期刊
FOOD CHEMISTRY
卷 135, 期 3, 页码 2029-2034出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.06.090
关键词
Lisosan G; Genotoxicity; Saccharomyces cerevisiae; Oxidative stress; ORAC
资金
- CNR (Consiglio Nazionale delle Ricerche, Italy)
- Agrisan (Larciano), Italy
In the present study the antimutagenic and antioxidant effects of a powder of grain (Lisosan G) in yeast Saccharomyces cerevisiae were studied. Results showed that Lisosan G treatment decreased significantly the intracellular ROS concentration and mutagenesis induced by hydrogen peroxide in S. cerevisiae D7 strain. The effect of Lisosan G was then evaluated by using superoxide dismutase (SOD) proficient and deficient strains of S. cerevisiae. Lisosan G showed protective activity in sod1 Delta and sod2 Delta mutant strains, indicating an in vivo antioxidant effect. A high radical scavenging activity of Lisosan G was also demonstrated in vitro using the oxygen radical absorbance capacity (ORAC) assay. The obtained results showed a protective effect of Lisosan G in yeast cells, indicating that its antioxidant capacity contributes to its antimutagenic action. (C) 2012 Elsevier Ltd. All rights reserved.
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