Editorial Material
Orthopedics
James B. Carr
Summary: PRP injections are increasingly used to treat musculoskeletal conditions, with evidence supporting their positive effects on soft tissue healing. While PRP has shown benefits for knee osteoarthritis, research on its efficacy for shoulder conditions is limited. The high concentration of growth factors and inflammatory modulators in PRP may aid in tendon regeneration and healing, making it an appealing treatment option for conditions like partial-thickness rotator cuff tears and tendinopathy.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hao Chen, Shih-Hsien Chen, Shih-Heng Chen, Andy Deng-Chi Chuang, T. G. Darshan, Jyh-Ping Chen
Summary: An anti-adhesive barrier membrane incorporating hyaluronic acid can prevent fibroblasts attachment and provide lubrication for tendon gliding, while platelet-rich plasma can release growth factors to facilitate tendon recovery and suppress inflammation. In this study, core-shell nanofiber membranes with HA/PRP-infused core and polycaprolactone shell were fabricated and evaluated. The results showed that the membranes could prevent cell penetration, reduce cell attachment, and promote tendon healing in vitro, and the HP11-P NFM exhibited improved efficacy in reducing tendon adhesion and inflammation and promoting tendon healing in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Mohammed A. H. Abdelhakiem, Ayman Hussein, Samia Moustafa Seleim, Abdelbaset Eweda Abdelbaset, Mahmoud Abd-Elkareem
Summary: This study investigated the effect of silver nanoparticles (AgNPs) and platelet-rich fibrin (PRF) on the healing of severed superficial digital flexor tendon (SDFT) in donkeys. Three groups of adult donkeys were used, with the first group serving as the control group and the second and third groups treated with AgNPs and PRF, respectively. The healing progress was evaluated clinically and through gross and microscopic examinations. Results showed that both PRF and AgNPs improved SDFT healing, with significant reduction in lameness observed in the third month after surgery.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Byron Chalidis, Panagiotis Givissis, Pericles Papadopoulos, Charalampos Pitsilos
Summary: Platelet-rich plasma (PRP) has been widely used in ligament and tendon injuries, with varying effects on cellular activities and tissue regeneration. In vitro studies have shown that PRP promotes cell proliferation, migration, viability, and collagen production. In vivo studies have demonstrated increased fibroblastic activity, collagen production, and vascularity in ligament and tendon tissues after PRP application. However, there is controversy regarding the optimal timing and dosage of PRP, as well as its potential negative effects on regeneration. Standardized protocols are needed to address these issues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Edward J. Calabrese, Rachna Kapoor, Gaurav Dhawan, Vittorio Calabrese
Summary: Platelet-rich plasma is widely accepted for wound healing, showing unique hormetic-like concentrations in its complex mixtures, making it a new area for biomedical research and applications.
WOUND REPAIR AND REGENERATION
(2022)
Article
Biotechnology & Applied Microbiology
Seo-Young Choi, Soochong Kim, Kyung-Mee Park
Summary: This study evaluated the initial healing effects of PRP gel and PRF on deep corneal wounds. The results showed that PRP gel promoted vascular healing and myofibroblast production, contributing to corneal remodeling. However, the use of PRF was not recommended due to its potential complications during tissue healing.
BIOENGINEERING-BASEL
(2022)
Article
Multidisciplinary Sciences
Wenhai Cao, Xiaotong Meng, Fangming Cao, Jinpeng Wang, Maowei Yang
Summary: Diabetic non-healing wounds pose a significant burden on patients and society. Platelet-rich plasma (PRP) has been widely used for tissue regeneration and PRP-derived exosomes (PRP-Exos) have shown to be more effective in tissue regeneration. This study investigated the therapeutic potential of PRP-Exos in diabetic wound healing and found that they can promote fibroblast functions and accelerate wound healing through a specific signaling pathway.
Article
Orthopedics
Tung-Yang Yu, Jong-Hwei S. Pang, Li-Ping Lin, Ju-Wen Cheng, Shih-Jung Liu, Wen-Chung Tsai
Summary: The experiment showed that PRPr treatment can increase collagen synthesis near the tendon cut, reduce the number of apoptotic cells, promote tendon cell proliferation, and inhibit macrophage infiltration. Additionally, tendons treated with PRPr exhibited higher ultimate tensile strength compared to those treated with saline.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jianying Zhang, Feng Li, Tyler Augi, Kelly M. Williamson, Kentaro Onishi, MaCalus Hogan, Matthew D. Neal, James H-C Wang
Summary: Platelet-rich plasma (PRP) containing PLT HMGB1 plays a crucial role in tendon wound healing by reducing inflammation, increasing local HMGB1 levels, and recruiting stem cells to the injured area. The efficacy of PRP treatment for tendon injuries in clinics may be dependent on the presence of PLT HMGB1 in PRP preparations.
Article
Biophysics
Ting Wang, Wanwan Yi, Yu Zhang, Hang Wu, Hengwei Fan, Jiulong Zhao, Shige Wang
Summary: In recent years, the healing of chronic wounds has become a challenging problem in clinical practice. This study aimed to address the challenges in wound care by designing a dual-network hydrogel composed of sodium alginate and platelet-rich plasma. The hydrogel showed a three-dimensional network structure and exhibited the potential for cell proliferation and vascular regeneration. When applied to wound skin in rats, the hydrogel effectively promoted wound closure. Overall, this strategy offers a simple and feasible approach for overcoming the shortcomings of conventional wound dressings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Cell Biology
Yundong Peng, Wenxia Wu, Xiaomei Li, Hengyi Shangguan, Luyu Diao, Haozhe Ma, Guanglan Wang, Shaohui Jia, Cheng Zheng
Summary: Leukocyte-rich platelet-rich plasma (LR-PRP) can effectively enhance the early stage of bone-tendon interface healing after rotator cuff repair, while leukocyte-poor platelet-rich plasma (LP-PRP) could enhance the later stages of healing after rotator cuff injury.
Article
Medicine, General & Internal
Julia Vidan-Estevez, Sergio Sanchez-Herraez, Fernando Escalante-Barrigon, Jesus Seco-Calvo
Summary: The study on treating chronic non-healing wounds with al-PRP showed that treatment duration significantly influenced wound healing, with the best results seen in cases where treatment extended beyond 13 weeks.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Renato Luiz Bevilacqua de Castro, Breno Pazinatto Antonio, Gustavo Atra Giovannetti, Joyce Maria Annichino-Bizzacchi
Summary: The prevalence of partial rotator cuff tears (PRCTs) is high in the general population. This study aimed to compare the effects of barbotage with or without platelet-rich plasma (PRP) on the healing of partial supraspinatus tendon tears (PSTTs). The results showed that both groups of patients experienced clinical improvement, but the PRP group had significantly better improvement and reduction in tear size at 6 months.
Article
Orthopedics
Yundong Peng, Xiaomei Li, Wenxia Wu, Haozhe Ma, Guanglan Wang, Shaohui Jia, Cheng Zheng
Summary: This study investigated the effect of mechanical stimulation combined with platelet-rich plasma (PRP) on rotator cuff repair in mice. The results showed that this combination can effectively promote the early stage of healing after a rotator cuff injury, leading to improved outcomes.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Faez Saleh Al-Hamed, Lina Abu-Nada, Rania Rodan, Stylianos Sarrigiannidis, Jose Luis Ramirez-Garcialuna, Hanan Moussa, Osama Elkashty, Qiman Gao, Tayebeh Basiri, Laura Baca, Jesus Torres, Lisa Rancan, Simon D. Tran, Marie Lordkipanidze, Mari Kaartinen, Zahi Badran, Faleh Tamimi
Summary: The study found that double-spin L-PRP showed better efficacy in promoting bone healing by significantly reducing the size of bone defects and decreasing the number of inflammatory cells in the defect area compared to single-spin or filtered L-PRP.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Surgery
Efstathios T. Pavlidis, Maria Lambropoulou, Nikolaos G. Symeonidis, Constantinos Anagnostopoulos, Alexandra Tsaroucha, Athanasia Kotini, Christina Nikolaidou, Anastasia Kiziridou, Constantinos Simopoulos
JOURNAL OF INVESTIGATIVE SURGERY
(2018)
Article
Surgery
Georgios Kyriakopoulos, Alexandra K. Tsaroucha, Georgia Valsami, Maria Lambropoulou, Nikolaos Kostomitsopoulos, Eirini Christodoulou, Zacharias Kakazanis, Constantinos Anagnostopoulos, Christos Tsalikidis, Constantinos E. Simopoulos
JOURNAL OF INVESTIGATIVE SURGERY
(2018)
Article
Surgery
Ilker Memet, Evanthia Tsalkidou, Alexandra K. Tsaroucha, Maria Lambropoulou, Ekaterini Chatzaki, Gregory Trypsianis, Dimitrios Schizas, Michael Pitiakoudis, Constantinos Simopoulos
JOURNAL OF INVESTIGATIVE SURGERY
(2018)
Article
Surgery
Alexandra K. Tsaroucha, Georgia Valsami, Nikolaos Kostomitsopoulos, Maria Lambropoulou, Constantinos Anagnostopoulos, Eirini Christodoulou, Evangelos Falidas, Afrodite Betsou, Michael Pitiakoudis, Constantinos E. Simopoulos
JOURNAL OF INVESTIGATIVE SURGERY
(2018)
Article
Oncology
Michael I. Koukourakis, Alexandra Giatromanolaki, Konstantina Fylaktakidou, Maria Kouroupi, Efthimios Sivridis, Christos E. Zois, Dimitra Kalamida, Achilleas Mitrakas, Stamatia Pouliliou, Ilias V. Karagounis, Konstantinos Simopoulos, David J. P. Ferguson, Adrian L. Harris
ANTICANCER RESEARCH
(2018)
Article
Oncology
Apostolos Gaitanidis, Michail Alevizakos, Christos Tsalikidis, Alexandra Tsaroucha, Constantinos Simopoulos, Michail Pitiakoudis
CLINICAL BREAST CANCER
(2018)
Article
Oncology
Apostolos Gaitanidis, Michail Alevizakos, Alexandra Tsaroucha, Christos Tsalikidis, Constantinos Simopoulos, Michail Pitiakoudis
Article
Oncology
Michael I. Koukourakis, Alexandra Giatromanolaki, Konstantina Fylaktakidou, Efthimios Sivridis, Christos E. Zois, Dimitra Kalamida, Achilleas Mitrakas, Stamatia Pouliliou, Ilias V. Karagounis, Konstantinos Simopoulos, David J. P. Ferguson, Adrian L. Harris
INVESTIGATIONAL NEW DRUGS
(2018)
Article
Gastroenterology & Hepatology
Alexandra K. Tsaroucha, Dimitrios Schizas, Michail G. Vailas, Evangelia Rachmani, Prodromos Kanavidis, Vyron Asimakopoulos, Sotirios Vlachos, Maria Sotiropoulou, Michael S. Pitiakoudis, Constantinos E. Simopoulos
Review
Gastroenterology & Hepatology
A. Gaitanidis, C. Simopoulos, M. Pitiakoudis
TECHNIQUES IN COLOPROCTOLOGY
(2018)
Article
Multidisciplinary Sciences
T. Mantso, S. Vasileiadis, I. Anestopoulos, G. P. Voulgaridou, E. Lampri, S. Botaitis, E. N. Kontomanolis, C. Simopoulos, G. Goussetis, R. Franco, K. Chlichlia, A. Pappa, M. I. Panayiotidis
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Charalampos Chrysovalantis Chytoudis-Peroudis, Nikistratos Siskos, Konstantinos Kalyviotis, Ioannis Fysekis, Petros Ypsilantis, Constantinos Simopoulos, George Skavdis, Maria E. Grigoriou
Article
Oncology
Theodora Mantso, Stavros Vasileiadis, Evangeli Lampri, Sotiris Botaitis, Sebachedin Perente, Constantinos Simopoulos, Katerina Chlichlia, Aglaia Pappa, Mihalis I. Panayiotidis
ANTICANCER RESEARCH
(2019)
Article
Medicine, Research & Experimental
Alexandros Charalabopoulos, Spyridon Davakis, Maria Lambropoulou, Apostolos Papalois, Cons Tantinos Simopoulos, Alexandra Tsaroucha
Article
Oncology
Nikolaos Symeonidis, Maria Lambropoulou, Efstathios Pavlidis, Constantinos Anagnostopoulos, Alexandra Tsaroucha, Athanasia Kotini, Christina Nikolaidou, Anastasia Kiziridou, Constantinos Simopoulos
CLINICAL MEDICINE INSIGHTS-ONCOLOGY
(2019)