Article
Medicine, Research & Experimental
Daniela Esteves Ferreira dos Reis Costa, Natalia Ferreira de Araujo, Natalia Ribeiro Cabacinha Nobrega, Naiara de Assis Rabelo Ribeiro, Amanda Carla Clemente de Oliveira, Luciano dos Santos Aggum Capettini, Adaliene Versiani Matos Ferreira, Daniella Bonaventura
Summary: The study revealed that the CAF diet induced obesity and metabolic disorders, but the contractile profile of perivascular adipose tissue may play a protective role in restoring impaired vascular contraction in the early stages.
Article
Multidisciplinary Sciences
Richard Perryman, Alexander Renziehausen, Hamidreza Shaye, Androniki D. Kostagianni, Antonis D. Tsiailanis, Thomas Thorne, Maria Chatziathanasiadou, Gregory B. Sivolapenko, Mohamed Ahmed El Mubarak, Gye Won Han, Barbara Zarzycka, Vsevolod Katritch, Guillaume Lebon, Cristiana Lo Nigro, Laura Lattanzio, Sophie Morse, James J. Choi, Kevin O'Neill, Zoi Kanaki, Apostolos Klinakis, Tim Crook, Vadim Cherezov, Andreas G. Tzakos, Nelofer Syed
Summary: This study reveals that AT(2)R is a therapeutic target for GBM and AngII promotes proliferation through this receptor. EMA401 and its derivative A3E can inhibit the proliferation and invasiveness of GBM, and show enhanced penetration in the CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Maksymilian Ziaja, Kinga Anna Urbanek, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The renin-angiotensin system (RAS) is not only involved in regulating cardiovascular function, but also plays a complex role in various processes such as memory and cancer. Maintaining the balance between individual elements of the RAS system is crucial for achieving homeostasis, and any disturbance in their expression or activity can lead to pathological processes.
Review
Biochemistry & Molecular Biology
Agnieszka Dettlaff-Pokora, Julian Swierczynski
Summary: SARS-CoV-2 impairs the renin-angiotensin-aldosterone system by binding the ACE2 enzyme, leading to an increase in angiotensin 2 and a decrease in angiotensin (1-7), potentially worsening damage to the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Medicine, General & Internal
Robert C. Speth
Summary: The article does not differentiate between ACE inhibitor therapy and ARB therapy in advanced CKD. The mechanisms of action of ACE inhibitors and ARBs differ substantially, with varying effects on renal function.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Amanda da Silva Chaves, Nathalia Santos Magalhaes, Daniella Bianchi Reis Insuela, Patricia Machado Rodrigues E Silva, Marco Aurelio Martins, Vinicius Frias Carvalho
Summary: This study investigates the role of the renin-angiotensin system (RAS) in the overproduction of corticosterone in diabetic mice. The results suggest that inhibition of angiotensin synthesis and AT(1) receptor activity can reduce corticosterone levels in diabetic mice. Furthermore, the protective effect of Olmesartan on corticosterone overproduction in diabetic mice depends on both AT(1) receptor blockade and AT(2) receptor activation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sebastian Andone, Zoltan Bajko, Anca Motataianu, Smaranda Maier, Laura Barcutean, Rodica Balasa
Summary: This article reviews the role of the renin-angiotensin system in stroke neuroprotection. The effects of the renin-angiotensin system on receptors were observed, and the neuroprotective properties seem to be independent of the blood pressure reduction mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Sizhu Gong, Fang Deng
Summary: Emotional disorders, such as depression and anxiety, have a significant impact on global morbidity. The renin-angiotensin system (RAS) plays a role in hypertension and emotional disorders, and elevated RAS activity is associated with depression and anxiety through neuroinflammation, stress, and oxidative stress. Blocking the RAS could potentially be a future treatment approach for anxiety and depression. The positive effects of RAS blockers on these disorders are reviewed, aiming to provide a promising target for novel medications and to improve the efficacy of current treatments independent of blood pressure management.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Lucas M. Kangussu, Natalia P. Rocha, Priscila A. C. Valadao, Thatiane C. G. Machado, Kivia B. Soares, Julliane V. Joviano-Santos, Leigh B. Latham, Gabriela D. Colpo, Ana Flavia Almeida-Santos, Erin Furr Stimming, Ana Cristina Silva, Antonio L. Teixeira, Aline Silva Miranda, Cristina Guatimosim
Summary: The imbalance of the Renin-Angiotensin System in the central nervous system may play a role in the pathophysiology of Huntington's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sam Siljee, Bridget Milne, Helen D. Brasch, Nicholas Bockett, Josie Patel, Paul F. Davis, Andrew Kennedy-Smith, Tinte Itinteang, Swee T. Tan
Summary: This study demonstrated the expression of PRR, ACE2, and AT(2)R by the CSCs within RCCC. Further studies may lead to novel therapeutic targeting of CSCs by manipulation of the RAS in the treatment of this aggressive cancer.
Review
Biochemistry & Molecular Biology
Lucile Yart, Edith Roset Bahmanyar, Marie Cohen, Begona Martinez de Tejada
Summary: Placental development and function are crucial for efficient maternal-fetal exchanges, pregnancy-specific hormone secretion, and immune modulation. Incorrect placental development can lead to serious pregnancy disorders, such as preeclampsia, endangering both the mother and the infant. The role of the uteroplacental renin-angiotensin system in placental development and function may have been underestimated.
Article
Multidisciplinary Sciences
Susanne Rysz, Jonathan Al-Saadi, Anna Sjostrom, Maria Farm, Francesca Campoccia Jalde, Michael Platten, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyren, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Summary: Studies suggest that RAAS imbalance worsens the prognosis in COVID-19 patients, and experiments in pigs show that over-activation of ACE2 and RAAS can lead to a disease state similar to COVID-19 in humans. Imbalanced RAAS state in animals can be ameliorated by angiotensin receptor blockers and low-molecular-weight heparin.
NATURE COMMUNICATIONS
(2021)
Review
Endocrinology & Metabolism
Yuanyuan Liu, Haomeng Hao, Tingting Lan, Rui Jia, Mingya Cao, Liang Zhou, Zhiming Zhao, Wensen Pan
Summary: The local Renin-Angiotensin System (RAS) plays a role in the female reproductive system, regulating follicle development and physiological functions of the placenta and uterus. Ang II and Ang-(1-7) have similar functions in this system and can influence the occurrence and development of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bongeka Cassandra Mkhize, Palesa Mosili, Phikelelani Sethu Ngubane, Ntethelelo Hopewell Sibiya, Andile Khathi
Summary: Type 2 diabetes is associated with osteoporosis, and the renin-angiotensin-aldosterone system (RAAS) has been found to play a role in this association. Upregulated RAAS activity may alter the bone microenvironment and inhibit bone formation. Additionally, RAAS promotes osteoclastogenesis and inhibits osteoblast formation. More research is needed to fully understand the effects of RAAS on T2D and osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
T. C. Travaglia, R. C. M. Berger, M. B. Luz, L. B. Furieri, R. F. Ribeiro Junior, D. V. Vassallo, J. G. Mill, I Stefanon, P. F. Vassallo
Article
Cell Biology
Rogerio Faustino Ribeiro, Karoline Sousa Ronconi, Elis Aguiar Morra, Patricia Ribeiro Do Val Lima, Marcella Leite Porto, Dalton Valentim Vassallo, Suely Gomes Figueiredo, Ivanita Stefanon
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2016)
Article
Environmental Sciences
Carolina Falcao Ximenes, Samya Mere Lima Rodrigues, Priscila Lang Podratz, Eduardo Merlo, Julia Fernandez Punal de Araujo, Livia Carla Melo Rodrigues, Juliana Barbosa Coitinho, Dalton Valentim Vassallo, Jones Bernardes Graceli, Ivanita Stefanon
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2017)
Article
Cell Biology
Rogerio Faustino Ribeiro Junior, Paula Lopes Rodrigues, Elis Aguiar Morra, Karoline Sousa Ronconi, Patricia Ribeiro Do Val Lima, Marcella Leite Porto, Maylla Ronacher Simoes, Dalton Valentim Vassallo, Suely Gomes Figueiredo, Ivanita Stefanon
Article
Biochemistry & Molecular Biology
Patrick W. Endlich, Erick R. G. Claudio, Leandro C. F. Lima, Rogerio F. Ribeiro Junior, Antonio A. B. Peluso, Ivanita Stefanon, Nazare S. Bissoli, Virginia S. Lemos, Robson A. S. dos Santos, Glaucia R. de Abreu
Article
Toxicology
Rogerio Faustino Ribeiro Junior, Vinicius Bermond Marques, Dieli Oliveira Nunes, Ivanita Stefanon, Leonardo dos Santos
TOXICOLOGY LETTERS
(2017)
Review
Cell Biology
R. F. Ribeiro Junior, K. S. Ronconi, I. C. G. Jesus, P. W. M. Almeida, L. Forechi, D. V. Vassallo, S. Guatimosim, I. Stefanon, A. A. Fernandes
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Review
Endocrinology & Metabolism
Karoline de Sousa Ronconi, Ivanita Stefanon, Rogerio F. Ribeiro Junior
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Environmental Sciences
C. L. V. Pereira, C. F. Ximenes, E. Merlo, A. S. Sciortino, J. S. Monteiro, A. Moreira, B. B. Jacobsen, J. B. Graceli, K. S. Ginsburg, R. F. Ribeiro Junior, D. M. Bers, I. Stefanon
ENVIRONMENTAL POLLUTION
(2019)
Article
Biochemistry & Molecular Biology
Elis Aguiar Morra, Paula Lopes Rodrigues, Itamar Couto Guedes de Jesus, Patricia Ribeiro do Val Lima, Renata Andrade Avila, Tadeu Eriton Caliman Zanardo, Breno Valentim Nogueira, Donald M. Bers, Silvia Guatimosim, Ivanita Stefanon, Rogerio Faustino Ribeiro Junior
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Multidisciplinary Sciences
Rafaela de Araujo Fernandes Correa, Rogerio Faustino Ribeiro Junior, Sara Bianca Oliveira Mendes, Priscila Mendonca dos Santos, Miracle Vitoria Albino da Silva, Daniel Ferron Silva, Igor Peixoto Biral, Priscila Rossi de Batista, Dalton Valentim Vassallo, Athelson Stefanon Bittencourt, Ivanita Stefanon, Aurelia Araujo Fernandes
Article
Cell Biology
Diogo A. Guimaraes, Nayara S. S. Aquino, Cibele Rocha-Resende, Itamar C. G. Jesus, Mario Morais Silva, Sergio A. Scalzo, Roberta Cristelli Fonseca, Marina T. Durand, Vanessa Pereira, Geisa C. S. Tezini, Andre Oliveira, Vania F. Prado, Ivanita Stefanon, Helio C. Salgado, Marco Antonio Maximo Prado, Raphael E. Szawka, Silvia Guatimosim
Summary: It is well known that cholinergic hypofunction contributes to cardiac pathology. This study found that mice with cholinergic deficit showed an increase in cardiac norepinephrine (NE) levels, enhanced sympathetic activity, and changes in cellular signaling pathways. These results reveal a previously unrecognized role of cholinergic signaling in modulating cardiac NE.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dalton Valentim Vassallo, Maylla Ronacher Simoes, Karina Giuberti, Bruna Fernandes Azevedo, Rogerio Faustino Ribeiro Junior, Mercedes Salaices, Ivanita Stefanon
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2019)
Article
Cardiac & Cardiovascular Systems
Thais de O. Faria, Maylla Ronacher Simoes, Dalton Valentim Vassallo, Ludimila Forechi, Camila Cruz Pereira Almenara, Bruna Antoniassi Marchezini, Ivanita Stefanon, Paula Frizera Vassallo
CARDIOVASCULAR TOXICOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Thais de Oliveira Faria, Jhuli Keli Angeli, Luiz Guilherme Marchesi Mello, Gustavo Costa Pinto, Ivanita Stefanon, Dalton Valentim Vassallo, Juliana Hott de Fucio Lizardo
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2017)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)