Article
Biochemistry & Molecular Biology
Yongheng Zhong, Ye Li, Qi Chen, Shengyang Ji, Minhao Xu, Yuqi Liu, Xiaodan Wu, Shimin Li, Kaimian Li, Baiyi Lu
Summary: In this study, the researchers investigated the degradation efficiency of cyanogenic glycosides in cassava using a cassava linamarase mutant. The results showed that the mutant had improved catalytic activity and thermal stability, leading to a higher degradation efficiency of cyanogenic glycosides. The study also highlighted the potential of the mutant in food applications. However, further research is needed to understand the catalytic mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Acoustics
Yongheng Zhong, Tao Xu, Shengyang Ji, Xiaodan Wu, Tian Zha, Shimin Li, Peng Zhang, Kaimian Li, Baiyi Lu
Summary: The study found that ultrasonic pretreatment (UPT) is an effective way to remove cyanide from cassava in a short period of time, enhancing the safety of cassava. UPT can improve the processing of cassava by directly eliminating hydrogen cyanide and indirectly degrading cyanogenic glycosides, while also promoting enzymatic hydrolysis.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Chemistry, Applied
Yongheng Zhong, Tao Xu, Xiaodan Wu, Kaimian Li, Peng Zhang, Shengyang Ji, Shimin Li, Lufei Zheng, Baiyi Lu
Summary: This paper evaluated the dietary risks of cassava cyanide and proposed a maximum residue limit for cyanogenic glycosides in cassava. The results showed no chronic health risk across all populations concerning cassava consumption. It is suggested that risk assessment of cyanide for foods rich in CNGs should be based on CNGs quantification rather than that of CN-.
Article
Food Science & Technology
Alicia A. Quinn, Harry Myrans, Roslyn M. Gleadow
Summary: This study investigated cassava food products in Melbourne, Australia and found that ready-to-eat cassava chips had the highest cyanide content, with imported products having higher levels than those manufactured in Australia. Cyanide was detected in frozen cassava products, but processing according to instructions significantly reduced the levels. The study emphasizes the need for ongoing testing of cassava food products.
Review
Plant Sciences
Jennifer McMahon, Richard Sayre, Tawanda Zidenga
Summary: Cassava is an important staple crop worldwide, but it has received the least investment compared to other major global crops. It is grown by subsistence farmers in countries with limited resources for crop improvement. The starchy roots of cassava are high in calories but low in protein and essential nutrients. They also contain potentially toxic levels of cyanogenic glycosides that must be reduced before consumption. Recent progress in understanding the metabolism of cyanogens in cassava may offer a solution to creating a safer and more nutritious crop.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Pharmacology & Pharmacy
T. Joseph, S. Sreejith, X. Joseph, V. P. Sangeetha, N. Prajitha, U. Vandana, C. A. Jayaprakas, P. Mohanan
Summary: Cassava, an important root crop in tropical countries, was formulated into biopesticide CCE to combat borer insect pests. Cell studies showed dose-dependent cytotoxicity of CCE on A549 cells, with different effects on free radical scavenging and nitrite radicals, and a negative correlation with mitochondrial and lysosomal functions. Higher concentrations of CCE led to necrotic cell death rather than apoptosis, indicating significant anti-proliferative ability.
Article
Food Science & Technology
Gerard M. O'Brien, Boon Jin Lim, Yi Lin Ong, Kian Han Toh, Cong Shan Sim, Rose Koh
Summary: Most of the fresh cassava roots and cassava products purchased in Singapore during 2016-2017 exceeded the Codex Alimentarius limit for 'sweet' (boil-and-eat) cassava, but the cyanogenic potential in all cassava flour and ready-to-eat chips was below 20 mg kg(-1).
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Toxicology
Anil Panghal, Claudia Munezero, Paras Sharma, Navnidhi Chhikara
Summary: Cassava, a drought resistant staple food in tropical areas, contains high levels of starch and has great potential in food security and industrial applications. However, its toxicity and safety concerns due to cyanogenic glycosides have led to various processing methods for detoxification.
Review
Biotechnology & Applied Microbiology
Egoamaka O. Egbune, Theresa Ezedom, Osuvwe C. Orororo, Olisemeke U. Egbune, Oghenetega J. Avwioroko, Eferhire Aganbi, Akpovwehwee A. Anigboro, Nyerhovwo J. Tonukari
Summary: Solid-state fermentation (SSF) is a promising technology for producing value-added products from cassava. It offers advantages such as lower costs, reduced water usage, and higher product yields. SSF can enhance the nutritional value of cassava-based products and minimize waste by utilizing cassava waste as a substrate. However, optimizing process conditions and developing cost-effective production processes are essential for successful commercialization.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
S. Sreejith, Joseph Tom, V. P. Sangeetha, U. Vandana, Joseph Xavier, C. A. Jayaprakas, P. Mohanan
Summary: The study tested the cytotoxic effect of cassava cyanide extract (CCE) on human glioblastoma cells (LN229). The results showed that CCE had a dose-dependent toxicity on glioblastoma cells, reducing cell viability by negatively affecting mitochondrial activity, lysosomal and cytoskeletal integrity. The CCE also interfered with the cell cycle and induced cell death, suggesting its potential as an antineoplastic agent against glioblastoma cells.
Article
Chemistry, Multidisciplinary
Adnan Mukhtar, Sajid Latif, Ziba Barati, Joachim Mueller
Summary: Cassava production generates significant by-products, such as leaves and tuber peel, which can be valorized instead of being considered as waste. However, the presence of cyanide and insoluble fibers presents challenges for their conversion into valuable products. This study investigated the changes in cyanide concentration and quality of cassava leaves after mechanical pressing and in tuber peel after enzyme treatment.
APPLIED SCIENCES-BASEL
(2023)
Article
Plant Sciences
Edwige Gaby Nkouaya Mbanjo, Jenna Hershberger, Prasad Peteti, Afolabi Agbona, Andrew Ikpan, Kayode Ogunpaimo, Siraj Ismail Kayondo, Racheal Smart Abioye, Kehinde Nafiu, Emmanuel Oladeji Alamu, Michael Adesokan, Busie Maziya-Dixon, Elizabeth Parkes, Peter Kulakow, Michael A. A. Gore, Chiedozie Egesi, Ismail Yusuf Rabbi
Summary: This study investigated the effectiveness of a pocket-sized SCiO molecular sensor to predict starch content in freshly ground cassava roots. The predictive ability of SCiO was compared to two commercially available near-infrared spectrometers. The study found that SCiO provided satisfactory prediction results and could be a cost-effective solution for phenotyping the starch content of fresh roots in resource-limited cassava breeding programs.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Matthew S. Bramble, Neerja Vashist, Arthur Ko, Sambhawa Priya, Celeste Musasa, Alban Mathieu, D' Andre Spencer, Michel Lupamba Kasendue, Patrick Mamona Dilufwasayo, Kevin Karume, Joanna Nsibu, Hans Manya, Mary N. A. Uy, Brian Colwell, Michael Boivin, J. P. Banae Mayambu, Daniel Okitundu, Arnaud Droit, Dieudonne Mumba Ngoyi, Ran Blekhman, Desire Tshala-Katumbay, Eric Vilain
Summary: Konzo, a distinct upper motor neuron disease associated with cyanogenic diet and chronic malnutrition, predominantly affects children and women of childbearing age in sub-Saharan Africa. The gut microbiome structure is highly variable depending on region of sampling, and unique enrichments of bacterial species and functional pathways have been identified in prone regions of the Congo that potentially modulate the susceptibility of konzo. Using metagenomic profiling in 180 individuals from the Democratic Republic of the Congo, associations between the gut microbiome and konzo have been found.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Ewa Jaszczak-Wilke, Zaneta Polkowska, Marek Koprowski, Krzysztof Owsianik, Alyson E. Mitchell, Piotr Balczewski
Summary: Amygdalin is a natural cyanogenic glycoside found in the seeds of some edible plants, with both anticancer activity and toxicity due to hydrogen cyanide production. Despite studies on cancer cell lines, clinical evidence for its anticancer properties is not fully confirmed. High dose exposures to amygdalin can lead to cyanide toxicity.
Article
Multidisciplinary Sciences
Rittikeard Prachumchai, Anusorn Cherdthong, Metha Wanapat, Sarong So, Sineenart Polyorach
Summary: This study assessed the effects of replacing cassava chips with fresh cassava roots on feed utilization, rumen metabolism, cyanide-utilizing bacteria, and milk quality in Thai Friesian dairy cows. The results showed that replacing 100% of the cassava chips with fresh cassava roots improved feed intake, milk yield, and milk quality.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Leila Mahmoudi, Felix Zelder, Reinhard Kissner
BIOELECTROCHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Marjorie Sonnay, Felix Zelder
DALTON TRANSACTIONS
(2018)
Review
Chemistry, Multidisciplinary
Felix Zelder
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2018)
Article
Chemistry, Multidisciplinary
Prerna Yadav, Marta Jakubaszek, Bernhard Spingler, Bruno Goud, Gilles Gasser, Felix Zelder
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Engineering, Chemical
Randi Phinney, Lucas D. Tivana, Ingegerd Sjoholm, Karolina Ostbring, Imaculada Jeje, Deize Guibundana, Marilyn Rayner
JOURNAL OF FOOD PROCESS ENGINEERING
(2020)
Article
Engineering, Chemical
Randi Phinney, Lucas Daniel Tivana, Karolina Ostbring, Ingegerd Sjoholm, Gayatri Dhulappanavar, Imaculada Jeje, Deize Guibundana, Marilyn Rayner
JOURNAL OF FOOD PROCESS ENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Prerna Yadav, Felix Zelder
Article
Entomology
Gervancio Covele, Anacleto Gulube, Lucas Tivana, Ana Ribeiro-Barros, Maria Otilia Carvalho, Alexis Ndayiragije, Rafael Nguenha
JOURNAL OF STORED PRODUCTS RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Christopher Brenig, Leila Mosberger, Katja Baumann, Olivier Blacque, Felix Zelder
Summary: This study describes the synthesis of 10-bromophenylethynylcobalamin and its conversion to 10-bromoaquacobalamin. It also reports the first electrochemical studies of organometallic ethynyl-Cbls.
HELVETICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Xuecong Li, Prerna Yadav, Bernhard Spingler, Felix Zelder
Summary: This study presents a new copper complex probe 1 for the selective fluorometric detection of Homocysteine (Hcy) in water. The probe exhibits enhanced fluorescence in the presence of Hcy and shows minimal reaction with other proteinogenic amino acids.
Article
Chemistry, Analytical
Prerna Yadav, Felix Zelder
Summary: This paper discusses the development of a test kit for the selective detection of glyphosate (GlyP). The kit allows for the detection of 20 mu M GlyP in tap water by the naked eye and quantifications as low as 2.66 mu M by smartphone analysis have been demonstrated in a proof-of-principle study.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Multidisciplinary
Christopher Brenig, Leila Mosberger, Olivier Blacque, Reinhard Kissner, Felix Zelder
Summary: This study presents a novel truncated Ni(II)-containing metalbilamin and discusses its reversible reduction to a catalytically active Ni(I) species with cofactor F430 model character. The results demonstrate that stabilization of Ni(I) is not limited to related hydroporphyrinoid ligands, but also relevant to the application of metallocorrins in (biomimetic) catalysis.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Prerna Yadav, Olivier Blacque, Andreas Roodt, Felix Zelder
Summary: The Fe-salen based probe showed promising results in detecting pyrophosphate through detailed UV-Vis and fluorescence mechanistic studies. The molecular subunits disassemble in the presence of pyrophosphate analyte, with the aqua form of the complex (1-OH2) identified as the active species. The flexibility in molecular recognition and binding of pyrophosphate by the probe explains its outstanding selectivity over other (poly)oxophosphates and potentially competing analytes.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Analytical
Mathias Cherbuin, Felix Zelder, Walter Karlen
Article
Social Sciences, Interdisciplinary
Pia Piroschka Otte, Lucas Daniel Tivana, Randi Phinney, Ricardo Bernardo, Henrik Davidsson
GENDER TECHNOLOGY & DEVELOPMENT
(2018)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
