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Medicine, General & Internal
Xiuqin Wei, Mei Xue, Chunbo Kang, Lei Gao, Mengqiao Zhang, Chao Ma, Wei Jia, Yufeng Zheng, Lei Cao, Pan Chen, Shujing Jiang, Fong-Fong Chu, Qiang Gao
Summary: This study aims to explore the association between oxidative stress, inflammation, and constipation by examining the expression levels of reactive oxygen species producers and pro-inflammatory cytokines in the colon. The findings suggest that NADPH oxidases and pro-inflammatory cytokines may be involved in the pathogenesis of chronic functional constipation.
Article
Immunology
Chenyang Han, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Caiqun Zhang, Li Guo, Yi Yang
Summary: By activating ROS, NOX4 promotes the M1 polarization of intestinal macrophages in inflammatory bowel disease (IBD), further exacerbating intestinal inflammation and mucosal barrier injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Andrea Finocchi, Lucia Pacillo, Maria Chiriaco, Gigliola Di Matteo, Paola Francalanci, Giulia Angelino, Tamara Caldaro, Beatrice Rivalta, Maurice O'Mara, Suisheng Zhang, Francesca Romana Lepri, Antonio Novelli, Paola De Angelis, Ulla G. Knaus, Francesca Rea
Summary: In this study, we report a case of a patient with compound heterozygous variants in the DUOX2 gene, which is responsible for monogenic neonatal-IBD. This expands our knowledge about the genetic causes of VEO-IBD and DUOX2 deficiency. We suggest that DUOX2 should be included in the diagnostic evaluation of patients with suspected monogenic VEO-IBD.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hui Zheng, Nannan Xu, Zihao Zhang, Fen Wang, Jie Xiao, Xiaoping Ji
Summary: This study found that GKT137831 can alleviate DOX-induced cardiomyocyte apoptosis by inhibiting NOX1/4-driven ROS production. The upregulation of the MAPK pathway induced by NOX1/4-derived ROS production may be the potential mechanism of GKT137831 action. GKT137831 may be a potential drug candidate to ameliorate DOX-induced cardiotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ju-Yeon Choi, Na-Kyung Lee, Yi-Yue Wang, Joon-Pyo Hong, So Ri Son, Da-Hye Gu, Dae Sik Jang, Jung-Hye Choi
Summary: Thai ginger extract exhibits cytotoxic activity and induces apoptosis in ovarian cancer cells. One of the major compounds, AEA, plays a key role in the induction of apoptosis by increasing ROS levels and activating the MAPK pathway.
Article
Neurosciences
Anahita Shahraz, Jannis Wissfeld, Aurelien Ginolhac, Mona Mathews, Lasse Sinkkonen, Harald Neumann
Summary: The study showed that mice deficient in NOX-2 exhibited attenuated loss of dopaminergic neurons in the substantia nigra pars compacta and a decreased inflammatory response after repeated systemic challenge with LPS. This suggests that NOX-2 may play a role in inflammatory neurodegeneration in this region of the brain.
Article
Multidisciplinary Sciences
Juan A. De la Cruz, Thota Ganesh, Becky A. Diebold, Weiping Cao, Amelia Hofstetter, Neetu Singh, Amrita Kumar, James McCoy, Priya Ranjan, Susan M. E. Smith, Suryaprakash Sambhara, J. David Lambeth, Shivaprakash Gangappa
Summary: TG6-44 can significantly reduce ROS and inflammatory mediators induced by influenza A virus infection, demonstrate antiviral effects in cells, and lead to decreased virus-induced cell death.
Review
Pharmacology & Pharmacy
Benjamin Misselwitz, Annika Wyss, Tina Raselli, Vuk Cerovic, Andreas W. Sailer, Niklas Krupka, Florian Ruiz, Caroline Pot, Oliver Pabst
Summary: The oxysterol receptor GPR183 and its ligands play a crucial role in immune cell positioning and migration in inflammatory bowel disease. Targeting GPR183-dependent cell migration could be a potential therapeutic strategy for IBD.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anne Mari Herfindal, Sergio Domingos Cardoso Rocha, Dimitrios Papoutsis, Siv Kjolsrud Bohn, Harald Carlsena
Summary: NOX1 plays a significant role in ROS/RNS production in the colon and modulation of the colonic microbiota.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Marta Massari, Callum R. Nicoll, Sara Marchese, Andrea Mattevi, Maria Laura Mascotti
Summary: This article investigates the phylogenetic analysis of the NADPH oxidase family in eukaryotes and finds that all known members share a common ancestor. Calcium-dependency is identified as the earliest form of NOX regulation, while the protein-protein mode of regulation is a more recent event generated by gene duplication.
Review
Medicine, Research & Experimental
Yawei Bi, Xiao Lei, Ningli Chai, Enqiang Linghu
Summary: NOX4 is upregulated in pancreatic cancer and primarily produces hydrogen peroxide, exhibiting different properties from other NOX family subtypes. Recent studies suggest that NOX4 promotes pancreatic cancer occurrence and development, making it a potential therapeutic target in pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ildiko Szanto
Summary: Cancer cells can adapt to hypoxic environments through metabolic rewiring and synthesis of antioxidant molecules. NOX4, a member of the NOX family enzymes, plays a key role in the oncogenic metabolic adaptation of cancer cells by regulating diverse metabolic processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Eva Boros, Zoltan Hegedus, Zoltan Kellermayer, Peter Balogh, Istvan Nagy
Summary: Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract, and miRNAs play important roles in its pathological processes, indicating potential targets for the diagnosis, prognosis, and treatment of IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Flavia Rezende, Pedro Felipe Malacarne, Niklas Mueller, Birgit Rathkolb, Martin Hrabe de Angelis, Katrin Schroeder, Ralf P. Brandes
Summary: The study found that Nox4 knockout mice exhibited similar weight loss and sodium sparing function under a low sodium diet, but showed reduced systolic blood pressure, heart-rate ratio, and heart to body weight ratio compared to wild-type mice, indicating that Nox4 plays a role in blood pressure regulation induced by low sodium diets.
Review
Neurosciences
Simona Gargiulo, Paola Gamba, Gabriella Testa, Gabriella Leonarduzzi, Giuseppe Poli
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Review
Biochemistry & Molecular Biology
Simona Gargiulo, Gabriella Testa, Paola Gamba, Erica Staurenghi, Giuseppe Poli, Gabriella Leonarduzzi
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Review
Biochemistry & Molecular Biology
Elisabetta Greco, Enrico Lupia, Ornella Bosco, Barbara Vizio, Giuseppe Montrucchio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Gastroenterology & Hepatology
Enrico Lupia, Luca Pigozzi, Emanuele Pivetta, Ornella Bosco, Barbara Vizio, Maria Loiacono, Manuela Lucchiari, Stefania Battista, Fulvio Morello, Corrado Moiraghi, Giulio Mengozzi, Giuseppe Montrucchio
Article
Cell & Tissue Engineering
Graziella Bellone, Barbara Vizio, Tiziana Scirelli, Giorgio Emanuelli
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Cell & Tissue Engineering
Graziella Bellone, Barbara Vizio, Tiziana Scirelli, Giorgio Emanuelli
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Review
Biochemistry & Molecular Biology
Gabriella Testa, Daniela Rossin, Giuseppe Poli, Fiorella Biasi, Gabriella Leonarduzzi
Review
Food Science & Technology
Barbara Sottero, Gabriella Leonarduzzi, Gabriella Testa, Simona Gargiulo, Giuseppe Poli, Fiorella Biasi
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Gabriella Testa, Erica Staurenghi, Serena Giannelli, Simona Gargiulo, Michela Guglielmotto, Massimo Tabaton, Elena Tamagno, Paola Gamba, Gabriella Leonarduzzi
Article
Biochemistry & Molecular Biology
Beyza Vurusaner, Simona Gargiulo, Gabriella Testa, Paola Gamba, Gabriella Leonarduzzi, Giuseppe Poli, Huveyda Basaga
Article
Biochemistry & Molecular Biology
Simona Gargiulo, Daniela Rossin, Gabriella Testa, Paola Gamba, Erica Staurenghi, Fiorella Biasi, Giuseppe Poli, Gabriella Leonarduzzi
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Gabriella Testa, Erica Staurenghi, Serena Giannelli, Barbara Sottero, Simona Gargiulo, Giuseppe Poli, Paola Gamba, Gabriella Leonarduzzi
Summary: Atherosclerosis is a degenerative disease characterized by lesions in the arteries due to the accumulation of LDL in the intima. Oxysterols and HNE are major contributors to plaque progression and destabilization. PCSK6 may play a role in plaque development by regulating MMPs and inflammation.
Review
Biochemistry & Molecular Biology
Martina Schiavello, Barbara Vizio, Ornella Bosco, Emanuele Pivetta, Filippo Mariano, Giuseppe Montrucchio, Enrico Lupia
Summary: Sepsis and COVID-19 patients often show an imbalance in inflammation and coagulation, known as thromboinflammation, which greatly impacts patient prognosis. Extracellular vesicles (EVs) are nanoparticles released by cells that play a significant role in cell-to-cell communication. Recent studies indicate that EVs are important factors in various pathologies, including cancer and cardiovascular disease. However, the biological properties of EVs in the mechanisms of thromboinflammation during sepsis and COVID-19 are not yet fully understood. This review summarizes the current experimental evidence on the role of EVs in thromboinflammation in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Simona Sapino, Giulia Chindamo, Elena Peira, Daniela Chirio, Federica Foglietta, Loredana Serpe, Barbara Vizio, Marina Gallarate
Summary: Repeated intravitreal injections can cause severe complications. Developing innovative drug delivery systems and preclinical models are necessary for preventing adverse reactions. This study developed an in vitro ocular flow cell model to simulate human eye conditions and successfully evaluated the effects of a potential ophthalmic formulation.
Article
Pharmacology & Pharmacy
Valentina Zunino, Giorgia Meineri, Graziella Bellone, Barbara Vizio, Adriana Prati, Maurizio Grandi, Elisabetta Radice, Federica Dal Bello, Claudio Medana
ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE
(2017)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)