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Cell Biology
Jakub Rok, Justyna Kowalska, Zuzanna Rzepka, Dominika Stencel, Anna Skorek, Klaudia Banach, Dorota Wrzesniok
Summary: Melanoma is the most dangerous form of skin cancer due to its high mortality, aggressiveness, and low effectiveness of therapy. Previous studies have shown the therapeutic potential of minocycline, doxycycline, and chlortetracycline on melanoma cells. This study aimed to evaluate the cytotoxicity of tigecycline, a third-generation tetracycline, on melanotic and amelanotic melanoma cell lines. The results demonstrated that tigecycline efficiently inhibited the proliferation of both types of melanoma cells, accompanied by dysregulation of the cell cycle, depolarization of the mitochondrial membrane, and alterations in various molecular levels. However, the drug induced apoptosis only in melanotic melanoma cells, while amelanotic cells exhibited resistance and showed increased autophagy marker levels.
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Chemistry, Multidisciplinary
Cai-Qin Wu, An-An Liu, Xu Li, Jia-Wei Tu, Juan Kong, Ling-Ling Yang, Jian-Hong Jia, Chuan Wang, Bin Hu, Zhi-Xiong Xie, Dai-Wen Pang
Summary: The intracellular redox environment plays a critical role in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Immunology
Lei Yang, You-Ling Shi, Yan Ma, Wei-Wei Ren, Guang-Ming Pang, Jiao Liu
Summary: The study revealed that the upregulation of KLF16 expression in OSCC cells, interfering with KLF16 resulted in cell cycle arrest, inhibited cell growth, and promoted cell apoptosis.
Article
Genetics & Heredity
Spandana Kotian, Rachel M. Carnes, Josh L. Stern
Summary: In this study, the introduction of the epithelial transcription factor GRHL2 enhanced the transcriptional reprogramming and apoptotic effects of HDAC inhibitors in glioblastoma (GBM). However, the presence of GRHL2 also caused cell-cycle dysregulation and aneuploidy in glioma stem cells (GSCs). These findings suggest that while genetic strategies to repress the mesenchymal properties of GBM may be effective, the biological interactions of epithelial factors in mesenchymal cancer cells can disrupt normal cellular mechanisms.
Article
Biochemistry & Molecular Biology
Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chang
Summary: The study confirmed that NSC139021 effectively inhibited the proliferation of glioblastoma cells and induced apoptosis by regulating the p53 signaling pathway and cell cycle kinase pathway, suggesting a potential therapeutic role in glioblastoma treatment.
Article
Oncology
Wenjing Zhang, Cui Wang, Xiaomei Hu, Yanzhen Lian, Caili Ding, Liang Ming
Summary: LDHA is upregulated in cervical cancer and its inhibition leads to reduced glucose consumption, lactate production, cell proliferation, and enhanced apoptosis. LDHA inhibition also affects cell cycle and mitochondrial apoptosis pathway.
Article
Oncology
Jun Zhou, Wanpin Nie, Jiajia Yuan, Zeyu Zhang, Liangliang Mi, Changfa Wang, Ranglang Huang
Summary: GSG2 plays a crucial role in the progression of CCA and its overexpression predicts disease deterioration. Experimental results demonstrate that downregulation of GSG2 inhibits proliferation, promotes apoptosis, arrests cell cycle, and weakens migration in CCA cells.
Article
Biochemistry & Molecular Biology
Byeol-Eun Jeon, Ji-Eun Lee, Jungwook Park, Hyejung Jung, Eun Gyung Park, Du Hyeong Lee, Young-Su Seo, Heui-Soo Kim, Ho-Jin Shin, Sang-Woo Kim
Summary: This study identified critical genes involved in neutrophil apoptosis and revealed the underlying mechanism through gene expression profiling analysis. These findings may present novel opportunities for the treatment of neutropenia and ultimately improve the prognosis of DLBCL patients.
Article
Multidisciplinary Sciences
Sara D'Alessandro, Elia Paradiso, Clara Lazzaretti, Samantha Sperduti, Carmela Perri, Francesco Antoniani, Sara Righi, Manuela Simoni, Giulia Brigante, Livio Casarini
Summary: PDE5 inhibitors do not affect the growth of thyroid cancer cells, according to this study.
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Cell Biology
Tao Ma, Yan Chen, Zhi-Gang Yi, Jia Liu, Yan-Hong Li, Jun Bai, Wen-Ting Tie, Mei Huang, Xiao-Feng Zhu, Ji Wang, Juan Du, Xiu-Qin Zuo, Qin Li, Fan-Li Lin, Liu Tang, Jing Guo, Hong-Wen Xiao, Qian Lei, Xiao-Li Ma, Li-Juan Li, Lian-Sheng Zhang
Summary: This study reveals that NORAD acts as an oncogene in multiple myeloma and exerts its effects through the BMP6/P-ERK1/2 axis. Knockdown of NORAD promotes apoptosis and induces cell cycle arrest, while inhibiting cell proliferation in multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Jessica Segales, Carlos Sanchez-Martin, Aleida Pujol-Morcillo, Marta Martin-Ruiz, Patricia de los Santos, Daniel Lobato-Alonso, Eduardo Oliver, Eduardo Rial
Summary: The role of UCP2 in energy metabolism and cell proliferation in lung adenocarcinoma cells was investigated. The results show that UCP2 silencing decreases basal respiration and cell proliferation, suggesting its involvement in metabolic adaptations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jia Lin, Geng Liu, Lidian Chen, Hang Fai Kwok, Yao Lin
Summary: This review summarizes the functions and mechanisms of lactate in cancer, and analyzes protein lactylation in different rat organs. The unresolved challenges in this field are discussed, along with the potential application of lactate-related cell cycle activities in targeted cancer therapy.
SEMINARS IN CANCER BIOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)