Article
Cell Biology
Vidhya Tangeda, Yu Kang Lo, Ananth Ponneri Babuharisankar, Han-Yu Chou, Cheng-Liang Kuo, Yung-Hsi Kao, Alan Yueh-Luen Lee, Jang-Yang Chang
Summary: Mitochondrial Lon plays a crucial role in cisplatin-induced mtDNA damage and oxidative stress by modulating calcium levels, resulting in increased resistance of cancer cells to cisplatin treatment.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Satish K. Raut, Madhu Khullar
Summary: Metabolic syndrome is a common condition associated with dyslipidemia, oxidative stress, and other factors, which may lead to complications such as diabetes and heart disease.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ines Tawfik, Benjamin Gottschalk, Angelo Jarc, Doruntina Bresilla, Rene Rost, Barbara Obermayer-Pietsch, Wolfgang F. Graier, Corina T. Madreiter-Sokolowski
Summary: Thyroid hormones regulate mitochondrial Ca2+ uptake, leading to increased energy metabolism and reactive oxygen species production.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jorge Reyes-Garcia, Abril Carbajal-Garcia, Annarita Di Mise, Yun-Min Zheng, Xiangdong Wang, Yong-Xiao Wang
Summary: Mitochondria play important roles in the development of pulmonary hypertension, including ROS production, regulation of Ca2+ signaling, fatty acid oxidation, and ketone synthesis. Dysfunction of mitochondrial ROS and Ca2+ signaling can lead to inflammatory responses and oxidative stress mediated by ketones, contributing to the progression of pulmonary hypertension and associated diseases.
Article
Endocrinology & Metabolism
R. Giancaspro, M. Cassano, M. Gelardi
Summary: This review aims to elucidate the mechanisms of oxidative stress and the development and progression of various diseases related to oxidative stress.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cell Biology
Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang, Qicheng Zou, Luxin Wang, Caihong Zhang, Yuting Cao, Beihua Shao, Yixin Zhang, Peidong Zhang, Dandan Liang, Yi Liu, Yi-Han Chen
Summary: The study reveals the role of glutamate in driving local Ca2+ release (LCR) in sinoatrial node pacemaker cells (SANPCs), adding a potentially important element to the coupled-clock theory of spontaneous firing origin. Mitochondrial excitatory amino acid transporter 1 (EAAT1) mediates mitochondrial glutamate import, promoting ROS generation and enhancing LCR. Depletion of EAAT1 reduces spontaneous firing rates of isolated pacemaker cells and heart rate, highlighting the central role of EAAT1 as a glutamate transporter in regulating cardiac autonomic rhythm.
Review
Pharmacology & Pharmacy
Yao Zhang, Yu Chen, Yue Wan, Yueshui Zhao, Qinglian Wen, Xiaolong Tang, Jing Shen, Xu Wu, Mingxing Li, Xiang Li, Jing Li, Wanping Li, Zhangang Xiao, Fukuan Du
Summary: Oxidative stress, caused by an imbalance between the production and elimination of reactive metabolites and free radicals, can lead to the development of various diseases. In recent years, circular RNA has been found to be closely associated with oxidative stress, playing a significant role in the process. However, the understanding of circRNAs in the mechanism of oxidative stress is currently limited.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jun Chen, Li Li, Xueyang Bai, Lili Xiao, Jiahong Shangguan, Wenjing Zhang, Xiangqin Zhang, Shen Wang, Gangqiong Liu
Summary: Panax notoginseng saponins (PNS) protects against thapsigargin-induced ER stress and associated apoptosis in cardiac myocytes by regulating mitochondrial injury and ROS overproduction through modulation of autophagy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Feiyu Han, Dongsheng Zhang, Sofia Salli, Jiani Ye, Yongwang Li, Federico Rosei, Xiao-Dong Wen, Hans Niemantsverdriet, Emma Richards, Ren Su
Summary: In this study, a copper-modified graphitic carbon nitride was used to synthesize alpha-haloketones from aromatic olefins under mild reaction conditions. This novel photosynthetic strategy offers environmental sustainability, high selectivity, and stability.
Article
Multidisciplinary Sciences
Catarina M. Quinzii, Luis C. Lopez
Summary: Mitochondrial disorders are genetic diseases with inadequate therapy due to the heterogeneity and tissue-specificity of pathomechanisms. Abnormalities in hydrogen sulfide (H2S) metabolism are emerging as a novel mechanism in mitochondrial dysfunction, but further studies are needed to understand the effects and relevance in mitochondrial diseases. The review focuses on derangement of H2S metabolism in primary Coenzyme Q (CoQ) deficiency and emphasizes the need for more research on the consequences of abnormalities in H2S and GSH synthesis on the oxidation pathway.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Ameer A. Imarah, Majid S. Jabir, Ali H. Abood, Ghassan M. Sulaiman, Salim Albukhaty, Hamdoon A. Mohammed, Riaz A. Khan, Hayder M. Al-Kuraishy, Ali Al-Gareeb, Waleed K. Al-Azzawi, Mazin A. Najm, Sabrean F. Jawad
Summary: In this study, the cytotoxic effects of graphene oxide nanoparticles (GONPs) were evaluated using MTT assays, observation of apoptotic markers, and oxidative stress. Significant cytotoxic and apoptotic effects were observed. Analyses of CYP2E1 and malondialdehyde concentrations confirmed the toxicity of GONPs, while the levels of glutathione showed a reduction compared to the control. The alterations in cytochrome CYP2E1, glutathione, malondialdehyde, and caspase-3 suggest an interlinked relationship.
Article
Engineering, Environmental
Zhiqiang Liu, Yeqing Lv, Shaona Wang, Biao Liu, Peng Liang, Hao Du, Lanjie Li, Yi Zhang
Summary: In this study, a new process using copper oxide catalytic oxidation intensified by oxygen microbubbles was introduced for the recovery of V and Cr from VCRS. The generation of HO2⋅/O2⋅- and its effect on the oxidation of V and Cr were examined using EPR. The amount of HO2⋅/O2⋅- was directly related to the CuO catalyst and oxygen microbubbles, and the V and Cr oxidative leaching process was dependent on the amount of HO2⋅/O2⋅-. An effective recovery of V and Cr, with leaching efficiencies of 98.1% and 98.5%, respectively, was achieved at 110 degrees C under atmospheric pressure using 50 wt% NaOH solution. This approach offers a promising alternative method for the clean treatment of VCRS.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Edoardo Bertero, Alexander Nickel, Michael Kohlhaas, Mathias Hohl, Vasco Sequeira, Carolin Brune, Julia Schwemmlein, Marco Abesser, Kai Schuh, Ilona Kutschka, Christopher Carlein, Kai Muenker, Sarah Atighetchi, Andreas Mueller, Andrey Kazakov, Reinhard Kappl, Karina von der Malsburg, Martin van der Laan, Anna-Florentine Schiuma, Michael Bohm, Ulrich Laufs, Markus Hoth, Peter Rehling, Michaela Kuhn, Jan Dudek, Alexander von der Malsburg, Leticia Prates Roma, Christoph Maack
Summary: BTHS cardiomyopathy is caused by mutations in the tafazzin gene, impacting mitochondrial cardiolipin maturation. This leads to systolic dysfunction in infancy transitioning to diastolic dysfunction and arrhythmic vulnerability. Studies in a mouse model reveal the role of mitochondrial Ca2+ uniporter downregulation, increased myofilament Ca2+ affinity, and preactivated sarcoplasmic reticulum Ca2+-ATPase in explaining the pathophysiology of BTHS cardiomyopathy.
Review
Biochemistry & Molecular Biology
Ester Sara Di Filippo, Franco Checcaglini, Giorgio Fano-Illic, Stefania Fulle
Summary: In order to respond to changes in the environment and carry out necessary metabolic functions, cells require a functional control center. This review identifies the mitochondrion as such a control center, where messengers like H2O2, Ca2+, and Zn2+ collaborate to activate adaptive response mechanisms. By exchanging information, these messengers generate a holistic response of the cell.
Article
Chemistry, Medicinal
Denes Kiss, Balazs Horvath, Tamas Hezso, Csaba Dienes, Zsigmond Kovacs, Leila Topal, Norbert Szentandrassy, Janos Almassy, Janos Prorok, Laszlo Virag, Tamas Banyasz, Andras Varro, Peter P. Nanasi, Janos Magyar
Summary: The study found that in canine ventricular cardiomyocytes, the late sodium current (I-NaL) depends on the magnitude of intracellular calcium concentration ([Ca2+]i) and this dependence is mediated by the Ca2+-dependent activation of CaMKII. Additionally, the augmentation of I-NaL is influenced by the baseline activity of CaMKII.
Article
Neurosciences
Kyu-Hee Lee, Hyunsu Lee, Che Ho Yang, Jeong-Soon Ko, Chang-Hwan Park, Ran-Sook Woo, Joo Yeon Kim, Woong Sun, Joung-Hun Kim, Won-Kyung Ho, Suk-Ho Lee
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Hye-Hyun Kim, Kyu-Hee Lee, Doyun Lee, Young-Eun Han, Suk-Ho Lee, Jong-Woo Sohn, Won-Kyung Ho
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Weonjin Yu, Jaehan Kwon, Jong-Woo Sohn, Suk Ho Lee, Sooyun Kim, Won-Kyung Ho
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Cell Biology
Young-Eun Han, Jung Nyeo Chun, Min Jeong Kwon, Young-Sun Ji, Myong-Ho Jeong, Hye-Hyun Kim, Sun-Hyun Park, Jong Cheol Rah, Jong-Sun Kang, Suk-Ho Lee, Won-Kyung Ho
Article
Biology
Sooyun Kim, Yoonsub Kim, Suk-Ho Lee, Won-Kyung Ho
Article
Neurosciences
Hye-Hyun Kim, Joo Min Park, Suk-Ho Lee, Won-Kyung Ho
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Weonjin Yu, Jong-Woo Sohn, Jaehan Kwon, Suk-Ho Lee, Sooyun Kim, Won-Kyung Ho
Article
Neurosciences
Kisang Eom, Jung Ho Hyun, Dong-gu Lee, Sooyun Kim, Hyeon-Ju Jeong, Jong-Sun Kang, Won-Kyung Ho, Suk-Ho Lee
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Kyung-Ran Kim, Seung Yeon Lee, Sang Ho Yoon, Yoonsub Kim, Hyeon-Ju Jeong, Sanghyeon Lee, Young Ho Suh, Jong-Sun Kang, Hana Cho, Suk-Ho Lee, Myoung-Hwan Kim, Won-Kyung Ho
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Che Ho Yang, Kyu-Hee Lee, Won-Kyung Ho, Suk-Ho Lee
Summary: Presynaptic mitochondria can both absorb and release Ca2+ during high frequency stimulation, enhancing short-term facilitation and steady state excitatory postsynaptic currents by increasing vesicular release probability. The role of mitochondrial Ca2+ release via mNCX in short-term plasticity during synaptic transmission is significant for maintaining stable synaptic transmission.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Ran Kim, Hyeon-Ju Jeong, Yoonsub Kim, Seung Yeon Lee, Yujin Kim, Hyun-Ji Kim, Suk-Ho Lee, Hana Cho, Jong-Sun Kang, Won-Kyung Ho
Summary: Calbindin plays a crucial role in shaping calcium signals in neurons, with knockout mice showing hyperexcitability and impaired pattern separation due to downregulated K+ current. The reduction of calcium buffering capacity in Tg2576 mice suggests calbindin as a target of oxidative stress. Regulation of CaMKII signaling by calcium buffering is essential for neuronal excitability regulation.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Neurosciences
Che Ho Yang, Won-Kyung Ho, Suk-Ho Lee
Summary: The study found that certain parameters of calyx synapses in rats and mice gradually approached mature levels at P14, and further matured at P16 or P18, indicating that the maturation process of calyx synapses continues at these stages.
Article
Neurosciences
Kisang Eom, Hyoung Ro Lee, Jung Ho Hyun, Hyunhoe An, Yong-Seok Lee, Won-Kyung Ho, Suk-Ho Lee
Summary: The study revealed that haploinsufficiency of Kv1.2 in CA3 leads to decreased threshold for long-term potentiation at PP-CA3 synapses, resulting in impaired pattern separation in Kcna2+/- mice. By examining neuronal ensembles in CA3 and DG, it was found that Kcna2+/- mice exhibit abnormal plastic changes in pattern separation.
Article
Neurosciences
Jaehan Kwon, Hyun Jin Kim, Hyoung-Ro Lee, Won-Kyung Ho, Joung-Hun Kim, Suk-Ho Lee
Summary: In this study, researchers found that unbalanced activity of medium spiny neurons mediates reward-related behaviors induced by addictive drugs. The results also showed that cocaine-induced alterations in PL-to-NAcC synapses play a crucial role in early locomotor sensitization. Additionally, the adaptive plastic changes at these synapses correlate well with behavioral sensitization.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Yoonsub Kim, Sooyun Kim, Won-Kyung Ho, Suk-Ho Lee
Summary: High frequency burst firing plays a crucial role in dendritic membrane potential depolarization. The physiological significance of burst firings in hippocampal dentate granule cells (GCs) remains unclear. This study found that GCs can be categorized into regular-spiking (RS) and burst-spiking (BS) cells based on their initial firing frequency (F-init) and investigated their differences in long-term potentiation (LTP) induced by high-frequency inputs. The results showed that Hebbian LTP at lateral perforant pathway (LPP) synapses required burst firing, which was dependent on persistent Na+ current and larger in BS cells. Calcium channels also played a role in LTP, with L-type channels involved in LPP synapses and T-type channels in medial perforant pathway (PP) synapses.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)