Article
Chemistry, Multidisciplinary
Yoko Hirata, Tomohiro Hashimoto, Kaori Ando, Yuji O. Kamatari, Hiroshi Takemori, Kyoji Furuta
Summary: This study identifies the structural features of N,N-dimethylaniline derivatives as potent ferroptosis inhibitors and demonstrates the localization of a specific compound, GIF-2197-r, in lysosomes through its aliphatic tertiary amine moiety.
Article
Food Science & Technology
Z. Pardo, I Seiquer
Summary: Zinc supplementation was found to reduce cell membrane damage, alleviate oxidative stress, promote antioxidant enzyme activity, and protect intestinal barrier function under heat stress conditions, which may be a beneficial nutritional strategy against intestinal damage caused by high temperatures.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Engineering, Environmental
You Zhang, Wenhong Fan, Xiaomin Li, Wen-Xiong Wang, Shu Liu
Summary: In this study, nanobubble technology and hydrogen water were combined for the first time to remove reactive oxygen species caused by environmental stress. Hydrogen nanobubbles showed remarkable capability in removing H2O2 and O(2)(center dot- ), and increasing the activity and expression of antioxidant enzymes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leanne E. Mocniak, Zachary T. Bitzer, Neil Trushin, John P. Richie
Summary: Tobacco smoke free radicals, which depend on the intrinsic nitrate levels in tobacco, are closely associated with adverse health effects. The levels of gas phase radicals are highly correlated with nitrate levels in different tobacco types and brands. Nitrate addition to tobacco leaves increases the production of gas phase radicals and NNK in smoke. Tobacco nitrate plays a key role in the production of gas phase radicals and has implications for health regulation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Junmin Zhang, Xinming Li, Zhengjia Zhao, Wenqing Cai, Jianguo Fang
Summary: This article reviews the importance of thioredoxin (Trx) in regulating cancer-related signaling pathways and its potential therapeutic opportunities. Research has shown that Trx participates in multiple signaling pathways that influence cancer development and treatment by modulating the dynamic changes in protein structure and function. Future research directions include further exploring Trx-related signaling pathways and their upstream and downstream regulatory proteins, as well as developing novel anticancer drugs targeting the Trx signaling pathways.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Marine & Freshwater Biology
Ye Zhao, Huiling Wang, Priscilla Agyemang Duah, Vladimir Retyunskiy, Yizheng Liu, Guoguang Chen
Summary: This study investigates the embryonic toxicogenomic responses induced by Zinc pyrithione (ZPT) in zebrafish. The results show that ZPT treatment causes embryogenesis toxicity, including irregular cell division and rearrangement, delayed differentiations of eyes and notochords, and defects in epiboly and germ ring formation and somite segmentation. ZPT exposure also alters gene expression during early embryonic development, leading to morphological abnormalities and metabolic dysfunctions. Additionally, ZPT induces oxidative stress, apoptosis, endoplasmic reticulum (ER) stress, and autophagy.
AQUATIC TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yang Zhang, Shan Liu, Jiu-Long Ma, Chen Chen, Peng Huang, Jia-Hua Ji, Di Wu, Li-Qun Ren
Summary: Apocynum venetum L. leaf extract alleviates doxorubicin-induced cardiomyocyte apoptosis by suppressing oxidative stress and apoptosis through the AKT/Bcl-2 signaling pathway.
Article
Pharmacology & Pharmacy
Yu-Ting Wu, Ling-Peng Xie, Yue Hua, Hong-Lin Xu, Guang-Hong Chen, Xin Han, Zhang-Bin Tan, Hui-Jie Fan, Hong-Mei Chen, Jun Li, Bin Liu, Ying-Chun Zhou
Summary: Tanshinone I (Tan I) protects cardiomyocytes against oxidative stress-induced injury by activating the Nrf2 signaling pathway, suggesting its potential therapeutic application for oxidative stress-induced cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Guoding Cao, Monan Lin, Wei Gu, Zaiyu Su, Yagan Duan, Wuqi Song, Hailiang Liu, Fengmin Zhang
Summary: The FOX family of transcription factors, including the FOXA to FOXS subfamilies, play important roles in various biological processes. FOXO3, a member of the FOXO subfamily, has diverse biological effects that are primarily regulated by its phosphorylation. Phosphorylation of FOXO3 affects its subcellular localization and transcriptional activity, and it is involved in various biological processes such as inflammation, autophagy, apoptosis, and DNA damage repair. Moreover, FOXO3 also contributes to the development of diseases and the aging process, and targeting FOXO3 may offer new therapeutic strategies for age-related diseases and longevity.
Article
Biochemistry & Molecular Biology
Huaxin Li, Mengxue Zhang, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang
Summary: This study demonstrates that Daidzein (DAI) can alleviate heart failure (HF) by regulating cardiac energy metabolism, improving cardiac function, reducing inflammation, oxidative stress, apoptosis, and fibrosis.
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Food Science & Technology
Iva Potocnjak, Lidija Simic, Lara Baticic, Hrvoje Krizan, Robert Domitrovic
Summary: Sinomenine has been found to alleviate kidney injury caused by cisplatin by targeting multiple signaling pathways to reduce oxidative stress, inflammation and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yuanyuan Xu, Yu Zhao, Shanji Liu, Sidi Lv, Ling Chen, Wanzhen Wang, Yueying Feng, Fen Fu, Hengyi Xu
Summary: This study found that zinc oxide nanoparticles have toxic effects on the ovaries of female mice, which are attributed to oxidative stress, endoplasmic reticulum stress, and activation of apoptosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Cell & Tissue Engineering
Yanting Sun, Hao Xu, Bin Tan, Qin Yi, Huiwen Liu, Tangtian Chen, Han Xiang, Rui Wang, Qiumin Xie, Jie Tian, Jing Zhu
Summary: This study aimed to illustrate the protective effect of andrographolide (AG) against glucose and serum deprivation under hypoxia (GSDH)-induced cell injury in BMSCs and investigate the possible underlying mechanisms. The results showed that AG can protect BMSCs from GSDH-induced cell injury by increasing cell viability and proliferation, enhancing mitochondrial function, and reducing apoptosis and oxidative stress.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Physiology
Rajiv Janardhanan, Sreenivasulu Kilari, Edward B. Leof, Sanjay Misra
JOURNAL OF VASCULAR RESEARCH
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rajiv Janardhanan, Binxia Yang, Sreenivasulu Kilari, Edward B. Leof, Debabrata Mukhopadhyay, Sanjay Misra
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2016)
Article
Multidisciplinary Sciences
Binxia Yang, Sreenivasulu Kilari, Akshaar Brahmbhatt, Deborah L. McCall, Evelyn Nieves Torres, Edward B. Leof, Debabrata Mukhopadhyay, Sanjay Misra
SCIENTIFIC REPORTS
(2017)
Article
Agriculture, Multidisciplinary
Kilari Sreenivasulu, Pullakhandam Raghu, Punjal Ravinder, K. Madhavan Nair
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2008)
Article
Agriculture, Multidisciplinary
Ravindranadh Palika, Purna Chandra Mashurabad, Sreenivasulu Kilari, Sunanda Kasula, Krishnapillai Madhavan Nair, Pullakhandam Raghu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Sreenivasulu Kilari, Indulekha Remadevi, Baofeng Zhao, Jing Pan, Robert Miao, Ramani Ramchandran, Paula E. North, Ming You, Nader Rahimi, George A. Wilkinson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Food Science & Technology
Kilari Sreenivasulu, Pullakhandam Raghu, K. Madhavan Nair
JOURNAL OF FOOD SCIENCE
(2010)
Article
Multidisciplinary Sciences
Sreenivasulu Kilari, Stephanie Cossette, Shabnam Pooya, Michelle Bordas, Yi-Wen Huang, Ramani Ramchandran, George A. Wilkinson
Article
Urology & Nephrology
Chuanqi Cai, Sreenivasulu Kilari, Chenglei Zhao, Michael L. Simeon, Avanish Misra, Yiqing Li, Andre J. van Wijnen, Debabrata Mukhopadhyay, Sanjay Misra
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Avishek K. Singh, Chuanqi Cai, Sreenivasulu Kilari, Chenglei Zhao, Michael L. Simeon, Edwin Takahashi, Elazer R. Edelman, Hyunjoon (Joon) Kong, Thanila Macedo, Ravinder J. Singh, Matthew W. Urban, Rajiv Kumar, Sanjay Misra
Summary: The study shows that local release of 1,25 NP from PLGA nanoparticles can reduce VNH/VS formation in AVFs, and decrease inflammation, apoptosis, and fibrosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Sanjay Misra, Sreenivasulu Kilari, Binxia Yang, Amit Sharma, Chih-Cheng Wu, Roberto I. Vazquez-Padron, John Broadwater
Summary: Blocking CX3CR1 reduces inflammation and inhibits the formation of venous neointimal hyperplasia (VNH) and venous stenosis (VS) in arteriovenous fistula (AVF). The study showed that hCX3CR1 VHH molecule can improve arterial flow in AVF, decrease neointima formation, and modulate proinflammatory cues.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Sreenivasulu Kilari, Ying Wang, Avishek Singh, Rondell P. Graham, Vivek Iyer, Scott M. Thompson, Michael S. Torbenson, Debabrata Mukhopadhyay, Sanjay Misra
Summary: The expression of NRP-1 is significantly reduced in the livers of patients with hereditary hemorrhagic telangiectasia (HHT), and the deletion of NRP-1 in smooth muscle cells (SMCs) leads to the formation of vascular malformations. The interaction between NRP-1, ALK1, and ENG in SMCs regulates the activity of the TGF-β pathway.
Article
Urology & Nephrology
Ameet K. Piryani, Sreenivasulu Kilari, Edwin Takahashi, Randall R. DeMartino, Jay Mandrekar, Allan B. Dietz, Sanjay Misra
Summary: This study discusses the safety and efficacy of autologous adipose-derived mesenchymal stem cells in promoting maturation in new upper-extremity AVFs. The aim is to address venous neointimal hyperplasia leading to inadequate fistula maturation.
Review
Urology & Nephrology
Edwin A. Takahashi, Sreenivasulu Kilari, Sanjay Misra
Summary: The hemodialysis population is growing, but challenges with vascular access persist. Issues like thrombosis and infection hinder long-term access and increase healthcare costs and patient morbidity. Recent innovations have been effective in addressing these problems.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)