Article
Plant Sciences
Minsol Choi, Jiwon Yoon, So Hwi Yang, Jae Kwang Kim, Sang Un Park
Summary: In this study, the optimal conditions for the hairy root culture of Salvia plebeia were determined, and its growth and accumulation of phenolic compounds were evaluated. The results showed that hairy roots cultured under optimal conditions exhibited enhanced phenolic compound accumulation and antioxidant activity, making them potential sources of antioxidants.
Article
Plant Sciences
Gulderen Yilmaz, Nuraniye Eruygur, Gulnur Eksi Bona, Mehmet Bona, Mehmet Akdeniz, Mustafa Abdullah Yilmaz, Abdulselam Ertas
Summary: In this study, the methanol extracts of five Salvia taxa were investigated for their antioxidant activity and enzyme inhibitory potentials. The S. aytachii extract showed the highest total phenolic and flavonoid contents, suggesting its potential for further phytochemical research.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Nadjat Righi, Sabah Boumerfeg, Amirouche Deghima, Pedro A. R. Fernandes, Elisabete Coelho, Faiza Baali, Susana M. Cardoso, Manuel A. Coimbra, Abderrahmane Baghiani
Summary: The hydromethanolic extract of Salvia verbenaca showed strong antioxidant and anti-inflammatory activities both in vitro and in vivo, with no acute/subacute toxicity effects on mice. This indicates its potential as a safe and effective option for wound healing and anti-ulcer treatments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Ranabir Sahu, Pritha Kundu, Avinash Sethi
Summary: In this study, two methods, hexane and supercritical carbon dioxide fluid extraction (SC-CO2), were used to extract phenolic acids from wheat whole grain, bran, and flour. SC-CO2 extraction yield higher oil content than hexane extraction, and the total phenolic content and individual phenolic acids content were significantly higher in SC-CO2 defatted wheat whole grain samples compared to hexane extraction. The wheat grain contained abundant ferulic acid and p-coumaric acid as phenolic acids, leading to elevated antioxidant and enzyme inhibitory activities in the defatted samples. Positive correlation was found between total phenolic content and antioxidant/enzyme inhibitory activities.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sayyedeh Fatemeh Askari, Razieh Avan, Zahra Tayarani-Najaran, Amirhossein Sahebkar, Samira Eghbali
Summary: Salvia is the largest genus of the Lamiaceae family, with over 900 species worldwide and about 60 species in Iran, 17 of which are endemic. Iranian Salvia species have a wide range of pharmacological activities, such as antidiabetic, antioxidant, antimicrobial, cytotoxic, and anti-inflammatory effects, and are traditionally used to treat various diseases.
Article
Chemistry, Applied
Jin Hwan Lee, Eun Young Seo, Young Min Lee
Summary: This research compares the nutritional constituents (isoflavone; anthocyanin; protein; fatty acid; oil) and biological properties (antioxidant, anti-aging) of black soybeans in whole seeds and seed coats for different crop years. Isoflavones and anthocyanins varied significantly among cultivars and growth years, while other components showed slight variations. The seed coats had higher levels of phenolic compounds and exhibited stronger antioxidant, tyrosinase inhibition, and elastase inhibition activities compared to whole seeds. The Socheong cultivar had high isoflavone content, and the Geomjeong 2 cultivar had high anthocyanin content, making them potential sources for functional agents and new cultivars.
Article
Plant Sciences
Mariana Oalde Pavlovic, Stoimir Kolarevic, Jelena Dordevic, Jovana Jovanovic Maric, Tanja Lunic, Marija Mandic, Margareta Kracun Kolarevic, Jelena Zivkovic, Ana Alimpic Aradski, Petar D. Marin, Katarina Savikin, Branka Vukovic-Gacic, Biljana Bozic Nedeljkovic, Sonja Duletic-Lausevic
Summary: This study evaluated the genoprotective, antigenotoxic, and antitumor potential of extracts from Melissa officinalis, Mentha x piperita, Ocimum basilicum, Rosmarinus officinalis, Salvia officinalis, and Satureja montana. The extracts showed strong antioxidant and genoprotective effects, while also modulating the production of ROS and NO in tumor cells, leading to genotoxicity and decreased proliferation.
Article
Biochemistry & Molecular Biology
Hatice Kiziltas, Ahmet Ceyhan Goren, Saleh H. Alwasel, Ilhami Gulcin
Summary: This study investigated the chemical composition, antioxidant activity, and enzyme inhibitory activity of Dactylorhiza osmanica. The results showed that D. osmanica has a high phenolic content and exhibits significant antioxidant and enzyme inhibitory effects. These findings support the traditional food and medicinal uses of this plant.
Article
Plant Sciences
Ramazan Ceylan, Gokhan Zengin, Gokalp Ozmen Guler, Abdurrahman Aktumsek
Summary: Lathyrus species, including Lathyrus czeczottianus, are economically important for their use as food, fodder, and folk medicine. The water extract of L. czeczottianus showed strong antioxidant potential, while the ethyl acetate extract displayed good inhibitory activities on enzymes. L. czeczottianus has the potential to be a valuable source of bioactive molecules for pharmaceuticals, food and agriculture, and nutraceutical applications.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Chemistry, Multidisciplinary
Beatrix Sik, Erika Hanczne Lakatos, Viktoria Kapcsandi, Rita Szekelyhidi, Zsolt Ajtony
Summary: This study aimed to analyze the stability of rosmarinic acid in ethanolic tinctures of various herbs, and found a significant decrease in rosmarinic acid concentration during 6-month storage, with some being converted to caffeic acid. Results showed a linear relationship between DPPH values and total phenolic or rosmarinic acid contents, with rosemary, peppermint, and oregano exhibiting the greatest stability of the marker compound.
Article
Biochemistry & Molecular Biology
Yongfeng Xie, Meiling Ding, Xuecui Yin, Guanfeng Wang, Bin Zhang, Lingxiang Chen, Pengda Ma, Juane Dong
Summary: This study investigated the regulatory mechanism of phenolic acid biosynthesis in Salvia miltiorrhiza and identified SmMAPK3 as an important factor that enhances phenolic acid accumulation through a cascade regulation. These findings deepen the understanding of the post-transcriptional regulatory mechanisms of phenolic acid biosynthesis and provide new insights for metabolic engineering in S. miltiorrhiza.
Article
Biochemistry & Molecular Biology
Simon Vlad Luca, Krystyna Skalicka-Wozniak, Cosmin-Teodor Mihai, Adina Catinca Gradinaru, Alexandru Mandici, Nina Ciocarlan, Anca Miron, Ana Clara Aprotosoaie
Summary: This study evaluated the phytochemical profile and potential antimicrobial, antioxidant, and cytotoxic activities of ten Salvia species from Eastern Europe. The results showed that S. officinalis exhibited the highest antimicrobial and antioxidant activities, but no significant cytotoxic effect on human breast carcinoma cells.
Article
Biochemistry & Molecular Biology
Xue Ren, Xin Yuan, Shan-Shan Jiao, Xiao-Ping He, Hong Hu, Juan-Juan Kang, Shi-Hong Luo, Yan Liu, Kai Guo, Sheng-Hong Li
Summary: Eleven clerodane diterpenoids, including six undescribed compounds, were isolated from Salvia deserta. One of the compounds showed potential immunosuppressive activity.
Article
Food Science & Technology
Carmen Duque-Soto, Isabel Borras-Linares, Rosa Quirantes-Pine, Irene Falco, Gloria Sanchez, Antonio Segura-Carretero, Jesus Lozano-Sanchez
Summary: The medicinal and aromatic plants from Granada's high plateau, including Origanum bastetanum, Thymus zygis gracilis, Thymus longiflorus, Thymus membranaceus and Ziziphora hispanica, are found to be rich sources of bioactive compounds with potential antioxidant and antiviral properties, making them valuable for the food industry.
Article
Chemistry, Applied
Cristhian Santos Oliveira, Carlos Jose Alvarez, Marcia Regina Pereira Cabral, Maria Helena Sarragiotto, Marcos Jose Salvador, Maria Elida Alves Stefanello
Summary: Three new diterpenoids were isolated from Salvia lachnostachys Benth leaves, along with five known compounds. Compound 1 was the most active in terms of antioxidant capacity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Organic
Ismail Celik, Meryem Erol, Ozlem Arpaci, Fatma Senol, Ilkay Orhan
Summary: This study evaluated the in vitro inhibitory activity of benzoxazole derivatives with p-tert-butyl at position 2 and acetamide bridged 4-substituted piperazine/piperidine at position 5 against important targets in reducing the adverse effects of Alzheimer's disease. The most active compound, 1 g, inhibited BChE by 54 +/- 0.75% at a concentration of 50 mu M. Molecular docking studies showed that Schrodinger docking scores were more consistent. The compounds exhibited compatible ADME profiles and bioactivity scores with Lipinski and other limiting rules.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Review
Chemistry, Medicinal
Ilkay Erdogan Orhan, Abdur Rauf, Muhammad Saleem, Anees Ahmed Khalil
Summary: This review summarizes the potential therapeutic applications of natural plant extracts and their bioactive constituents as PDE inhibitors. The most promising class of compounds with PDE-inhibiting property belongs to phenolics, including flavonoids, while other plant compounds like coumarins, saponins, lignans, terpenes, anthraquinones, and alkaloids have also shown inhibitory effects. Further clinical studies exploring the synergistic use of different therapies are recommended to achieve multi-targeted results.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Serena Fiorito, Francesco Epifano, Lorenzo Marchetti, Lucia Palumbo, Ilkay Erdogan Orhan, Majid Sharifi-Rad, Salvatore Genovese
Summary: This comprehensive review explores the pharmacological activities and modulatory properties of O-Prenylcoumarins and their potential to regulate lipid and sugar metabolism. The study highlights their presence in common fruits and vegetables, emphasizing their nutraceutical role in promoting health.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Shynggys Sergazy, Anastassiya Vetrova, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz, Ahmet Kahraman, Jian-Ye Zhang, Mohamad Aljofan
Summary: This study is the first to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species. Four of the tested species showed potential antitumor action against all the tumor cells used, by inducing cellular defense mechanisms called autophagy and apoptosis.
Review
Chemistry, Medicinal
Fatma Sezer Senol Deniz, Gokcen Eren, Ilkay Erdogan Orhan
Summary: Sirtuins (SIRTs) are NAD(+)-dependent deacetylases involved in various biological processes, with SIRT1 being the most well-characterized. Flavonoids are reported to modulate SIRTs, particularly interacting frequently with SIRT1 and SIRT3. Popular flavonoid derivatives like resveratrol, quercetin, and catechin have shown potential in SIRT modulation.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Applied
Nurten Abaci, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan
Summary: Kombucha, a sour and sweet-tasted drink originated in China, is prepared through fermentation of black tea. It contains B complex vitamins, polyphenols, and organic acids, and has bioactivities such as antimicrobial, antioxidant, and anticancer effects.
Article
Biochemistry & Molecular Biology
Ilkay Erdogan Orhan, F. Sezer Senol Deniz, Ramin Ekhteiari Salmas, Sule Irmak, Ozden Ozgun Acar, Gurbet Celik Turgut, Alaattin Sen, Ana-Maria Zbancioc, Simon Vlad Luca, Adrianna Skiba, Krystyna Skalicka-Wozniak, Gabriela Tataringa
Summary: This study tested a series of synthetic coumarin derivatives for their inhibitory effects on enzymes associated with Alzheimer's disease and simulated their interactions with key amino acids. Coumarin compounds 9, 13, and 16 showed potential anti-Alzheimer properties.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Multidisciplinary Sciences
Mahmoud Fahmi Elsebai, Hazem A. Ghabbour, Ramin Ekhteiari Salmas, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz
Summary: In this study, a glycosidal flavonoid 1 was isolated from Wild Egyptian Artichoke, and its inhibitory activity against AChE and BChE enzymes, as well as its absolute configuration, were determined for the first time. Compound 1 showed potent inhibition against AChE and BChE, indicating its potential as a molecule against Alzheimer's disease.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Nurten Abaci, F. Sezer Senol Deniz, Ramin Ekhteiari Salmas, Fatma Uysal Bayar, Kenan Turgut, Ilkay Erdogan Orhan
Summary: The ethanol extracts of Salvia fruticosa Mill.'s leaves from two new cultivars, Uysal-SFU and Turgut-SFT, were found to be promising inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) relevant to Alzheimer's disease. The extracts showed IC50 values of 30.62 +/- 3.27 and 32.97 +/- 2.33 μg/mL against AChE for SFU and SFT, respectively, and IC50 values of 69.91 +/- 1.08 and 86.55 +/- 1.26 μg/mL against BChE. The essential oils in the extracts exhibited weak inhibition against AChE and no inhibition against BChE. Additionally, the extracts showed strong DPPH radical scavenging activity and ferric-reducing antioxidant power.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Chemistry, Physical
Bilal Ahmad Khan, Syeda Shamila Hamdani, Bshra A. Alsfouk, Syeda Abida Ejaz, Mubashir Aziz, Pervaiz Ali Channar, F. Sezer Senol Deniz, Ilkay Erdogan Orhan, Shahid Hameed, Aamer Saeed, Saquib Jalil, Jamshed Iqbal
Summary: This study synthesized a novel class of multi-targeted compounds and evaluated their inhibitory potential against cholinesterases and monoamine oxidases. Compound 16 showed the maximum inhibitory potential against all four targeted enzymes, indicating its potential as a lead molecule for the treatment of AD.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Medicinal
Abdulselam Ertas, Serkan Yigitkan, Ilkay Erdogan Orhan
Summary: Salvia species, particularly hydroalcoholic extracts and essential oils of S. officinalis and S. lavandulaefolia leaves, have shown positive effects on cognitive dysfunction in patients with mild to moderate Alzheimer's disease in clinical studies. However, further long-term clinical studies with larger sample sizes and standardized sage preparations are needed to validate these effects.
Article
Biochemistry & Molecular Biology
Lukasz Pecio, Mostafa Alilou, Solomiia Kozachok, Ilkay Erdogan Orhan, Gokcen Eren, Fatma Sezer Senol Deniz, Hermann Stuppner, Wieslaw Oleszek
Summary: The absolute configurations of spiro-flavostilbenoids found in the bark of Yucca schidigera were determined using density functional theory simulation. The compounds were found to be biosynthetic derivatives of (2R)-naringenin and trans-resveratrol or trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene. Gloriosaols were direct derivatives of yuccaols. Yuccaol B and gloriosaol A showed moderate inhibitory effects against acetyl-/butyrylcholinesterases.
Meeting Abstract
Physiology
Ahmet Onur Dastan, Okan Arihan, Asli San Dagli Gul, Gulderen Yilmaz, Aysen Erdem
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
