期刊
FOOD CHEMISTRY
卷 134, 期 3, 页码 1256-1262出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.01.086
关键词
Eugenia brasiliensis; Myrtaceae; Anthocyanins; Cyanidin; Delphinidin; IL-8; COPD
资金
- NIH-NHLBI [5SC1HL096016]
- NIH-NCCAM [F31AT00801]
- Spanish Ministry of Science and Innovation
Nine anthocyanins (1-9) from the edible fruits of Eugenia brasiliensis were identified by HPLC-PDA and LC-MS, and seven of these are described for the first time in this Brazilian fruit. Two of the major anthocyanins, delphinidin (8) and cyanidin (9), were studied for their inhibitory activity against chemokine interleukin-8 (IL-8) production before and after cigarette smoke extract (CSE) treatment of cells. In non-treated cells the amount of IL-8 was unchanged following treatment with cyanidin and delphinidin in concentrations 0.1-10 mu M. Both delphinidin (8) and cyanidin (9) decreased the production of IL-8 in treated cells, at 1 and 10 mu M, respectively. Delphinidin (8) demonstrated IL-8 inhibition in the CSE treated cells in a dose-dependent manner. (C) 2012 Elsevier Ltd. All rights reserved.
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