-Yu Chou, Cheng-Liang Kuo, Yung-Hsi Kao, Alan Yueh-Luen Lee, Jang-Yang Chang
Summary: Mitochondrial Lon plays a crucial role in cisplatin-induced mtDNA damage and oxidative stress by modulating calcium levels, resulting in increased resistance of cancer cells to cisplatin treatment.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Zhihui Tian, Haohao Liu, Xinghai Chen, Michael D. Losiewicz, Rui Wang, Xingde Du, Bingqian Wang, Ya Ma, Shiyu Zhang, Linjia Shi, Xing Guo, Yongshui Wang, Bingyu Zhang, Shumeng Yuan, Xin Zeng, Huizhen Zhang
Summary: The study revealed that oxidative stress induced by MC-LR can activate the DNA damage-mediated ATM/p53 signaling pathway to induce autophagy in male germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Lei Wang, Thilina U. Jayawardena, Jimin Hyun, Kaiqiang Wang, Xiaoting Fu, Jiachao Xu, Xin Gao, Youngjin Park, You-Jin Jeon
Summary: Fucoidans isolated from brown seaweeds, such as Turbinaria ornata, have been found to have antioxidant and photoprotective effects. In this study, the fucoidan TO-F10 was shown to protect Vero cells and zebrafish from oxidative stress and photodamage induced by AAPH and UVB irradiation, respectively. These findings suggest that TO-F10 has potential as an ingredient in the cosmetic industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Celia Andres Juan, Jose Manuel Perez de la Lastra, Francisco J. Plou, Eduardo Perez-Lebena
Summary: Living species are constantly exposed to oxidants, leading to oxidative stress and disease. The induction of oxidative stress is caused by an imbalance between radical species and antioxidant defense systems, which can damage cellular biomolecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Microbiology
Li Dong, Jianran Qin, Luyang Tai, Kangyi Mou, Xiaojun Liao, Fang Chen, Xiaosong Hu
Summary: The curcumin-mediated photodynamic technology (Cur-PDT) was found to effectively inactivate Bacillus subtilis by inducing cell redox state imbalance, damaging DNA, and disrupting membrane structures.
Article
Environmental Sciences
Priyanka Prasad, Sushant Kumar Singh, Sukanya Ghosh, Suchisnigdha Dutta, Dona Sinha
Summary: This study investigated the impact of different exposure levels of arsenic in groundwater on cellular redox status, DNA damage, and repair mechanisms in rural women of West Bengal. The results showed a dose-dependent relationship between arsenic exposure levels and oxidative stress, DNA damage, and suppression of DNA repair proteins. Additionally, the exposed population had a very high risk of cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
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Cell Biology
Fanghua Li, Emil Mladenov, Rositsa Dueva, Martin Stuschke, Beate Timmermann, George Iliakis
Summary: The current understanding of the involvement of PI3-kinases in checkpoint responses after DNA damage reveals that ATM is the key regulator of G(1), S, or G(2)-phase checkpoints, ATR is only partly involved in the regulation of S and G(2)-phase checkpoints, and DNA-PKcs is not involved in checkpoint regulation. However, recent studies have shown complex integrations and interactions among ATM, ATR, and DNA-PKcs in checkpoint responses to ionizing radiation (IR), depending on the cell cycle phase and the load of DNA double-strand breaks (DSBs). These findings highlight the importance of these kinases in optimizing DSB processing.
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Polymer Science
Lei Wang, Xiaoting Fu, Jimin Hyun, Jiachao Xu, Xin Gao, You-Jin Jeon
Summary: In this study, the anti-inflammatory and antioxidant activities of agaro-oligosaccharides (AO) from Gracilaria lemaneiformis were investigated. AO showed significant scavenging abilities for various radicals and protected cells against oxidative damage. In vivo experiments demonstrated that AO reduced intracellular reactive oxygen species levels and lipid peroxidation in zebrafish, suggesting its potential applications in cosmetics and functional foods.
Editorial Material
Ethics
Guillermo Palchik, Celeste Chen, James Giordano
Article
Multidisciplinary Sciences
Giulia Antoniali, Fabrizio Serra, Lisa Lirussi, Mikiei Tanaka, Chiara D'Ambrosio, Shiheng Zhang, Slobodanka Radovic, Emiliano Dalla, Yari Ciani, Andrea Scaloni, Mengxia Li, Silvano Piazza, Gianluca Tell
NATURE COMMUNICATIONS
(2017)
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Biochemistry & Molecular Biology
Mengxia Li, Xiao Yang, Xianfeng Lu, Nan Dai, Shiheng Zhang, Yi Cheng, Lei Zhang, Yuxin Yang, Yie Liu, Zhenzhou Yang, Dong Wang, David M. Wilson
NUCLEIC ACIDS RESEARCH
(2018)
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Multidisciplinary Sciences
Zhimin Zhang, Feng Jin, Xiaojuan Lian, Mengxia Li, Ge Wang, Baohua Lan, Hao He, Guo-Dong Liu, Yan Wu, Guiyin Sun, Cheng-Xiong Xu, Zhen-Zhou Yang
SCIENTIFIC REPORTS
(2018)
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Oncology
Xiao Yang, Yu Peng, Xuan Jiang, Xianfeng Lu, Wei Duan, Shiheng Zhang, Nan Dai, Jinlu Shan, Yan Feng, Xuemei Li, Yi Cheng, Yuxin Yang, Laura Baugh, Gianluca Tell, Dong Wang, Mengxia Li
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Cell Biology
Guo-Shou Lu, Mengxia Li, Cheng-Xiong Xu, Dong Wang
CELL DEATH & DISEASE
(2018)
Article
Oncology
Liang Zhang, Mengxia Li, Bo Deng, Nan Dai, Yan Feng, Jinlu Shan, Yuxin Yang, Chengyi Mao, Ping Huang, Chengxiong Xu, Dong Wang
CANCER MANAGEMENT AND RESEARCH
(2019)
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Biotechnology & Applied Microbiology
Wei Liang, Chongyi Li, Mengxia Li, Dong Wang, Zhaoyang Zhong
ONCOTARGETS AND THERAPY
(2019)
Article
Health Care Sciences & Services
H. Paul Chin, Guillermo Palchik
Summary: The COVID-19 pandemic has accelerated the use of telepsychiatry, raising ethical issues such as patient benefit, distributive justice, privacy, and autonomy. It is considered a vital aspect of providing psychiatric care and should continue to be offered beyond the pandemic. Further investigation and advocacy efforts are needed to determine its exact role in psychiatric care and expand its availability for those most in need.
CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS
(2021)
Editorial Material
Health Care Sciences & Services
Thomasine Kushner, Gil Palchik
CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS
(2021)
Editorial Material
Ethics
Paul Chin, Guillermo A. Palchik
JOURNAL OF MEDICAL ETHICS
(2022)
Editorial Material
Health Care Sciences & Services
Robert Osorio, Guillermo Palchik
CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS
(2022)
Article
Biochemistry & Molecular Biology
Wei-Min Chen, Jui-Chung Chiang, Zengfu Shang, Guillermo Palchik, Ciara Newman, Yuanyuan Zhang, Anthony J. Davis, Hsinyu Lee, Benjamin P. C. Chen
Summary: DNA-PKcs plays a key role in DNA double-strand break repair and is involved in the cellular response to oxidative stress. It interacts with mitochondria proteins ANT2 and VDAC2 to maintain oxidative phosphorylation and mitochondrial membrane potential. The formation of the DAV complex is important for energizing the cell and its dissociation under oxidative stress helps reduce ROS production and promote cellular recovery.
Article
Biochemistry & Molecular Biology
Mengxia Li, Nan Dai, Dong Wang, Zhaoyang Zhong
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2019)
Article
Oncology
Meng-Xia Li, Hao He, Zhi-Hua Ruan, Yu-Xi Zhu, Rong-Qing Li, Xiao He, Bao-Hua Lan, Zhi-Min Zhang, Guo-Dong Liu, Hua-Liang Xiao, Yan Wu, Bo Zhu, Ge Wang, Zhen-Zhou Yang
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)