Review
Biochemistry & Molecular Biology
Ziqiang Guan, Howard Goldfine
Summary: Studies of clostridia lipidomes show significant diversity among different species, even within the Clostridium sensu stricto group. Each clade of species within this group exhibits distinct polar lipids, which may play crucial roles in their survival and growth in specific environments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Beibei Duan, Eun-Sik Hong, Jung-Ah Shin, Yan Qin, Jeung-Hee Lee, Chi-Woo Lee, Ki-Teak Lee
Summary: The study found a positive correlation between fat content and phospholipid content in human milk, with fat droplet size having a smaller impact on fat content. Furthermore, the composition and content of different phospholipid species in human milk varied according to fat content.
Article
Pharmacology & Pharmacy
Saranya Ramadurai, Chloe Andrews, Sukhinder Cheema, Raymond Thomas, Carol L. Wagner, Sarbattama Sen
Summary: This study investigated the composition of ethanolamine-containing plasmalogens in breastmilk and their associations with maternal predictors. Higher maternal body mass index was found to be associated with lower levels of plasmalogens in breastmilk. Plasmalogens in breastmilk were shown to have an impact on infant anthropometrics but not on neurodevelopmental outcomes.
CLINICAL THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Eun-Sik Hong, Ji-Hyun Kim, Hee-Jin So, Eun-Ah Park, Ye-Lim Park, Jeung-Hee Lee, Jung-Ah Shin, Ki-Teak Lee
Summary: In this study, the compositions of plasmalogens and phospholipids in dried big head shrimp, opossum shrimp, mussel, and sea cucumber were qualitatively and quantitatively analyzed. Phosphatidyl choline (PtdCho) was found to be the most abundant phospholipid in big head shrimp, opossum shrimp, and mussel, while plasmalogen choline (PlsCho) was the most abundant in sea cucumber. Furthermore, the fatty acid composition of PlsCho was determined, revealing variations in the most abundant fatty acid among the different samples.
Article
Pharmacology & Pharmacy
Saranya Ramadurai, Chloe Andrews, Sukhinder Cheema, Raymond Thomas, Carol L. Wagner, Sarbattama Sen
Summary: The study investigated the composition of ethanolamine-containing plasmalogens in breastmilk and their associations with maternal predictors and infant development. Higher maternal body mass index was associated with lower levels of plasmalogens in breastmilk, while plasmalogen concentrations were related to infant fat mass index and fat-free mass index. No correlation was found between breastmilk plasmalogens and neurodevelopmental outcomes.
CLINICAL THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Katharina Lackner, Sabrina Sailer, Jan-Bert van Klinken, Eric Wever, Mia L. Pras-Raves, Adrie D. Dane, Masanori Honsho, Yuichi Abe, Markus A. Keller, Georg Golderer, Gabriele Werner-Felmayer, Yukio Fujiki, Frederic M. Vaz, Ernst R. Werner, Katrin Watschinger
Summary: AGMO degrades plasmanyl lipids, while PEDS1 synthesizes plasmalogens. Plasmalogens are associated with neurological diseases. AGMO-deficient mice show moderate accumulation of plasmanyl and plasmenyl lipids, while Peds1 knockout mice have reduced plasmenyl lipids but increased plasmanyl lipids. The rate-limiting enzyme FAR1 is not upregulated in Peds1-deficient mice.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biochemistry & Molecular Biology
Helena Beatriz Ferreira, Tania Melo, Andreia Monteiro, Artur Paiva, Pedro Domingues, M. Rosario Domingues
Summary: Multiple sclerosis is a neurodegenerative disease that causes disability in young adults, and has been associated with alterations in metabolism and lipid profile. This study reveals a distinctive lipid signature of multiple sclerosis, particularly in certain phospholipid species, and suggests that specific phospholipids may serve as potential biomarkers for clinical applications in multiple sclerosis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
Remi Karadayi, Charlotte Pallot, Stephanie Cabaret, Julie Mazzocco, Pierre-Henry Gabrielle, Denis S. Semama, Corinne Chantegret, Ninon Ternoy, Delphine Martin, Aurelie Donier, Stephane Gregoire, Catherine P. Creuzot-Garcher, Alain M. Bron, Lionel Bretillon, Olivier Berdeaux, Niyazi Acar
Summary: The study suggests that the accumulation of n-6 PUFAs and the decrease of n-3 PUFAs in the blood of preterm infants may be partly due to plasmalogens, which are associated with the development of retinopathy of prematurity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Larry D. Spears, Sangeeta Adak, Guifang Dong, Xiaochao Wei, George Spyropoulos, Qiang Zhang, Li Yin, Chu Feng, Donghua Hu, Irfan J. Lodhi, Fong-Fu Hsu, Rithwick Rajagopal, Kevin K. Noguchi, Carmen M. Halabi, Lindsey Brier, Annie R. Bice, Brian Lananna, Erik S. Musiek, Oshri Avraham, Valeria Cavalli, Jerrah K. Holth, David M. Holtzman, David F. Wozniak, Joseph P. Culver, Clay F. Semenkovich
Summary: Endothelium-derived ether lipids affect blood pressure, behavior, and neurodegeneration in mice.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Chemistry, Organic
Yiwen Ding, Chu Zhang, Min Zhou, Yu Xiang, Aijun Tong
Summary: In this study, a highly efficient fluorescent labeling method based on hetero-Diels-Alder cycloaddition reaction is developed for selective labeling and identification of Plasmalogens (Pls) from complex lipid samples. By combining this method with high-performance liquid chromatography, individual chromatographic signatures of Pls from human plasma samples can be accurately identified. This technique is cost-effective and simple in terms of instrumentation, suggesting its promising potential for early screening and diagnosis of diseases associated with Pls abnormalities.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Talat Bashir Ahmed, Merete Eggesbo, Rachel Criswell, Olaf Uhl, Hans Demmelmair, Berthold Koletzko
Summary: This study aimed to investigate the relationship between fatty acid (FA) and polar lipid species composition in human milk. The results showed that there were no differences in major FA, phosphatidylcholine, or sphingomyelin species percentages between milk with high or low fat content. However, milk with high fat content had lower ratios of phospholipid-to-total-FA and sphingomyelin-to-phosphatidylcholine compared to milk with low fat content.
Article
Agriculture, Multidisciplinary
Yue Shi, Binsong Han, Lina Zhang, Peng Zhou
Summary: Human and camel milk contain higher concentrations of OSs compared to bovine, caprine, and ovine milk. Camel milk is more similar to human milk in terms of OSs. The study provides insights into the potential applications of OSs in medical and functional foods based on the characteristics and concentrations of OSs in milk from different species.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Laurie C. Miller, Sumanta Neupane, Neena Joshi, Mahendra Lohani, Keshav Sah, Bhola Shrestha
Summary: The COVID-19 pandemic has negatively impacted the diet of children and families in small-holder farming households in low- and middle-income countries. Despite a decline in overall diet quality, households owning dairy animals and those producing more milk per day were able to mitigate this decline.
Article
Biochemistry & Molecular Biology
Kaushalya Amunugama, Matthew J. Jellinek, Megan P. Kilroy, Carolyn J. Albert, Valerio Rasi, Daniel F. Hoft, Michael G. S. Shashaty, Nuala J. Meyer, David A. Ford
Summary: This study identified novel very long carbon chain plasmalogens in human neutrophils, which undergo oxidation during activation to produce chlorolipid products. Elevated levels of these chlorolipids were found in septic patients, indicating their potential role in the pathophysiology of sepsis.
Article
Chemistry, Applied
Shaolei Wang, Siming Li, Baochao Hou, Baolei Li, Cristabelle De Souza, Mythili Ramachandran, Huaxi Yi, Lanwei Zhang, Kai Lin
Summary: This study measured the phospholipid composition of cow, goat, donkey, and yak milk and identified 33 fatty acids and 74 molecular species of phospholipids. The major fatty acids in the phospholipids of these animal milks were C16:0, C18:0, and C18:1, which were mainly saturated fatty acids. Additionally, the molecular species of phospholipids varied among the different animal milks, with 18:0/18:2 being the most abundant. The results of this study provide valuable insights into the functional and nutritional properties of phospholipids in different animal milks and can enhance their utilization.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Review
Food Science & Technology
Francisco J. Barba, Cyrielle Garcia, Amandine Fessard, Paulo E. S. Munekata, Jose M. Lorenzo, Aouatif Aboudia, Adbelouahab Ouadia, Fabienne Remize
Summary: Cactus Opuntia ficus indica is a widely distributed plant in arid regions, and its fruit and cladodes are processed into various food products. With its high antioxidant activity, rich nutritional content, and functional features, this cactus has great potential for applications in flour, bakery products, and fermented foods.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Lenie van Rossem, Henriette A. Smit, Martine Armand, Jonathan Y. Bernard, Hans Bisgaard, Klaus Bonnelykke, Signe Bruun, Barbara Heude, Steffen Husby, Henriette B. Kyhl, Kim F. Michaelsen, Ken D. Stark, Carel Thijs, Rebecca K. Vinding, Alet H. Wijga, Lotte Lauritzen
Summary: In this meta-analysis of seven European birth cohorts, no evidence was found to support the association between breast milk n-3 LC PUFAs and blood pressure in children.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Medicine, General & Internal
Pierre Daude, Patricia Ancel, Sylviane Confort Gouny, Alexis Jacquier, Frank Kober, Anne Dutour, Monique Bernard, Benedicte Gaborit, Stanislas Rapacchi
Summary: This study proposed an automated method for quantifying the area of epicardial adipose tissue (EAT) using deep learning segmentation with multi-frame fully convolutional networks (FCN) in cardiac magnetic resonance imaging (MRI). The method demonstrated comparable performance to inter-observers' bias and provided precise quantification of EAT area, which can assess patients' risk of EAT overload.
Article
Biology
Marion Nabot, Marie Guerin, Dharini Sivakumar, Fabienne Remize, Cyrielle Garcia
Summary: Bacteria can produce different types of homopolysaccharides, and the synthesis of these compounds is influenced by various factors. Controlling the catalyzing enzyme and environmental conditions can guide the production of specific polysaccharides in bacteria, which has applications in improving food texture.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Monique Bernard
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Nutrition & Dietetics
Wen Lun Yuan, Jonathan Y. Bernard, Martine Armand, Catherine Sarte, Marie Aline Charles, Barbara Heude
Summary: This study examined the association between maternal dairy product consumption and fatty acid levels in developing offspring. The results suggest that C15:0 could be a good biomarker for maternal dairy fat consumption in perinatal biofluids.
Article
Pediatrics
Aurelie Garbi, Martine Armand, Any-Alejandra Beltran-Anzola, Catherine Sarte, Veronique Brevaut-Malaty, Barthelemy Tosello, Catherine Gire
Summary: The use of vegetable oil for massage did not provide additional benefits for the development of premature newborns, nor did it change lipid metabolism or the status of polyunsaturated fatty acids, which does not support the existence of percutaneous absorption of oil lipids. The reason for the differences in nervonic acid and plasmalogen levels in red blood cells needs further exploration.
Review
Biochemistry & Molecular Biology
Norbert W. Lutz, Monique Bernard
Summary: This article provides a broad overview and critical review of a specific group of ex vivo and in vitro metabolic NMR spectroscopic methods. It discusses pitfalls in the literature and offers background information to guide the selection of methods. The article also compares these methods with other metabolic analysis protocols and discusses their relation.
Article
Food Science & Technology
Faith Seke, Vimbainashe E. Manhivi, Marie Guerin, Tinotenda Shoko, Stephen A. Akinola, Cyrielle Garcia, Fabienne Remize, Retha M. Slabbert, Dharini Sivakumar
Summary: This study focused on the co-encapsulation of Natal plum juice with Lactiplantibacillus plantarum 75 and evaluated their in vitro release. The results showed that this co-encapsulation system improved the survival rate of lactic acid bacteria and the bioaccessibility of cyanidin 3-sambubioside, and exhibited stability and controlled release.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Monique Bernard
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Charline Quiclet, Martine Armand, Herve Dubouchaud, Guillaume Vial, Eric Fontaine, Cecile Batandier, Karine Couturier
Summary: The perinatal exposome can modify offspring metabolism and health. This study aimed to evaluate the effects of maternal exercise during lactation on offspring pancreatic function and glucose homeostasis, as well as the potential link with changes in breast milk composition.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Cardiac & Cardiovascular Systems
Caroline Choquet, Pierre Sicard, Juliette Vahdat, Thi Hong Minh Nguyen, Frank Kober, Isabelle Varlet, Monique Bernard, Sylvain Richard, Robert G. Kelly, Nathalie Lalevee, Lucile Miquerol
Summary: The transcription factor Nkx2-5 plays a crucial role in the maturation and maintenance of a functional Purkinje fiber network in the cardiac conduction system. Deletion of Nkx2-5 in neonatal mice leads to hypoplasia and defects in the Purkinje fiber network, resulting in conduction defects and reduced cardiac function with age. These findings emphasize the importance of Nkx2-5 expression in postnatal development for the preservation of cardiac function and contraction synchrony.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anthony Tessier, Anthony J. Ruze, Isabelle Varlet, Estelle M. H. Laib, Emilien Royer, Monique Bernard, Angele Viola, Teodora-Adriana Perles-Barbacaru
Summary: This study aims to validate a quantitative time-resolved MRI technique for mapping the kinetics of contrast agent in the brain upon intraperitoneal administration. It was a prospective study using mice as an animal model.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Horticulture
Abacar Chakira, Cyrielle Garcia, Christian Soria, Jerome Minier, Marc Chillet
Summary: The study examines the chemical composition of ylang-ylang essential oils at different stages of flower development, finding qualitative and quantitative variations in the compounds. It shows that oxygenated compounds increase significantly with flower maturity, contributing more to fragrance, while terpenes decrease in value.
Article
Multidisciplinary Sciences
Alexandre Xerri, Frederic Gallardo, Frank Kober, Calypso Mathieu, Natacha Fourny, Thi Thom Tran, Jean-Louis Mege, Mervyn Singer, Nathalie Lalevee, Monique Bernard, Marc Leone
Summary: This study investigated the influence of hormonal status on cardiac function in septic female rats and found that ovariectomized rats showed a more significant decline in cardiac function after sepsis induction compared to control rats. The underlying mechanisms were related to inflammation, inhibition of the adrenergic pathway, and calcium efflux defects. A short-acting selective beta 1-adrenergic blocker, landiolol, improved cardiac function in ovariectomized rats but had deleterious effects in control rats.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
