Article
Biochemistry & Molecular Biology
Rashmi S. Tupe, Nilima Bangar, Akib Nisar, Amruta Kulkarni, Neena Sankhe, Rohan Chauhan, Nidhi Mistry, Shamim Shaikh
Summary: Piperine demonstrates preventive, protective, and therapeutic effects on albumin glycation, while also safeguarding red blood cells from oxidative damage induced by glycated albumin.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Cell Biology
Szymon Sekowski, Ewa Olchowik-Grabarek, Alina T. Dubis, Lokesh Sharan, Ashutosh Kumar, Nodira Abdulladjanova, Paula Markiewicz, Maria Zamaraeva
Summary: This study demonstrated the inhibitory effect of hydrolysable tannin from Sumac on the generation of glycation markers under high glucose treatment, while also stabilizing protein structure. It also showed neuroprotective effects in high glucose-exposed neuro2A cells.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Chemistry, Medicinal
Grzegorz Biedrzycki, Blanka Wolszczak-Biedrzycka, Justyna Dorf, Daniel Michalak, Malgorzata Zendzian-Piotrowska, Anna Zalewska, Mateusz Maciejczyk
Summary: This study compares the antioxidant and antiglycation potentials of popular H2 antagonists (ranitidine, cimetidine, and famotidine) on protein glycoxidation. The results show that ranitidine is the only H2 blocker that significantly inhibits protein glycation and has antioxidant properties. It can compete with proteins for the addition of carbonyl groups.
Review
Food Science & Technology
Matheus Thomaz Nogueira Silva Lima, Eric Boulanger, Frederic J. Tessier, Jacqueline Aparecida Takahashi
Summary: The world is currently experiencing a demographic change with an increasing number of elderly citizens. This aging process is characterized by a decline in physiological capacity and oxidative stress, which is linked to various aging-related disorders. Although there are currently no prescribed therapies to control oxidative stress, adopting nutritional strategies such as the consumption of herbal teas like hibiscus, rooibos, and yerba mate, which are rich in antioxidants, can help elevate antioxidant defenses and overcome related health challenges. This paper reviews the literature on the potential of hibiscus, rooibos, and yerba mate teas in attenuating oxidative stress-related glycoxidation and neurodegeneration, with a specific focus on Alzheimer's Disease as an example.
Review
Biochemistry & Molecular Biology
Daria A. Belinskaia, Polina A. Voronina, Vladimir I. Shmurak, Richard O. Jenkins, Nikolay V. Goncharov
Summary: Albumin, a main protein in humans and many animal species, plays a crucial role in transporting ions and maintaining blood colloidal osmotic pressure. It also binds to drugs, nutraceuticals, and toxic substances, impacting their pharmacokinetics. Albumin is not only passive, but also actively involved in enzymatic activities and redox processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lezhen Dong, Yunzhen Zhang, Ying Li, Yahui Liu, Qin Chen, Lingyi Liu, Mohamed Farag, Lianliang Liu
Summary: This study found that oat phenolic acids can inhibit the formation of AGEs and POPs in dairy products, and protect whey protein structure. The inhibitory effects of oat phenolic acids on AGEs and POPs may be related to the binding of key amino acid residues in whey proteins, the inhibitory role of early fructosamine, and the trapping of reactive α-dicarbonyl groups to form adducts.
Review
Biochemistry & Molecular Biology
Fuka Tabata, Yasuaki Wada, Satomi Kawakami, Kazuhiro Miyaji
Summary: Serum albumin, the most abundant circulating protein in mammals, has three isoforms based on its redox state, traditionally considered a biomarker of systemic oxidative stress but recent research indicates oxidized albumin itself may worsen pathological conditions. Experimental evidence also suggests its potential as a sensitive protein nutrition biomarker.
Review
Biochemistry & Molecular Biology
Milosz Nesterowicz, Malgorzata Zendzian-Piotrowska, Jerzy Robert Ladny, Anna Zalewska, Mateusz Maciejczyk
Summary: Amantadine does not significantly affect protein glycoxidation, lacks antioxidant and antiglycation effects, and may even have some glycoxidant, proglycation, and prooxidant properties.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Domenico Corica, Giorgia Pepe, Monica Curro, Tommaso Aversa, Angelo Tropeano, Riccardo Ientile, Malgorzata Wasniewska
Summary: Advanced glycation end-products (AGEs) play a crucial role in the pathogenesis of metabolic and cardiovascular diseases, chronic degenerative diseases, neurological diseases, and cancer. Immunological and bioanalytical techniques are commonly used for the measurement of AGEs, but the lack of reference values, standardized molecules, and methods hinders their clinical application.
Article
Multidisciplinary Sciences
Binish Arif, Zarina Arif, Jamal Ahmad, Kahkashan Perveen, Najat A. Bukhari, Jalaluddin M. Ashraf, Moinuddin, Khursheed Alam
Summary: This study examines the effectiveness of aminoguanidine in preventing the production of early glycation products in alloxan-diabetic rabbits. The administration of aminoguanidine is shown to control hyperglycemia, reduce levels of amadori adducts, and restore antioxidant defenses.
Article
Chemistry, Multidisciplinary
K. M. Abdullah, Afrah Arefeen, Anas Shamsi, Fahad A. Alhumaydhi, Imrana Naseem
Summary: The study suggests that thiamine can inhibit glycation and improve insulin secretion to control diabetes.
Article
Medicine, Research & Experimental
Nada H. Eisa, Ahmed E. Khodir, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Eman Said
Summary: PEITC showed renal protective effects against DN in rats induced by STZ, improving kidney and liver functions, histopathological features, tissue fibrosis, macrophage infiltration, and blood glucose levels. The mechanisms involved modulation of glycation, oxidative stress, and inflammatory response, including activation of GLO1 and Nrf2 pathways and suppression of NLRP3 inflammasome activation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Medicine, Research & Experimental
Krzysztof Drygalski, Eliza Fereniec, Anna Zalewska, Adam Kretowski, Malgorzata Zendzian-Piotrowska, Mateusz Maciejczyk
Summary: The study found that phloroglucinol has strong and broad anti-glycation and anti-oxidative effects, making it a potential adjunct therapy for diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Natalia Ruggeri Barbaro, Justin Van Beusecum, Liang Xiao, Luciana do Carmo, Ashley Pitzer, Roxana Loperena, Jason D. Foss, Fernando Elijovich, Cheryl L. Laffer, Kim R. Montaniel, Cristi L. Galindo, Wei Chen, Mingfang Ao, Raymond L. Mernaugh, Aseel Alsouqi, Talat A. Ikizler, Agnes B. Fogo, Heitor Moreno, Shilin Zhao, Sean S. Davies, David G. Harrison, Annet Kirabo
Summary: High salt exposure can activate human monocytes, leading to inflammation and enhancing their ability to activate T cells. The activation capacity of monocytes is correlated with cardiovascular disease risk factors.
CARDIOVASCULAR RESEARCH
(2021)
Article
Environmental Sciences
Sukanta Kumar Pradhan, Upendra Kumar, Nihar Ranjan Singh, Hrudayanath Thatoi
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jade Delveaux, Chloe Turpin, Bryan Veeren, Nicolas Diotel, Susana B. Bravo, Floran Begue, Ezequiel Alvarez, Olivier Meilhac, Emmanuel Bourdon, Philippe Rondeau
Article
Multidisciplinary Sciences
Chloe Turpin, Aurelie Catan, Alexis Guerin-Dubourg, Xavier Debussche, Susana B. Bravo, Ezequiel Alvarez, Jean Van den Elsen, Olivier Meilhac, Philippe Rondeau, Emmanuel Bourdon
Article
Environmental Sciences
Sukanta Kumar Pradhan, Nihar Ranjan Singh, Sasmita Das, Hrudayanath Thatoi
SOIL & SEDIMENT CONTAMINATION
(2020)
Article
Chemistry, Medicinal
Nawraj Rummun, Philippe Rondeau, Emmanuel Bourdon, Elisabete Pires, James McCullagh, Timothy D. W. Claridge, Theeshan Bahorun, Wen-Wu Li, Vidushi S. Neergheen
Article
Biochemistry & Molecular Biology
Jonathan Bonneville, Philippe Rondeau, Bryan Veeren, Julien Faccini, Marie-Paule Gonthier, Olivier Meilhac, Cecile Vindis
Summary: This study evaluated the antioxidant and cytoprotective effects of polyphenol-rich extracts from two medicinal plants, A. borbonica and D. apetalum, from Reunion Island. The results showed that the polyphenol extracts of these plants could limit LDL oxidation and intracellular oxidative stress, and protect the endothelium.
Article
Biochemistry & Molecular Biology
Janice Taile, Matthieu Bringart, Cynthia Planesse, Jessica Patche, Philippe Rondeau, Bryan Veeren, Patricia Clerc, Anne Gauvin-Bialecki, Steeve Bourane, Olivier Meilhac, David Couret, Marie-Paule Gonthier
Summary: This study evaluated the effects of polyphenols extracted from Antirhea borbonica on obesity and diabetes-related cerebrovascular damages during stroke. The results showed that polyphenols reduced insulin resistance, hyperglycemia, and dyslipidemia caused by obesity, and attenuated brain infarct, hemorrhagic transformation, and blood-brain barrier disruption. Polyphenols also exhibited anti-inflammatory and antioxidant properties, and decreased MMP-2 activity in hyperglycemic condition. Furthermore, the protective effects of polyphenols were associated with their circulating metabolites.
Article
Chemistry, Medicinal
Sai Sandhya Narra, Sarah Rosanaly, Philippe Rondeau, Jessica Patche, Bryan Veeren, Marie-Paule Gonthier, Wildriss Viranaicken, Nicolas Diotel, Palaniyandi Ravanan, Christian Lefebvre d' Hellencourt, Olivier Meilhac
Summary: This study aimed to improve the bioavailability of curcumin and evaluate the synergistic effect of curcumin-reconstituted high-density lipoprotein nanoparticles on MGO-induced endothelial dysfunction in diabetic patients. The results showed that Cur-rHDL nanoparticles can alleviate MGO-induced cytotoxicity and oxidative stress, protect endothelial cell barrier integrity, and enhance the bioavailability of curcumin.
Article
Biochemistry & Molecular Biology
Chloe Turpin, Olivier Meilhac, Emmanuel Bourdon, Francois Canonne-Hergaux, Philippe Rondeau
Summary: Red blood cells play a crucial role in circulation and their aging process, as well as the phagocytosis by professional and non-professional phagocytes, can contribute to disease progression. Investigating the mechanisms of erythrophagocytosis is vital for understanding pathologies.
Article
Food Science & Technology
Awadhesh Kumar, Upasana Sahoo, Milan Kumar Lal, Rahul Kumar Tiwari, Sangram Keshari Lenka, Nihar Ranjan Singh, Om Prakash Gupta, Rameswar Prasad Sah, Srigopal Sharma
Summary: Recent studies suggest that dietary fibre rich wholegrain foods with low starch digestibility and high resistant starch content may contribute to low glycemic index and glycemic load. To prevent the development of type-II diabetes, rice based low GI foods with high resistant starch content have been developed. The increase in amylose and resistant starch content in rice, along with the action of starch debranching enzyme and the inhibition of starch digestibility by phytic acid, have been achieved through mechanical processing and modern technologies like CRISPR.
JOURNAL OF CEREAL SCIENCE
(2022)
Article
Cell Biology
Chloe Turpin, Marie Laurine Apalama, Bastian Carnero, Alberto Otero-Cacho, Alberto P. Munuzuri, Maria Teresa Flores-Arias, Erick Velia, Olivier Meilhac, Emmanuel Bourdon, Ezequiel Alvarez, Philippe Rondeau
Summary: This study investigates the impact of glycation on the structure and ability of erythrocytes to alter endothelial cell function. Results show that glycation enhances oxidative stress and erythrophagocytosis by endothelial cells, leading to impaired endothelial cell function. These findings have important implications for understanding the mechanism of diabetic vascular complications.
Article
Education, Scientific Disciplines
Anne -Claire Dorsemans, M. Faadiel Essop, Emmanuel Bourdon
Summary: Authentic teaching approach introduces real-world scenarios into the classroom, which can engage Generation Z students. This study introduced an authentic learning practical exercise to biology students, which resulted in long-lasting changes in terms of breakfast behavioral patterns.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Review
Biochemistry & Molecular Biology
Chloe Turpin, Aurelie Catan, Olivier Meilhac, Emmanuel Bourdon, Francois Canonne-Hergaux, Philippe Rondeau
Summary: This review highlights the role of erythrocytes as potent contributors to atherosclerotic plaque progression, going beyond their traditional role as passive gas carriers. The review describes the physiology of erythrocytes and pathology of ATH, as well as the links between erythrocytes and atherogenesis. It also discusses the potential pathological consequences of extravasated erythrocytes in plaque iron homeostasis, particularly in diabetic patients with hyperglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Entomology
Sujit Kumar Das, Sukanta Kumar Pradhan, Kailash Chandra Samal, Nihar Ranjan Singh
Summary: The study analyzed 58 Cry proteins from three insect orders, revealing that structural and functional divergence of Bt may have occurred due to inner-molecular domain shift or domain insertion/deletion during the evolutionary process. The research findings contribute to understanding the diversity and specificity of insecticidal proteins, and their potential application as biopesticides in agriculture.
EGYPTIAN JOURNAL OF BIOLOGICAL PEST CONTROL
(2021)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
