Article
Engineering, Environmental
Jun Liang, Kexin Chen, Xiaoguang Duan, Ling Zhao, Hao Qiu, Xiaoyun Xu, Xinde Cao
Summary: This study evaluates the activation of persulfate (PS) by different carbonaceous materials under various pH values, and finds that pH has a significant impact on the degradation of sulfamethoxazole (SMX). High pH values are unfavorable for both radical and nonradical oxidation reactions. The activation mechanisms of different carbonaceous materials vary under different pH conditions.
Article
Polymer Science
Julian Sobieski, Sajjad Dadashi Silab, Lucas Thevenin, Krzysztof Matyjaszewski, Christophe Fliedel, Rinaldo Poli
Summary: The termination processes of the tertiary carbomethoxyisopropylradical, (COOMe)Me2C & BULL;, were investigated by H-1 NMR. The investigation assessed the contributions of the Cu-I/L-catalyzed radical termination (CRT) and the reductive radical termination (RRT) to the spontaneous bimolecular radical terminations (RT). It also reassessed the product distribution for the RT of the diffused and caged radicals obtained from the thermal activation of V-601.
Article
Pharmacology & Pharmacy
Alberto Berardi, Diego Romano Perinelli, Lorina Bisharat, Beatrice Sabbatini, Giulia Bonacucina, Mattia Tiboni, Giovanni Filippo Palmieri, Marco Cespi
Summary: This study investigates the colloidal behavior of carbomers 974 and 980 in hydroalcoholic media and provides insights for the correct formulation of alcohol-based hand sanitizers. Carbomer 980 is recommended for hydrogel formulation with a high alcohol percentage, while aminomethyl propanol is more suitable for preparing carbomer dispersions with a higher alcohol content.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Stanciu, Florin Aonofriesei, Simona Lupsor, Elena Oancea, Magdalena Mititelu
Summary: The aim of this study was to identify and exploit the local plant resources with biologically active properties from the Dobrogea area, Romania. Black poplar buds were collected and macerated to evaluate their qualities as antioxidant and antimicrobial agents. The results showed that the hydroalcoholic macerates of black poplar buds contained high concentrations of phenolic compounds and exhibited potent antioxidant and antimicrobial activities.
Review
Biochemistry & Molecular Biology
Janusz M. Gebicki, Thomas Nauser
Summary: Ionizing radiations cause chemical damage to proteins, commonly mediated by hydroxyl free radicals generated from water. Protein damage is significant in biological systems, as proteins are the main targets of radiation-generated radicals. Polyphenols and other compounds have the potential to repair protein radicals and prevent the formation of new reactive species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Thermodynamics
Akira Matsugi, Shunsuke Suzuki
Summary: The reaction pathways between propargyl and indenyl radicals, leading to the formation of acenaphthylene, were investigated. Quantum chemical methods were used to explore the potential energy surfaces for the reactions. Several reaction pathways for the formation of tricyclic species, which eventually produce acenaphthylene, were identified. The results indicate that acenaphthylene can be formed via three different routes, depending mainly on temperature. A simplified reaction mechanism for the major reaction pathways is proposed for kinetic modeling.
COMBUSTION AND FLAME
(2024)
Article
Biochemistry & Molecular Biology
Ana-Maria Neculai, Gabriela Stanciu, Magdalena Mititelu
Summary: In recent years, there has been significant interest in using drugs with active ingredients of natural origin for alternative therapies. This study aimed to investigate the chemical and mineral composition of the Vinca minor plant grown in the Dobrogea area and its potential use in dermal preparations. The hydroalcoholic macerates of different concentrations obtained from the plant materials were analyzed for bioactive compounds and antioxidant properties. The results showed the presence of four indole alkaloids and significant antioxidant activity. The concentrations of toxic metals in the plant were found to be below detection limits.
Article
Engineering, Environmental
Chu Chu, Shengye Jin, Richard Spinney, Dionysios D. Dionysiou, Haijun Zhang, Ruiyang Xiao
Summary: This article introduces the application of laser flash photolysis (LFP) in transient radical processes. By introducing the development process, principles, and compositions of LFP, comparing the specificity and suitability of different spectral modes, and discussing the generation, detection, and environmental implications of hydroxyl radicals, sulfate radicals, and reactive chlorine species, a critical review of the implementation of LFP for kinetic quantification and mechanism elucidation is conducted. The remaining challenges and future perspectives are highlighted.
Review
Engineering, Environmental
F. Javier Rivas
Summary: The kinetics of monopersulfate based systems in the elimination of potential harmful contaminants has been studied from a theoretical perspective. A detailed reaction mechanism has been proposed and solved numerically. The effect of various parameters on the system has been theoretically obtained and compared with experimental data. The study suggests that simplistic pseudo first order kinetics is not recommended, and a generic model improves the accuracy of the results.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Sebastian Barata-Vallejo, Konrad Skotnicki, Carla Ferreri, Bronislaw Marciniak, Krzysztof Bobrowski, Chryssostomos Chatgilialoglu
Summary: The conversion of ribonucleosides to 2'-deoxyribonucleosides is catalyzed by ribonucleoside reductase enzymes. This study achieved the bioinspired conversion of ketones to alcohols through the intermediacy of disulfide radical anion of cysteine in water, with high concentrations of cysteine and pH 10.6 required for high-yielding reactions. The research also found that the rate constants of three cyclic ketones ranged from 10^4 to 10^5 M(-1)s(-1) at approximately 22 degrees C.
Article
Biochemistry & Molecular Biology
Saba Didarataee, Neeraj Joshi, Juan C. Scaiano
Summary: The free radical chemistry of lipoic acid (LA) and dihydrolipoic acid (DHLA) plays different roles, with DHLA being an excellent hydrogen donor and LA being an excellent hydrogen acceptor. Experimental evidence supports that DHLA is the real antioxidant, while LA is not.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Engineering, Environmental
Ruiyang Xiao, Yunxiang Meng, Yifu Fu, Stanislaw Waclawek, Zongsu Wei, Richard Spinney, Dionysios D. Dionysiou, Weizhi Zeng, Wei-Ping Hu
Summary: This study investigated the CO3·-mediated oxidation of the frequently detected micropollutant ibuprofen. The results showed that the H atom abstraction pathway dominated the degradation process, regardless of the protonation state. Calculation of the reaction rate constant considering explicit solvent molecules yielded a value in agreement with the measured one. Significant charge transfer was observed from the CO3 center to the solvation shells. The study also constructed a contour plot demonstrating the contribution of CO3·- to the elimination of various micropollutants, highlighting the importance of CO3·- in sunlit surface waters.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hugo Semrad, Ctibor Mazal, Marketa Munzarova
Summary: The experimentally motivated study on the acetylene bromoboration mechanism explored different addition-elimination pathways using various computational methods. The results revealed distinct rotation modes and potential energy surfaces involved in the reaction, with the activation energy of the elimination step depending on the attacking position.
Article
Chemistry, Physical
Mingguang Pan, Liuzhou Gao, Junchuan Liang, Pengbo Zhang, Shuyu Lu, Yan Lu, Jing Ma, Zhong Jin
Summary: This study reports a highly-soluble organic redox pair that exhibits high cell voltage and long cycling life in aqueous organic redox flow batteries. The study also reveals the interaction between the redox-active species and water, as well as the capacity degradation mechanism of the battery system.
ADVANCED ENERGY MATERIALS
(2022)
Article
Engineering, Environmental
Olga S. Arvaniti, Alexandra A. . Ioannidi, Angeliki Politi, Kleopatra Miserli, Ioannis Konstantinou, Dionissios Mantzavinos, Zacharias Frontistis
Summary: This study investigates the efficient decomposition of DEX using the thermally activated persulfate process, and examines the effectiveness of various variables. The results show that the TAP process can effectively remove DEX under certain conditions.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Polymer Science
Djamila Kerrouche, Tahar Sadoun, Nabila Rouba, G. Sotclet, Vincent Sol, Vincent Gloaguen, Vincent Chaleix
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
(2018)
Article
Materials Science, Biomaterials
Chantal Damia, David Marchat, Charly Lemoine, Nathalie Douard, Vincent Chaleix, Vincent Sol, Nathanael Larochette, Delphine Logeart-Avramoglou, Joel Brie, Eric Champion
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Chemistry, Applied
Amandine Dieu, Lengo Mambu, Yves Champavier, Vincent Chaleix, Vincent Sol, Vincent Gloaguen, Marion Millot
NATURAL PRODUCT RESEARCH
(2020)
Article
Chemistry, Medicinal
Evelyne Poli, Amandine Magnaudeix, Chantal Damia, Fabrice Lalloue, Vincent Chaleix, Eric Champion, Vincent Sol
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Applied
Soukaina Bouramtane, Ludovic Bretin, Aline Pinon, David Leger, Bertrand Liagre, Laurence Richard, Frederique Bregier, Vincent Sol, Vincent Chaleix
CARBOHYDRATE POLYMERS
(2019)
Article
Oncology
Ludovic Bretin, Aline Pinon, Soukaina Bouramtane, Catherine Ouk, Laurence Richard, Marie-Laure Perrin, Alain Chaunavel, Claire Carrion, Frederique Bregier, Vincent Sol, Vincent Chaleix, David Yannick Leger, Bertrand Liagre
Article
Chemistry, Multidisciplinary
Frederique Bregier, Jeremy Godard, Jordan Thiais, Soukaina Bouramtane, Alexia Moulin, Yves Champavier, Alexis Mailleau, Vincent Chaleix, Vincent Sol
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2019)
Article
Polymer Science
Soukaina Bouramtane, Ludovic Bretin, Aline Pinon, David Leger, Bertrand Liagre, Denilson Da Silva Perez, Yann Launay, Frederique Bregier, Vincent Sol, Vincent Chaleix
Summary: In this study, glucuronoacetylxylan was extracted from chestnut sawdust, pheophorbide-a was semisynthesized and covalently attached to xylan. The resulting conjugates spontaneously formed water-soluble spherical nanoparticles, exhibiting dose-dependent phototoxicity against colorectal cancer cells when irradiated with red light.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Medicinal
Gautier M. A. Ndong Ntoutoume, Robert Granet, Jean-Pierre Mbakidi, Elena Constantin, Ludovic Bretin, David Y. Leger, Bertrand Liagre, Vincent Chaleix, Frederique Bregier, Vincent Sol
Summary: Two protoporphyrin IX (PpIX) adamantane derivatives metallated with zinc were synthesized and encapsulated into the hydrophobic cavity of cyclodextrins. These encapsulated adamantanylporphyrins exhibited enhanced in vitro cytotoxicity compared with the free photosensitizers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Multidisciplinary Sciences
Cynthia Sinyeue, Theophile Garioud, Monika Lemestre, Michael Meyer, Frederique Bregier, Vincent Chaleix, Vincent Sol, Nicolas Lebouvier
Summary: The potential of Pinus caribaea Morelet sawdust for removing nickel ions and other metallic trace ions from aqueous solutions was studied, showing fast and effective biosorption. Modifying the sawdust with acidic and oxidative treatments increased its selectivity for certain metal ions, indicating its potential as an inexpensive and renewable material for water depollution.
Article
Biochemistry & Molecular Biology
Cynthia Sinyeue, Mariko Matsui, Michael Oelgemoller, Frederique Bregier, Vincent Chaleix, Vincent Sol, Nicolas Lebouvier
Summary: In this study, a series of 2,3-dihydroflavanone derivatives were synthesized and investigated for their anti-inflammatory activities. The most active compounds showed higher inhibition of NO production compared to pinocembrin, suggesting the importance of pharmacomodulation in enhancing the biological potential of natural molecules. The study also identified new bioactive flavanones as promising candidates for the development of new anti-inflammatory agents.
Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas, Vincent Chaleix, Vincent Sol
Summary: In this study, cationic porphyrin-xylan conjugate hydrogels were successfully synthesized and showed good mechanical properties and antibacterial activity against common bacterial strains under light irradiation.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas-Roper, Vincent Chaleix, Vincent Sol
Summary: This study presents a synthesis method for light-triggered antibacterial hydrogels based on xylan chains chemically bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). TCPP not only acts as an efficient photosensitizer against Gram-positive bacteria, but also serves as a cross-linking agent for the hydrogels. The hydrogels were characterized using infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and swelling and rheological tests. Under visible light irradiation, the hydrogels showed interesting antimicrobial activity against Staphylococcus aureus and Bacillus cereus, suggesting their potential for the treatment of skin bacterial infections through photodynamic antimicrobial chemotherapy (PACT).
Article
Materials Science, Biomaterials
Morgane Daurat, Christophe Nguyen, Sofia Dominguez Gil, Vincent Sol, Vincent Chateix, Clarence Charnay, Laurence Raehm, Khaled El Cheikh, Alain Morere, Michele Bernasconi, Andrea Timpanaro, Marcel Garcia, Frederique Cunin, Jochen Roessler, Jean-Olivier Durand, Magali Gary-Bobo
BIOMATERIALS SCIENCE
(2020)
Article
Oncology
Soraya Dib, Dina Aggad, Chiara Mauriello Jimenez, Ahmed Lakrafi, Guillaume Hery, Christophe Nguyen, Denis Durand, Alain Morere, Khaled El Cheikh, Vincent Sol, Vincent Chaleix, Sofia Dominguez Gil, Karim Bouchmella, Laurence Raehm, Jean-Olivier Durand, Makhlouf Boufatit, Xavier Cattoen, Michel Wong Chi Man, Nadir Bettache, Magali Gary-Bobo
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)