Article
Biology
Saad Alkahtani, Saud Alarifi, Abdullah A. Alkahtane, Gadah Albasher, Mohammed AL-Zharani, Norah M. Alhoshani, Norah S. AL-Johani, Nada H. Aljarba, Md Saquib Hasnain
Summary: Hyperglycemia, a common metabolic disorder in diabetes, causes oxidative stress, which can be alleviated by antioxidants like pyrroloquinoline quinine (PQQ). PQQ inhibits AGEs formation and reduces oxidative damage during hyperglycemia, showing potential as a therapeutic antioxidant.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Huong Thi Lan Nguyen, Stefan Kasapis, Nitin Mantri
Summary: The study compared the effects of Manuka honey and newly developed honeys on oxidative stress and cholesterol homeostasis, showing that Arjuna, Guggul, and Manuka honeys had significant antioxidant activities and reduced total cholesterol levels, while Jiaogulan honey exhibited the most cytotoxic effects.
Article
Biochemistry & Molecular Biology
Sumaira Yousuf, Shabnam Shabir, Simran Kauts, Tarun Minocha, Ahmad A. A. Obaid, Anmar A. A. Khan, Abdulrahman Mujalli, Yahya F. F. Jamous, Sarah Almaghrabi, Bandar K. K. Baothman, Ahmed Hjazi, Sandeep K. K. Singh, Emanuel Vamanu, Mahendra P. P. Singh
Summary: Natural antioxidants derived from plants have been found to effectively prevent chronic conditions and provide leads for pharmacotherapy discovery. In this study, the ethnopharmacological roles of Urtica dioica, Capsella bursa-pastoris, and Inula racemosa were examined. It was found that the ethanol extract of Urtica dioica exhibited the highest antioxidant activity and total phenolic and flavonoid contents, followed by Capsella bursa-pastoris and Inula racemosa. HPLC analysis revealed differences in the quercetin and rutin contents among the different plant extracts. Additionally, all the extracts showed significant cytotoxicity against HepG2 cells.
Article
Food Science & Technology
Jingting Guo, Yawen Li, Yangbing Yuan, Xusheng Li, Xiao Li, Xinwei Jiang, Weibin Bai, Rui Jiao
Summary: This study found that 10-gingerol is more effective in reducing cholesterol levels compared to 6-gingerol and 8-gingerol. It also up-regulates LDLR expression through the SREBP-2 pathway and down-regulates PCSK9 expression. Additionally, 10-gingerol enhances genes related to cholesterol efflux and bile acid expression through LXR alpha, PPAR gamma, and CYP7A1.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Shuqi He, Zhiyuan Xu, Jie Li, Yueping Guo, Qianxia Lin, Huoxi Jin
Summary: Three oligopeptides, KA-8, LR-7, and PG-7, derived from Harpadon nehereus hydrolysate, showed significant improvement in cell morphology and reduction in AST, ALT, and ROS levels in high glucose-induced HepG2 cells. LR-7 demonstrated good performance in regulating antioxidant and glucose metabolism, while PG-7 performed better in reducing TG and TC levels and enhancing SOD and GSHPx activity. KA-8 showed stronger effects on improving LDL-C, HDL-C, p-AKT, and p-GSK-313 levels. The results suggest that these peptides protect against high glucose-induced HepG2 damage through different molecular mechanisms, with LR-7 and KA-8 showing specific pathways of glycolipid metabolism regulation and AKT/GSK-313 signaling activation, respectively.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Irfan Dar, Sahar Rafat, Kapil Dev, Sageer Abass, Mohammad Umar Khan, Walaa A. Abualsunun, Samar S. Murshid, Sayeed Ahmad, Mohammad Irfan Qureshi
Summary: This study investigated the potential anti-diabetic effects and mechanism of action of Pterocarpus marsupium heartwood extract (MPME) in HepG2 cells. The results showed that MPME protected against oxidative stress and improved glucose uptake in the cells. These findings suggest the potential therapeutic value of Pterocarpus marsupium heartwood in the treatment of diabetes.
Article
Environmental Sciences
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Summary: In this study, it was found that cadmium exposure induced cell death in HepG2 cells via a ROS-mediated PERK-CHOP-related apoptotic signaling pathway, providing a novel insight into the mechanisms of cadmium-induced hepatotoxicity. Inhibitors targeting oxidative stress and ER stress might be potential strategies for preventing or treating this disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Darya Tarbeeva, Evgeny A. Pislyagin, Ekaterina S. Menchinskaya, Dmitrii Berdyshev, Anatoliy Kalinovskiy, Valeria P. Grigorchuk, Natalia P. Mishchenko, Dmitry L. Aminin, Sergey A. Fedoreyev
Summary: This study investigated the neuroprotective effects of polyphenolic compounds from Lespedeza bicolor on rotenone-, paraquat-, and 6-hydroxydopamine-induced neurotoxicity. The results showed that certain compounds increased cell survival rate and decreased ROS levels, indicating potential neuroprotective activity.
Article
Biochemistry & Molecular Biology
Qian Zhou, Lanxiang Wang, Bin Liu, Jianbo Xiao, Ka-Wing Cheng, Feng Chen, Mingfu Wang
Summary: The extract of rose flower shows significant anti-alcohol and hepatoprotective effects by partially reducing ethanol-induced cell apoptosis through the activation of the AMPK/SIRT1 signaling pathway. A specific component, N1,N5,N10-(E)-tri-p-coumaroylspermidine, in this extract exhibits remarkable hepatoprotective activity.
Article
Biochemistry & Molecular Biology
Yangbing Yuan, Yuanqin Zhu, Yawen Li, Xusheng Li, Rui Jiao, Weibin Bai
Summary: This study compared the cholesterol-lowering activities of Vitisin A with Cyanidin-3-O-glucoside (C3G) and found that Vitisin A inhibited cholesterol biosynthesis and enhanced LDL uptake in HepG2 cells. It also regulated the expression of genes and proteins associated with cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Lakshmi Thangavelu, Royapuram Veeraragavan Geetha, Ezhilarasan Devaraj, Kamal Dua, Dinesh Kumar Chellappan, Sri Renukadevi Balusamy
Summary: The study evaluates the cytotoxic potentials of Acacia catechu ethanolic seed extract in human hepatocellular carcinoma cells, finding that it induces cytotoxicity through increased ROS production, oxidative stress regulation, and apoptosis pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gemma K. Kinsella, Stefania Cannito, Valentina Bordano, John C. Stephens, Arianna C. Rosa, Gianluca Miglio, Valeria Guaschino, Valeria Iannaccone, John B. C. Findlay, Elisa Benetti
Summary: GPR21 mediates negative effects on glucose uptake by liver cells, and its inhibition leads to activation of the insulin signaling pathway and increased glucose uptake. In addition, inhibition of GPR21 also reduces ERK activation in liver cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Ji Yeon Lee, Hyemin Kim, Yulah Jeong, Chang-Ho Kang
Summary: This study evaluated the protective effects of different lactic acid bacteria strains in ethanol-induced liver cells, with nine strains increasing ALDH levels and reducing lipid peroxidation and liver transferase. Specifically, L. brevis MG5280 and MG5311, L. reuteri MG5458, and L. fermentum MG4237 and MG4294 protected cells by regulating various factors involved in alcohol-induced liver damage.
Article
Public, Environmental & Occupational Health
Martin Roursgaard, Monika Hezareh Rothmann, Juliane Schulte, Ioanna Karadimou, Elena Marinelli, Peter Moller
Summary: This study investigated the extraction of nanoplastic particles from food containers and found that these nanoparticles can cause genotoxicity in cell cultures, while their cytotoxic effects were limited.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Yiyuan Ye, Bingyan Liu, Zijian Wang, Ling Liu, Qiu Zhang, Qingzhu Zhang, Wei Jiang
Summary: This study compared the toxic effects of OBS and PFOS on human hepatoma cells. OBS showed higher cytotoxicity than PFOS, inducing oxidative stress and necroptosis by downregulating catalase (CAT) levels. The findings are important for evaluating the safety of OBS as a substitute for PFOS.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Biochemistry & Molecular Biology
Simone Di Micco, Veronica Di Sarno, Martina Rossi, Vincenzo Vestuto, Takumi Konno, Sara Novi, Mario Felice Tecce, Valeria Napolitano, Tania Ciaglia, Andrea Vitale, Isabel Maria Gomez-Monterrey, Giuseppe Bifulco, Alessia Bertamino, Carmine Ostacolo, Paolo Blasi, Alessio Fasano, Pietro Campiglia, Simona Musella
Summary: Different mechanisms contribute to cancer multidrug resistance, including increased drug efflux, enhanced cellular repair mechanisms, and alterations of drug metabolism or targets. ABCG2, a transporter protein, promotes drug efflux and causes chemotherapeutic resistance in malignant cells. Through a multidisciplinary approach, a new selective inhibitor (8) of ABCG2 has been identified, which effectively improves the cytotoxicity of mitoxantrone in hepatocellular carcinoma and transfected breast cancer cell lines. This inhibitor also demonstrates its efficacy in reversing multidrug resistance with the overexpression of the ABCG2 pump.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vincenzo Vestuto, Veronica Di Sarno, Simona Musella, Giorgio Di Dona, Ornella Moltedo, Isabel Maria Gomez-Monterrey, Alessia Bertamino, Carmine Ostacolo, Pietro Campiglia, Tania Ciaglia
Summary: The endoplasmic reticulum (ER) has various functions including calcium storage, protein synthesis, and lipid metabolism. ER stress, caused by disturbances in ER homeostasis, triggers unfolded protein response (UPR) to counteract the stress. Calcium levels are crucial in maintaining ER homeostasis and regulating cell fate, and dysregulation of calcium signaling is associated with diseases like neurodegeneration, cancer, and metabolic disorders. Recent research suggests that TRP channels play a role in UPR-mediated ER stress and can influence cell survival or death, making them a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Donatella Ambroselli, Fabrizio Masciulli, Enrico Romano, Giuseppina Catanzaro, Zein Mersini Besharat, Maria Chiara Massari, Elisabetta Ferretti, Silvia Migliaccio, Luana Izzo, Alberto Ritieni, Michela Grosso, Caterina Formichi, Francesco Dotta, Francesco Frigerio, Eleonora Barbiera, Anna Maria Giusti, Cinzia Ingallina, Luisa Mannina
Summary: The definition of metabolic syndrome (MetS) has changed over time due to the difficulty in establishing universal criteria. MetS is associated with a pro-inflammatory state related to altered glucose metabolism, leading to increased cardiovascular risk. Complications of MetS include cardiovascular diseases (CVDs) and type 2 diabetes (T2D). Genetic factors, human microbiota, and diet play complex roles in the predisposition to MetS. This review summarizes the literature of the past decade on MetS, including its definition, pathophysiology, treatment approaches, prediction and diagnosis using advanced methodologies, and the role of specific foods in prevention and/or treatment.
Article
Biochemistry & Molecular Biology
Marco Persico, Paola Galatello, Maria Grazia Ferraro, Carlo Irace, Marialuisa Piccolo, Avazbek Abduvakhidov, Oleh Tkachuk, Maria Luisa d'Aulisio Garigliota, Pietro Campiglia, Patrizia Iannece, Michela Varra, Anna Ramunno, Caterina Fattorusso
Summary: A series of tetrasubstituted pyrrole derivatives (TSPs) were synthesized based on a previous hypothesis and showed significant toxicity against human epithelial melanoma A375 cells. The most active compound, 10a, resulted as the most soluble among previous and present TSPs and exhibited apoptotic cell-death pathways activation. The molecular mechanism of action based on the ability of TSPs to mimic the hydrophobic side chains of protein motifs was suggested.
Review
Nutrition & Dietetics
Sara Novi, Vincenzo Vestuto, Pietro Campiglia, Nicola Tecce, Alessia Bertamino, Mario Felice Tecce
Summary: Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are major causes of chronic liver disease worldwide. Both conditions lead to liver damage, inflammation, and a vicious cycle of ongoing damage and progression. Anti-angiogenic therapy has shown potential in treating these liver disorders and preventing their exacerbation. This review focuses on the role of natural anti-angiogenic compounds in steatohepatitis and their therapeutic benefits in diet-induced liver inflammation.
Article
Food Science & Technology
Alfonso Narvaez, Luana Izzo, Luigi Castaldo, Sonia Lombardi, Yelko Rodriguez-Carrasco, Alberto Ritieni
Summary: Breakfast cereals are highly susceptible to mycotoxin contamination, posing a concerning risk to human health, especially for children. This study aimed to monitor multiple mycotoxins in Italian breakfast cereal samples using advanced analytical techniques. The results revealed that 93% of the samples contained at least one mycotoxin, with beauvericin being the most prevalent toxin. Multiple mycotoxins were found to co-occur in 73% of the positive samples. These findings highlight the need for improved analytical methodologies to detect non-regulated mycotoxins that may go unnoticed with current methods.
Article
Pharmacology & Pharmacy
Giovanni Vivenzio, Maria Carmina Scala, Pasquale Marino, Michele Manfra, Pietro Campiglia, Marina Sala
Summary: In recent years, peptides have become more successful as therapeutic compounds. The preferred method for obtaining peptides, solid-phase peptide synthesis (SPPS), does not follow the principles of green chemistry due to the use of toxic reagents and solvents. This study aimed to find an environmentally sustainable solvent to replace DMF in Fmoc SPPS. Dipropyleneglycol dimethylether (DMM), a green solvent with low toxicity and biodegradability, was tested for its applicability in various steps of SPPS. It was found that DMM is a valuable alternative to DMF in all steps of solid-phase peptide synthesis.
Review
Biochemistry & Molecular Biology
Pasquale Marino, Giacomo Pepe, Manuela Giovanna Basilicata, Vincenzo Vestuto, Stefania Marzocco, Giuseppina Autore, Alfredo Procino, Isabel Maria Gomez-Monterrey, Michele Manfra, Pietro Campiglia
Summary: Nutrition plays a crucial role in disease prevention, especially cancer. The consumption of fruits and vegetables and a sedentary lifestyle are closely linked to cancer. Nutraceuticals, with their pleiotropic effects and non-toxic behaviors, have gained attention in cancer research. Recent clinical studies highlight the efficacy of dietary phytochemicals in cancer prevention and treatment.
Article
Food Science & Technology
Antonella Vitiello, Luana Izzo, Luigi Castaldo, Ivana d'Angelo, Francesca Ungaro, Agnese Miro, Alberto Ritieni, Fabiana Quaglia
Summary: Food supplements containing red yeast rice are commonly used to reduce lipid levels in the blood. The main active ingredient, monacolin K, is a natural compound with similar structure as lovastatin. In this study, the quality profile of red yeast rice supplements marketed in Italy was evaluated, and variations in dosage form uniformity and disintegration time were observed. The bioaccessibility of monacolin K and the contamination of citrinin were also investigated, with no contamination found. These findings suggest the need for greater attention to the quality and safety of marketed products.
Article
Plant Sciences
Aurora Cirillo, Giulia Graziani, Lucia De Luca, Marco Cepparulo, Alberto Ritieni, Raffaele Romano, Claudio Di Vaio
Summary: The effects of climate change on Mediterranean regions have led to increased drought periods and extreme temperatures. The use of anti-transpirant products, such as kaolin, has been found to reduce the damage caused by extreme environmental conditions on olive plants. This study evaluated the effect of kaolin on the quantitative and qualitative parameters of drupes and oil in a little-known olive cultivar. The results showed that kaolin treatments increased the oil content, anthocyanins, total polyphenols, antioxidant activity, and certain fatty acids in the drupes and oil of the olive cultivar.
Article
Horticulture
Aurora Cirillo, Lucia De Luca, Luana Izzo, Marco Cepparulo, Giulia Graziani, Alberto Ritieni, Raffaele Romano, Claudio Di Vaio
Summary: The Vesuvian apricot includes numerous varieties originating from the same production area and with a long tradition of cultivation. The presence of secondary metabolites, many of which act as antioxidants, makes apricot fruit and its derivatives important for human health. This study analyzed 12 Vesuvian apricot accessions using chemical-physical and nutraceutical analyses. The results showed a wide range of organoleptic characteristics in Vesuvian apricot accessions, providing options for consumers and processors.
Article
Biochemistry & Molecular Biology
Maria Carmina Scala, Magda Marchetti, Fabiana Superti, Mariangela Agamennone, Pietro Campiglia, Marina Sala
Summary: This study aimed to synthesize a new library of peptidomimetics active against the influenza virus and conducted a preliminary screening using biophysical assays. Through biological and computational studies on the most interesting compounds, a small peptide sequence with high activity was identified, providing a good starting point for the design of new peptidomimetics and small molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Annalisa Lombardi, Antonia Voli, Andrea Mancusi, Santa Girardi, Yolande Therese Rose Proroga, Biancamaria Pierri, Renato Olivares, Luigi Cossentino, Elisabetta Suffredini, Giuseppina La Rosa, Giovanna Fusco, Antonio Pizzolante, Amalia Porta, Pietro Campiglia, Ida Torre, Francesca Pennino, Alessandra Tosco
Summary: This study monitored the presence of SARS-CoV-2 RNA in raw wastewater samples from six wastewater treatment plants and mollusk samples from eight harvesting sites in Campania, Italy. The results showed a high rate of positive wastewater samples and mollusk samples, indicating the potential use of both sample types as sentinels for detecting SARS-CoV-2 in the environment. The lower positivity rate in mollusks compared to sewages was attributed to the dilution effect of seawater.
Article
Nutrition & Dietetics
Hammad Ullah, Eduardo Sommella, Alessandro Di Minno, Roberto Piccinocchi, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Costanza Riccioni, Alessandra Baldi, Hesham R. El-Seedi, Shaden A. M. Khalifa, Gaetano Piccinocchi, Pietro Campiglia, Roberto Sacchi, Maria Daglia
Summary: This study aimed to evaluate the efficacy of a new food supplement based on a chemically characterized pomegranate extract and hydro-soluble vitamins (B complex and C) in reducing prolonged fatigue in healthy subjects. The food supplement showed significant reductions in fatigue severity scores but had no considerable effect on psychological well-being.
Article
Plant Sciences
Maria Giordano, Michele Ciriello, Luigi Formisano, Christophe El-Nakhel, Antonio Pannico, Giulia Graziani, Alberto Ritieni, Marios C. Kyriacou, Youssef Rouphael, Stefania De Pascale
Summary: The success of space missions and colonization of extraterrestrial environments require ensuring adequate nutrition for astronauts and independence from terrestrial resources. Microgreens, such as tatsoi, coriander, green basil, and purple basil, can provide a balanced diet and improve the overall nutraceutical profile of astronaut meals. The addition of potassium iodide (KI) at different concentrations increased the level of iodine (I) in the microgreens, resulting in improved antioxidant activity and increased concentration of phenolic acids and flavonoids.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
