Review
Pharmacology & Pharmacy
Khosrow Kashfi, Kush K. Patel
Summary: This article reviews the history of carbon monoxide, highlighting its toxic effects as well as its roles as an endogenously produced molecule and therapeutic agent. The research into its physiological functions and therapeutic applications are often overshadowed by its reputation as a lethal substance.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yixiao Luo, Rafi Ullah, Jinfeng Wang, Yuru Du, Shihao Huang, Li Meng, Yuan Gao, Miao Gong, Ewa Galaj, Xi Yin, Haishui Shi
Summary: The study demonstrated that carbon monoxide (CO) has significant antidepressant and anxiolytic effects, providing protection through activation of HO-1 and exogenous CO administration. This research revealed a novel function of the HO-1/CO system, offering a promising therapeutic target for the treatment of depression and anxiety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Giuseppe Broggi, Sebastiano Giallongo, Maria Failla, Lidia Puzzo, Teresio Avitabile, Daniele Tibullo, Alfio Distefano, Valeria Pittala, Michele Reibaldi, Guido Nicola Zanghi, Antonio Longo, Andrea Russo, Rosario Caltabiano, Giovanni Li Volti, Nicolo Musso
Summary: The study revealed the important role of HO-1 in regulating uveal melanoma progression, with an increase of HO-1 promoting cellular proliferation and wound healing ability of tumor cells, suggesting HO-1 protein expression may serve as a potential prognostic and therapeutic factor in UM patients.
Article
Biochemistry & Molecular Biology
Tao Wu, Xiaotian Liu, Ting Wang, Li Tian, Hao Qiu, Feng Ge, Jing Zhu, Liang Shi, Ailiang Jiang, Hanshou Yu, Ang Ren
Summary: This study found that the HO/CO system can respond to heat stress and regulate Ganoderma lucidum's ganoderic acid biosynthesis and cell wall integrity by regulating the Slt-MAPK phosphorylation level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yoon Kyung Choi, Young-Myeong Kim
Summary: Heme oxygenase and its metabolites have dual roles in neurovascular diseases, potentially causing cytotoxic ferroptosis via iron accumulation, but also exhibiting regenerative potential and neurovascular protective effects through CO-mediated signaling pathway, antioxidant properties of bilirubin, and iron-mediated ferritin synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Inorganic & Nuclear
Ana C. Pena, Ana Pamplona
Summary: Transition metals, especially iron, play important roles in the chemistry of life. Hemoproteins, including hemoglobin, are common targets for binding with biologically active gases such as NO and CO. Heme oxygenases, particularly HO-1, are crucial enzymes involved in heme metabolism and have documented antioxidant and anti-inflammatory properties. However, their role in infection, such as malaria, can be dual, either limiting pathogen burden or promoting pathogen growth. CO-releasing molecules have been considered as a potential alternative to CO gas inhalation for therapeutic purposes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Libor Vitek
Summary: The liver has evolved defense systems to protect against harmful stimuli, including antioxidant substances and enzymes, anti-inflammatory tools, enzymatic biotransformation systems, and metabolic pathways. Recent research indicates the significant role of the heme catabolic pathway in regulating the pathogenesis of liver and other diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Health Care Sciences & Services
Jun Fang, Rayhanul Islam, Shanghui Gao, Cheng Zhang, Ryotaro Kunisaki, Shogo Sakaguchi, Naoya Honda, Jian-Rong Zhou, Kazumi Yokomizo
Summary: Heme oxygenase (HO-1) is crucial for cellular protection against stresses and diseases, but its overexpression in tumors is also commonly observed. Maintaining a balance of HO-1 levels in both host and tumor cells is essential for cancer occurrence, progression, and prognosis, with high HO-1 levels in the host being beneficial for cancer prevention and suppressing HO-1 in tumor cells possibly becoming a therapeutic strategy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Stefan W. Ryter
Summary: Heme molecule is essential for oxygen transport, cellular metabolic enzyme activities, and can promote human diseases if dysfunction occurs. It has pro-oxidant properties, inducing cytotoxicity and injury, while also modulating inflammatory and immune system functions. Therapeutic strategies targeting the heme/HO-1 pathway show potential in inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xiaodi Rong, Yiyuan Peng, Caiyun Liu, Mingzhu Li, Jiafan Shi, Miaohui Yu, Shuaikang Ba, Wenlong Sheng, Baocun Zhu
Summary: In this study, the issues of sensitivity, selectivity, and water solubility of CO fluorescent probes were investigated. A probe named HS-CO was designed to greatly increase the rigid plane of the probe through intramolecular cyclization, resulting in high sensitivity for CO detection. The probe was successfully used to detect CO in HeLa cells and zebrafish, demonstrating its great potential as a tool for functional analysis of CO in organisms.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Kinga Krukowska, Marcin Magierowski
Summary: Gastrointestinal tract cancers present a challenge for researchers in terms of finding effective molecular agents for targeted therapies. Ongoing clinical trials offer new perspectives, but long-term treatments remain unsuccessful. Novel pharmacological and molecular approaches are being studied for the prevention and treatment of GI cancers. Additionally, pharmacological tools that release carbon monoxide have shown therapeutic properties in treating GI pathologies.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tamas Gall, David Petho, Annamaria Nagy, Gyorgy Balla, Jozsef Balla
Summary: The study shows that oxidized hemoglobins, globin-derived peptides, and heme trigger diverse biological responses, including toll-like receptor 4 activation with inflammatory response, reprogramming of cellular metabolism, differentiation, stress, and even death. The damage caused by oxidized hemoglobin and heme to cells and tissues is related to the pathological consequences of hemorrhage and hemolysis in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Slawomir Nowak, Przemyslaw Gilun, Katarzyna Koziol, Maria Romerowicz-Misielak, Magdalena Koziorowska-Gilun, Barbara Wasowska
Summary: Exogenous CO regulates mRNA transcription and protein expression of HO-1, HO-2, and PCNA, similar to a light cue.
Article
Multidisciplinary Sciences
David Nemecek, Eva Chmelikova, Jaroslav Petr, Tomas Kott, Marketa Sedmikova
Summary: The gasotransmitter carbon monoxide (CO) has antioxidant properties in porcine oocytes and may be involved in the regulation of meiotic maturation, but exogenously delivered CO at higher concentrations may inhibit meiotic maturation.
Article
Biochemistry & Molecular Biology
Cesare Mancuso
Summary: Biliverdin is a by-product of heme oxygenase activity and can be transformed into bilirubin by biliverdin reductase. When this enzyme is inhibited, biliverdin accumulates in cells and leads to a clinical syndrome called green jaundice. Biliverdin has been shown to have antioxidant effects and target various signaling pathways, making it potentially beneficial in multiple diseases, including ischemia/reperfusion-related diseases, inflammatory diseases, graft-versus-host disease, viral infections, and cancer.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Ophthalmology
Raquel Beneish, Allison L. Dorfman, Ayesha Khan, Robert C. Polomeno, Pierre Lachapelle
Summary: In this study, data from 24 children with functional amblyopia were analyzed, revealing that some patients continued to show central scotomas and retinal anomalies after treatment, indicating a potential organic defect impairing macular function.
DOCUMENTA OPHTHALMOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Li Yue, Xuexin Lu, Phyllis A. Dennery, Hongwei Yao
Summary: Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants, associated with dysregulated metabolism and several comorbidities. Current research suggests that metabolic dysregulation may serve as a biomarker of BPD and play important roles in the pathogenesis of this disease. Targeting metabolic pathways could be employed in the prevention and treatment of BPD.
Article
Biochemistry & Molecular Biology
Sara Touhami, Fanny Beguier, Tianxiang Yang, Sebastien Augustin, Christophe Roubeix, Frederic Blond, Jean Baptiste Conart, Jose Alain Sahel, Bahram Bodaghi, Cecile Delarasse, Xavier Guillonneau, Florian Sennlaub
Summary: Hypoxia is an essential trigger for wet age-related macular degeneration (wetAMD), promoting subretinal inflammation and inhibiting inflammation resolution. Thrombospondin 1 plays a key role in this process, and hypoxia suppresses its expression. Recombinant Thrombospondin 1 protein can counteract the pathogenic effect of hypoxia and be used as a therapeutic intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Michel Paques, Nathaniel Norberg, Celine Chaumette, Florian Sennlaub, Ethan Rossi, Yse Borella, Kate Grieve
Summary: Time-lapse imaging of GA progression revealed extensive changes in the pattern of marginal hyperreflective spots, suggesting a centrifugal motion ahead of atrophy. This process likely reflects the underlying inflammatory and degenerative process. Multimodal time-lapse imaging is valuable for documenting cell-scale dynamics during GA progression.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Ahmad Samir Alfaar, Lucas Stuerzbecher, Maria Diedrichs-Moehring, Marion Lam, Christophe Roubeix, Julia Ritter, Kathrin Schumann, Balasubramaniam Annamalai, Inga-Marie Pompoes, Baerbel Rohrer, Florian Sennlaub, Nadine Reichhart, Gerhild Wildner, Olaf Strauss
Summary: This study found that FoxP3 is upregulated in RPE cells under age and cellular stress, and it may play an important role in maintaining the immune privilege status of the eye.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Scaffa, George A. Tollefson, Hongwei Yao, Salu Rizal, Joselynn Wallace, Nathalie Oulhen, Jennifer F. Carr, Katy Hegarty, Alper Uzun, Phyllis A. Dennery
Summary: This study reveals the potential DNA binding domains of HO-1 protein through experiments and structural modeling, and further demonstrates HO-1's ability to regulate the expression of target genes. This provides a foundation for developing specific drugs to modulate gene expression and cellular function.
Article
Physiology
Daniella Teape, Abigail Peterson, Nagib Ahsan, Kimberlyn Ellis, Nicholas Correia, Ryan Luo, Katy Hegarty, Hongwei Yao, Phyllis Dennery
Summary: Supplemental oxygen is important for premature infants, but it may cause alveolar simplification and loss of airway epithelial cilia. The mechanism by which hyperoxia leads to ciliary dysfunction is not well understood. This study found that hyperoxia causes intraflagellar transport dysfunction, resulting in decreased cilia length. Proteomic analysis revealed aberrant expression of multiple proteins related to intraflagellar transport, and metabolomic analysis showed dysregulated metabolism in response to hyperoxia.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Hajime Maeda, Katy Hegarty, Phyllis Dennery, Hongwei Yao
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Neurosciences
Paul-Alexandre Dechelle-Marquet, Xavier Guillonneau, Florian Sennlaub, Cecile Delarasse
Summary: This article discusses the potential involvement of P2X7 in the development of AMD and uveitis, as a sensor for high concentrations of released ATP, and its participation in various physiological and pathological processes.
Review
Ophthalmology
Christina Zeitz, Jerome E. Roger, Isabelle Audo, Christelle Michiels, Nuria Sanchez-Farias, Juliette Varin, Helen Frederiksen, Baptiste Wilmet, Jacques Callebert, Marie-Laure Gimenez, Nassima Bouzidi, Frederic Blond, Xavier Guilllonneau, Stephane Fouquet, Thierry Leveillard, Vasily Smirnov, Ajoy Vincent, Elise Heon, Jose-Alain Sahela, Barbara Kloeckener-Gruissemi, Florian Sennlaub, Catherine W. Morgansj, Robert M. Duvoisinj, Andrei V. Tkatchenko, Serge Picaud
Summary: Myopia is a common eye disorder caused by genetic and environmental factors. High myopia is often associated with rare inherited retinal disorders. Genes involved in myopia are related to various biological processes, including eye development, matrix organization, visual perception, circadian rhythms, and retinal signaling. Animal models mimicking myopia can help identify candidate genes implicated in human myopia. Complete congenital stationary night blindness represents an interesting model for studying myopia and retinal signaling defects. Transcriptome analysis in mouse models of cCSNB identified new candidate genes for myopia. Integration of transcriptomic data and genome-wide association studies provides insights into the potential mechanisms underlying myopia development in cCSNB subjects. These findings have implications for the development of pharmacological therapies for myopia.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hongwei Yao, Joselynn Wallace, Abigail L. Peterson, Alejandro Scaffa, Salu Rizal, Katy Hegarty, Hajime Maeda, Jason L. Chang, Nathalie Oulhen, Jill A. Kreiling, Kelsey E. Huntington, Monique E. De Paepe, Guilherme Barbosa, Phyllis A. Dennery
Summary: Senescence contributes to both age-related diseases and stress-related injury, but it is also crucial for organismal development. This study reveals that lung senescence occurs at birth and decreases during the saccular stage in mice. Hyperoxia exposure during the saccular stage induces senescence in specific cell types, leading to lung injury. The findings highlight the importance of programmed senescence in postnatal lung development and offer potential therapeutic strategies for mitigating neonatal hyperoxic lung injury by targeting senescence.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Teresa E. Daniels, Emily K. Zitkovsky, Zachary J. Kunicki, Destiny J. Price, Abigail L. Peterson, Phyllis A. Dennery, Hung-Teh Kao, Lawrence H. Price, Audrey R. Tyrka, Ana M. Abrantes
Summary: This study examined the associations between cell-free DNA (cfDNA) and metabolic syndrome risk. The results showed significant associations between cfDNA from the nucleus (cf-nDNA) and C-reactive protein (CRP) with metabolic risk, while cfDNA from the mitochondria (cf-mtDNA) was not significantly associated. This suggests a role for cf-nDNA in inflammatory processes associated with metabolic syndrome, with distinct roles for cf-nDNA and cf-mtDNA.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)
Article
Respiratory System
Hajime Maeda, Hongwei Yao, Hayato Go, Kelsey E. E. Huntington, Monique E. De Paepe, Phyllis A. A. Dennery
Summary: This study found that hyperoxia can induce senescence in lung epithelial cells and increase the expression of miR-34a-5p, which is partly regulated by the upregulation of the KLF4 signaling pathway. Inhibiting miR-34a-5p or KLF4 can mitigate the detrimental effects of hyperoxia on the neonatal lung.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Jason L. Chang, Jiannan Gong, Salu Rizal, Abigail L. Peterson, Julia Chang, Chenrui Yao, Phyllis A. Dennery, Hongwei Yao
Summary: This study found that upregulating Cpt1a by baicalin or l-carnitine can improve hyperoxia-induced lung endothelial cell dysfunction and persistent lung injury. These findings provide potential therapeutic avenues for using l-carnitine and baicalin as Cpt1a upregulators to prevent persistent lung injury in premature infants with BPD.
RESPIRATORY RESEARCH
(2022)
Article
Pediatrics
David Garcia, Jennifer F. Carr, Felix Chan, Abigail L. Peterson, Kimberlyn A. Ellis, Alejandro Scaffa, Andrew J. Ghio, Hongwei Yao, Phyllis A. Dennery
Summary: This research reveals that even a very short exposure to high oxygen concentrations can lead to long-term cellular injury in lung epithelial cells, affecting mitochondrial function and alveolarization. The study highlights the long-term residual effects of a short period of hyperoxia on cellular metabolism and the development of alveolar simplification in neonatal mice. The findings suggest that any exposure to clinical hyperoxia can result in persistent lung dysfunction.
PEDIATRIC RESEARCH
(2021)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)