Review
Nutrition & Dietetics
Emiliana Giacomello, Luana Toniolo
Summary: Aging is a biological process influenced by multiple cellular mechanisms leading to functional decline. The growth of the elderly population and their susceptibility to diseases drive the search for anti-aging interventions, with calorie restriction identified as an effective approach.
Editorial Material
Multidisciplinary Sciences
Shaunak Deota, Satchidananda Panda
Summary: By combining calorie restriction, fasting, and regulating circadian rhythms, mice can achieve a long and healthy life.
Article
Plant Sciences
Hyo-Moon Cho, Mi Zhang, Eun-Jin Park, Ba-Wool Lee, Yeon-Joo Park, Hyun-Woo Kim, Ha-Thanh-Tung Pham, Young-Won Chin, Won-Keun Oh
Summary: This study discovered several flavonostilbenes from the stems of Rhamnoneuron balansae, and evaluated their effects on SIRT1 deacetylase activity. One compound showed promising anti-aging activity in vitro.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Multidisciplinary Sciences
Libia Alejandra Garcia-Flores, Cara L. Green, Sharon E. Mitchell, Daniel E. L. Promislow, David Lusseau, Alex Douglas, John R. Speakman
Summary: Caloric restriction affects the metabolome in a tissue-specific manner, with only a small number of common metabolic features responding in the same way across all tissues. The top modulated pathways were related to biosynthesis and degradation processes, suggesting each tissue has its own unique way of coping with reduced energy intake, supporting the clean cupboards hypothesis over the disposable soma interpretation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Daniel C. Levine, Hsin-Yu Kuo, Hee-Kyung Hong, Jonathan Cedernaes, Chelsea Hepler, Alexandra G. Wright, Meredith A. Sommars, Yumiko Kobayashi, Biliana Marcheva, Peng Gao, Olga R. Ilkayeva, Chiaki Omura, Kathryn M. Ramsey, Christopher B. Newgard, Grant D. Barish, Clara Bien Peek, Navdeep S. Chandel, Milan Mrksich, Joseph Bass
Summary: Through genetic uncoupling of nutrient state from NADH redox state, the study demonstrates that the hepatic NADH cycle regulates whole-body energetics by affecting SIRT1, thereby linking nutrient status with circadian transcriptional cycles.
Article
Cell Biology
David G. Le Couteur, Samantha M. Solon-Biet, Benjamin L. Parker, Tamara Pulpitel, Amanda E. Brandon, Nicholas J. Hunt, Jibran A. Wali, Rahul Gokarn, Alistair M. Senior, Gregory J. Cooney, David Raubenheimer, Victoria C. Cogger, David E. James, Stephen J. Simpson
Summary: Diet composition has a significant impact on the hepatic proteome, influencing not only metabolic pathways but also fundamental processes like mitochondrial function and RNA splicing.
Article
Biochemistry & Molecular Biology
Siamak Tabibzadeh
Summary: Aging is associated with aberrant function in multiple signaling pathways, including AMPK, sirtuins, FOX proteins, and Klotho. Loss of factors like Klotho can lead to premature aging, while other factors such as hydrogen sulfide and p53 play crucial roles in protecting cells against damage during aging.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Biochemistry & Molecular Biology
Yuanyuan Huang, Jianlin Lu, Li Zhan, Ming Wang, Ronghua Shi, Xiao Yuan, Xinjiao Gao, Xing Liu, Jianye Zang, Wei Liu, Xuebiao Yao
Summary: The study identified LKB1 as a direct activator of Sirt1 induced by resveratrol, showing that resveratrol promotes the binding between LKB1 and Sirt1. Furthermore, the LKB1-mediated phosphorylation of Sirt1 leads to increased mitochondrial biogenesis and respiration.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Andrea Annibal, Rebecca George Tharyan, Maribel Fides Schonewolff, Hannah Tam, Christian Latza, Markus Max Karl Auler, Adam Antebi
Summary: The study identifies a shared regulation of the folate and methionine cycles in canonical longevity pathways, with genetic manipulation and supplementation of metabolites showing a causal role in longevity regulation. This comparative approach reveals key metabolic nodes to enhance healthy ageing.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Daniel J. Ham, Anastasiya Boersch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtman, Alexander S. Ham, Marco Thuerkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rueegg
Summary: The anti-aging intervention calorie restriction (CR) is thought to act via the nutrient-sensing multiprotein complex mTORC1. However, this study showed that the mTORC1-inhibitor rapamycin and CR use largely distinct mechanisms to slow mouse muscle aging.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Patrick C. Bradshaw
Summary: Acetyl-CoA plays important roles in regulating gene expression and promoting longevity, with decreased cytoplasmic levels potentially contributing to longevity and increased nuclear levels aiding in histone acetylation and lifespan extension. Future research should focus on the role of nuclear acetyl-CoA and histone acetylation in controlling hypothalamic inflammation, a key driver of organismal aging.
Article
Biochemistry & Molecular Biology
Yi Jiang, Zongrui Luo, Yuanchao Gong, Yan Fu, Yongzhang Luo
Summary: NAD(+) levels decrease with age and in certain diseases, but the role of NAD(+) in triple-negative breast cancer (TNBC) is still unclear. In this study, NAD(+) supplementation was found to suppress tumor metastasis in a TNBC patient-derived xenograft (PDX) model. SIRT1, a lysine deacetylase, is required for this effect, as SIRT1 knockdown blocked NAD(+)-suppressed tumor metastasis. Overexpressing SIRT1 effectively reduced the metastatic potential of TNBC. The interaction between SIRT1 and p66Shc leads to the inactivation of p66Shc and inhibits epithelial-mesenchymal transition (EMT), highlighting the potential of SIRT1 activators as interventions for TNBC.
Article
Cell Biology
Xu Liu, Zengguang Jin, Stephanie Summers, Davina Derous, Min Li, Baoguo Li, Li Li, John R. Speakman
Summary: Caloric restriction, either by reducing food intake or providing diluted diet, is an effective intervention to increase lifespan. However, the effects of caloric dilution are not as prominent as caloric restriction in terms of fat loss, hormonal changes, and metabolic rate. This study suggests that increased hunger signaling under caloric restriction may be a key process mediating its benefits.
Article
Food Science & Technology
Rosario Pardo, Marc Velilla, Laura Herrero, Luis Cervela, Marcelo L. Ribeiro, Rafael Simo, Josep A. Villena
Summary: Calorie restriction (CR) and SIRT1 have distinct yet converging effects on white adipose tissue (WAT) gene expression, with CR enhancing mitochondrial biogenesis and reducing WAT inflammation, while SIRT1 downregulates extracellular matrix-related gene networks. These findings suggest that while SIRT1 may not mediate most of CR's effects on WAT gene expression, the two pathways work together to ameliorate WAT inflammation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shihao Zhang, Xilan Yu, Yuan Zhang, Xiangyan Xue, Qi Yu, Zitong Zha, Madelaine Gogol, Jerry L. Workman, Shanshan Li
Summary: Telomeres, organized into heterochromatin, require maintenance of silent heterochromatin for chromosome stability. The study shows that Pyruvate kinase Pyk1 phosphorylates histone H3T11 and regulates gene expression through the SESAME complex. SESAME phosphorylates H3T11 at telomeres to maintain SIR complex occupancy and prevent autophagy-mediated Sir2 degradation, ultimately enhancing telomere silencing and protecting against compromised telomere silencing during aging.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Dongqing Wang, Heying Chen, Li Lei, Jun Chen, Jimin Gao, Jiahe Liu, Qianyin Li, Yajun Xie, Yi Hu, Yilu Ni
Summary: Effective skin wound healing involves anti-inflammation, fibrosis, matrix reconstruction, and angiogenesis. This study aimed to integrate macrophage-mediated anti-inflammation and fibroblast-assisted matrix reconstruction to enhance wound healing. The results showed that M2 macrophage cytomembranes promoted wound closure, and the addition of fibroblast membranes contributed to better matrix reconstruction and angiogenesis.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Chuan-dong Cheng, Cheng Chen, Li Wang, Yong-fei Dong, Yang Yang, Yi-nan Chen, Wan-xiang Niu, Wen-chao Wang, Qing-song Liu, Chao-shi Niu
Summary: This study comprehensively analyzed DNA copy number variations (CNV) in glioblastoma (GBM) and gliosarcoma (GSM), revealing both shared and distinct CNV patterns between the two tumors. Pathway analysis of genes with CNV showed similar mechanisms of tumor development in GBM and GSM, but also identified disparate CNV patterns in certain genes unique to GSM.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Huamin Liang, Fengming Zou, Liyi Fu, Qingwang Liu, Beilei Wang, Xiaofei Liang, Jing Liu, Qingsong Liu
Summary: Drug nanocrystals, a common drug delivery system, have the potential to enhance the delivery of poorly water-soluble drugs. However, their rapid clearance and uncontrolled drug release limit their effectiveness. In this study, an amphiphilic co-polymer was synthesized as a stabilizer to fabricate high-drug-loading nanocrystal micelles. These micelles exhibited small size, high drug loading, and controlled release in vitro, as well as long circulation and high drug accumulation in vivo. This research provides new possibilities for the development of more efficient nanocrystal-based injection formulations and the potential clinical application of a CML candidate drug.
Article
Engineering, Biomedical
Lifo Ruan, Jun Chen, Chuanchao Du, Huiru Lu, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Wenchu Lin, Zhifang Chai, Guangjun Nie, Yi Hu
Summary: The use of mitochondrial temperature-responsive drug delivery system can prevent drug efflux, facilitate drug accumulation and mitochondrial targeting in drug-resistant tumors. This technology enhances drug toxicity and reverses drug resistance, representing a significant advancement in combating cancer drug resistance.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zuo-wei Wang, Feng-ming Zou, Ao-li Wang, Jing Yang, Rui Jin, Bei-lei Wang, Li-juan Shen, Shuang Qi, Juan Liu, Jing Liu, Wen-chao Wang, Qing-song Liu
Summary: In this study, the researchers discovered that AZD4547, a previously reported FGFR inhibitor, can interfere with Necroptosis by directly targeting RIPK1 kinase. They found that AZD4547 blocked RIPK1-dependent Necroptosis in both human and mouse cell models and rescued animals from TNF-induced lethal shock and inflammatory responses.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Analytical
Lifo Ruan, Haijing Li, Jiayu Zhang, Mengxue Zhou, Hui Huang, Juncai Dong, Jinxia Li, Feng Zhao, Zhonghua Wu, Jun Chen, Zhifang Chai, Yi Hu
Summary: Iron oxide nanoparticles (IONPs) are widely used in biomedical research, but their subcellular transformation and biological effects are not well understood. In this study, we prepared three types of IONPs, including those targeting mitochondria (IONP-TPP) and lysosomes (IONP-APM), and a control group with no specific target (IONP). Results showed that mitochondria-targeted IONP-TPP induced significant cytotoxicity and mitochondrial membrane depolarization in MCF-7 cells. X-ray absorption spectroscopy (XAS) analysis revealed remarkable edge defects and oxidation of IONP-TPP inside the cell. These findings highlight the potential chemical transformation of IONPs at mitochondria and the vulnerability of mitochondria to IONP accumulation.
Article
Chemistry, Multidisciplinary
Qing Zhu, Yue Sun, Manlin Fu, Mianli Bian, Xiaomei Zhu, Kai Wang, Haoxing Geng, Wei Zeng, Wei Shen, Yi Hu
Summary: The study indicates that mitochondrial temperature in cancer cells may be higher than in normal cells, providing critical evidence for reevaluating cancer metabolism. By using the specially designed near-infrared probe MTN, the fluctuations of mitochondrial temperature in cancer cells can be monitored.
Article
Pharmacology & Pharmacy
Chen Hua, Lijuan Shena, Fengming Zoua, Yun Wua, Beilei Wanga, Aoli Wanga, Chao Wud, Li Wanga, Jing Liua, Wenchao Wanga, Qingsong Liua
Summary: The study reveals a novel resistance mechanism for CDK9 inhibitors mediated by the L156F mutation, which disrupts the binding of inhibitors with CDK9 due to steric hindrance, and affects the thermal stability and catalytic activity of CDK9 protein. A new compound IHMT-CDK9-36 showed potent inhibition activity for both CDK9 WT and L156F mutant, providing a new chemical scaffold for the future development of CDK9 inhibitors.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Medicinal
Qianmao Liang, Beilei Wang, Fengming Zou, Gongrui Guo, Wenliang Wang, Wei Wang, Qingwang Liu, Lijuan Shen, Chen Hu, Wenchao Wang, Aoli Wang, Tao Huang, Yuying He, Ruixiang Xia, Jian Ge, Jing Liu, Qingsong Liu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Aoli Wang, Juan Liu, Xixiang Li, Fengming Zou, Ziping Qi, Shuang Qi, Qingwang Liu, Zuowei Wang, Jiangyan Cao, Zongru Jiang, Beilei Wang, Juan Ge, Li Wang, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: In this study, a highly potent pan-RAF inhibitor, IHMT-RAF-128, was developed, which demonstrated strong anti-tumor efficacy against cancer cells harboring RAF or RAS mutations, especially the KRAS-G12C secondary mutations resistant to AMG510. IHMT-RAF-128 also exhibited excellent pharmacokinetic profile and dose-dependent anti-tumor efficacy in xenograft mouse tumor models without obvious toxicities. These findings support further investigation of IHMT-RAF-128 as a potential clinical drug candidate for cancer patients with RAF or RAS mutations.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junjie Wang, Ziping Qi, Yun Wu, Aoli Wang, Qingwang Liu, Fengming Zou, Beilei Wang, Shuang Qi, Jiangyan Cao, Chen Hu, Chenliang Shi, Qianmao Liang, Li Wang, Jing Liu, Wenchao Wang, Qingsong Liu
Summary: Insulin-producing pancreatic beta cell death is the fundamental cause of type 1 diabetes (T1D) and a contributing factor to type 2 diabetes (T2D). MST1 contributes to the progression of diabetes mellitus through apoptosis induction and acceleration of pancreatic beta cell dysfunction. Activation of AMPK has been suggested as a treatment option for metabolic diseases, making the pharmacological inhibition of MST1 and activation of AMPK simultaneously a promising approach for diabetes therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Husheng Mei, Hong Wu, Jing Yang, Bin Zhou, Aoli Wang, Chen Hu, Shuang Qi, Zongru Jiang, Fengming Zou, Beilei Wang, Feiyang Liu, Yongfei Chen, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: Enhancer of zeste homolog 2 (EZH2), as an enzymatic subunit of the PRC2 complex, plays a crucial role in tumor development and has gained research interest as a potential therapeutic target. Overexpression or mutations of EZH2 have been associated with tumor cell proliferation in TNBC and DLBCL. Current EZH2 inhibitors have shown promise but resistance can occur due to noncatalytic or transcriptional activity. Researchers have discovered a new irreversible EZH2 inhibitor, IHMT-337, which degrades EZH2 and inhibits cell proliferation in TNBC and DLBCL models in vitro and in vivo. This finding suggests that destroying EZH2 in addition to enzymatic inhibition may be a promising therapeutic strategy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Chemistry, Medicinal
Yun Wu, Ziping Qi, Beilei Wang, Junjie Wang, Qingwang Liu, Aoli Wang, Chenliang Shi, Bin Zhou, Qianmao Liang, Wenliang Wang, Fengming Zou, Shuang Qi, Zuowei Wang, Li Wang, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: A novel, potent, and selective MST1 inhibitor 19 was discovered, which protected ss cells from inflammatory cytokines in vitro and showed potential in treating diabetes in animal models.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Dongqing Wang, Heying Chen, Yi Hu
Summary: Immunotherapy is recognized as a promising strategy for cancer treatment, and reprogramming tumor-associated macrophages from M2 to M1 type is a potential approach. In this study, autologous mouse bone marrow cells were engineered into M1 macrophages and embedded in a gel, which demonstrated the ability to repolarize M2 macrophages to M1 type and activate immune responses, effectively inhibiting tumor recurrence after surgical removal. This suggests that implanting autologous M1 macrophages could be a promising strategy for preventing postoperative tumor recurrence.
Review
Nanoscience & Nanotechnology
Yi Hu, Rui Dou, Xiaomeng Cai, Lifo Ruan, Jiayu Zhang, Aisha Rouzi, Jun Chen, Zhifang Chai
Summary: Mitochondrion is a crucial organelle in cells and a significant target for antitumor therapy. Differentiating mitochondria in cancer cells from those in normal cells is challenging using conventional mitochondrial targeting strategies, raising concerns about biosafety. Recent studies have identified a relatively high mitochondrial temperature in cancer cells, and this difference can be exploited for specific delivery of therapeutic agents.
ACS APPLIED BIO MATERIALS
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
