Review
Chemistry, Analytical
Sebastien Allard, Frants R. Lauritsen
Summary: This review summarizes the progress in the use of MIMS for DBP analysis in water since 2010. It highlights advancements in instrumentation, quantification, and new applications in swimming pools, water treatment, mechanistic studies, and kinetic modelling. The review discusses the use of high resolution mass spectrometry for distinguishing between isobaric isomers, analysis of hydrophilic and less volatile DBPs using condensed phase MIMS, and quantification based on univariate and multivariate mathematical algorithms. MIMS has been proven to be a valuable tool for implementing water treatment strategies focusing on DBP mitigation.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Renato C. Nogueira, Magdalena Minnion, Anna D. Clark, Alex Dyson, Jose E. Tanus-Santos, Martin Feelisch
Summary: Nitrite concentrations in blood play a crucial role in assessing intracellular nitric oxide (NO) activity and endothelial function. However, using nitrosylhemoglobin (HbNO) as an early marker of COVID-19 patient risk may be premature.
Article
Biochemical Research Methods
Dimitrios Tsikas
Summary: A new experimental method using stable-isotope dilution GC-MS assay was reported to study reactions of nitrite in hemolysate, revealing reactions that are hidden at physiological nitrite concentrations. This approach allows for the measurement of unlabelled and labelled nitrite and nitrate species in the reactions.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Juan de Dios Hernandez, Ana Castell, Natalia Arroyo-Manzanares, Isidro Guillen, Pascuali Vizcaino, Ignacio Lopez-Garcia, Manuel Hernandez-Cordoba, Pilar Vinas
Summary: The article presents a method to detect and quantify nitrite from different sources added to meat products, using headspace gas chromatography-mass spectrometry to measure the area of the N2O peak. This method allows the quantification of added nitrite within a concentration range of 10 to 100 mg kg(-1), providing technical support for distinguishing between products truly made without nitrite and those containing nitrite.
Article
Biochemistry & Molecular Biology
Cristina Manis, Antonio Murgia, Alessia Manca, Antonella Pantaleo, Giacomo Cao, Pierluigi Caboni
Summary: Our study using a hyphenated ion mobility mass spectrometric platform for lipid profiling of human erythrocytes expands the understanding of cellular processes and stress due to microgravity. We identified complex lipids associated with microgravity conditions, such as oxidized phosphocholines, phosphocholines bearing arachidonic in their moiety, as well as sphingomyelins and hexosyl ceramides. These findings provide insights into molecular alterations and erythrocyte lipidomics signatures associated with microgravity conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Jie Jiang, Yuchen Cao, Jilin Liu, Hong Zhang, Guangfeng Kan, Kai Yu
Summary: The newly developed EC-NR-MS technique successfully allowed for online investigation of the electrooxidation process of dopamine, confirming the formation of various reaction products and demonstrating their presence in the mass spectrum.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Madisson Chabas, Olivier Pible, Jean Armengaud, Beatrice Alpha-Bazin
Summary: To accurately and rapidly identify microorganisms from complex microbiota for clinical diagnostic purposes, an innovative label-free multiplexing method for the identification of microorganisms using tandem mass spectrometry is proposed in this paper. The method involves offline reversed-phase fractionation of individual peptidomes and achieves multiplexing by mixing fractions of staged hydrophobicity. This approach enables the identification of up to 21 microorganisms in a single 60-minute run without the use of labeling reagents, providing new perspectives for high-throughput proteotyping of bacteria in large culturomics projects.
ANALYTICAL CHEMISTRY
(2023)
Article
Geosciences, Multidisciplinary
Rakesh Mogul, Sanjay S. Limaye, M. J. Way, Jaime A. Cordova
Summary: A re-examination of mass spectral data from the Pioneer Venus Large Probe Neutral Mass Spectrometer suggests redox disequilibria in Venus' middle clouds, revealing the presence of reducing power in the clouds and the potential for yet-to-be-discovered chemistries. Assignments to the data indicate a potential signature of anaerobic phosphorus metabolism, an electron donor for anoxygenic photosynthesis, and major constituents of the nitrogen cycle in Venus' clouds.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Review
Medical Laboratory Technology
Neha Yadav, Amit Kumar Mandal
Summary: Fasting blood glucose and glycated hemoglobin (HbA1c) are widely used biomarkers for diabetes screening and monitoring. While blood glucose level reflects short-term control, HbA1c provides an average measure of long-term glucose control. However, quantification of HbA1c can be affected by genetic variants of hemoglobin. Mass spectrometry, which measures total glycation of hemoglobin, is not impacted by the presence of genetic variants and may be a better analytical choice for diabetes.
CLINICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Oliver J. Hale, Helen J. Cooper
Summary: This study demonstrates a mass spectrometry analysis method for the direct analysis of intact oligomeric membrane proteins from tissue. By characterizing protein assembly directly from sheep eye lens sections without sample pre-treatment, our approach allows for simultaneous analysis of soluble protein assemblies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Minmin Guo, Mingjian Zhang, Shunkai Gao, Lu Wang, Jichuan Zhang, Zejian Huang, Yiyang Dong
Summary: A portable pyrolysis-membrane inlet mass spectrometry (PY-MIMS) approach was developed to rapidly and accurately identify the rubber content in Eucommia ulmoides gum. The method involves pyrolyzing the gum into small molecules, which are then diffusively transported for quantitative analysis. The results showed a limit of detection of 1.36 μg/mg and a recovery rate ranging from 95.04% to 104.96%. Compared to pyrolysis-gas chromatography (PY-GC), the average relative error was 1.153%, and the detection time was reduced to less than 5 minutes, demonstrating the reliability, accuracy, and efficiency of the procedure. This method has the potential to be used for precise identification of rubber content in natural rubber-producing plants.
Article
Plant Sciences
Jaekyeong Kim, Mei Tong He, Jae-Seoun Hur, Jin Woo Lee, Kyo Bin Kang, Ki Sung Kang, Sang Hee Shim
Summary: Feature-based molecular networking analysis revealed the presence of naphthol tetramers in a different strain of Daldinia childae (047219) compared to the one previously used for the discovery of naphthol trimers. These new tetramers were composed of 5-methoxy-4-naphthol connected in various positions. Six previously unreported naphthol tetramers and 13 known polyketides, including naphthol monomers, dimers, and trimers, were isolated and their structures were determined through NMR and mass spectroscopic analysis. The new compounds exhibited less anti-inflammatory activity compared to nodulisporin A, nodulisporin B, and 1,1',3,3'-ternaphthalene-5,5',5''-trimethoxy-4,4',4''-triol.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Corinne A. Lutomski, Tarick J. El-Baba, Joshua D. Hinkle, Idlir Liko, Jack L. Bennett, Neha V. Kalmankar, Andrew Dolan, Carla Kirschbaum, Kim Greis, Leonhard H. Urner, Parth Kapoor, Hsin-Yung Yen, Kevin Pagel, Christopher Mullen, John E. P. Syka, Carol V. Robinson
Summary: By using an infrared laser in a high-pressure linear ion trap, researchers were able to remove detergent micelles and obtain good sequence coverage for membrane proteins and their complexes through top-down mass spectrometry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Ruifeng Zhang, Masao Gen, Tzung-May Fu, Chak K. Chan
Summary: The study indicates that particulate nitrate photolysis can generate oxidants in aqueous droplets, promoting the formation of secondary organic aerosol (SOA). However, the oxidation of high concentrations of glyoxal by OH radicals produced from nitrate photolysis may not significantly contribute to SOA formation, as formic acid is found to be the main oxidation product. This new insight into the production of formic acid/formate and the sink of glyoxal in the atmosphere may help bridge the gap between model predictions and field measurements.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Yuming Jiang, Alexandre Hutton, Caleb W. Cranney, Jesse G. Meyer
Summary: This article introduces an improved direct infusion and ion mobility method for proteome analysis, and proposes a label-free quantification method DISPA-LFQ, which can rapidly identify and quantify proteins in complex mixtures. This technology has important applications in drug screening, biomarker discovery, and clinical analysis.
ANALYTICAL CHEMISTRY
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)