期刊
FOOD CHEMISTRY
卷 135, 期 4, 页码 2922-2929出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.07.085
关键词
Bioavailability; Dose-response; Olive oil phenols; Plasma phenolic metabolites
资金
- Spanish Ministry of Education and Science [AGL2009-13517-C03-01/ALI, AGL2009-13517-C03-02/ALI, AGL2009-13517-C03-03/ALI]
- Spanish Ministry of Health (FIS-FEDER) [PI021307]
- CIBERDEM
- CIBEROBN [CB06/03]
- University of Lleida
- DIUE de la Generalitat de Catalunya [2009 SGR 718]
Three different functional phenol-enriched virgin olive oils (FVOO) were prepared with a phenolic content of 250 (L-FVOO), 500 (M-FVOO), and 750 mg (H-FVOO) total phenols/kg. In a randomised, cross-over study with 12 healthy volunteers, the pharmacokinetics of phenolic biological metabolites was assessed. An increasing linear trend was observed for hydroxytyrosol sulfate, the main phenolic metabolite quantified in plasma, with C-max values of 1.35, 3.32, and 4.09 mu mol/l, and AUC mean values of 263.7, 581.4, and 724.4 mu mol/min for L-FVOO. M-FVOO, and H-FVOO, respectively. From our data an acute intake of phenol-enriched olive oils promotes a dose-dependent response of phenol conjugate metabolites in human plasma. Also, we point out for the first time hydroxytyrosol acetate sulfate as a main biological metabolite of hydroxytyrosol from olive oil ingestion. (C) 2012 Elsevier Ltd. All rights reserved.
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