Article
Biochemistry & Molecular Biology
Vincent Hamani, Pascaline Ory, Pierre-Edouard Bodet, Laurence Murillo, Marianne Graber
Summary: This study investigated the impact of copper on the metabolism of the variegated scallop, identifying 28 metabolites clearly modulated by copper that reflect its effects on various biological functions such as osmoregulation, oxidative stress, reproduction, and energy metabolism.
Article
Biochemical Research Methods
Bowen Huang, Adabelle Ong, Wenli Wang, Yu He, Yongjun Xiao
Summary: The detection and understanding of emerging contaminants (ECs) pose new challenges to water pollution control. Triclosan (TCS), an emerging contaminant widely found in the environment, is a commonly used antibacterial agent. Microdialysis (MD), a sampling technique, combined with UHPLC-QTOF/MS analysis, was used to identify endogenous metabolites as biomarkers of TCS exposure in living crucian carp. The quantification of these biomarkers using UHPLC-MS/MS provided continuous monitoring of the effect of TCS on endogenous metabolites, contributing to a better understanding of its toxicological effect.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Niels Agerbirk, David Pattison, Terezie Mandakova, Martin A. Lysak, Sabine Montaut, Dan Staerk
Summary: The GSL profiles of four Limnanthaceae species, including the oil crop Limnanthes alba, were investigated using ultrahigh-performance liquid chromatographyquadrupole time-of-flight tandem mass spectrometry (UHPLC-QToF-MS/MS) analysis. The study provided an overview of biosynthetic capabilities in the genera Floerkea and Limnanthes and proposed potential biosynthetic schemes and gene families relevant for tailoring GSL profiles in Limnanthes crops.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Yiming Zhang, Lanlan Zhan, Quan Wen, Yulin Feng, Yun Luo, Ting Tan
Summary: This study discovered that taxifolin is able to effectively trap methylglyoxal (MGO), an important precursor of advanced glycation end products (AGEs), by forming MGO adducts in vitro and in vivo. Quantification studies showed that taxifolin and its metabolites can dose-dependently trap MGO. Similar results were observed in diabetic mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Mariola Wicka, Krzysztof Grucza, Aleksandra Drapala, Patryk Konarski, Dorota Kwiatkowska
Summary: Glucocorticoids are important drugs used for their anti-inflammatory, antiallergenic, and immunosuppressive effects. Misuse of glucocorticoids can lead to addiction. This study developed analytical methods for identifying glucocorticoids in human urine, which can be used for prosecution in cases of abuse, clinical toxicology, medical jurisprudence, and routine testing of athletes. The method utilized Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS) with the UniSprayTM ionization source, allowing for the simultaneous detection of 27 glucocorticoids with low LOD and LOQ values ranging from 0.06 ng/mL to 0.14 ng/mL and 0.75 ng/mL, respectively.
Article
Chemistry, Analytical
Ge Xun, Yuhuan Tian, Yanhua Gao, Jia Zhang, Xin Liu, Shuo Sun, Qi Qian, Fangfang Liu, Qiao Wang, Xu Wang
Summary: This study identified and compared chemical compounds in three types of commercial Tripterygium wilfordii genus preparations (TWGP) using UHPLC-QTOF-MS/MS and molecular networking (MN) technology. A total of 103 compounds were identified, with 26 of them being discovered as main differential compounds in Tripterygium glycoside tablets. This study lays the foundation for classifying effective and toxic substances and TWGP quality control, utilizing MN technology for compound analysis in TWGP.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Joanna Wittckind Manoel, Gabriele Bordignon Primieri, Livia Maronesi Bueno, Camila F. A. Giordani, Julia Medeiros Sorrentino, Alexsandro Dallegrave, Clesio Soldateli Paim, Elfrides Eva Scherman Schapoval, Cassia Virginia Garcia, Martin Steppe
Summary: A simple and fast analytical method was developed and validated to determine EMPA and its synthetic impurities using UHPLC-QTOF-MS, with parameters such as specificity, linearity, precision, and accuracy within acceptable ranges. Additionally, two new degradation products were observed under exposure conditions, contributing to the understanding of the EMPA impurity profile.
MICROCHEMICAL JOURNAL
(2021)
Article
Biochemical Research Methods
Michela Burico, Giada Fodaroni, Enrico Flamini, Nicola Ascani, Giacomo Proietti, Sara Tamimi, Claudio Marzio Quintiero, Luca Massa, Mattia Gianni, Luisa Mattoli
Summary: The evolution of the regulatory framework for medical devices in the EU has led to the study of emerging properties of complex systems. This has created a need for new analytical approaches, such as omics approaches and advanced analytical methods, to characterize complex natural substrates. In this context, a new approach based on suspect screening was developed to detect gallotannins. This method was successfully applied to identify and semi-quantify gallotannins in molecules extracted from Witch-hazel leaves.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Chemistry, Applied
Allan dos Santos Polidoro, Claissa Nied Peixoto, Vitoria Carolina Prestes de Souza, Anai Loreiro dos Santos, Adriano de Araujo Gomes, Rosangela Assis Jacques
Summary: This study aimed to develop strategies to elucidate the phenolic composition of yerba mate samples from Brazil, Argentina, Uruguay, and Paraguay. The results showed that Brazilian samples had higher pigment content, while samples from other countries had higher phenolic content.
Article
Chemistry, Applied
Costanza Ceccanti, Gabriele Rocchetti, Luigi Lucini, Gianluca Giuberti, Marco Landi, Stefano Biagiotti, Lucia Guidi
Summary: This study compared the phytochemical profiles of common garlic and elephant garlic, finding that elephant garlic had lower fiber content but higher sulfur-containing compounds. The distinct phytochemical signature of elephant garlic was maintained during in vitro gastrointestinal digestion, supporting the unique sensory attributes of the bulbs.
Article
Plant Sciences
Xiaoli Wang, Qiaoyu He, Qian Chen, Beibei Xue, Jia Wang, Tao Wang, Hong Liu, Xiaopeng Chen
Summary: This study combined network pharmacology and metabolomics to explore the potential mechanism of Shenyan Kangfu Tablets (SYKFT) in treating diabetic nephropathy (DN), identifying potential active components, related targets, and biomarkers. The results suggest that the potential mechanism of SYKFT in treating DN is most related to insulin resistance (IR), demonstrating the feasibility of using network pharmacology and metabolomics to study the mechanisms of herbal treatments for complex diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
P. Ory, V Hamani, P-E Bodet, L. Murillo, M. Graber
Summary: This study investigated the effects of zinc exposure on the metabolic profiles of variegated scallops, finding that 11 identified metabolites were down-modulated in exposed scallops. These variations could reflect potential zinc effects on several biological processes. Among the identified metabolites, four were reported for the first time in an aquatic organism exposed to zinc. The study demonstrates the diversity of interactions between bivalves and metals, as well as the complexity of the physiological response of marine bivalves to pollutants.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
(2021)
Article
Chemistry, Applied
Diletta Piatti, Simone Angeloni, Filippo Maggi, Giovanni Caprioli, Massimo Ricciutelli, Lolita Arnoldi, Stefania Bosisio, Giacomo Mombelli, Ettore Drenaggi, Gianni Sagratini
Summary: The polar extracts and essential oils of sea fennel cultivated in central Italy were analyzed. The extracts contained 21 bioactive compounds, with 5-O-caffeoylquinic acid being the most abundant. Melatonin, a hormone that regulates sleep/wake cycle, was identified for the first time in sea fennel extract. The essential oil was mainly composed of monoterpene hydrocarbons and oxygenated monoterpenes. This study highlights the potential use of sea fennel as an edible plant and a source of nutraceutical compounds.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Agriculture, Dairy & Animal Science
Linli Zhang, Li Li, Qingwu Xin, Zhiming Zhu, Zhongwei Miao, Nenzhu Zheng
Summary: The chemical composition of breast meats of Liancheng white duck and Cherry Valley duck were examined, revealing significant differences in meat quality between the two breeds. Liancheng white duck had higher shear force and pH values, but lower cooking loss, lightness, redness, and yellowness compared to Cherry Valley duck. Metabolomic analysis identified significant differences in metabolites between the two duck breeds, with Liancheng white duck exhibiting higher nutritional and medicinal value.
Article
Biochemistry & Molecular Biology
Simon-Okomo Aloo, Fred-Kwame Ofosu, Deog-Hwan Oh
Summary: The study found that sprouts are healthier and more nutritionally rich than raw seeds, with stronger antioxidant, antidiabetic, and antiobesity activities. Sprouting leads to higher levels of metabolites in sprouts compared to raw seeds, making it a suitable technique for altering the functional properties of edible seeds depending on the desired activity.
Article
Biochemical Research Methods
Federico Ponzetto, Florence Mehl, Julien Boccard, Norbert Baume, Serge Rudaz, Martial Saugy, Raul Nicoli
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2016)
Review
Chemistry, Analytical
Raul Nicoli, Davy Guillarme, Nicolas Leuenberger, Norbert Baume, Neil Robinson, Martial Saugy, Jean-Luc Veuthey
ANALYTICAL CHEMISTRY
(2016)
Article
Hematology
Nicolas Leuenberger, Laura Barras, Raul Nicoli, Neil Robinson, Norbert Baume, Niels Lion, Stefano Barelli, Jean-Daniel Tissot, Martial Saugy
Article
Hematology
Nicolas Leuenberger, Laura Barras, Raul Nicoli, Neil Robinson, Norbert Baume, Niels Lion, Stefano Barelli, Jean-Daniel Tissot, Martial Saugy
AMERICAN JOURNAL OF HEMATOLOGY
(2016)
Letter
Hematology
Olivier Salamin, Laura Barras, Neil Robinson, Norbert Baume, Jean-daniel Tissot, Yannis Pitsiladis, Martial Saugy, Nicolas Leuenberger
AMERICAN JOURNAL OF HEMATOLOGY
(2016)
Article
Biochemical Research Methods
L. Perrenoud, C. Schweizer Grundisch, N. Baume, M. Saugy, R. Nicoli
DRUG TESTING AND ANALYSIS
(2016)
Article
Biochemical Research Methods
Nicolas Leuenberger, Emanuele Bulla, Olivier Salamin, Raul Nicoli, Neil Robinson, Norbert Baume, Martial Saugy
DRUG TESTING AND ANALYSIS
(2017)
Article
Multidisciplinary Sciences
Olivier Salamin, Laetitia Jaggi, Norbert Baume, Neil Robinson, Martial Saugy, Nicolas Leuenberger
Article
Biochemical Research Methods
Federico Ponzetto, Julien Boccard, Norbert Baume, Tiia Kuuranne, Serge Rudaz, Martial Saugy, Raul Nicoli
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2017)
Article
Biochemical Research Methods
Mario Thevis, Oliver Krug, Hans Geyer, Katja Walpurgis, Norbert Baume, Andreas Thomas
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2018)
Article
Biochemical Research Methods
Neil Robinson, Jonas Saugy, Frederic Schutz, Raphael Faiss, Norbert Baume, Sylvain Giraud, Martial Saugy
DRUG TESTING AND ANALYSIS
(2019)
Article
Biochemical Research Methods
Reid Aikin, Norbert Baume, Tristan Equey, Olivier Rabin
Article
Hematology
Tristan Equey, Camilla Sletten, Yvette Dehnes, Giuseppe D'Onofrio, Carlo Brugnara, Norbert Baume, Reid Aikin
Summary: The athlete biological passport uses blood variables to detect blood doping. A study comparing the XN and XT/XE series of blood analyzers found a bias towards higher RET% values on the Sysmex XN instruments. The bias was proportional and slightly higher than previously observed across most RET% values, suggesting a model for comparing data across the two technologies.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Tristan Equey, Antoni Pastor, Rafael de la Torre Fornell, Andreas Thomas, Sylvain Giraud, Mario Thevis, Tiia Kuuranne, Norbert Baume, Osquel Barroso, Reid Aikin
Summary: Longitudinal profiling of hGH biomarkers has the potential to flag hGH abuse.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Tristan Equey, Olivier Salamin, Federico Ponzetto, Raul Nicoli, Tiia Kuuranne, Jonas Saugy, Martial Saugy, Reid Aikin, Norbert Baume
Summary: The inclusion of new target compounds and the use of prior knowledge obtained from anti-doping data can improve the detection of doping practices with endogenous anabolic androgenic steroids. This is particularly effective for individuals with low levels of biomarkers excreted in urine.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
