期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 49, 期 5, 页码 900-907出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2010.06.021
关键词
Superoxide radicals; Radiolysis; ROS; NADPH-oxidase; Free radicals
资金
- EDF [RB 2008-11]
- French National Agency for Research [JCJC06-137200]
NADPH-oxidase (Nox) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS) In phagocyte cells, in which ROS are produced in huge amounts, Nox is naturally assailed by the action of its own ROS We have subjected each individual component of Nox or the whole complex at various times during the assembly process either to oxygen free radicals produced by radiolysis or to hydrogen peroxide Membrane components presented the highest irradiation sensitivity Irradiation of p67(Phox) drastically decreased its interaction with arachidonic acid and destabilized the [p47(phox)-p67(phox)] complex When the system was irradiated during its assembly process, we could identify an initial irradiation-sensitive phase followed by a resistant form when the complex was assembled (C) 2010 Elsevier Inc All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据