期刊
FOOD CHEMISTRY
卷 161, 期 -, 页码 353-360出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2014.04.016
关键词
Extra virgin olive oil; Unsaponifiable fraction; Inflammatory bowel disease; T cells
资金
- Swedish Medical Research Council [22273]
- Health AMP
- Medical Care Committee of the Regional Executive Board
- Region Vastra Gotaland, Mag-Tarm Fonden
- Swedish Society of Medicine
- Foundations of Nanna Svartz, Magnus Bergvall, Sahlgrenska University Hospital, Wilhelm AMP
- Martina Lundgren
The unsaponifiable fraction (UF) of extra virgin olive oil (EV00) possesses anti-inflammatory properties and exerts preventative effects in murine models of inflammatory bowel disease (IBD). The present study was designed to determine the in vitro effects of UF on blood and intestinal T cells from IBD patients and healthy subjects. The T cell phenotype was investigated by flow cytometry and cytokine secretion was determined by ELISA. The presence of UF of EVO0 promoted apoptosis and attenuated activation of intestinal and blood T cells isolated from IBD patients, decreasing the frequency of CD69(+) and CD25(+) T cells and, also, the secretion of IFN-gamma. Moreover, UF reduced the expression of the gut homing receptor integrin beta 7 on blood T cells from IBD patients. In conclusion, UF modulates the activity and the gut homing capacity of T cells, and might therefore be considered as a dietary complement with an anti-inflammatory role in IBD patients. (C) 2014 Published by Elsevier Ltd.
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