Article
Biochemistry & Molecular Biology
Carla Ferreri, Alessandra Ferocino, Gessica Batani, Chryssostomos Chatgilialoglu, Vanda Randi, Maria Vittoria Riontino, Fabrizio Vetica, Anna Sansone
Summary: Plasmalogens are membrane phospholipids that play a role in peroxidation and have the potential for cis-trans double bond isomerization. Through experiments using representative molecules and liposomes under specific conditions, the reactivity and outcomes of these processes were studied. The results provide important insights for lipidomic applications and understanding radical stress in living organisms.
Article
Multidisciplinary Sciences
Yuta Matsuoka, Masatomo Takahashi, Yuki Sugiura, Yoshihiro Izumi, Kazuhiro Nishiyama, Motohiro Nishida, Makoto Suematsu, Takeshi Bamba, Ken-ichi Yamada
Summary: This study constructed a library of 465 oxPCs using mass spectrometry and found that doubly oxygenated polyunsaturated fatty acid (PUFA)-PCs are generated in the early phase of acetaminophen-induced acute liver failure.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Agriculture, Dairy & Animal Science
Yuanyuan Chen, Yan Tang, Shengbin Luo, Hongdou Jia, Qiushi Xu, Renxu Chang, Zhihao Dong, Shuang Gao, Qian Song, Hao Dong, Xuan Wang, Zhuo Li, Ahmad Aboragah, Juan J. Loor, Chuang Xu, Xudong Sun
Summary: The study explored the role of NFE2L2 in mitochondrial function of bovine mammary epithelial cells under hyperlipidemic conditions. Results indicated that FFA challenge inhibits NFE2L2, resulting in mitochondrial dysfunction and ROS production in these cells. NFE2L2 has been identified as a promising therapeutic target against metabolic challenge-driven mitochondrial dysfunction and oxidative stress in bovine mammary epithelial cells.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemical Research Methods
Paul E. Goers, Pia Wittenhofer, Juan F. Ayala-Cabrera, Sven W. Meckelmann
Summary: Due to the importance of fatty acids in biological systems, accurate quantification is still crucial. A novel GC-MS method using pentafluorobenzyl bromide as a derivatization agent was developed and characterized, and different ionization techniques were compared. The GC-APCI-MS method showed the lowest limits of detection and a similar response for various fatty acids, reducing the need for internal standards and labor-intensive sample pretreatment.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Afraz Ahmad Raja, Abdullahi Dandare, Muhammad Jawad Khan, Muhammad Jadoon Khan
Summary: This study investigates the impact of lipotoxicity on endothelial cells and identifies differentially expressed genes associated with processes such as mitochondrial dysfunction and apoptosis. The findings provide insights for future experiments on the role of fatty acids in endothelial cell damage.
Article
Biochemistry & Molecular Biology
Bozidarka L. Zaric, Mirjana T. Macvanin, Esma R. Isenovic
Summary: This review provides a systematic summary of the biochemical characteristics of various types of reactive species and specifies their localization and mechanisms of production in cells. Additionally, it discusses the specific roles of free radicals in cellular physiology, focusing on the current research aiming to identify the cascades of reactions initiated by reactive oxygen species that result in adaptive or pathological cellular responses. Finally, recent findings regarding therapeutic modulations of intracellular levels of reactive oxygen species are presented, which may have significant implications for developing novel agents for treating several diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maroula G. Kokotou, Christiana Mantzourani, Charikleia S. Batsika, Olga G. Mountanea, Ioanna Eleftheriadou, Ourania Kosta, Nikolaos Tentolouris, George Kokotos
Summary: This study presents a fast and straightforward liquid chromatography-high resolution mass spectrometry method for the simultaneous determination of 74 free fatty acids (FFAs) in human plasma. The method avoids derivatization steps and tedious sample preparation, making it suitable for the diagnosis and monitoring of metabolic disorders.
Article
Nutrition & Dietetics
Ariel Frajerman, Boris Chaumette, Dominique Farabos, Gaetan Despres, Christelle Simonard, Antonin Lamaziere, Marie-Odile Krebs, Oussama Kebir
Summary: This study explored the role of sterols, fatty acids, and phospholipids in individuals at ultra-high risk of psychosis for the first time. The study found that elevated baseline membrane linoleic acid level was associated with conversion to psychosis, and combining sterols, fatty acids, and phospholipids improved the prediction of psychosis onset.
Article
Food Science & Technology
Christiana Mantzourani, Charikleia S. Batsika, Maroula G. Kokotou, George Kokotos
Summary: A new method was developed to simultaneously determine multiple fatty acids in yogurt samples, including both common and uncommon ones. The concentrations of various fatty acids in the samples allowed the discrimination between cow and sheep yogurt.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Carla Ferreri, Anna Sansone, Chryssostomos Chatgilialoglu, Rosaria Ferreri, Javier Amezaga, Mercedes Caro Burgos, Sara Arranz, Itziar Tueros
Summary: Fatty acids play a crucial role in both biology and nutrition, and their impact on the onset and development of diseases, including cancer, is well known. Using fatty acid-based food and supplements to support cancer therapy requires multidisciplinary research. The composition of membrane fatty acids is essential in membrane lipid therapy. Additionally, fatty acids also serve as biomarkers for cancer and can be personalized for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
David M. Whalley, Jayasree Seayad, Michael F. Greaney
Summary: The ring-opening of 3-aminocyclobutanone oximes leads to the formation of primary alkyl radicals, enabling a novel strain-release, desulfonylative radical Truce-Smiles rearrangement process, which allows for the divergent synthesis of valuable 1,3 diamines and unnatural beta-amino acids. The protocol is characterized by mild conditions and a wide range of migrating species, facilitating the modular assembly of sp(3)-aryls under transition metal-free, room-temperature conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Carla Ferreri, Anna Sansone, Marios G. Krokidis, Annalisa Masi, Barbara Pascucci, Mariarosaria D'Errico, Chryssostomos Chatgilialoglu
Summary: Oxygen plays a crucial role in lipid metabolism, especially in cells with impaired repair mechanisms. This study examined the effects of different oxygen tensions on fatty acid-based membrane remodeling in two cell models. The results showed that oxygen tension influences enzymatic activity and fatty acid composition, suggesting a relationship between oxygen and cellular functions.
Article
Biochemistry & Molecular Biology
M. Kerr, K. M. J. H. Dennis, C. A. Carr, W. Fuller, G. Berridge, S. Rohling, C. L. Aitken, C. Lopez, R. Fischer, J. J. Miller, K. Clarke, D. J. Tyler, L. C. Heather
Summary: The bioactive lipid intermediate palmitoyl CoA (PCoA) inhibits mitochondrial ADP/ATP transport, protecting mitochondrial energetics during ischemia. However, this protective effect is blunted in diabetes, contributing to impaired energy metabolism during myocardial ischemia in the diabetic heart.
Article
Biology
Lin Jin, Ziwei Zhang, Pin Pan, Yuchen Zhao, Mengqi Zhou, Lianghu Liu, Yuanfang Zhai, Han Wang, Li Xu, Dan Mei, Han Zhang, Yining Yang, Jinghan Hua, Xianzheng Zhang, Lingling Zhang
Summary: The study found that ethanol consumption can reduce the severity of autoimmune arthritis by affecting the levels of the gut microbiota metabolite acetate. Acetate plays a role by regulating neutrophil activity and inhibiting the formation of neutrophil extracellular traps.
COMMUNICATIONS BIOLOGY
(2023)
Article
Hematology
Kosha Mehta, Pamela Greenwell, Derek Renshaw, Mark Busbridge, Mitla Garcia, Sebastien Farnaud, Vinood B. Patel
BLOOD CELLS MOLECULES AND DISEASES
(2015)
Review
Neurosciences
Jonathon Hull, Vinood B. Patel, Susan M. Hutson, Myra E. Conway
JOURNAL OF NEUROSCIENCE RESEARCH
(2015)
Article
Hematology
Kosha Mehta, Mark Busbridge, Derek Renshaw, Robert W. Evans, Sebastien Farnaud, Vinood B. Patel
BLOOD CELLS MOLECULES AND DISEASES
(2016)
Article
Biochemistry & Molecular Biology
Kosha J. Mehta, Sebastien Farnaud, Vinood B. Patel
MOLECULAR BIOLOGY REPORTS
(2017)
Article
Obstetrics & Gynecology
Daniel Gyamfi, Yaw Amo Wiafe, Kwabena Owusu Danquah, Ernest Adankwah, Gertrude Akua Amissah, Angela Odame
BMC PREGNANCY AND CHILDBIRTH
(2018)
Article
Cardiac & Cardiovascular Systems
Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah
INTERNATIONAL JOURNAL OF HYPERTENSION
(2018)
Article
Biochemistry & Molecular Biology
Maya El Hindy, Mohammed Hezwani, David Corry, Jonathon Hull, Farah El Amraoui, Matthew Harris, Christopher Lee, Thomas Forshaw, Andrew Wilson, Abbe Mansbridge, Martin Hassler, Vinood B. Patel, Patrick Gavin Kehoe, Seth Love, Myra Elizabeth Conway
ANTIOXIDANTS & REDOX SIGNALING
(2014)
Article
Biotechnology & Applied Microbiology
Otchere Addai-Mensah, Daniel Gyamfi, Richard Vikpebah Duneeh, Kwabena O. Danquah, Max E. Annani-Akollor, Lillian Boateng, Eddie-Williams Owiredu, Francis A. Amponsah, Edward Y. Afriyie, Renate Asare, David Ntiamoah Ofosu
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Endocrinology & Metabolism
Daniel Gyamfi, Yaw Amo Wiafe, Enoch Awuah, Evans Asamoah Adu, Emmanuel Kodie Boadi
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2020)
Review
Gastroenterology & Hepatology
Lucy Petagine, Mohammed Gulrez Zariwala, Vinood B. Patel
Summary: Non-alcoholic fatty liver disease (NAFLD) is a significant global disease burden and a leading cause of mortality. The precise triggers for disease progression and the propagation to cirrhosis are still not fully understood. Treatment options have been explored, but an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical utility.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Reem Ghazali, Kosha J. Mehta, S. W. Annie Bligh, Ihab Tewfik, Dahn Clemens, Vinood B. Patel
WORLD JOURNAL OF HEPATOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Kwabena Owusu Danquah, Ernest Adjei, Solomon Quayson, Ernest Adankwah, Daniel Gyamfi, Paul Poku Sampene Ossei, Gideon Dzikunu, Portia Mensah, Cecilia Lepkor
PAN AFRICAN MEDICAL JOURNAL
(2017)
Article
Rehabilitation
Iona Bramati-Castellarin, Vinood B. Patel, Ian P. Drysdale
JOURNAL OF BODYWORK AND MOVEMENT THERAPIES
(2016)
Article
Neurosciences
Jonathon Hull, Vinood Patel, Maya El Hindy, Christopher Lee, Esther Odeleye, Mohammed Hezwani, Seth Love, Patrick Kehoe, Katy Chalmers, Myra Conway
JOURNAL OF ALZHEIMERS DISEASE
(2015)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)