Review
Biochemistry & Molecular Biology
Anthony R. Carroll, Brent R. Copp, Rohan A. Davis, Robert A. Keyzers, Michele R. Prinsep
Summary: This review summarizes the literature on marine natural products (MNPs) published in 2019, covering a wide range of organisms and compounds, with a focus on new compounds and their biological activities and country of origin. Methods for studying marine fungi and their chemical diversity are also discussed.
NATURAL PRODUCT REPORTS
(2021)
Review
Chemistry, Medicinal
Claudiu T. T. Supuran
Summary: Carbonic anhydrases (CAs) are widely present in organisms and play important roles in various physiological and pathological processes. Marine natural products have been valuable resources for discovering CA inhibitors, such as sulfonamides, phenols, and polyamines. Psammaplin C and bromophenols have been extensively studied as potential antitumor agents by inhibiting the activities of human CA XII and P-glycoprotein. Marine natural products offer great potential for the development of novel pharmacological agents.
Review
Microbiology
Arumugam Ganeshkumar, Juliana Caparroz Goncale, Rajendran Rajaram, Juliana Campos Junqueira
Summary: This review discusses the significance of marine natural products in controlling the proliferation and metabolism of Candida species, including drug-resistant strains. It highlights the research value of sponges that produce compounds with inhibitory activity against Candida strains. Additionally, the review reveals the mechanisms and synergistic activity of marine products with conventional antifungals. Overall, the majority of compounds derived from the marine environment are capable of controlling specific functions of Candida microorganisms, providing insights into the design of new anti-candidal therapies.
Article
Biochemistry & Molecular Biology
Wenkang Ye, Sin Tung Lui, Qirui Zhao, Yuk Ming Wong, Aifang Cheng, Herman H. -Y. Sung, Ian D. Williams, Pei-Yuan Qian, Pingbo Huang
Summary: This study explored marine-derived natural products as potential TRPV1 modulators for pain management. Chrexanthomycins, identified as a family of hexacyclic xanthones, exhibited significant inhibitory effects on TRPV1. In vivo assays demonstrated their capability to suppress capsaicin-induced pain sensation in mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Stefano Alberti, Maria Sotiropoulou, Elena Fernandez, Nicoleta Solomou, Maurizio Ferretti, Elefteria Psillakis
Summary: Nicotine, an important emerging contaminant in water, mainly originates from human waste and discarded tobacco products. Its UV254 photolytical fate is affected by pH, humic acids, and concentration, with by-products formed during degradation. UV254 irradiation effectively removes nicotine but leaves behind organic carbon due to the formation of photo-products.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Assunta Saide, Sara Damiano, Roberto Ciarcia, Chiara Lauritano
Summary: Marine organisms provide a potential source of novel bioactive metabolites for the treatment of hematological tumors. Despite many marine-derived compounds showing promising properties in treating leukemia and lymphoma, there is still a lack of understanding regarding their mechanisms of action. Ongoing advancements in omics technologies have the potential to further explore the therapeutic potential of marine natural products.
Article
Chemistry, Multidisciplinary
Wei Hu, Taotao Qiang, Chenchen Li, Longfang Ren, Fei Cheng, Baoshuai Wang, Mingli Li, Xinjian Song, Tony D. James
Summary: Small-molecule NIR imaging is a popular technique for tracking biological species and events due to its advantages such as deep tissue penetration, low autofluorescence, non-invasive visualization, and simple operation. However, the small Stokes shift of most NIR dyes often leads to low signal-to-noise ratio and self-quenching. In this research, a NIR-based fluorescent probe was developed for hypochlorous acid detection, which successfully addressed the issue of crosstalk between excitation and emission spectra. Imaging studies demonstrated the probe's potential for endogenous HOCl detection and imaging in living cells.
Review
Biochemistry & Molecular Biology
Taitusi Taufa, Ramesh Subramani, Peter T. Northcote, Robert A. Keyzers
Summary: The islands of the South Pacific Ocean, especially the Kingdom of Tonga, have a rich diversity of flora and fauna, with many unique marine organisms producing biologically active natural products. Research on Tongan marine organisms has shown that the majority of these natural products exhibit cytotoxicity as their main biological activity, with significant geographic variability in the chemistry of organisms collected from different locations.
Article
Chemistry, Multidisciplinary
Jiayan Lang, Xiaojing Ma, Pengyu Chen, Max D. Serota, Nicole M. Andre, Gary R. Whittaker, Rong Yang
Summary: CeO2-x nanorods with optimized aspect ratio demonstrated strong antiviral efficacies against human coronavirus OC43.
Review
Cardiac & Cardiovascular Systems
Bo Liang, Xin-Yi Cai, Ning Gu
Summary: Coronary artery disease is a major cause of mortality worldwide, with pharmacological interventions like antiplatelet drugs, anticoagulant drugs, and statins commonly used to manage symptoms and prevent cardiovascular events. However, existing drugs have limitations and adverse effects, highlighting the need for new drug development. Marine natural products, known for their chemical diversity and biological activities, show promise in treating coronary artery disease, with substances like organic small molecules, polysaccharides, proteins, and lipids showing efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Microbiology
Jinwang Ding, Baochuan Wu, Liqun Chen
Summary: As the cosmetics industry expands, there is a greater demand for new products that are safe and effective. Marine micro-organisms produce natural products with unique structures, high diversity, and significant biological activities. The search for effective, safe, and natural cosmetic ingredients from marine micro-organisms has become a focus. However, the difficulty in culturing marine micro-organisms due to their specific environmental requirements can be addressed by metagenomics technology. Furthermore, using marine species for biotransformation to produce more environmentally friendly products is a new option for cosmetic manufacturers.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xuelian Bai, Yang Liu, Hao Wang, Huawei Zhang
Summary: Reniera sponges, as an important subgenus of Haliclona, have been chemically investigated for over four decades and are mainly distributed in the Mediterranean Sea and Atlantic area. This review provides a comprehensive summary of all natural products from Reniera sponges and their endozoic microbes, as well as their biological properties, and suggests perspectives on strengthening the chemical study of Reniera sponges for new drug-lead discovery.
Review
Chemistry, Medicinal
Neshatul Haque, Sana Parveen, Tingting Tang, Jiaen Wei, Zunnan Huang
Summary: Marine natural products, with their diverse characteristics and mechanisms of action, are promising sources of drugs. The number of marine drugs approved for clinical use has significantly increased in recent decades, thanks to research efforts worldwide. Researchers and clinicians are optimistic about discovering more drugs as more marine compounds are being investigated in studies.
Review
Biochemistry & Molecular Biology
Eleonora Montuori, Caroline A. C. Hyde, Francesco Crea, Jon Golding, Chiara Lauritano
Summary: Prostate cancer is the most common cancer in men, and current diagnostic and treatment approaches have limitations. The scientific community is seeking new chemotherapeutic agents for this disease. This review focuses on compounds and extracts from marine organisms as potential sources of new drugs against prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Yanting Zhang, Miaoping Lin, Yuning Qin, Humu Lu, Xinya Xu, Chenghai Gao, Yonghong Liu, Wenfang Luo, Xiaowei Luo
Summary: The emergence of drug-resistant Vibrio poses a serious threat to aquaculture and human health. Therefore, there is a need to discover new antibiotics related to this. Marine microorganisms have been identified as important sources of antibacterial natural products, and a review of 214 anti-Vibrio natural products isolated from marine microorganisms is presented in this study. These compounds, including 108 new ones, show great structural diversity and have potential applications in agriculture and human health.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
