期刊
FOOD CHEMISTRY
卷 132, 期 1, 页码 186-193出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2011.10.052
关键词
Ficus racemosa; High-fat diet-fed; STZ; DPP-IV; PPAR-gamma; PTB-1B; Glucose uptake; Bergenin
资金
- Board of Research and Nuclear Sciences, Department of Atomic Energy, Government of India [2003/36/27/BRNS/2014]
The present study was designed to investigate the effects of the ethanol extract of Ficus racemosa (FRE) on biochemical parameters in type 2-like diabetes, induced by a combination of standardised high-fat diet and low-dose streptozotocin (25 mg kg(-1), i.p.) in rats. To elucidate the mode of action of FRE, its effects on a battery of targets involved in glucose homeostasis was evaluated. FRE (200 and 400 mg kg(-1), p.o.), in a dose-dependent manner, altered the biochemical parameters and significantly improved glucose tolerance and HDL-c levels. In different bioassays, FRE showed inhibition of PTP-1B (IC50 12.1 mu g/mL) and DPP-IV (42.5%). FRE exhibited 82.6% binding to PPAR-gamma. Furthermore FRE exhibited stimulation of glucose uptake by skeletal muscles (hemi-diaphragm). Bergenin was quantified in bioactive-FRE by high-performance liquid chromatography (0.15% w/w). This is the first report demonstrating the effectiveness of F. racemosa stem bark in type 2 diabetes and targets involved in it. (C) 2011 Elsevier Ltd. All rights reserved.
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