Article
Multidisciplinary Sciences
Michael Schmalz, Xiao- Xuan Liang, Ines Wieser, Caroline Gruschel, Lukas Muskalla, Martin Thomas Stoeckl, Roland Nitschke, Norbert Linz, Alfred Leitenstorfer, Alfred Vogel, Elisa Ferrando-May, Wei Yang
Summary: Understanding and predicting the outcome of light-DNA interaction is crucial for DNA repair and radiotherapy. This study combines laser microirradiation, imaging, and modeling to investigate the damage pathways in live cells. The results show that photochemical damage dominates at 515 nm, while electron-mediated damage dominates at wavelengths ≥620 nm. The study provides a conceptual framework for interpreting the wavelength-dependent DNA damage induced by laser and electron interactions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Physics, Multidisciplinary
Xiangduo Kong, Nicole M. Wakida, Kyoko Yokomori
Summary: Laser microirradiation has become a powerful tool to investigate DNA damage response and repair mechanisms in mammalian cells by inducing damage at a sub-micron level in the cell nucleus. Different irradiation conditions lead to varying DNA damage signaling responses, highlighting the importance of understanding the features of laser-induced DNA damage.
FRONTIERS IN PHYSICS
(2021)
Article
Plant Sciences
Martina Nespor Dadejova, Michal Franek, Martina Dvorackova
Summary: This study presents a method for studying the DNA damage response in plants using plant protoplasts. DNA lesions were generated using laser microirradiation, and fluorescently tagged proteins were introduced to study the localization and function of uncharacterized plant proteins in the protoplasts. The results demonstrate that laser microirradiation in protoplasts induces a physiological cellular response and recruits factors involved in DNA repair.
Review
Biochemistry & Molecular Biology
Siti A. M. Imran, Muhammad Dain Yazid, Wei Cui, Yogeswaran Lokanathan
Summary: TRF2 plays a crucial role in protecting telomeres and preventing DNA instability and diseases like cancer. Despite its ability to inhibit DNA damage response factors, more research is needed to understand its interactions outside of telomeres.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Maria Sol Jacome Burbano, Jerome D. Robin, Serge Bauwens, Marjorie Martin, Emma Donati, Lucia Martinez, Peipei Lin, Sabrina Sacconi, Frederique Magdinier, Eric Gilson
Summary: TRF2 and FOXO3a play important roles in regulating skeletal muscle aging. Loss of TRF2 leads to oxidative stress, which triggers FOXO3a binding to telomeres and protects against ATM activation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Marta Markiewicz-Potoczny, Anastasia Lobanova, Anisha M. Loeb, Oktay Kirak, Teresa Olbrich, Sergio Ruiz, Eros Lazzerini Denchi
Summary: The loss of TRF2 in mouse embryonic stem cells triggers a compensatory transcriptional program that renders TRF2 dispensable for cell survival and proliferation. The unique DNA damage response in TRF2-null ES cells is controlled by telomere-associated protein POT1B and chromatin remodelling factor BRD2, and is characterized by the upregulation of ZSCAN4.
Article
Cell Biology
Joydeep Mukherjee, Ajay Pandita, Chatla Kamalakar, Tor-Christian Johannessen, Shigeo Ohba, Yongjian Tang, Cecilia L. Dalle-Ore, Rolf Bjerkvig, Russell O. Pieper
Summary: Approximately 10% of tumors, including lower-grade astrocytomas, rely on the ALT mechanism to resolve telomeric shortening. Cells dependent on ALT mechanism are hypersensitive to a subset of PARPi due to PARP1-induced telomere fusion. This study provides a mechanistic insight into how PARP1 recruitment to telomeres in ALT-dependent cells blocks chromosomal fusion, highlighting chromosome fusion as a potential biomarker for PARPi treatment in ALT-dependent tumors.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Angela Rizzo, Carmen Maresca, Carmen D'Angelo, Manuela Porru, Serena Di Vito, Erica Salvati, Andrea Sacconi, Francesco Berardinelli, Antonella Sgura, Sergey Kuznetsov, Swapnil Potdar, Antti Hassinen, Antonella Stoppacciaro, Pasquale Zizza, Annamaria Biroccio
Summary: Drug repositioning strategy is an effective tool for accelerating drug development by discovering new applications for existing compounds. This study identified FK866 as a molecule that can induce telomere damage and tumor cell death, providing a potential therapeutic strategy for triple-negative breast cancer.
Article
Biochemistry & Molecular Biology
Gaelle Pennarun, Julien Picotto, Laure Etourneaud, Anna-Rita Redavid, Anais Certain, Laurent R. Gauthier, Paula Fontanilla-Ramirez, Didier Busso, Caroline Chabance-Okumura, Benoit Theze, Francois D. Boussin, Pascale Bertrand
Summary: The study reveals that overexpression of lamin B1 disrupts the shelterin complex, leading to telomere instability, telomeric fusions, and telomere losses in human cells. Additionally, new interactions between lamin B1 and shelterin proteins may play a crucial role in telomere stability.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Gaelle Pennarun, Julien Picotto, Laure Etourneaud, Anna-Rita Redavid, Anais Certain, Laurent R. Gauthier, Paula Fontanilla-Ramirez, Didier Busso, Caroline Chabance-Okumura, Benoit Theze, Francois D. Boussin, Pascale Bertrand
Summary: Overexpression of lamin B1 disrupts the shelterin complex, leading to telomere instability and aberrations in human cells. This dysregulation is associated with mislocalization of TRF2, and the interaction between lamin B1 and TRF2 at the nuclear periphery may play a role in telomere stability.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lara Lee, Ana Belen Perez Olivaz, Elena Martinez-Balsalobre, Dmitri Churikov, Joshua Peter, Dalicya Rahmouni, Gilles Audoly, Violette Azzoni, Stephane Audebert, Luc Camoin, Victoriano Mulero, Maria L. Cayuela, Yogesh Kulathu, Vincent Geli, Christophe Lachaud
Summary: UFM1 is involved in neural and erythroid development, deficiency of which leads to telomere shortening, developmental delay, impaired hematopoiesis, and premature aging. MRE11-UFMylation plays a key role in regulating telomere length by recruiting PP1-alpha and affecting the phosphorylation status of NBS1, thereby impacting MRN recruitment to telomeres.
Article
Multidisciplinary Sciences
Rekha Rai, Kevin Biju, Wenqi Sun, Tori Sodeinde, Amer Al-Hiysat, Jaida Morgan, Xianwen Ye, Xueqing Li, Yong Chen, Sandy Chang
Summary: This study reveals that the basic domain of TRF2 (TRF2(B)) and RAP1 cooperate to repress homology directed repair (HDR) at telomeres and prevent the formation of ultrabright telomere structures.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Samar Ali, Emilia Puig Lombardi, Deepanjan Ghosh, Tao Jia, Geraldine Vitry, Lina Saker, Joel Poupon, Marie-Paule Teulade-Fichou, Alain Nicolas, Arturo Londono-Vallejo, Sophie Bombard
Summary: Pt-ttpy shows dual targeting efficiency on DNA by inducing telomere dysfunction and genomic DNA damage at specific loci, while not particularly accumulating in potential G4 forming sequences.
Article
Biochemistry & Molecular Biology
Mitsunori Higa, Yukihiro Matsuda, Jumpei Fujii, Nozomi Sugimoto, Kazumasa Yoshida, Masatoshi Fujita
Summary: TRF2-mediated recruitment of ORC contributes to the suppression of telomere instability, while the biological significance of the TRF2-ORC interaction for telomere maintenance remains largely elusive.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Cell Biology
Alex Penev, Marta Markiewicz-Potoczny, Agnel Seir, Eros Lazzerini Denchi
Summary: This review discusses the differences in telomere protection in embryonic stem cells and somatic cells, and summarizes the findings on telomerase regulation and pluripotency function.
TRENDS IN CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
LiRen Tu, Nazmul Huda, Brenda R. Grimes, Roger B. Slee, Alison M. Bates, Liang Cheng, David Gilley
MOLECULAR CARCINOGENESIS
(2016)
Article
Oncology
Samrat Roy Choudhury, Yi Cui, Anoop Narayanan, David P. Gilley, Nazmul Huda, Chiao-Ling Lo, Feng C. Zhou, Dinesh Yernool, Joseph Irudayaraj
Article
Biochemistry & Molecular Biology
Marc S. Mendonca, William T. Turchan, Melanie E. Alpuche, Christopher N. Watson, Neil C. Estabrook, Helen Chin-Sinex, Jeremy B. Shapiro, Imade E. Imasuen-Williams, Gabriel Rangel, David P. Gilley, Nazmul Huda, Peter A. Crooks, Ronald H. Shapiro
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Neil C. Estabrook, Helen Chin-Sinex, Anthony J. Borgmann, Ryan M. Dhaemers, Ronald H. Shapiro, David Gilley, Nazmul Huda, Peter Crooks, Christopher Sweeney, Marc S. Mendonca
FREE RADICAL BIOLOGY AND MEDICINE
(2011)
Article
Biochemistry & Molecular Biology
Nazmul Huda, Hiromi Tanaka, Marc S. Mendonca, David Gilley
MOLECULAR AND CELLULAR BIOLOGY
(2009)
Article
Multidisciplinary Sciences
Hiromi Tanaka, Satoshi Abe, Nazmul Huda, LiRen Tu, Matthew J. Beam, Brenda Grimes, David Gilley
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Cell & Tissue Engineering
Nagarajan Kannan, Nazmul Huda, LiRen Tu, Radina Droumeva, Geraldine Aubert, Elizabeth Chavez, Ryan R. Brinkman, Peter Lansdorp, Joanne Emerman, Satoshi Abe, Connie Eaves, David Gilley
Review
Gastroenterology & Hepatology
Bilon Khambu, Shengmin Yan, Nazmul Huda, Gang Liu, Xiao-Ming Yin
SEMINARS IN LIVER DISEASE
(2018)
Correction
Medicine, Research & Experimental
Bilon Khambu, Nazmul Huda, Xiaoyun Chen, Daniel J. Antoine, Yong Li, Guoli Dai, Ulrike A. Kohler, Wei-Xing Zong, Satoshi Waguri, Sabine Werner, Tim D. Oury, Zheng Dong, Xiao-Ming Yin
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Cell Biology
Nazmul Huda, Yan Xu, Alison M. Bates, Deborah A. Rankin, Nagarajan Kannan, David Gilley
Review
Gastroenterology & Hepatology
Nazmul Huda, Gang Liu, Honghai Hong, Shengmin Yan, Bilon Khambu, Xiao-Ming Yin
WORLD JOURNAL OF GASTROENTEROLOGY
(2019)
Review
Biochemistry & Molecular Biology
Shengmin Yan, Bilon Khambu, Honghai Hong, Gang Liu, Nazmul Huda, Xiao-Ming Yin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Bilon Khambu, Shengmin Yan, Nazmul Huda, Xiao-Ming Yin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Shengmin Yan, Nazmul Huda, Bilon Khambu, Xiao-Ming Yin
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)