Article
Plant Sciences
Meng-Yuan Zhou, Chang-Heng Yao, Yu-Jie Yang, Xue Li, Jin Yang, Ji-Hua Liu, Bo-Yang Yu, Wen-Ling Dai
Summary: This study aims to identify active compounds in Corydalis Rhizome (RC) that regulate spinal central sensitization and inhibit neuropathic pain. Through in vitro experiments and animal studies, it was found that glaucine in RC has significant analgesic effects specifically on neuropathic pain.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Physical
Damian Krzyzanowski, Marcin Kruszewski, Agnieszka Grzelak
Summary: Silver nanoparticles (AgNPs) have unique properties that have attracted significant attention, showing antibacterial, antifungal, and anticancer properties. However, they can also exhibit cytotoxic effects and modulate the activity and expression of ABC transporters.
Article
Multidisciplinary Sciences
Harlan L. Pietz, Ata Abbas, Zachary Lee Johnson, Michael L. Oldham, Hiroaki Suga, Jue Chen
Summary: This study identifies a macrocyclic peptide CPI1 that inhibits the function of MRP1 and blocks substrate transport. The findings suggest that CPI1 could be a potential therapeutic candidate.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Jan Viglas, Petra Olejnikova
Summary: The ABC transporter superfamily plays a crucial role in transporting various molecules across biological membranes, including antifungal compounds in filamentous fungi. Understanding the physiological substrates and roles of individual subfamilies of ABC transporters in fungi is important for clarifying their significance in clinical and agricultural settings.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jianfang Sun, Xin Liu, Shangfeng Zhao, Suli Zhang, Liying Yang, Jinghai Zhang, Mingyi Zhao, Yijia Xu
Summary: In this study, the active components of Corydalis yanhusuo were investigated for their potential targets and mechanisms of action. The results indicated that these components may exert analgesic and anti-arrhythmic effects through the modulation of sodium ion channels. These findings provide valuable insights for the future use of traditional Chinese medicine in the treatment of pain and cardiovascular disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Yuval Bin Kanner, Qiu-Xu Teng, Assaf Ganoth, Dan Peer, Jing-Quan Wang, Zhe-Sheng Chen, Yossi Tsfadia
Summary: This study aimed to investigate whether three antidepressant drugs from the SSRI family could be repurposed as inhibitors of MRP1 and MRP7 transporters and reverse multidrug resistance in cancer cells. The results show that these drugs exhibited inhibitory/reversal effects on both MRP1-overexpressed cells and MRP7-overexpressed cells in the presence of chemotherapies, suggesting their potential in targeting multidrug resistance in cancer cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Manasi S. Pote, Rajesh N. Gacche
Summary: This review provides updated information on the structure, function, and regulatory mechanisms of major multidrug resistance (MDR) related ATP binding cassette (ABC) transporters, which play a significant role in limiting the efficacy of anticancer drugs. The effects of modulators on the functions of ABC transporters such as P-glycoprotein, MRP1, and BCRP are discussed. Additionally, the potential use of these ABC transporter modulators in clinical practice to alleviate the emerging MDR crisis in cancer treatment is highlighted.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Sonia Saib, Xavier Delavenne
Summary: Inflammation can impact the expression and functionality of ABC transporters, leading to variability in drug response, especially for drugs with a narrow therapeutic index. Existing contradictory data and lack of standardization in the models used have resulted in a less conclusive interpretation of these findings.
Article
Biochemistry & Molecular Biology
Gao-Jie Ye, Chao-Yun Cai, Zhuo-Xun Wu, Qiu-Xu Teng, Jing-Quan Wang, Zhe-Sheng Chen, Bo Wang
Summary: Three series of phenylurea indole derivatives were synthesized with potent inhibitory activities on ABCG2. Four phenylurea indole derivatives with extended 7C system showed the most potent ABCG2 inhibition and no inhibition on ABCB1. Further investigation on two compounds revealed that they increased the accumulation of mitoxantrone in ABCG2-overexpressing cells and stimulated the ATP hydrolysis of ABCG2 transporter.
BIOORGANIC CHEMISTRY
(2023)
Article
Oncology
Lucia Pavlikova, Mario Seres, Albert Breier, Zdena Sulova
Summary: This paper provides an overview of the possible role of miRNAs in the molecular mechanisms that lead to multidrug resistance (MDR). miRNAs regulate post-transcriptional processes in the proteosynthetic pathway and may serve as specific effectors or interesting targets for cancer therapy.
Article
Biochemistry & Molecular Biology
Chao-Yun Cai, Qiu-Xu Teng, Megumi Murakami, Suresh V. Ambudkar, Zhe-Sheng Chen, Vijaya L. Korlipara
Summary: A series of 22 quinazolinamine derivatives with potent inhibitory activities on BCRP and P-gp were synthesized. Compound 22 was identified as a dual BCRP and P-gp inhibitor, while compound 33 showed BCRP inhibitory activity. These compounds changed the localization of BCRP and P-gp, inhibiting the efflux of anticancer drugs by the two ABC transporters. Compounds 22 and 33 also stimulated ATP hydrolysis, increasing the accumulation of mitoxantrone in BCRP-overexpressing cells.
Article
Oncology
Raul Munoz Velasco, Paula Jimenez Sanchez, Ana Garcia Garcia, Raquel Blanco Martinez-Illescas, Angela Pastor Senovilla, Marian Lozano Yague, Alfonsina Trento, Rosa Maria Garcia-Martin, Diego Navarro, Bruno Sainz Jr, Jose Luis Rodriguez Peralto, Victor Javier Sanchez-Arevalo Lobo
Summary: This study explores the role of the chromatin remodeler BPTF in pancreatic ductal adenocarcinoma (PDA). The findings suggest that reducing BPTF levels can inhibit cell proliferation and migration in PDA, as well as enhance the therapeutic effect of gemcitabine. The study also reveals that BPTF is required for c-MYC recruitment to the promoter of ABC-transporters, which affects gemcitabine accumulation in tumor cells and DNA damage.
Article
Oncology
Maciej Sobczak, Magdalena Strachowska, Karolina Gronkowska, Agnieszka Robaszkiewicz
Summary: In this research, the CoREST complex is identified as a key factor that controls the expression of ABC transporters in cisplatin-treated cancer cells, preventing multidrug resistance. The CoREST complex occupancy at gene promoters suppresses the EP300-dependent increase in ABCC transcription induced by cisplatin and gene overexpression in cisplatin-resistant phenotypes. The EP300-mediated activation of ABCC10 in response to cisplatin is only possible in the presence of p53.
Review
Biochemistry & Molecular Biology
Narakorn Khunweeraphong, Karl Kuchler
Summary: Multidrug resistance can be a major issue in cancer treatment and microbial infections, with dysregulated overexpression of ATP-binding cassette transporter members being linked to this phenomenon. High-resolution atomic structures from X-ray crystallography or cryo-EM are helping to improve understanding of the mechanisms and dynamics driving these transporters, offering new perspectives for therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yuchen Zhang, Cheukfai Li, Chenglai Xia, Keneth Kin Wah To, Zhixing Guo, Chongyang Ren, Lingzhu Wen, Fang Wang, Liwu Fu, Ning Liao
Summary: The study showed that MRTX849 can effectively overcome multidrug resistance by attenuating ABCB1 efflux activity in drug-resistant cancer cells, enhancing the anticancer efficacy of drugs in ABC1-overexpressing cells.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Widad Ben Bakrim, Agustina Dwi Retno Nurcahyanti, Malak Dmirieh, Ismail Mahdi, Abdelbaset M. Elgamal, Mohamed A. El Raey, Michael Wink, Mansour Sobeh
Summary: This study explored the phytochemical constituents and biological activities of the leaf extract from X. americana. The results showed that the leaves contain various secondary metabolites and exhibit antioxidant, antibacterial, and antiaging activities. The extract also demonstrated the ability to reverse oxidative stress and inhibit the activity of skin infection pathogens.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Food Science & Technology
Michael Wink
Summary: Plants produce a variety of PSMs with different biological activities, which can act as antioxidants, anti-inflammatory agents, and antimicrobials, benefiting health and disease prevention. PSMs can act alone or in combinations, exhibiting characteristics of multitarget drugs.
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biodiversity Conservation
Liviu G. Parau, Erjia Wang, Michael Wink
Summary: The population of Red-backed Shrikes is declining, and although genetic studies have shown considerable variability, there is no clear genetic structure indicating a panmictic population.
Article
Biodiversity Conservation
Vladimir G. Grinkov, Andreas Bauer, Helmut Sternberg, Michael Wink
Summary: Extra-pair copulation (EPC) is common in socially monogamous bird species, but its mechanisms and functions are still debated. This study on European pied flycatchers in Western Siberia found that about 20% of birds engage in extra-pair paternity (EPP), with loss of paternity more common in young males. EPCs can involve multiple partners, and the mates are mainly neighbors. The occurrence of EPP is higher in females nesting in high-quality territories. Fitness of within-pair offspring, EPO, and half-siblings did not differ significantly. This suggests that EPCs may be incidental side effects of selection.
Article
Zoology
Roberto Carlos Frias-Soler, Andreas Bauer, Markus A. Grohme, Georgina Espinosa Lopez, Maria Gutierrez Costa, Alexander Llanes-Queved, Frank Van Slobbe, Marcus Frohme, Michael Wink
Summary: By developing a library of microsatellite loci primers and using genetic markers, researchers conducted genetic and population genetics studies on flamingos. They found that the flamigos can be grouped into two major clades, and there is limited connectivity between Caribbean flamingo populations. The small Galapagos colony is threatened due to low genetic diversity.
ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
(2022)
Article
Biodiversity Conservation
Tamer Albayrak, Jose Antonio Davila Garcia, Ozlem Ozmen, Filiz Karadas, Duygu Ates, Michael Wink
Summary: The Chukar Partridge is one of the most important game birds in its native range, with two main genetic lineages. Farming and releasing Chukar Partridges can lead to genetic differentiation from wild populations. Wild populations in Turkey can be divided into six management units, with the population from Gokceada Island showing the highest genetic divergence. Intraspecific hybridization between wild and captive populations causes introgression and homogenization. Considering the genetic structure and management units of Chukar Partridge is crucial for preserving the genetic integrity of the species.
Review
Nutrition & Dietetics
Agustina Dwi Retno Nurcahyanti, Fonny Cokro, Martha P. Wulanjati, Mona F. Mahmoud, Michael Wink, Mansour Sobeh
Summary: Metabolic syndrome (MS) is a multifactorial syndrome associated with economic burden and healthcare costs, requiring multiple drug treatments that may have interactions and side effects. Therefore, developing new safe and effective drugs for MS is necessary.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Abeer H. A. Abdelhafiz, Rabah A. T. Serya, Deena S. Lasheen, Nessa Wang, Mansour Sobeh, Michael Wink, Khaled A. M. Abouzid
Summary: A novel compound with strong cytotoxic activity against doxorubicin-resistant cancer cells was discovered in this study. This compound also demonstrated ABCB1 inhibitory activity, which could potentially overcome multidrug resistance in cancer cells by reducing the resistance to doxorubicin.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Shaoxiong Zhang, Chatrawee Duangjan, Tewin Tencomnao, Liangyu Wu, Michael Wink, Jinke Lin
Summary: Oolong tea polyphenols have neuroprotective and neuritogenesis properties, offering potential therapeutic effects against neurodegenerative diseases and aging.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Multidisciplinary Sciences
Eman M. Kabbash, Zeinab T. Abdel-Shakour, Sherweit H. El-Ahmady, Michael Wink, Iriny M. Ayoub
Summary: This study analyzed the chemical composition of ethanolic extracts of olive leaves from different cultivars using HPLC/PDA/ESI-MS/MS, and identified 49 phytochemicals. Seasonal variation was observed to impact the chemical composition.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Paloma Lucia Guerra-Avila, Tereso J. Guzman, Jose Alfredo Dominguez-Rosales, Pedro Macedonio Garcia-Lopez, Alejandra Beatriz Cervantes-Garduno, Michael Wink, Carmen Magdalena Gurrola-Diaz
Summary: This study evaluated the antidiabetic effect of different dose combinations of C gamma and lupanine on a T2D rat model, and assessed the biochemical parameters and liver gene expression profile. The combination of 28 mg/kg BW C gamma + 20 mg/kg BW lupanine significantly reduced glycemia and lipid levels, and positively influenced the expression of several genes associated with oxidative stress, apoptosis regulation, and glucose and fatty-acid homeostasis.
Article
Ornithology
Justyna Kubacka, Anna Dubiec, Judith Korb, Volker Salewski, Andrzej Dyrcz, Julien Foucher, Benedikt Giessing, Bernd Leisler, Karl Schulze-Hagen, Michael Wink, Hanna Panagiotopoulou
Summary: The loss of breeding habitat and depletion of genetic diversity can have significant negative effects on species, particularly habitat specialists. This study focused on the Aquatic Warbler, a threatened European songbird that breeds in fens which have been fragmented and lost over time. Using microsatellite loci, the researchers compared samples collected recently with those obtained about two decades earlier to explore changes in genetic diversity, population size, structure, and gene flow. The results indicate low genetic diversity, changes in allele frequencies, and high gene flow between distant breeding sites, suggesting resilience to habitat fragmentation and potential success in recolonizing restored habitat patches.
Review
Biodiversity Conservation
Rano Mamadalieva, Vahobjon Khujaev, Michal Soral, Nilufar Z. Mamadalieva, Michael Wink
Summary: The genus Allochrusa, native to Central Asia, Turkey, Iran, Afghanistan, and the Caucasus, has been widely used in folk medicine and in the preparation of sweets and detergents. It contains a variety of secondary metabolites, including triterpene glycosides, ecdysteroids, flavonoids, volatile compounds, fatty acids, polysaccharides, pectins, hemicelluloses, and other phytochemicals. Pharmacological studies have shown that compounds and extracts from Allochrusa species exhibit anti-inflammatory, adjuvant, hemolytic, cytotoxic, antifungal, analgesic, antioxidant, and other activities. This review summarizes the chemical compounds and diverse biological activities of the Allochrusa genus.
Article
Chemistry, Applied
Rano Mamadalieva, Vaxobjon Xujayev, Farukh S. Sharopov, Michael Wink
Summary: A crude methanol extract from the roots of Allochrusa gypsophiloides was characterized chemically, revealing the presence of six major bisdesmosidic saponins. Five of these compounds were reported for the first time in this species. The water extract of A. gypsophiloides exhibited the highest cytotoxicity among the tested extracts, with IC50 values of 23.6 and 31.9 μg/mL in CCR-CEM and CEM/ADR5000 cell lines, respectively.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
