Article
Chemistry, Multidisciplinary
Indrek Kalvet, Mary Ortmayer, Jingming Zhao, Rebecca Crawshaw, Nathan M. Ennist, Colin Levy, Anindya Roy, Anthony P. Green, David Baker
Summary: In this study, a high-affinity heme-binding protein, dnHEM1, was designed with an axial histidine ligand, a vacant coordination site, and a tunable distal pocket. This protein was converted into a proficient peroxidase and enantiocomplementary carbene transferases by reconfiguring the distal pocket. This approach allows for the custom design of enzymes with a variety of shapes and functionalities.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Daniel Bim, Anastassia N. Alexandrova
Summary: Heme-iron oxidoreductases rely on the intramolecular electric fields exerted by the protein hosts to control enzyme specificity in redox reactions. The direction and magnitude of the electric fields at the active sites vary depending on the axial ligands, affecting the reactivity and selectivity of these enzymes. This study highlights the crucial role of protein scaffolds and axial ligands in modulating heme-iron chemistry.
Review
Food Science & Technology
Yilin Xing, Shanxing Gao, Xinyu Zhang, Jiachen Zang
Summary: Heme-containing proteins are promising dietary sources for iron supplementation with higher bioavailability and fewer side effects. They have been widely utilized as food ingredients and antibacterial agents. This review provides a detailed summary of the structural characterization of heme-containing proteins and highlights their recent applications as dietary iron sources in the field of food science and nutrition.
Article
Biochemistry & Molecular Biology
Shifeng Zhao, Xueqiao Wang, Xiaoqing Zheng, Xiu Liang, Zhigang Wang, Juanlian Zhang, Xudong Zhao, Shougang Zhuang, Qiuhui Pan, Fenyong Sun, Wenjun Shang, Jonathan Barasch, Andong Qiu
Summary: Iron deficiency is identified as a risk factor for nephrotoxic intrinsic acute kidney injury (iAKI), exacerbating damage by increasing catalytic iron species. Targeting specific iron types may be a strategy to mitigate diverse forms of kidney injury in patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Robert Gawecki, Jaroslaw Polanski, Anna Mrozek-Wilczkiewicz
Summary: Photodynamic therapy is a patient-friendly and promising anticancer treatment that enhances the oxygen-triggered phototoxic reaction. The concentration of protoporphyrin IX, the active ingredient, can be increased by using iron chelators. In this study, a thiosemicarbazone derivative was found to universally enhance the phototoxic effect. Despite the presence of elevated ABCG2 levels responsible for PpIX efflux, the concentration in the cell was sufficient to trigger the photodynamic reaction. This effect was not observed with 5-ALA alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Arleta Sierakowska, Beata Jasiewicz, Lukasz Piosik, Lucyna Mrowczynska
Summary: Structurally diverse groups of C8-substituted caffeine derivatives were synthesized and evaluated for their chemical and biological properties. Characterizations of these derivatives were performed using mass spectrometry, FT-IR, and NMR. The derivatives showed significant antioxidant and cytoprotective potential dependent on their chemical structure.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Multidisciplinary
Vanessa J. Lee, Samuel E. Janisse, Marie C. Heffern
Summary: Transition metal dysregulation is linked to various pathologies, and therapeutic interventions involving chelators and ionophores have been explored. These compounds, inspired by or derived from plant molecules and peptides, aim to restore homeostasis by sequestering or transporting endogenous metal ions. This review focuses on the potential of plant-based small molecule and peptide chelators and ionophores in treating metabolic diseases. Understanding the chemistry, bioavailability, and bioactivity of these molecules provides insights for further research and applications.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Feng Tang, Jun Yuan, Bi-Feng Yuan, Yinsheng Wang
Summary: The researchers developed a method called DPC-Seq for genome-wide mapping of Tg in human cells. By employing this method, they detected thousands of Tg sites and found that Tg is depleted in regions associated with active transcription but enriched at nucleosome-binding sites.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Clinical Neurology
Samuel David, Fari Ryan, Priya Jhelum, Antje Kroner
Summary: Iron accumulation in the CNS is common in neurological disorders and can contribute to neuropathology through the generation of free radicals. Ferroptosis, a form of cell death induced by iron, has been shown to occur under conditions of deficient antioxidant defense. Iron chelation has limited success in treating neurological diseases, leading to increased interest in ferroptosis as a potential therapeutic target.
Article
Chemistry, Multidisciplinary
Xiaoyu Tong, Ze-Peng Yang, Carlos E. Del Angel E. Aguilar, Gregory C. Fu
Summary: This study reports an iron catalyst for cross-coupling reactions of alkyl electrophiles using olefins and hydrosilanes instead of alkylmetal reagents. Carbon-carbon bond formation occurs at room temperature, and the method utilizes commercially available components. Mechanistic studies suggest the generation of an alkyl radical from the alkyl electrophile and reversible elementary steps.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Immunology
Bing Wu, Yanwei Wu, Chen Fan, Chunlan Feng, Haoyu Wang, Fang Bai, Jianping Zuo, Wei Tang
Summary: Heme plays an important role in the pathogenesis of systemic lupus erythematosus (SLE), and supplementation of heme can significantly improve lupus symptoms, reduce proteinuria levels, and alleviate organ enlargement.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jared C. Paris, Sha Hu, Aiwen Wen, Andrew C. Weitz, Ronghai Cheng, Leland B. Gee, Yijie Tang, Hyomin Kim, Arturo Vegas, Wei-chen Chang, Sean J. Elliott, Pinghua Liu, Yisong Guo
Summary: This study reports the first observation of a spin iron(IV) species in non-heme iron enzymes, which enables the formation of C-S bond catalyzed by OvoA in Methyloversatilis thermotolerans. This finding paves the way for understanding the mechanism of enzymatic oxidative C-S bond formation in the OSHA biosynthesis pathway.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Food Science & Technology
Zishan Liu, Wanqi Zheng, Chunjun Shen, Huiling Yang, Minxin He, Yizhuo Zhang, Changqing Zhao, Zhifeng Zhao
Summary: By comparing the effects of drying pork jerky using a drying oven and a baking oven, the experimental results showed that the baking oven was better at retaining the redness value (a*), but the increasing metmyoglobin content negatively affected the color of the meat samples.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Henry J. Thompson, Elizabeth S. Neil, John N. McGinley
Summary: Population studies, systematic reviews, and meta-analyses have shown mixed results regarding the relationship between iron status and breast cancer risk, with some suggesting a protective effect and others indicating a weak positive association. Preclinical experiments did not provide convincing evidence to support further evaluation of the iron-breast cancer risk hypotheses, highlighting the need for redefining the referent group in population-based studies of iron-cancer hypotheses in other tissues.
Review
Medicine, Research & Experimental
Hosam M. Habib, Sahar Ibrahim, Aamnah Zaim, Wissam H. Ibrahim
Summary: Iron overload is increasingly seen as a contributor to the pathogenesis of COVID-19, triggering inflammation, hypercoagulation, hyperferritinemia, and immune dysfunction. Iron chelators, including the naturally occurring lactoferrin, may hold therapeutic value in COVID-19 by modulating the immune response and blocking the entry of coronaviruses into host cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Faiza Benaouda, Stuart A. Jones, Jasminder Chana, Benedetta M. Dal Corno, David J. Barlow, Robert C. Hider, Clive P. Page, Ben Forbes
MOLECULAR PHARMACEUTICS
(2018)
Article
Nanoscience & Nanotechnology
Robert A. Harper, Mais M. Saleh, Guy Carpenter, Vincenzo Abbate, Gordon Proctor, Richard D. Harvey, Robert J. Gambogi, Anthony Geonnotti, Robert Hider, Stuart A. Jones
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2018)
Article
Chemistry, Medicinal
Ria Fisher, Louise Lincoln, Michael J. Jackson, Vincenzo Abbate, Peter Jenner, Robert Hider, Andrew Lees, Sarah Rose
PHYTOTHERAPY RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
Kuo-Ching Mei, Artur Ghazaryan, Er Zhen Teoh, Huw D. Summers, Yueting Li, Belen Ballesteros, Justyna Piasecka, Adam Walters, Robert C. Hider, Volker Mailaender, Khuloud T. Al-Jamal
ADVANCED MATERIALS
(2018)
Article
Biochemical Research Methods
Tao Zhou, Sinan Battah, Francesca Mazzacuva, Robert C. Hider, Paul Dobbin, Alexander J. MacRobert
BIOCONJUGATE CHEMISTRY
(2018)
Review
Chemistry, Multidisciplinary
Agostino Cilibrizzi, Vincenzo Abbate, Yu-Lin Chen, Yongmin Ma, Tao Zhou, Robert C. Hider
Article
Biophysics
Robert A. Harper, Guy H. Carpenter, Gordon B. Proctor, Richard D. Harvey, Robert J. Gambogi, Anthony R. Geonnotti, Robert Hider, Stuart A. Jones
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Review
Biochemistry & Molecular Biology
W. H. Koppenol, R. H. Hider
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Chemistry, Multidisciplinary
Sveva Pelliccia, Vincenzo Abbate, Fiorella Meneghetti, Nunzianda Frascione, Robert Charles Hider, Ettore Novellino, Gian Cesare Tron, Mariateresa Giustiniano
Article
Food Science & Technology
Kai Chen, Le-Le Shao, Yun-Feng Huo, Jia-Min Zhou, Qing Zhu, Robert C. Hider, Tao Zhou
Article
Engineering, Biomedical
A. Jabeen, B. Reeder, D. Svistunenko, S. Hisaindee, S. Ashraf, S. Al-Zuhair, S. Battah
Article
Chemistry, Physical
Huihui Yan, Robert C. Hider, Yongmin Ma
Article
Food Science & Technology
Le-Le Shao, Jia-Min Zhou, Qing Zhu, Xiao-Ling Wang, Robert C. Hider, Tao Zhou
FOOD SCIENCE AND BIOTECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Chris E. Cooper, Gary G. A. Silkstone, Michelle Simons, Badri Rajagopal, Natalie Syrett, Thoufieq Shaik, Svetlana Gretton, Elizabeth Welbourn, Leif Bulow, Nelida Leiva Eriksson, Luca Ronda, Andrea Mozzarelli, Andras Eke, Domokos Mathe, Brandon J. Reeder
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Nelida Leiva Eriksson, Brandon J. Reeder, Michael T. Wilson, Leif Bulow
BIOCHEMICAL JOURNAL
(2019)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)