Article
Cell Biology
Wenwen Cheng, Cifeng Cai, Yifan Xu, Xueqi Xiao, Tiantian Shi, Yueling Liao, Xiaoyi Wang, Shasha Chen, Meiliang Zhou, Zhiyong Liao
Summary: This study identified a signaling pathway associated with hyperglycemia-induced apoptosis and proposed tartary buckwheat flavonoids as a potential treatment.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Yoko Hirata, Tomohiro Hashimoto, Kaori Ando, Yuji O. Kamatari, Hiroshi Takemori, Kyoji Furuta
Summary: This study identifies the structural features of N,N-dimethylaniline derivatives as potent ferroptosis inhibitors and demonstrates the localization of a specific compound, GIF-2197-r, in lysosomes through its aliphatic tertiary amine moiety.
Article
Biochemistry & Molecular Biology
Huaxin Li, Mengxue Zhang, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang
Summary: This study demonstrates that Daidzein (DAI) can alleviate heart failure (HF) by regulating cardiac energy metabolism, improving cardiac function, reducing inflammation, oxidative stress, apoptosis, and fibrosis.
Article
Biochemistry & Molecular Biology
Diana Alejandra Quintero-Espinosa, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio
Summary: This study reported the transdifferentiation of menstrual stromal cells into dopamine-like neurons in a new medium and demonstrated the usefulness of this medium in a rotenone-induced Parkinson's disease model. The study also revealed the role of LRRK2 kinase in regulating apoptotic cell death and autophagy in DALNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hector Flores-Romero, Lisa Hohorst, Malina John, Marie-Christine Albert, Louise E. King, Laura Beckmann, Tamas Szabo, Vanessa Hertlein, Xu Luo, Andreas Villunger, Lukas P. Frenzel, Hamid Kashkar, Ana J. Garcia-Saez
Summary: This study reveals a previously unrecognized activity of tBID in mediating mitochondrial permeabilization independently of BAX and BAK, which has physiological relevance in immune response and cancer therapy. This novel function of tBID is dependent on a specific helix structure and can be blocked by anti-apoptotic proteins, providing potential implications for therapeutic intervention in bacterial infections and cancer treatment.
Review
Biochemistry & Molecular Biology
Daniel Barriuso, Lucia Alvarez-Frutos, Lucia Gonzalez-Gutierrez, Omar Motino, Guido Kroemer, Roberto Palacios-Ramirez, Laura Senovilla
Summary: The Bcl-2 family of proteins, known for regulating apoptosis, is also involved in cellular senescence. These proteins play a role in determining the entry into senescence and the expression levels are modulated during senescence, promoting cell survival. Manipulation of Bax and Bcl-2 expression affects the appearance and survival of tetraploid cells. Understanding the role of Bcl-2 family proteins in senescence can lead to new therapeutic strategies for targeting cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Lin Lin Wang, Rong Sheng Du, Jian Li, Zi Jian Cai, Ling Han, Yun Mao, Yu Yu Zhou, Qun Li Yu, Lian Hong Chen
Summary: The study demonstrates that the iNOS-derived NO plays a significant role in mitochondrial apoptosis and yak meat tenderization, influencing these processes by regulating the apoptosis pathway, oxidative stress levels, and mitochondrial function during aging.
Article
Multidisciplinary Sciences
Joachim Lauterwasser, Franziska Fimm-Todt, Aline Oelgeklaus, Annabell Schreiner, Kathrin Funk, Hugo Falquez-Medina, Ramona Klesse, Guenther Jahreis, Ralf M. Zerbes, Katelyn O'Neil, Martin van der Laan, Xu Luo, Frank Edlich
Summary: This study reveals that hexokinase 1 and hexokinase 2 inhibit apoptotic activator truncated BID, as well as effectors BAX and BAK, by retrotranslocation from mitochondria to cytosol. Mitochondrial hexokinase localization and interactions with BH3 motifs of BCL-2 proteins are essential for the protection against TRAIL- and FasL-induced cell death, independent of glucose phosphorylation. Hexokinase-dependent retrotranslocation of truncated BID serves as a selective protective mechanism against death receptor-induced apoptosis on the mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Deeksha Kaloni, Sarah T. Diepstraten, Andreas Strasser, Gemma L. Kelly
Summary: Acquired resistance to cell death is a key characteristic of cancer. The BCL-2 protein family members have important roles in regulating apoptotic cell death. Abnormal expression of pro-survival BCL-2 family proteins or reduction in pro-apoptotic BCL-2 family proteins, both leading to inhibition of apoptosis, are commonly observed in various types of cancer. The critical role of pro-survival and pro-apoptotic BCL-2 family proteins in apoptosis regulation makes them attractive targets for cancer treatment. This review discusses the roles of different pro-survival and pro-apoptotic members of the BCL-2 protein family in normal development and organismal function, as well as how defects in apoptosis control contribute to cancer development and therapy resistance. Lastly, the development of inhibitors targeting pro-survival BCL-2 proteins, known as BH3-mimetic drugs, as novel agents for cancer therapy is discussed.
Article
Biochemistry & Molecular Biology
Vijay Kumar Veena, Ahana Roy Choudhury, Adhikesavan Harikrishnan
Summary: A newly synthesized 4H-chromene carbonitrile derivative was found to strongly interact with Bcl-2 and Bax proteins, leading to downregulation of these antiapoptotic proteins and induction of apoptosis in leukemic cells. The compound showed potential as an inhibitor of antiapoptotic machinery and demonstrated selective inhibition towards certain target proteins essential for cancer cell survival.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Jing Li, Junhua Li, Yuji Pu, Sai Li, Wenxia Gao, Bin He
Summary: This study introduced a novel nanocomplex PAF for enhanced cancer treatment through photodynamic therapy, demonstrating potent anticancer effects. The PAF showed excellent biocompatibility and enhanced photodynamic and near-infrared absorption capabilities under acidic conditions. The findings suggest that PDT-enhanced ferroptosis in PAF could be a promising strategy for nanotherapeutics due to its high potency, tumor selectivity, and excellent biocompatibility.
Article
Nutrition & Dietetics
Hai Jia, Yunchang Zhang, Xuemeng Si, Yuhang Jin, Da Jiang, Zhaolai Dai, Zhenlong Wu
Summary: This study demonstrates that quercetin can alleviate diquat-induced cell injury in enterocytes by upregulating the protein abundance of Nrf2 and regulating GSH-related redox homeostasis.
Article
Environmental Sciences
Reham M. Abd-Elsalam, Shymaa A. El Badawy, Hanan A. Ogaly, Faten M. Ibrahim, Ola M. Farag, Kawkab A. Ahmed
Summary: Eruca sativa seed extract (ESS) has a protective effect on acrylamide-induced hypogonadism in male rats, improving sperm quality, restoring testosterone level, and reducing testicular degeneration and cell death.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Ophthalmology
Qiongtao Song, Fuwen Zhang, Xue Han, Yanrong Yang, Ying Zhao, Junguo Duan
Summary: SAA exhibits significant protective effects against retinal iron overload, which may be associated with its ability to reduce iron content, regulate iron-handling proteins, and inhibit oxidative stress and apoptosis.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Shuxin Li, Hongmin Zhang, Jing Chang, Dongming Li, Pengxiu Cao
Summary: Pulmonary fibrosis is a chronic, progressive lung disease with limited treatment options. Recent research has shown that iron accumulation and mitochondrial damage play key roles in its development, highlighting a promising direction for finding effective therapeutics.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Dan Li, Qiannan Xu, Wennian Yu, Bing Wang
IET COMPUTER VISION
(2020)
Article
Engineering, Electrical & Electronic
Tao Fang, Peng Chen, Jun Zhang, Bing Wang
JOURNAL OF ELECTRONIC IMAGING
(2020)
Article
Chemistry, Analytical
Baohua Yang, Lin Qi, Mengxuan Wang, Saddam Hussain, Huabin Wang, Bing Wang, Jingming Ning
Article
Biochemistry & Molecular Biology
Aijun Deng, Huan Zhang, Wenyan Wang, Jun Zhang, Dingdong Fan, Peng Chen, Bing Wang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Cheng Wang, Wenyan Wang, Kun Lu, Jun Zhang, Peng Chen, Bing Wang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Computer Science, Interdisciplinary Applications
Wenyan Wang, Jun Zhang, Fang Zhou, Peng Chen, Bing Wang
Summary: This paper proposes a method that combines institution and author features to predict paper acceptance, achieving a higher ranking in acceptance rate by calculating institution scores, constructing collaborative networks, and extracting author influence indicators. The experimental results demonstrate the effectiveness of the proposed method in predicting paper acceptance rates.
Article
Biochemical Research Methods
ShanShan Hu, DeNan Xia, Benyue Su, Peng Chen, Bing Wang, Jinyan Li
Summary: This paper introduces a novel deep learning-based prediction system for identifying interactions between drugs and targets, achieving good performance in terms of accuracy and AUC value.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Article
Integrative & Complementary Medicine
Qiao Zhou, Jian Liu, Ling Xin, Yanyan Fang, Lei Wan, Dan Huang, Jinchen Guo, Jianting Wen, Bing Wang
Summary: This study investigated the treatment of osteoarthritis using Traditional Chinese Medicine (TCM) and complex network methods, summarizing common drug pairs and evaluating therapeutic efficacy. Results showed that different drug combinations have significant differences in treating osteoarthritis, and drug combinations can optimize laboratory indexes more effectively.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biology
Min Yang, Huandong Yang, Lei Ji, Xuan Hu, Geng Tian, Bing Wang, Jialiang Yang
Summary: This study identified the potential biomarkers associated with colorectal cancer (CRC) survival at mRNA, miRNA, and tissue microbiome levels. The microbiome of CRC tissue showed the best predictive power in determining the three-year survival of CRC patients. Additionally, differential microbial communities and expression genes were found between short-term survival (ST) and long-term survival (LT) groups. The results suggest that tissue bacterial communities can serve as potential biomarkers for predicting CRC survival.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemical Research Methods
Peng Chen, Huimin Shen, Youzhi Zhang, Bing Wang, Pengying Gu
Summary: Protein-ligand binding is important in many fields, and accurately predicting the binding affinity between molecules is challenging. This paper proposes a new method called SGNet, which fuses molecular graph information and amino acid sequence information to predict binding affinity. Experimental results demonstrate its superior performance.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2023)
Article
Engineering, Electrical & Electronic
Xin Xiang, Zenghui Wang, Jun Zhang, Yi Xia, Peng Chen, Bing Wang
Summary: Surface defect detection is crucial in steel production. Attention mechanisms are used to ensure quality, but they struggle to differentiate steel surface and natural images. To address this, we propose an adaptive graph channel attention (AGCA) module that incorporates graph convolutional theory. AGCA treats each channel as a feature vertex and uses adjacency matrices to represent their relationship. The non-local operations performed using AGCA's constructed graphs significantly enhance feature representation. Experimental results demonstrate AGCA's superiority over existing methods when integrated into defect detection networks. The code is available at https://github.com/C1nDeRainBo0M/AGCA.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Engineering, Electrical & Electronic
Wenyan Wang, Chunfeng Mi, Ziheng Wu, Kun Lu, Hongming Long, Baigen Pan, Dan Li, Jun Zhang, Peng Chen, Bing Wang
Summary: Surface defect inspection is crucial to ensure the quality of hot rolled steel surface. However, current advanced detection methods have high precision but low detection speed, which hampers their application in production. This study proposes a real-time detection network (RDN) that focuses on both speed and accuracy for steel surface defect detection. The proposed method achieves state-of-the-art recognition speed and accuracy on a standard dataset.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Biochemical Research Methods
Bing Wang, Changqing Mei, Yuanyuan Wang, Yuming Zhou, Mu-Tian Cheng, Chun-Hou Zheng, Lei Wang, Jun Zhang, Peng Chen, Yan Xiong
Summary: Protein-protein interactions play essential roles in biological processes, but experimental determined interaction sites are fewer than protein sites in complexes, leading to imbalanced samples. This study introduced three imbalance data processing strategies to reconstruct the dataset and improve prediction bias, achieving better performance in predicting protein interaction sites.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Article
Biochemical Research Methods
Wenyan Wang, Yuming Zhou, Mu-Tian Cheng, Yan Wang, Chun-Hou Zheng, Yan Xiong, Peng Chen, Zhiwei Ji, Bing Wang
Summary: Pathogenicity-related studies are essential for understanding complex diseases and improving clinical medicine. This research proposed a bioinformatics scheme to analyze cancer-related gene mutations and identify potential disease-associated genes from protein domain-domain interaction networks. The study applied centrality lethality principles to prioritize the significance of genes and successfully identified potential pathogenic domains related to malignant melanoma. Moreover, a web-based tool, called Human Cancer Related Domain Interaction Network Analyzer, was developed for prioritizing potential pathogenic genes for 26 types of human cancers.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2021)
Article
Biotechnology & Applied Microbiology
Yanyan Fang, Jian Liu, Ling Xin, Yue Sun, Lei Wan, Dan Huang, Jianting Wen, Ying Zhang, Bing Wang
BIOMED RESEARCH INTERNATIONAL
(2020)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
