Article
Biochemistry & Molecular Biology
Orlando Santoro, Miryam Chiara Malacarne, Francesco Sarcone, Luca Scapinello, Stefania Pragliola, Enrico Caruso, Viviana Teresa Orlandi, Lorella Izzo
Summary: In this study, two compounds from the BODIPY family were bound to amino-pendant groups of three random copolymers with varying amounts of MMA and DMAEMA. The copolymers showed inherent bactericidal activity due to the presence of amino groups and quaternized nitrogens bound to BODIPY. Coated filter paper discs with copolymers conjugated to BODIPY inhibited the growth of E. coli and S. aureus under green light irradiation, with the highest efficiency observed in the copolymer containing 43% DMAEMA and approximately 0.70 wt/wt% BODIPY. The copolymers also exhibited residual antimicrobial activity after dark incubation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xianjin Hu, Lu Yang, Ying Zhang, Bingbing Shou, Hai-Tao Ren, Jia-Horng Lin, Ching-Wen Lou, Ting-Ting Li
Summary: This study designed a novel co-electrospun cellulose acetate/thermoplastic polyurethane photodynamic helical fiber antibacterial membrane, which exhibited excellent antibacterial performance through the synergistic effects of photodynamic antimicrobial therapy and antimicrobial agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Carolina Ramos Hurtado, Gabriela Ramos Hurtado, Gabrielle Lupeti de Cena, Rafaela Campos Queiroz, Alexandre Vieira Silva, Milton Faria Diniz, Veronica Ribeiro dos Santos, Vladimir Trava-Airoldi, Mauricio da Silva Baptista, Ncediwe Tsolekile, Oluwatobi Samuel Oluwafemi, Katia Conceicao, Dayane Batista Tada
Summary: The conjugation of diamond nanoparticles with the photosensitizer Meso-5, 10, 15, 20-tetrakis (3-hydroxyphenyl) phorphyryn (mTHPP) showed promising antibacterial activity against Escherichia coli, while also demonstrating non-cytotoxic effects on murine embryonic fibroblast cells. These results suggest that the ND-mTHPP nanoconjugate could be a potential platform for antimicrobial photodynamic therapy.
Article
Biochemistry & Molecular Biology
Viviana Teresa Orlandi, Eleonora Martegani, Fabrizio Bolognese, Nicola Trivellin, Francesco Garzotto, Enrico Caruso
Summary: Antimicrobial photodynamic therapy (aPDT) is gaining attention as a promising tool for treating microbial infections and sanitizing environments. A study on a panel of photosensitizers found that dicationic diaryl-porphyrins show potential in efficiently photoinactivating Pseudomonas aeruginosa, including inhibiting biofilm formation. These findings suggest the potential applicability of dicationic diaryl-porphyrins in different fields for combating difficult-to-treat microbes like P. aeruginosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sara R. D. Gamelas, Isabel N. N. Sierra-Garcia, Augusto C. C. Tome, Angela Cunha, Leandro M. O. Lourenco
Summary: Antimicrobial photodynamic therapy (aPDT) is an innovative therapeutic approach that can effectively inactivate microbial forms without harming host tissues or causing resistance. This study evaluates the antifungal/sporicidal activity of tetra- and octasubstituted phthalocyanine dyes with ammonium groups. Both photosensitizers tested showed high efficiency in inactivating conidia, with the tetrasubstituted dye being the most effective. These phthalocyanines have the potential to be potent antifungal drugs due to their low concentrations and moderate energy doses required for inactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Laura Adriane de Moraes Pinto, Adriane Frizzo, Carlos Eduardo Benito, Ranulfo Combuca da Silva Junior, Lucas Kind Alvares, Andre Nata Pinto, Caio Tellini, Jessica de Oliveira Monteschio, Jovanir Ines Mueller Fernandes
Summary: One disadvantage of commercially displaying cooled chicken breast in an illuminated store window is addressed by evaluating the effects of an edible photoactive biofilm coating containing curcumin and oregano essential oil. Through antimicrobial photodynamic therapy (aPDT), the photodynamic potential of curcumin is explored. The biofilm shows good distribution and surface homogeneity, and the blend of curcumin and oregano essential oil, along with aPDT, reduces the quantity of evaluated microorganisms while maintaining the quality attributes of the chicken breasts.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ying Wang, Yixuan Xu, Xianghuan Guo, Lei Wang, Jing Zeng, Haixia Qiu, Yizhou Tan, Defu Chen, Hongyou Zhao, Ying Gu
Summary: This article reviews the recent progress in the combination therapy using ultrasound and antimicrobial photodynamic therapy (aPDT) and discusses the potential mechanisms underlying the enhanced antimicrobial effect. The future research directions are also highlighted.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Oncology
Gabriela Alves da Collina, Fernanda Viana Cabral, Carolina Montovam Monteiro, Gabriela Benedito Machado, Jose Marcelo Lacerda Alves Goncalves, Fernanda Freire, Renato Araujo Prates, Martha Simoes Ribeiro, Christiane Pavani
Summary: This study evaluated the photodynamic inactivation (PDI) effects of an oral formulation (OF) containing 0.005% methylene blue (MB) on Candida albicans biofilm using multiple methodologies. The results showed that PDI mediated by MB-OF significantly reduced the colony forming units (CFU) and virulence of the biofilm, but did not have a significant impact on metabolic activity. The crystal violet (CV) staining data were inconclusive due to interference from the components of the formulation.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Tim Maisch, Konstantin J. Scholz, Eva-Maria Forster, Verena Wenzl, David L. Auer, Fabian Cieplik, Karl-Anton Hiller
Summary: The widespread occurrence of multi-resistant bacteria is a global health problem. Using antiseptics in combination with antibacterial photodynamic therapy can be lethal to bacteria, and effective concentration combinations can reduce the dosage of antibacterial agents.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Applied
T. M. Ebaston, Faina Nakonechny, Efrosiniia Talalai, Gary Gellerman, Leonid Patsenker
Summary: The study introduces new NIR photosensitizers based on iodinated xanthene-cyanine dyes, which exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration and NIR light dose.
Article
Chemistry, Physical
M. Karimi, E. Sadeghi, S. Khosravi Bigdeli, M. Zahedifar
Summary: In this study, ZnO:Eu nanoparticles were synthesized using the co-precipitation method. XRD, SEM, PL, UV-Vis spectroscopy, and FTIR were used to analyze the properties of the nanoparticles. The results confirmed the inhibitory effect of ZnO:Eu nanoparticles on the growth of various bacterial species.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Antonella Battisti, Paola Morici, Antonella Sgarbossa
Summary: Bacterial biofilms create a strong barrier against drugs and the host immune system; Helicobacter pylori's biofilm makes it resistant to antibiotics; Antimicrobial PhotoDynamic Therapy could be an effective strategy against bacterial infections.
Article
Chemistry, Multidisciplinary
Hao Liu, Yikai Chen, Luoqi Mo, Fangdong Long, Yixiao Wang, Zhouyi Guo, Haolin Chen, Chaofan Hu, Zhiming Liu
Summary: This study proposes a new teeth whitening technique using afterglow photodynamic therapy (aPDT), which can efficiently whiten teeth without the use of harmful chemicals or strong light irradiation. The method of embedding carbon dots in silica nanoparticles extends the lifetime of reactive oxygen species, thereby allowing for the thorough removal of deep enamel stains.
Article
Chemistry, Multidisciplinary
Jipsa Chelora, Yuchao Liang, Wei-Chih Wei, Xiao Cui, Yafang Xiao, Yingpeng Wan, Zhongming Huang, Shuang Tian, Shengliang Li, Yi-Hsuan Huang, Ken-Tsung Wong, Chun-Sing Lee
Summary: The development of small molecule-based nanoparticles that can perform effective photothermal therapy and overcome hypoxia for cancer photodynamic therapy shows promising results in vitro and in vivo studies.
Article
Oncology
J. Arentz, H-J Von der Heide
Summary: The study aimed to develop a simplified PDI therapy option in the nose and throat area using low dose methylene blue as a photosensitizer to reduce the viral load of coronaviruses. The results showed that a minimum concentration of 0.0001% MB and a minimum radiation intensity of 20000 lx led to a 99.99% reduction of intracellular and extracellular viruses after one minute exposure.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Chemistry, Multidisciplinary
Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Hossein Mahmudi, Mehdi Jaymand, Zohreh Amoozgar, Mohsen Akbari, Michael R. Hamblin, Rana Jahanban-Esfahlan
Summary: Hypoxia in solid tumors contributes to drug resistance, metastasis, and cancer relapse, but also provides an opportunity for targeting hypoxic tumor regions. This study discusses various strategies for dealing with hypoxia in deep-seated tumor cells, including their combination with other approaches like photodynamic therapy. The potential and limitations of these approaches, as well as current 3D hypoxia modeling systems, are also examined. Additionally, the potential and current status of preclinical tumor hypoxia approaches in clinical trials for advanced cancer are discussed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Afshin Taheriazam, Ghazaleh Gholamiyan Yousef Abad, Shima Hajimazdarany, Mohammad Hassan Imani, Setayesh Ziaolhagh, Mohammad Arad Zandieh, Seyedeh Delaram Bayanzadeh, Sepideh Mirzaei, Michael R. Hamblin, Maliheh Entezari, Amir Reza Aref, Ali Zarrabi, Yavuz Nuri Ertas, Jun Ren, Romina Rajabi, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Kiavash Hushmandi
Summary: Nanotechnology offers great potential in the field of nanomedicine for the treatment of various diseases, especially cancer. Graphene oxide nanoparticles have emerged as promising carbon-based nanocarriers for drug and gene delivery, photothermal therapy, overcoming chemotherapy resistance, and imaging. This review focuses on the biological functions of graphene oxide nanoparticles as regulators of apoptosis and autophagy, and their potential toxicity in major body organs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Psychiatry
Masoumeh Beheshti, Nikta Rabiei, Mohammad Taghizadieh, Pariya Eskandari, Samaneh Mollazadeh, Ehsan Dadgostar, Michael R. Hamblin, Arash Salmaninejad, Raziye Emadi, Amir Hossein Mohammadi, Hamed Mirazei
Summary: Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder characterized by intrusive thoughts and repetitive or ritualized actions. It is believed to have a genetic component, but the specific genetic factors involved are still unknown. This review summarizes the single nucleotide polymorphisms associated with OCD symptoms, early onset disease, neuroimaging results, and response to therapy. This information can help to understand the genetic basis of OCD, characterize individual patients, predict prognosis, and develop personalized treatment approaches.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Spectroscopy
Faezeh Fallahi, Atarodalsadat Mostafavinia, Zahranadia Sharifi, Leila Mohaghegh Shalmani, Abdollah Amini, Houssein Ahmadi, Hamidreza Omidi, Masoumeh Hajihosseintehrani, Sahar Bayat, Michael R. Hamblin, Sufan Chien, Mohammad Bayat
Summary: This study reports the effects of photobiomodulation (PBM) on diabetic adipose-derived stem cells (ADSCs) in vitro. The results showed that PBM significantly increased ATP levels and mitochondrial membrane potential (MMP), while decreasing reactive oxygen species (ROS) levels and the expression of PINK1 and PARKIN genes in diabetic-ADSCs. These findings suggest that PBM has the potential to improve the function and quality of mitochondrial diabetic-ADSCs, making it a promising approach for treating diabetic foot ulcers in diabetic patients.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Ali Arash Anoushirvani, Arezoo Jafarian Yazdi, Sanaz Amirabadi, Sahar Ahmadi Asouri, Rana Shafabakhsh, Amirhossein Sheida, Maryam Sadat Hosseini Khabr, Ameneh Jafari, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Leila Kalantari, Sayyed Alireza Talaei Zavareh, Hamed Mirzaei
Summary: Neuroblastoma is the most common extracranial malignancy in childhood and is derived from neural crest. Non-coding RNAs (ncRNAs) have been found to play important roles in various cancers, including glioma and gastrointestinal cancers, by regulating cancer gene networks. Recent studies have shown that ncRNA genes are deregulated in human cancers through various mechanisms, and disturbances in their expression can act as either oncogenes or tumor suppressor genes, leading to the development of cancer. Moreover, ncRNAs can be secreted from tumor cells in exosomes and transferred to other cells, exerting their functions. However, further research is needed to fully understand the roles of ncRNAs in neuroblastoma.
CANCER GENE THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Nasim Ebrahimi, Elmira Fardi, Hajarossadat Ghaderi, Sahar Palizdar, Roya Khorram, Reza Vafadar, Masoud Ghanaatian, Fatemeh Rezaei-Tazangi, Payam Baziyar, Amirhossein Ahmadi, Michael R. Hamblin, Amir Reza Aref
Summary: Targeted therapy is a new approach in cancer treatment, using drugs that specifically target proteins in cancer cells. Inhibiting these proteins can impede cancer progression. Understanding the structures, activation mechanisms, and functions of receptor tyrosine kinases (RTKs) has led to the development of targeted drug therapies, including RTK inhibitors (RTKIs), some of which have been used in clinical settings. This article discusses RTKs and their role in cancer treatment, as well as the potential effects of combination drug therapy for drug resistant cancers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Irina Pereira, Carina Monteiro, Miguel Pereira-Silva, Diana Peixoto, Claudia Nunes, Salette Reis, Francisco Veiga, Michael R. Hamblin, Ana Claudia Paiva-Santos
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Chemistry, Physical
Houra Nekounam, Javad Malakootikhah, Donya Shaterabadi, Babak Negahdari, Mohammad Reza Kandi, Michael R. Hamblin
Summary: This article summarizes the advances in the preparation, optimization, and applications of silica nanoparticles in biomedical nanotechnology, as well as the inevitable human, environmental, and industrial contacts with these particles. Understanding the physicochemical properties of silica nanoparticles and their interactions with biological systems at the cellular level is crucial for the rational design of these particles. Control of toxicity risk can guide the design of silica nanoparticles for drug delivery and bioimaging systems.
Review
Microbiology
Weitao Zhu, Michael R. Hamblin, Xiang Wen
Summary: Rosacea is a chronic inflammatory skin disorder affecting the centrofacial region. Its etiology and treatment methods are still unclear. This review examines common bacterial species found in the skin and gut microbiota of rosacea patients and their role in pathogenesis. Additionally, it summarizes the impact of factors such as temperature and age on rosacea and reviews commonly used clinical treatment methods, including antibiotics and probiotics, along with their mechanisms and precautions.
FRONTIERS IN MICROBIOLOGY
(2023)
Correction
Nanoscience & Nanotechnology
Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Abdullah Aldhaher, Pooyan Makvandi, Rassoul Dinarvand, Maryam Jouyandeh, Mohammad Reza Saeb, Masoud Mozafari, Mohammadreza Shokouhimehr, Michael R. Hamblin, Rajender S. Varma
ACS APPLIED BIO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Arefeh Ebadati, Mojgan Oshaghi, Sara Saeedi, Parastoo Parsa, Vahid Pirhajati Mahabadi, Morteza Karimi, Atefeh Jahandideh Hajiebrahimdehi, Michael R. Hamblin, Mahdi Karimi
Summary: Multi-drug resistant bacteria pose a significant challenge in the treatment of infectious diseases. Cationic nanopolymers, specifically poly(DABCO-BBAC) nanoparticles, exhibit high efficiency as antimicrobial agents. These nanoparticles effectively inhibit and kill multi-drug resistant Pseudomonas aeruginosa, making them a potential therapeutic option for drug-resistant clinical pathogens.
BIOORGANIC CHEMISTRY
(2023)
Review
Microbiology
Hanane Joudaki, Negar Aria, Roya Moravej, Mohamadreza Rezaei Yazdi, Zarrindokht Emami-Karvani, Michael R. Hamblin
Summary: Microbial phytases are enzymes that can break down phytic acid, providing several benefits in the food industry such as improved nutrient utilization, enhanced mineral bioavailability, and improved taste and functionality of food products. Factors like enzyme production and engineering techniques play a crucial role in effectively using microbial phytases.
CURRENT MICROBIOLOGY
(2023)
Article
Oncology
Przemys law Gnatowski, Edyta Pilat, Justyna Kucinska-Lipka, Mohammad Reza Saeb, Michael R. Hamblin, Masoud Mozafari
Summary: Cancerous tumors are highly fatal, claiming almost 10 million lives in 2020 worldwide. Accurately modeling tumors is a challenging task due to their complex and dynamic nature. Hydrogel-based 3D bioprinting is emerging as a promising approach to overcome the limitations of current models and mimic cancer development and behavior.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Engineering, Biomedical
Fahimeh Ghasemi Moravej, Abdollah Amini, Reza Masteri Farahani, Samira Mohammadi-Yeganeh, Atarodalsadat Mostafavinia, Houssein Ahmadi, Hamidreza Omidi, Fatemehalsadat Rezaei, Latif Gachkar, Michael R. Hamblin, Sufan Chien, Mohammad Bayat
Summary: Diabetic wounds lead to chronic inflammation and the development of diabetic foot ulcers, which can cause amputation and death. This study examined the effect of photobiomodulation (PBM) plus allogeneic diabetic adipose tissue-derived stem cells (ad-ADS) on wound healing in type I diabetic rats. The results showed that the ad-ADS plus PBM treatment group had significantly better histological results compared to the other experimental groups.
LASERS IN MEDICAL SCIENCE
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)