Article
Biochemistry & Molecular Biology
Lingxia Wang, Xixi Zhang, Haiwei Zhang, Kaili Lu, Ming Li, Xiaoming Li, Yangjing Ou, Xiaoming Zhao, Xiaoxia Wu, Xuanhui Wu, Jianling Liu, Mingyan Xing, Han Liu, Yue Zhang, Yongchang Tan, Fang Li, Xiaoxue Deng, Jiangshan Deng, Xiaojie Zhang, Jinbao Li, Yuwu Zhao, Qiurong Ding, Haikun Wang, Xiuzhe Wang, Yan Luo, Ben Zhou, Haibing Zhang
Summary: This study found that T-cell-specific Rip1 KO mice show age-related T cell changes and accelerated aging-like phenotypes. Rip1-deficient T cells undergo excessive apoptosis and promote chronic inflammation. Blocking apoptosis rescues T cell imbalance and aging-like phenotypes, prolonging lifespan.
Article
Biochemistry & Molecular Biology
Yuguo Yi, Weigao Zhang, Liang Tao, Qianchao Shao, Qian Xu, Yuxin Chen, Haibing Zhang, Jianfa Zhang, Dan Weng
Summary: This study investigated the role of RIP1 kinase in APAP-induced acute liver injury through genetic or pharmacological inhibition, providing evidence that RIP1 kinase activity plays an important role in the pathogenesis of APAP-induced liver injury. The results demonstrated that RIP1 kinase inactivation significantly attenuated APAP-induced liver injury and mortality, and that Nec-1, a RIP1 kinase inhibitor formulated with PEG400, could efficiently alleviate hepatotoxicity induced by APAP.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Xiaoli Yin, Xueqi Zhuang, Weitao Luo, Meiqiu Liao, Lin Huang, Qiqian Cui, Jiayi Huang, Chunxia Yan, Zixiang Jiang, Yuan Liu, Weina Wang
Summary: In this study, the effect of Andr on the growth, immunity, and resistance to V. alginolyticus infection in L. vannamei was investigated. The results showed that dietary Andr improved the growth performance and non-specific immune function of shrimps. Furthermore, Andr protected shrimps against V. alginolyticus by regulating inflammation and apoptosis via a ROS-JNK dependent pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fenghong Wang, Qingqing Liang, Yuexiao Ma, Mengqi Sun, Tianyu Li, Lisen Lin, Zhiwei Sun, Junchao Duan
Summary: Exposure to SiNPs may lead to cardiac hypertrophy and pyroptosis, possibly through the ROS/NLRP3/Caspase-1 signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Research & Experimental
Mengyang Wang, Jinfeng Sun, Tianxiang Yu, Minxiu Wang, Leiming Jin, Shiqi Liang, Wu Luo, Yi Wang, Gao Li, Guang Liang
Summary: This study evaluates the pharmacological effects and potential mechanisms of Diacerin in APAP-induced liver injury. The results show that Diacerin can protect the liver from APAP-induced damage by inhibiting JNK kinase phosphorylation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Michittra Boonchan, Hideki Arimochi, Kunihiro Otsuka, Tomoko Kobayashi, Hisanori Uehara, Thiranut Jaroonwitchawan, Yuki Sasaki, Shin-ichi Tsukumo, Koji Yasutomo
Summary: The study demonstrates that RIPK3 and MLKL-mediated necroptosis has protective effects in acute pancreatitis, cautioning against the use of necroptosis inhibitors as a treatment for acute pancreatitis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Kaiqi Wu, Thea A. Vedelaar, Viraj G. Damle, Aryan Morita, Julie Mougnaud, Claudia Reyes San Martin, Yue Zhang, Denise P. van der Pol, Heidi Ende-Metselaar, Izabela Rodenhuis-Zybert, Romana Schirhagl
Summary: This study demonstrates the utility of diamond magnetometry in studying the free radical response during Semliki Forest virus infection. The alterations in free radical concentration near infectious viruses were measured using the spin-lattice relaxation of NV defect ensembles in intracellular nanodiamonds. The study provides insights into the real-time free radical variation during the early infectious process.
Article
Biochemistry & Molecular Biology
Liang Tao, Yuguo Yi, Yuxin Chen, Haibing Zhang, Pontus Orning, Egil Lien, Jiapeng Jie, Weigao Zhang, Qian Xu, Yang Li, Zhao Ding, Chao Wu, Qiurong Ding, Junsong Wang, Jianfa Zhang, Dan Weng
Summary: The study revealed that RIP1 kinase plays a critical role in NASH, mainly by regulating inflammation and cell death in liver macrophages. Experimental and clinical data demonstrated that RIP1 kinase is primarily phosphorylated and activated in liver macrophages in NASH.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Anatomy & Morphology
Zhengguang Wang, Yongfang Tan, Fei Xu
Summary: This study aimed to investigate the effects of zonisamide (ZNS) on a degenerative cervical myelopathy (DCM) rat model and explore the potential mechanisms. The results showed that ZNS promoted motor recovery, reversed histopathological injury and cell apoptosis in DCM rats. Additionally, ZNS attenuated DCM injury through the regulation of Fas and FasL signaling. Therefore, this study provided a new theoretical approach for subsequent academic and clinical research on DCM injury.
Article
Pharmacology & Pharmacy
Kushal Kandhari, Jai P. N. Mishra, Rajesh Agarwal, Rana P. Singh
Summary: Acacetin (AC), a naturally occurring flavonoid, has been found to have anticancer potential. This study revealed that AC inhibits cell proliferation and induces cell death in breast carcinoma cells through regulating cell cycle and CDKs levels, as well as inducing ROS generation and RIP1-dependent necroptosis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jun-Kyu Choi, Sangkyu Park, Jeong-A Park, Ha-Eun Shin, Yeram Choi, Younghee Lee
Summary: This study investigated the cleavage of HSP90 in mouse pluripotent stem cells. HDAC inhibitors and proteasome inhibitors were found to induce HSP90 cleavage through ROS generation and caspase 10 activation. The cleaved HSP90 was secreted out of the cells via exosome secretion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Liran Shi, Qixing Hu, Lin Li, Runan Yang, Xiumei Xu, Junpei Du, Lifang Zou, Guilin Li, Shuangmei Liu, Guodong Li, Shangdong Liang
Summary: This study found that lncRNA-UC.360+ shRNA can alleviate dyslipidemia in type 2 diabetic rats, reduce serum adrenaline and ROS production in the stellate ganglion under hyperglycemia conditions. Additionally, UC.360+ shRNA also modulates the inflammatory pathway by reducing the expression of NF-KB, NLRP3, ASC, caspase-1, IL-1β, IL-18, and inhibiting the phosphorylation of p38 MAPK, thus alleviating diabetic heart sympathetic nerve damage.
Article
Immunology
Yifan Wang, Wen Zhu, Dandan Lu, Chuzhao Zhang, Yue Wang
Summary: The study found that tetrahydropalmatine (THP) can alleviate MSU-induced gouty arthritis by suppressing NLRP3 inflammasome activation and reducing ROS generation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sahar M. AlMotwaa, Waad A. Al-Otaibi
Summary: The synthesized nanoemulsion containing Pulicaria crispa essential oil and gemcitabine showed a synergistic effect in inhibiting cancer cell growth and inducing apoptosis. This formulation may reduce the dose of gemcitabine and eliminate its associated side effects.
Article
Oncology
Wei Zheng, Jihua Yang, Juyi Wen, Junzhao Sun, Jing Wang, Xinhong Zhang, Xia Zhang, Xiangfei Zhao, Henghu Fang, Qi Zhu, Shanshan Wu, Zejun Lu, Heng Sun, Rugang Zhao, Siyuan Huai, Lipin Gao, Yongzhen Liu, Jingjiao Li, Gaowa Guan, Wei Yang, Yi Hu
Summary: This study demonstrates that ligustrazine can induce apoptosis in A549 cells through upregulation of the Fas and caspase-activating death receptor pathway expression.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Anette Wu, Geoffroy P. J. C. Noel, Richard Wingate, Heike Kielstein, Takeshi Sakurai, Suvi Viranta-Kovanen, Chung-Liang Chien, Hannes Traxler, Jens Waschke, Franziska Vielmuth, Mandeep Gill Sagoo, Shuji Kitahara, Yojiro Kato, Kevin A. Keay, Jorgen Olsen, Paulette Bernd
ANNALS OF GLOBAL HEALTH
(2020)
Article
Oncology
Duen-Yi Huang, Wei-Yu Chen, Chi-Long Chen, Nan-Lin Wu, Wan-Wan Lin
Article
Chemistry, Multidisciplinary
Anthony Yan-Tang Wu, Yun-Chieh Sung, Yen-Ju Chen, Steven Ting-Yu Chou, Vanessa Guo, Jasper Che-Yung Chien, John Jun-Sheng Ko, Alan Ling Yang, Hsi-Chien Huang, Ju-Chen Chuang, Syuan Wu, Meng-Ru Ho, Maria Ericsson, Wan-Wan Lin, Chantal Hoi Yin Cheung, Hsueh-Fen Juan, Koji Ueda, Yunching Chen, Charles Pin-Kuang Lai
Article
Biochemistry & Molecular Biology
Ling-Ya Chiu, Nan-Lin Wu, Chi-Feng Hung, Peter Bai, Yang-Shia Dai, Wan-Wan Lin
Summary: UV irradiation can damage the epidermis, leading to inflammation and tissue disorders. PARP-1 and EGFR play crucial roles in mediating the response to UVB-induced skin injury, with interactions affecting inflammatory gene expression. Inhibition of PARP-1 or EGFR can mitigate UVB-induced inflammation, suggesting regulatory loops among these factors in response to UVB stress.
Article
Immunology
Yi-Gen Pan, Ming-Ting Huang, Ponarulselvam Sekar, Duen-Yi Huang, Wan-Wan Lin, Shie-Liang Hsieh
Summary: The study demonstrated that DcR3's HBD can reduce MSU crystal-induced NLRP3 inflammasome activation by regulating mitochondrial and lysosomal functions, suggesting a potential new therapeutic approach for gout.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Anatomy & Morphology
Anette Wu, Ann Chen Xi Yu, Cynthia Soledad Chang, Rahul Goel, Mandeep Gill Sagoo, Takeshi Sakurai, Suvi Viranta-Kovanen, Chung-Liang Chien, Hannes Traxler, Jens Waschke, Shuji Kitahara, Kevin Keay, Jorgen Olsen, Cecilia Brassett, Salma El Batti, Franziska Vielmuth, Anna Magdalena Sigmund, Mina Zeroual, Carol Kunzel, Paulette Bernd, Richard Wingate, Heike Kielstein, Geoffroy P. J. C. Noel
Summary: Anatomy courses can trigger students' thinking about life's passing, with different themes identified at various schools associated with anatomy formats and elements. Courses that offer hands-on cadaveric dissections may play a significant role in initiating these sentiments.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Biochemistry & Molecular Biology
Ling-Ya Chiu, Duen-Yi Huang, Wan-Wan Lin
Summary: PARP-1 positively regulates NLRP3 inflammasome activation by increasing ROS production and interacting with TXNIP and NLRP3.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Nutrition & Dietetics
Chien-Hsieh Chiang, Yi-Han Sheu, Fei-Ran Guo, Wan-Wan Lin, Guan-Ru Chen, Kuo-Chin Huang
Summary: The study found that the FIT2 program is associated with a reduced risk of developing type 2 diabetes and an increased probability of regression to normoglycemia. Simultaneously promoting smoking abstinence and lifestyle coaching can help prevent the development of type 2 diabetes.
Article
Pharmacology & Pharmacy
Hyemin Lee, Duen-Yi Huang, Hua-Ching Chang, Chia-Yee Lin, Wan-Yu Ren, Yang-Shia Dai, Wan-Wan Lin
Summary: B lymphocyte-induced maturation protein-1 (Blimp-1) can be transcriptionally upregulated by various stimuli in keratinocytes and squamous cell carcinoma (SCC) via EGFR transactivation and the AP-1 pathway. The nuclear localization of Blimp-1 remains unchanged under stimulation, and silencing Blimp-1 can enhance SCC cell migration. These findings suggest a potential therapeutic target in SCC by targeting Blimp-1 as a negative regulator of cell migration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chien-Hsieh Chiang, Ching-Yuan Cheng, Yi-Ting Lien, Kuo-Chin Huang, Wan-Wan Lin
Summary: This study demonstrates that P2X7 enhances lipid accumulation during adipogenesis by suppressing the expression of sirtuin-3/5 and the browning genes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Shen Chen, Wei-Chu Chuang, Hsiu-Ni Kung, Ching-Yuan Cheng, Duen-Yi Huang, Ponarulselvam Sekar, Wan-Wan Lin
Summary: In addition to inducing apoptosis, caspase inhibition can also contribute to necroptosis and/or autophagy depending on the cell type and context. This study investigated the signaling pathways and mechanisms of cell death induced by co-treatment with Toll-like receptor (TLR) ligands and a caspase inhibitor in macrophages. The results showed that necrostatin-1 and autophagy inhibitor 3-methyladenine could inhibit cell death in bone marrow-derived macrophages (BMDMs) induced by the TLR ligands and caspase inhibitor. The study also revealed the involvement of different molecular pathways and factors in the cell death process.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Nan-Lin Wu, Duen-Yi Huang, Shie-Liang Hsieh, Yang-Shia Dai, Wan-Wan Lin
Summary: DcR3 is regulated by EGFR in keratinocytes and involved in modulating the pattern of terminal differentiation. It interacts with PKC to enhance PKC activity. This study reveals the mechanism of how DcR3 regulates abnormal keratinocyte development in psoriasis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Education, Scientific Disciplines
Anette Wu, Vinay Maddula, Jasmine Singh, Mandeep Gill Sagoo, Chung-Liang Chien, Richard Wingate, Heike Kielstein, Hannes Traxler, Cecilia Brassett, Jens Waschke, Fransziska Vielmuth, Takeshi Sakurai, Mina Zeroual, Jorgen Olsen, Salma El-Batti, Suvi Viranta-Kovanen, Shuji Kitahara, Kevin Keay, Carol Kunzel, Paulette Bernd, Geoffroy P. J. C. Noel
Summary: Internationalization of medical education through structured online peer exchanges at home can provide students with cross-cultural skills and networking opportunities typically achieved through international in-person travel. This socially just and equitable approach can improve students' cultural competency, preparing them for global health work and ultimately enhancing global health outcomes.
MEDICAL SCIENCE EDUCATOR
(2021)
Article
Education, Scientific Disciplines
Anette Wu, Vinay Maddula, Ann Chen Xi Yu, Rahul Goel, Haruna Shimizu, Chung-Liang Chien, Richard Wingate, Mandeep Gill Sagoo, Heike Kielstein, Hannes Traxler, Cecilia Brassett, Jens Waschke, Fransziska Vielmuth, Kevin Keay, Mina Zeroual, Takeshi Sakurai, Jorgen Olsen, Salma El-Batti, Suvi Viranta-Kovanen, Shuji Kitahara, Carol Kunzel, Paulette Bernd, Geoffroy P. J. C. Noel
Summary: This study explores the sentiments of preclinical healthcare professions students during the 2020 COVID-19 pandemic, ranging from positive emotions like pride and respect to negative emotions such as anxiety, guilt, disappointment, and anger. While students showed respect for the healthcare profession, they also acknowledged its limitations and risks. Healthcare profession educators should recognize the emotional impact of the pandemic on students, which could have long-lasting effects on the global healthcare industry.
MEDICAL SCIENCE EDUCATOR
(2021)
Article
Biochemistry & Molecular Biology
Chi-Ming Chan, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Wan-Wan Lin
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)