期刊
FOOD CHEMISTRY
卷 138, 期 1, 页码 84-89出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.10.029
关键词
Selenium-exopolysaccharides; Antioxidation activity; Immunomodulatory activity; Lactococcus lactis subsp lactis
资金
- Natural Science Foundation of China [30972130, 31101314, 41276121]
- State Science and Technology Ministry of the People's Republic of China [2012BAK08B01]
- Natural Science Foundation of Zhejiang Province [Z3110211]
- Ningbo Key Project Innovation and Entrepreneurship Fund [2010C92024]
- K. C. Wong Magna Fund in Ningbo University
- Natural Science Foundation of Jiangsu Province [BK2011787]
- Natural Science Fund for Colleges and Universities in Jiangsu Province [10KJB550003]
- High Level Talents Fund of Nanjing Normal University
Exopolysaccharide (EPS) was isolated and purified from Lactococcus lactis subsp. Lactis culture broth. Selenium chloride oxide (SeCl2O) was added to the EPS to synthesize selenium-exopolysaccharide (Se-EPS). The in vitro and in vivo antioxidant and in vivo immunomodulatory activity of EPS and Se-EPS were compared. EPS and Se-EPS scavenged superoxide anions and hydroxyl radicals. They also increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, while decreasing malondialdehyde (MDA) levels in serum and in the livers of mice. Se-EPS showed stronger in vitro and in vivo antioxidant activity than were shown by EPS. The in vivo immunoenhancement activity of EPS and Se-EPS induced by cyclophosphamide (CY) treatment in immunosuppressed mice was researched. EPS and Se-EPS treatments increased macrophage phagocytosis, spleen and thymus indices and haemolytic complement activity (HC50). Se-EPS showed stronger immunomodulatory activity than did EPS. (C) 2012 Elsevier Ltd. All rights reserved.
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