Article
Emergency Medicine
Ekrem Taha Sert, Kamil Kokulu, Huseyin Mutlu
Summary: This study identified predictors of delayed neurological sequelae (DNS) after acute charcoal-burning carbon monoxide (CO) poisoning, including lower initial Glasgow Coma Scale (GCS) score, longer duration of CO exposure, and abnormal findings on diffusion-weighted imaging. The multivariate regression model created demonstrated high accuracy in predicting DNS development.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Emergency Medicine
Shan Liu, Yan Liu, Chanjuan Yang, Dedong Xie, Xia Zhang
Summary: This study indicates that domestic carbon monoxide poisoning caused by charcoal burning is more likely to trigger delayed neurological sequelae than gas-emitting heaters.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Emergency Medicine
Abdullah Arslan
Summary: It is essential to closely monitor and treat pregnant women with carbon monoxide poisoning due to the potential fetal harm. HBO treatment is recommended for all pregnant patients, regardless of clinical symptoms. The study evaluated pregnant CO poisoning patients who received HBO treatment and found no harmful effects on the mother and fetus.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Youssef Nouma
Summary: Charcoal burning (CB) suicide, considered soft and painless, has re-emerged as a prevalent method of suicide across multiple countries, with internet and suicide forums playing a potentially influential role in its spread. This paper presents the first documented case of CB suicide in Tunisia, highlighting the need for increased attention towards this method of suicide to prevent potential epidemic spread.
PAN AFRICAN MEDICAL JOURNAL
(2021)
Article
Emergency Medicine
Hiba Anaqrah, Daniel J. McCabe
Summary: This article reports a case of chronic carbon monoxide poisoning caused by smoking hookah, resulting in chronic carboxyhemoglobinemia. The case highlights the importance of a patient's social history in evaluating severe carboxyhemoglobinemia.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Medicine, Legal
Francesco Simonit, Ugo Da Broi, Federica Angeli, Dario Innocenti, Lorenzo Desinan
Summary: The analysis of charred bodies is challenging and requires an interdisciplinary approach. In this case, forensic pathology, forensic radiology, toxicology, and fire investigations were used to determine the cause and manner of death. The findings suggested a complicated suicide hypothesis, but intentional arson could not be completely ruled out.
JOURNAL OF FORENSIC SCIENCES
(2023)
Article
Clinical Neurology
Shu-Sen Chang, Chien-Yu Lin, Chia-Yueh Hsu, Ying-Yeh Chen, Paul S. F. Yip
Summary: The charcoal restriction program in New Taipei City did not show a significant reduction in charcoal-burning or overall suicide rates. Future suicide prevention strategies should focus on optimizing program sustainability, ensuring comprehensive means restriction, and monitoring long-term intervention effectiveness.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Erdogan Oz, Osman Kucukkelepce, Osman Kurt, Aski Vural
Summary: This study aimed to investigate the impact of poisoning on the mortality rate and the development of new morbidities in survivors. The findings showed that individuals who survived carbon monoxide poisoning should be closely monitored for one year due to the possibility of developing new morbidities that increase the risk of mortality.
Article
Public, Environmental & Occupational Health
Long Sun, Keqing Li, Yunshu Zhang, Lili Zhang
Summary: This study aimed to investigate the association between carbon monoxide poisoning (CMP) and lifetime suicidal ideation/suicide plan among community residents. The results showed that CMP experience was associated with lifetime suicidal ideation, while being female was another risk factor. However, the association between CMP and suicide plan was no longer significant after false discovery rate correction. For CMP patients, experiencing CMP at least twice was associated with a higher risk of lifetime suicidal ideation.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Article
Chemistry, Physical
Kohei Inagawa, Daiju Matsumura, Masashi Taniguchi, Shinya Uegaki, Tomohito Nakayama, Junnosuke Urano, Takuro Aotani, Hirohisa Tanaka
Summary: Passive autocatalytic recombiner (PAR) is a potential technology for ensuring process safety in the hydrogen society by catalytically oxidizing hydrogen to water, effectively mitigating the risk of explosions. CO is a catalyst poison that hampers catalytic reactions. In situ and time-resolved X-ray absorption spectroscopy analyses revealed that the Pt-Fe/CZY catalyst exhibited notable hydrogen oxidation activity even in the presence of CO, attributed to the combined effects of Pt-Fe alloy composition and CZY support materials.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Public, Environmental & Occupational Health
Daniela Gentile, Richard Adams, Michal Klatka, Sally Bradberry, Laurence Gray, Ruben Thanacoody, Gillian Jackson, Euan A. Sandilands
Summary: This study analyzed unintentional carbon monoxide exposures in the UK, with most incidents occurring in domestic settings and often linked to faulty boilers. While the majority of patients experienced only minor symptoms, fatalities still occurred. Blood carboxyhaemoglobin concentration, although important for confirming exposure, did not show a significant correlation with severity. Public health policy should focus on raising awareness of the dangers of carbon monoxide.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Piotr Hydzik, Renata Francik, Slawomir Francik, Ewa Gomolka, Ebru Derici Eker, Miroslaw Krosniak, Maciej Noga, Kamil Jurowski
Summary: In conventional clinical toxicology practice, the blood level of carboxyhemoglobin is commonly used as a biomarker for carbon monoxide poisoning. However, this does not reflect the complete clinical picture and severity of the poisoning. This article aims to explore the potential use of oxidative-stress-related parameters as biomarkers for evaluating CO poisoning severity and guiding treatment decisions. Preliminary studies involving CO-poisoned patients showed significant changes in antioxidative parameters, such as catalase and glutathione levels, but further research is needed to fully understand their role as biomarkers for CO poisoning severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Medicine, General & Internal
Fred M. Henretig, Diane P. Calello, Kevin C. Osterhoudt
Summary: This article provides evidence supporting the association between epidemic carbon monoxide poisoning caused by severe storms and power outages, with portable generators being identified as the primary culprits. These generators produce large amounts of carbon monoxide and account for a significant proportion of such poisoning cases.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Letter
Medicine, General & Internal
Christopher M. Worsham, Jaemin Woo, Michael J. Kearney, Charles F. Bray, Anupam B. Jena
Summary: The risk of carbon monoxide poisoning is significantly increased during major power outages, according to a review of claims data from a commercially insured population in Texas.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qiyue Mao, Xuansu Zhao, Akiko Kiriyama, Shigeru Negi, Yasutaka Fukuda, Hideki Yoshioka, Akira T. Kawaguchi, Roberto Motterlini, Roberta Foresti, Hiroaki Kitagishi
Summary: In this study, an injectable antidote against simultaneous poisoning by carbon monoxide (CO) and hydrogen cyanide (CN-) was invented. The antidote showed remarkable protective effects in mouse and rat models, improving survival rates and reducing CO and CN- levels in the blood. Pharmacokinetic data demonstrated fast urinary excretion and short elimination half-life of the antidote. Furthermore, the antidote was effective in improving survival and promoting rapid recovery from physical incapacitation in a simulated fire accident scenario.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Infectious Diseases
C. J. Lerche, L. J. Christophersen, M. Kolpen, P. R. Nielsen, H. Trostrup, K. Thomsen, O. Hyldegaard, H. Bundgaard, P. O. Jensen, N. Hoiby, C. Moser
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2017)
Article
Pediatrics
Louise Aarup Brodersen, Pia Rude Nielsen, Helle Charlotte Thiesson, Peter Marckmann
PEDIATRIC TRANSPLANTATION
(2011)
Article
Immunology
Sara Louise Dahl, Joshua S. Woodworth, Christian Johann Lerche, Elisabeth Praestekjaer Cramer, Pia Rude Nielsen, Claus Moser, Allan Randrup Thomsen, Niels Borregaard, Jack Bernard Cowland
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Clinical Neurology
Ausrine Areskeviciute, Peter Hogh, Anna Bartoletti-Stella, Linea Cecilie Melchior, Pia Rude Nielsen, Piero Parchi, Sabina Capellari, Helle Broholm, David Scheie, Eva Lobner Lund
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2019)
Article
Hematology
Lise M. Lindahl, Andreas Willerslev-Olsen, Lise M. R. Gjerdrum, Pia R. Nielsen, Edda Blumel, Anne H. Rittig, Pamela Celis, Bjorn Herpers, Juergen C. Becker, Birgitte Stausbol-Gron, Mariusz A. Wasik, Maria Gluud, Simon Fredholm, Terkild B. Buus, Claus Johansen, Claudia Nastasi, Lukas Peiffer, Linda Kubat, Michael Bzorek, Jens O. Eriksen, Thorbjorn Krejsgaard, Charlotte M. Bonefeld, Carsten Geisler, Tomas Mustelin, Erik Langhoff, Michael Givskov, Anders Woetmann, Mogens Kilian, Thomas Litman, Lars Iversen, Niels Odum
Article
Multidisciplinary Sciences
Christian J. Lerche, Lars J. Christophersen, Jens Peter Goetze, Pia R. Nielsen, Kim Thomsen, Christian Enevold, Niels Hoiby, Peter O. Jensen, Henning Bundgaard, Claus Moser
Article
Dermatology
Tengpeng Hu, Thorbjorn Krejsgaard, Claudia Nastasi, Terkild Brink Buus, Anneline Nansen, Andreas Hald, Pieter Spee, Pia Rude Nielsen, Edda Bluemel, Maria Gluud, Andreas Willerslev-Olsen, Anders Woetmann, Michael Bzorek, Jens O. Eriksen, Niels Odum, Lise Mette Rahbek Gjerdrum
Letter
Dermatology
Pia Rude Nielsen, Jens Ole Eriksen, Lise Maria Lindahl, Ulrike Wehkamp, Michael Bzorek, Gitte Andersen, Anders Woetmann, Lars Iversen, Niels Odum, Thomas Litman, Lise Mette Rahbek Gjerdrum
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ausrine Areskeviciute, Thomas Litman, Helle Broholm, Linea C. Melchior, Pia R. Nielsen, Alison Green, Jens O. Eriksen, Colin Smith, Eva L. Lund
Summary: The study found regional and sub-regional differences in the expression patterns of neuroinflammation in the frontal cortex and cerebellum of patients with sporadic Creutzfeldt-Jakob disease, indicating a variable neuroinflammatory response. These differences were not influenced by molecular subtypes of the disease, and there may be overlap in biological processes. Therefore, smaller-scale spatial data are needed to explain the observed differential gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Franziska A. Schwartz, Lars Christophersen, Anne Sofie Laulund, Rasmus Lundquist, Christian Lerche, Pia Rude Nielsen, Henning Bundgaard, Niels Hoiby, Claus Moser
Summary: The study established an in vitro vegetation simulation model of IE with relevant pathogens, including S. aureus, Streptococcus spp (S. mitis group), and Enterococcus faecalis. The model mirrors the natural IE process and has the potential for fast screening of treatment candidates. The patch exhibited stable bacterial colonization with increased tolerance to antibiotics compared to planktonic bacteria.
Article
Oncology
Cheng Chi, Lisa Harth, Marina Ramirez Galera, Marina Passos Torrealba, Chella Krishna Vadivel, Carsten Geisler, Charlotte Menne Bonefeld, Pia Rude Nielsen, Michael Bzorek, Juergen C. Becker, Lise Mette Rahbek Gjerdrum, Niels Odum, Anders Woetmann
Summary: In this study, researchers found that FASN is highly expressed in CTCL cells, and inhibition of FASN affects cell viability and proliferation. The upregulation of FASN induced by FASN inhibitors can be partially reversed by SREBP. Therefore, the combination of FASN and SREBP inhibitors may have promising therapeutic effects in CTCL.
Article
Dermatology
Pia Rude Nielsen, Jens Ole Eriksen, Mia Dahl Sorensen, Ulrike Wehkamp, Lise M. Lindahl, Michael Bzorek, Lars Iversen, Anders Woetman, Niels Odum, Thomas Litman, Lise Mette Rahbek Gjerdrum
Summary: Mycosis fungoides is the most common cutaneous T-cell lymphoma, and it has been found that B-cells play an important role in the disease and show upregulation during disease progression. These findings could potentially lead to new treatment strategies for mycosis fungoides.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Dermatology
Pia Rude Nielsen, Jens Ole Eriksen, Ulrike Wehkamp, Lise Maria Lindahl, Robert Gniadecki, Hanne Fogh, Susanne Fabricius, Michael Bzorek, Niels Odum, Lise Mette Rahbek Gjerdrum
ACTA DERMATO-VENEREOLOGICA
(2019)
