Article
Chemistry, Analytical
Graeme Cochrane, Jennifer K. Field, Matthew C. Hulme, Nicolas Gilbert, Ryan E. Mewis, Melvin R. Euerby, Oliver B. Sutcliffe
Summary: In this study, Supercritical Fluid Chromatography (SFC-UV) was used to rapidly analyze 31 novel, regioisomeric diphenidine-derived psychoactive substances. The polarity of the stationary phases had a significant impact on the retention time and elution order of the compounds. SFC demonstrated good retention for hydrophilic compounds that were poorly retained on a C18 reverse phase column.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Younis Abiedalla, Ahmad J. Almalki, Jack DeRuiter, C. Randall Clark
Summary: This study prepared and evaluated twelve secondary amines representing structural analogues of the classic NBOMe category of novel psychoactive substances. The compounds were compared in terms of GC properties and correlated EI-MS fragmentation products, providing differentiation data from the current NBOMe drugs of abuse.
FORENSIC CHEMISTRY
(2021)
Article
Medicine, Legal
Cui-Mei Liu, Lin Xu, Hong-Yuan He, Wei Jia, Zhen-Dong Hua
Summary: This study demonstrated the ability of Raman spectroscopy to distinguish phenethylamines, even for highly similar structural analogues. Raman showed high distinguishing ability for phenethylamine regioisomers with different substitution positions and structural analogues with different groups. The study also validated the practical use of the Raman method in forensic field by correctly identifying 95% of seized samples.
JOURNAL OF FORENSIC SCIENCES
(2021)
Article
Chemistry, Analytical
Jennifer K. Field, Christine Hinz, Christopher M. Titman, Matthew C. Hulme, Rhona M. Cowan, Jack B. Ainsworth-McMillan, Nicolas Gilbert, Robert J. Lee, Jack Marron, Andrew Costello, Ryan E. Mewis, Melvin R. Euerby, Oliver B. Sutcliffe
Summary: This study presents the development of a rapid gradient UHPLC method with targeted MS/MS for the detection and confirmation of the identity of 33 substituted diphenidine derivatives in solid drug samples. The study also investigates the influence of substituents on the elution order and the retention mechanism of diphenidines under reverse-phase UHPLC conditions. The developed method was proven to be specific through the assessment of common adulterants, and it was successfully applied to confirm the identity of psychoactive components in seized bulk samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Younis Abiedalla, Ahmad J. Almalki, Jack DeRuiter, C. Randall Clark
Summary: The study describes a potential category of novel psychoactive substances synthesized via a specific synthetic pathway. Gas chromatographic separations of different subseries of molecules revealed specific ion fragments in the mass spectra. Vapor phase infrared spectra provided information on the position of substitution of the methoxy groups on the aromatic ring.
FORENSIC CHEMISTRY
(2021)
Article
Biochemical Research Methods
Younis Abiedalla, C. Randall Clark
Summary: The electron ionization (EI)-mass spectroscopy (MS) fragmentation of methoxymethylene substituted benzoate esters was studied. The aliphatic oxygen of the alkoxymethylene group plays a more active role in the fragmentation profile compared to the direct aromatic ring linked oxygen of the ethoxy group.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2023)
Article
Food Science & Technology
Liangchen Zhang, Puxiang Shi, Jian Sun, Mengxi Xie, Haixin Wang, Taiyuan Shi, Miao Yu
Summary: This study used GC-MS and GC-IMS to analyze the volatile flavor substances in 30 roasted peanut samples. The peanuts were divided into four groups based on their characteristic flavor substances. Descriptive sensory analysis and PLSR were performed to identify flavor differences and predict the appeal of roasted peanuts based on their composition, suggesting a potential avenue for improving food flavor quality.
FOOD SCIENCE & NUTRITION
(2023)
Article
Food Science & Technology
Guowu Yang, Juanxiang Zhang, Rongfeng Dai, Xiaoyong Ma, Chun Huang, Wenwen Ren, Xiaoming Ma, Jianwei Lu, Xue Zhao, Renqing Ji, Lao Zha, Xian Guo, Min Chu, Yongfu La, Pengjia Bao, Chunnian Liang
Summary: This study aimed to investigate the nutritional properties of yak milk in various areas of Gannan. The fat content of Meiren yak milk was significantly higher than that of Maqu yak and Xiahe yak, while the protein content of Meiren yak milk was significantly higher than that of Xiahe yak. The flavor compounds detected in yak milk samples from different regions varied, with Meiren yak milk containing ethyl acetate, n-valeraldehyde, acetic acid, heptanal, and n-hexanal.
Article
Food Science & Technology
Kuan Lu, Lin Liu, Jiwei Zi, Lin Song, Wancui Xie
Summary: This study compared the effects of four heating methods on the volatile components of shrimp paste and found that different heating methods had different effects on the taste and aroma of shrimp paste. In addition, steaming, frying, microwaving, and infrared heating improved the aroma quality of shrimp paste.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
A. Dusart, B. Mertens, E. Van Hoeck, M. Simon, S. Goscinny, S. Collin
Summary: The study developed an effective method for analyzing flavoring substances, identifying and quantifying five suspected genotoxic compounds and two confirmed genotoxic flavoring substances in a selection of ten alcohol-free beers.
Article
Food Science & Technology
Yongzhen Gou, Xinmiao Ma, Xiyue Niu, Xiaopu Ren, Geminguli Muhatai, Qian Xu
Summary: This study analyzed the characteristic aromatic compounds in traditional fermented koumiss from different regions of Xinjiang using GC-IMS and GC-MS. A total of 87 volatile substances were detected, with esters, acids, and alcohols identified as the main aroma compounds. While the types of aroma compounds were similar across regions, there were significant differences in their concentrations, indicating clear regional characteristics. Eight distinctive volatile compounds, including ethyl butyrate, were identified as markers to distinguish between different origins using GC-IMS and PLS-DA analysis. Sensory evaluation and OVA value analysis revealed variations in aroma components among the regions studied. This research provides theoretical guidance for the industrial production of Kazakh koumiss products.
Article
Environmental Sciences
Mette Torsbjerg Moller, Heidi Birch, Karina Knudsmark Sjoholm, Rikke Hammershoj, Karen Jenner, Philipp Mayer
Summary: Testing and assessing the persistency, bioaccumulative and toxic properties of UVCBs pose major technical and analytical challenges. This study successfully combined whole substance biodegradation testing with constituent-specific analytics to determine primary biodegradation kinetics of the main UVCB constituents. The experiments revealed the degradation rate constants of the main constituents and the absence of nonpolar degradation products.
Article
Biochemistry & Molecular Biology
Larissa Costa de Almeida, Felipe Antunes Calil, Natalia Cestari Moreno, Paula Rezende-Teixeira, Luiz Alberto Beraldo de Moraes, Paula Christine Jimenez, Carlos Frederico Martins Menck, Joao Agostinho Machado-Neto, Leticia Veras Costa-Lotufo
Summary: DNA-targeting agents have clinical significance in anticancer chemotherapy, but their widespread use is limited due to toxicity. This study used in silico modeling and transcriptomics to characterize the DNA repair pathways activated by pradimicin-IRD treatment. Pradimicin-IRD was found to be a DNA intercalating agent and can potentially inhibit DNA-binding proteins. Genes related to DNA repair functions were modulated by pradimicin-IRD, providing insights for further research on this compound as a new antineoplastic agent.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemical Research Methods
Michela Begala, Michele Mancinelli, Elias Quezada, Giovanna Lucia Delogu
Summary: The study presents a method for the unambiguous identification and differentiation of 3-benzoyl isomers from their 4- and 6-regioisomers in crude reaction mixtures of benzoylbenzofurans. This method simplifies the workflow of extensive isolation and purification for structure elucidation by solely using GC/MSn analysis.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2021)
Article
Chemistry, Physical
Camilla Pfeffer, Nick Wannenmacher, Wolfgang Frey, Rene Peters
Summary: Enynes are important motifs in bioactive compounds and can be synthesized through various mechanisms and reaction conditions. Bimetallic catalysts can achieve the synthesis of (E)-configured enynes, leading to different reaction products. Mechanistic studies have identified the significance of acetylide Pd bridging in influencing the reaction outcomes.
Article
Chemistry, Analytical
Sohila M. Elonsy, Fawzy A. El Yazbi, Rasha A. Shaalan, Hytham M. Ahmed, Tarek S. Belal
Summary: This study describes two new methods for simultaneous determination of amlodipine and bisoprolol, utilizing micellar electrokinetic capillary chromatography and liquid chromatography with fluorescence detection. Both methods were validated and successfully applied for the analysis of these drugs in fixed-dose combination tablets.
JOURNAL OF AOAC INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Dina S. El-Kafrawy, Ahmed G. Abdelhamid, Magdi M. Abdel-Khalek, Tarek S. Belal
Summary: An eco-friendly stability-indicating HPLC method was developed for simultaneous determination of allopurinol and benzbromarone. The method was carefully validated and shown to have good reliability and stability. High specificity of the method was demonstrated through resolution with other related pharmaceutical compounds.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Biochemical Research Methods
Dina A. Gawad, Mai M. Elnaggar, Tarek S. Belal
Summary: This study presents an optimized and validated HPLC-DAD method for concurrent estimation of nine antimicrobials and proton pump inhibitors. The method was successfully applied in various laboratory-prepared dosage forms and simulated intestinal fluid.
Article
Chemistry, Analytical
Amira F. El-Yazbi, Karin M. Guirguis, Mona M. Bedair, Tarek S. Belal
Summary: This research developed a specific HPLC-DAD method for the simultaneous quantitation of paracetamol and lornoxicam with their related substances and toxic impurities. The method demonstrated excellent separation, linearity, and specificity for the determination of the target compounds.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Dina S. El-Kafrawy, Amira H. Abo-Gharam, Magdy M. Abdel-Khalek, Tarek S. Belal
Summary: This study presents the development of new eco-friendly HPLC and HPTLC methods for simultaneous quantification of MLK, BAM, and TER. The adopted methods were validated according to the ICH guidelines and successfully applied for the concurrent analysis of MLK and BAM.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Haydi S. Elbordiny, Sohila M. Elonsy, Hoda G. Daabees, Tarek S. Belal
Summary: Four greenness assessment tools were tested to evaluate two proposed methods for the simultaneous determination of a drug and two preservatives. Both methods showed good analytical performance.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Chemistry, Multidisciplinary
Haydi S. Elbordiny, Sohila M. Elonsy, Hoda G. Daabees, Tarek S. Belal
Summary: The design of novel validated methodologies targeting goals like simplicity, greenness and sustainability is gaining concern in quality control units. Fast, white and sustainable analytical procedures were optimized and validated for estimation of ALP with either BZB or TIO, and compared with 7 reported methods using the RGB12 model.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Chemistry, Multidisciplinary
Dina S. El-Kafrawy, Amira H. Abo-Gharam, Magdy M. Abdel-Khalek, Tarek S. Belal
Summary: This study developed and validated novel green multi-analyte methods for the quantitative estimation of five drugs, demonstrating high linearities and greenness compared to other reported chromatographic methods.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Chemistry, Multidisciplinary
Haydi S. Elbordiny, Sohila M. Elonsy, Hoda G. Daabees, Tarek S. Belal
Summary: Rosuvastatin-Metformin is an emerging fixed dose combination for the treatment of diabetes mellitus-associated dyslipidemia. Two validated analytical methodologies have been implemented for the simultaneous estimation of metformin and rosuvastatin in a fast and sustainable manner. Both methods meet the International Council for Harmonization validation criteria and green analytical chemistry principles, outperforming traditional methods.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Article
Chemistry, Analytical
Dina S. El-Kafrawy, Ahmed G. Abdelhamid, Magdi M. Abdel-Khalek, Tarek S. Belal
Summary: A stability-indicating HPLC-DAD procedure was developed for the concurrent analysis of ALO and THA. The method showed good separation and accuracy, and can be used for the determination of the content and stability of ALO and THA drugs.
JOURNAL OF AOAC INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Pottabattula Mahesh, M. Akiful Haque, Baher I. I. Salman, Tarek S. S. Belal, Adel Ehab Ibrahim, Sami El Deeb
Summary: Plaque psoriasis is a chronic skin condition with significant negative impacts on physical health, well-being, and work ability. Deucravacitinib (DEU), an oral Janus kinase (JAK) inhibitor, is the first medication used for its treatment. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach was used to analyze DEU in plasma samples, with trimethoprim as an internal standard (IS) and liquid-liquid extraction (LLE) for the separation of DEU and IS.
Article
Multidisciplinary Sciences
Hadeel A. Khalil, Eman I. El-Kimary, Amira F. El-Yazbi, Tarek S. Belal
Summary: Four simple, sensitive, economical, and eco-friendly spectrophotometric and spectrofluorimetric methods have been developed for the assay of erdosteine (ERD). These methods showed linear relationships between the measured signals and the corresponding concentrations of ERD. The suggested methods were successfully applied to ERD analysis in pure form and in commercial capsules, and they also described the determination of ERD spectrofluorimetrically for the first time in the literature.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Haydi S. Elbordiny, Sohila M. Elonsy, Hoda G. Daabees, Tarek S. Belal
Summary: A novel micellar electrokinetic capillary chromatography method was developed for the simultaneous estimation of four antihyperlipidemic drugs. The method demonstrated rapid separation, high sensitivity, and routine applicability in quality control laboratories.
Article
Chemistry, Multidisciplinary
Mai M. Elnaggar, Amira F. El-Yazbi, Tarek S. Belal, Hadil M. Elbardisy
Summary: This study presents a highly sensitive, sustainable, white and green spectrofluorometric method for detecting Nifuroxazide (NFX) using nitrogen and sulphur co-doped carbon quantum dots. The method shows a quantitative quenching of the luminescence of the NSC-dots in the presence of NFX. The proposed method has been validated and demonstrates superior performance compared to other reported methods.
Article
Chemistry, Multidisciplinary
Hala F. Labib, Hytham M. Ahmed, Yousef S. Elshamy, Wael Talaat, Tarek S. Belal
Summary: The present study established validated chromatographic methods for analysis of the antidepressant drug agomelatine in bulk powder and tablets, showing good performance and compliance with international standards.
EGYPTIAN JOURNAL OF CHEMISTRY
(2021)
Article
Medicine, Legal
Heitor S. D. Correa, Ivano Alessandri, Andrea Verzeletti
Summary: This research assessed the usefulness of Raman spectroscopy and gas chromatography-mass spectrometry in analyzing bones. The techniques were found to be useful in molecular taphonomy studies and forensic genetics.
FORENSIC SCIENCE INTERNATIONAL
(2024)
